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Il Farmaco; edizione scientifica最新文献

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3-diazopyrroles: key intermediates in the synthesis of antineoplastic agents. 3-重氮吡咯:合成抗肿瘤药物的关键中间体。
Il Farmaco; edizione scientifica Pub Date : 1988-12-01 DOI: 10.1002/CHIN.198929326
A. Almerico, G. Cirrincione, E. Aiello, G. Dattolo
{"title":"3-diazopyrroles: key intermediates in the synthesis of antineoplastic agents.","authors":"A. Almerico, G. Cirrincione, E. Aiello, G. Dattolo","doi":"10.1002/CHIN.198929326","DOIUrl":"https://doi.org/10.1002/CHIN.198929326","url":null,"abstract":"","PeriodicalId":13279,"journal":{"name":"Il Farmaco; edizione scientifica","volume":"1 1","pages":"1047-52"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82895980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
3-diazopyrroles: key intermediates in the synthesis of antineoplastic agents. 3-重氮吡咯:合成抗肿瘤药物的关键中间体。
Il Farmaco; edizione scientifica Pub Date : 1988-12-01
A M Almerico, G Cirrincione, E Aiello, G Dattolo
{"title":"3-diazopyrroles: key intermediates in the synthesis of antineoplastic agents.","authors":"A M Almerico, G Cirrincione, E Aiello, G Dattolo","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13279,"journal":{"name":"Il Farmaco; edizione scientifica","volume":"43 12 Suppl","pages":"1047-52"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14374677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The chemistry of trazodone. 曲唑酮的化学性质。
Il Farmaco; edizione scientifica Pub Date : 1988-12-01
L Baiocchi
{"title":"The chemistry of trazodone.","authors":"L Baiocchi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13279,"journal":{"name":"Il Farmaco; edizione scientifica","volume":"43 12 Suppl","pages":"1053-62"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14206638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
3,5-Diphenyl-1H-pyrazole derivatives. II--N-substituted 1-(2-aminoethyl)-3,5-diphenyl-1H-pyrazoles and their 4-bromo derivatives with analgesic and other activities. 3, 5-Diphenyl-1H-pyrazole衍生品。具有镇痛和其他活性的II- n -取代1-(2-氨基乙基)-3,5-二苯基- 1h -吡唑及其4-溴衍生物。
Il Farmaco; edizione scientifica Pub Date : 1988-12-01
F Bondavalli, O Bruno, A Ranise, P Schenone, S Russo, A Loffreda, V De Novellis, C Lo Sasso, E Marmo
{"title":"3,5-Diphenyl-1H-pyrazole derivatives. II--N-substituted 1-(2-aminoethyl)-3,5-diphenyl-1H-pyrazoles and their 4-bromo derivatives with analgesic and other activities.","authors":"F Bondavalli,&nbsp;O Bruno,&nbsp;A Ranise,&nbsp;P Schenone,&nbsp;S Russo,&nbsp;A Loffreda,&nbsp;V De Novellis,&nbsp;C Lo Sasso,&nbsp;E Marmo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The synthesis of N-substituted 1-(2-aminoethyl)-3,5-diphenyl-1H-pyrazoles and their 4-bromo derivatives (V) by reaction of primary and secondary amines with the tosylates of 1-(2-hydroxyethyl)-3,5-diphenyl-1H-pyrazole and its 4-bromo derivative is described. Some of compounds (V) showed a remarkable analgesic activity in mice. Moreover, the above compounds usually exhibited moderate hypotensive, bradycardiac and antiinflammatory activities in rats, infiltration anesthesia in mice, as well as a weak platelet antiaggregating activity in vitro.</p>","PeriodicalId":13279,"journal":{"name":"Il Farmaco; edizione scientifica","volume":"43 12","pages":"1019-34"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14376784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolation and structure determination of the main related substances of teicoplanin, a glycopeptide antibiotic. 糖肽类抗生素teicoplanin主要有关物质的分离与结构测定。
Il Farmaco; edizione scientifica Pub Date : 1988-12-01
A Cometti, G G Gallo, J Kettenring, G B Panzone, G Tuan, L F Zerilli
{"title":"Isolation and structure determination of the main related substances of teicoplanin, a glycopeptide antibiotic.","authors":"A Cometti,&nbsp;G G Gallo,&nbsp;J Kettenring,&nbsp;G B Panzone,&nbsp;G Tuan,&nbsp;L F Zerilli","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Teicoplanin is a complex formed by five closely related glycopeptides and by a small amount of a hydrolysis product. Minor quantities of related substances are also present. Two of them (named RS-1 and RS-2) were isolated and purified starting from the tailing fractions of a teicoplanin batch. Preparative reversed-phase liquid chromatography on large low-pressure and medium high-pressure scales, concentration, desalting, and freeze-drying steps were applied. 300 mg of RS-1 and 900 mg of RS-2 were obtained in a purity grade (about 90%) sufficient for structural investigation. Starting from considerations on the HPLC retentivity and on biosynthesis, the structures were assigned on the basis of 1H-N.M.R. spectra and homonuclear CO-SY 2D experiments, FAB-MS spectrometry, and GC-MS of the esters of the fatty acids obtained by hydrolysis. RS-1 and RS-2 are teicoplanins having 10-methyl-undecanoic acid and n-dodecanoic acid, respectively as fatty acid chains. No major difference in the in vitro activity of these teicoplanins emerged in comparison with teicoplanin complex.</p>","PeriodicalId":13279,"journal":{"name":"Il Farmaco; edizione scientifica","volume":"43 12","pages":"1005-18"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14113479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Penems: conception and evolution of a new class of beta-lactam antibiotics. 一类新的-内酰胺类抗生素的概念和演变。
Il Farmaco; edizione scientifica Pub Date : 1988-12-01
E Perrone
{"title":"Penems: conception and evolution of a new class of beta-lactam antibiotics.","authors":"E Perrone","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13279,"journal":{"name":"Il Farmaco; edizione scientifica","volume":"43 12 Suppl","pages":"1075-95"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14206640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How medicinal chemistry triggers fundamental research in heterocyclic chemistry. The chemistry of 4-hydroxy-2-pyrones and a new imidazole antifungal agent. 药物化学如何引发杂环化学的基础研究。4-羟基-2-吡咯酮和一种新型咪唑类抗真菌剂的化学性质。
Il Farmaco; edizione scientifica Pub Date : 1988-12-01 DOI: 10.1002/CHIN.198929334
M. Moreno‐Mañas
{"title":"How medicinal chemistry triggers fundamental research in heterocyclic chemistry. The chemistry of 4-hydroxy-2-pyrones and a new imidazole antifungal agent.","authors":"M. Moreno‐Mañas","doi":"10.1002/CHIN.198929334","DOIUrl":"https://doi.org/10.1002/CHIN.198929334","url":null,"abstract":"The results herein described point out that the efforts devoted to the preparation of significant molecules can not be separated from those devoted to the discovery of new synthetic methodologies and to the solution of fundamental chemical problems. The border between basic and applied research vanishes very frequently.","PeriodicalId":13279,"journal":{"name":"Il Farmaco; edizione scientifica","volume":"1 1","pages":"1165-73"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79882480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
[Synthesis, antisecretory, and anti-ulcer activity of new 5-arylidene-2-ureidoalkyl-3-pyridazinones]. [新型5-芳基烯-2-脲烷烷基-3-吡嗪酮的合成、抗分泌和抗溃疡活性]。
Il Farmaco; edizione scientifica Pub Date : 1988-12-01
C Rubat, P Coudert, J Couquelet, P Bastide, J Bastide
{"title":"[Synthesis, antisecretory, and anti-ulcer activity of new 5-arylidene-2-ureidoalkyl-3-pyridazinones].","authors":"C Rubat,&nbsp;P Coudert,&nbsp;J Couquelet,&nbsp;P Bastide,&nbsp;J Bastide","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>By addition of methylisocyanate to 5-arylidene 2-aminoalkyl 3-pyridazinones a series of derivatives substituted in the 2-position by an ureidoalkyl moiety was obtained in good yields. Gastric antisecretory and anti-ulcer activities of these new compounds were evaluated. The influence of the substituents attached to the pyridazine ring was discussed.</p>","PeriodicalId":13279,"journal":{"name":"Il Farmaco; edizione scientifica","volume":"43 12","pages":"1035-44"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14376785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Spectral and thermal characterization of cephalosporins. I. Cefadroxil and cefalexin]. 头孢菌素的光谱和热表征。1 .头孢丙塞和头孢氨苄]。
Il Farmaco; edizione scientifica Pub Date : 1988-12-01
J L Delarbre, L Maury, J Rambaud, B Pauvert, M S de Buochberg
{"title":"[Spectral and thermal characterization of cephalosporins. I. Cefadroxil and cefalexin].","authors":"J L Delarbre,&nbsp;L Maury,&nbsp;J Rambaud,&nbsp;B Pauvert,&nbsp;M S de Buochberg","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cefadroxil and cefalexine were characterized by thermal and spectral analysis. A vibrational study by infrared and Raman spectroscopies was made to connect the structural data with the antibacterial activity.</p>","PeriodicalId":13279,"journal":{"name":"Il Farmaco; edizione scientifica","volume":"43 12","pages":"961-78"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14376787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Penems: conception and evolution of a new class of beta-lactam antibiotics. 一类新的-内酰胺类抗生素的概念和演变。
Il Farmaco; edizione scientifica Pub Date : 1988-12-01 DOI: 10.1002/CHIN.198929328
E. Perrone
{"title":"Penems: conception and evolution of a new class of beta-lactam antibiotics.","authors":"E. Perrone","doi":"10.1002/CHIN.198929328","DOIUrl":"https://doi.org/10.1002/CHIN.198929328","url":null,"abstract":"","PeriodicalId":13279,"journal":{"name":"Il Farmaco; edizione scientifica","volume":"15 1","pages":"1075-95"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78254328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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