Indian Journal of Paediatric Dermatology最新文献

{"title":"Pediatric teledermatology: Current concepts and road ahead","authors":"A. Mohta, B. Ghiya, R. Mehta","doi":"10.4103/ijpd.ijpd_146_21","DOIUrl":"https://doi.org/10.4103/ijpd.ijpd_146_21","url":null,"abstract":"","PeriodicalId":13275,"journal":{"name":"Indian Journal of Paediatric Dermatology","volume":"23 1","pages":"328 - 329"},"PeriodicalIF":0.2,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48885062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strategies to enhance pediatric clinical trial participation","authors":"K. Manobalan, Divya Gupta","doi":"10.4103/ijpd.ijpd_79_22","DOIUrl":"https://doi.org/10.4103/ijpd.ijpd_79_22","url":null,"abstract":"","PeriodicalId":13275,"journal":{"name":"Indian Journal of Paediatric Dermatology","volume":"23 1","pages":"268 - 270"},"PeriodicalIF":0.2,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41716244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The diagnostic dilemma of rothmund-thomson syndrome Type II: A rare disorder with a novel mutation in the RECQL4 gene in an Indian Boy","authors":"Manisha Goyal, Lalit Bharadia, Ashok K. Gupta, U. Kotecha","doi":"10.4103/ijpd.ijpd_149_21","DOIUrl":"https://doi.org/10.4103/ijpd.ijpd_149_21","url":null,"abstract":"Rothmund-Thomson syndrome (RTS) is a rare autosomal recessive disorder caused by homozygous or compound heterozygous mutations in RECQL4 gene and has characteristic clinical features of poikiloderma, congenital bone defects, gastrointestinal disturbances such as chronic diarrhea and vomiting, and an increased susceptibility to malignancy. A 2½-year-old Indian boy presented with reticulate hyperpigmented erythema with superimposed hypopigmented atrophic macular lesions over the cheeks and diffuse background hyperpigmentation with multiple discrete atrophic hypopigmented macules of variable size over the abdomen and extensor aspects of the forearms. X-rays suggested metaphyseal irregularity around knee joint and radioulnar synostosis. Whole-exome sequencing was suggestive of a de novo novel RECQL4 gene mutation causing RTS Type II. There is an overlapping of clinical features of the group of syndrome associated with skin lesions, skeletal, and gastric manifestations. All these conditions present a challenge to the clinician. Thus, molecular diagnosis is the only way to resolve these phenotypically similar conditions. This report expands the RECQL4 gene pathogenic mutations spectrum.","PeriodicalId":13275,"journal":{"name":"Indian Journal of Paediatric Dermatology","volume":"23 1","pages":"322 - 324"},"PeriodicalIF":0.2,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46415358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individualized dupilumab therapy in the treatment of pediatric patients with severe atopic dermatitis: Case series in a Malaysian Tertiary Center","authors":"Wai L. Lee, S. Nordin, Sabeera Begum Kader Ibrahim, K. Leong","doi":"10.4103/ijpd.ijpd_177_21","DOIUrl":"https://doi.org/10.4103/ijpd.ijpd_177_21","url":null,"abstract":"To look at patient characteristics, response to dupilumab, and adverse events due to treatment. This was a retrospective review of all pediatric patients on dupilumab and topical corticosteroids for severe atopic dermatitis in Paediatric Dermatology Clinic, Women and Children Hospital, Kuala Lumpur, from 2020 to 2021. In this cohort, 50% achieved Eczema area and severity index (EASI) -75 by week 12, 25% at week 16, and 25% at week 56. Three of four patients achieved EASI-75 at a median of 12 weeks of treatment, despite not receiving loading doses of dupilumab. None of our patients had conjunctivitis or upper respiratory tract infection while treated with dupilumab. In conclusion, dupilumab is a safe and effective drug to induce remission in severe pediatric eczema, without undesirable side effects in our cohort. In a resource-limited setting, individualized treatment regimen without loading doses is as effective as fixed-dose regimens with loading doses to achieve EASI-75.","PeriodicalId":13275,"journal":{"name":"Indian Journal of Paediatric Dermatology","volume":"23 1","pages":"309 - 313"},"PeriodicalIF":0.2,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43389576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aeroallergen sensitization predominates in children with atopic dermatitis","authors":"HM Thilanka Seneviratne, KM K. Somaratne, Subhani Brabaharan, GDilan Dileepa Jayarathne Bandara, AR. T Vindya Alahakoon, Priyanka Senevivikrama, PV Rangith Kumarasiri","doi":"10.4103/ijpd.ijpd_160_21","DOIUrl":"https://doi.org/10.4103/ijpd.ijpd_160_21","url":null,"abstract":"Background: Children with atopic dermatitis (AD) suffer from frequent flare-ups. Correct identification of allergens responsible for flare-ups is important in managing AD. Suspecting food allergens as culprits may result in unnecessary food restrictions which adversely affect the growth of these children. In view of this fact, we aimed to assess the allergen sensitization pattern of children with AD in Sri Lanka. Objective: The objective is to assess the food and aeroallergen sensitization pattern of children with AD. Materials and Methods: This study was conducted among 100 consecutive patients refereed to the dermatology clinics of a specialized children's hospital and a tertiary care hospital with the clinical diagnosis of AD. Age ranged from 1 to 18 years. All underwent a Skin prick test (SPT), using prick test solutions for house dust mite Dermatophagoids pteronyssinus (HDM-DP), Aspergillus fumigatus (AF), cat epithelia (CE), cow's milk (CM), egg white (EW), and peanut. Results: Of 100 patients 53.0% had positive SPT for HDM-DP. 15.0% were positive for CE, 9.0% positive for AF. All above three are aeroallergens, food allergen sensitivities were 9.0% for CM, 2.0% for EW, and 1.0% for peanuts. It is of note that the wheal size of HDM-DP SPT showed a very strong correlation with the age of the subject (R2 = 0.0723, P = 0.007). Conclusion: Aeroallergen sensitization predominate over food allergen sensitization in children with AD. HDM and CE were the most common aeroallergen sensitivities. The wheal size of HDM-DP had a very strong positive correlation with age.","PeriodicalId":13275,"journal":{"name":"Indian Journal of Paediatric Dermatology","volume":"23 1","pages":"282 - 287"},"PeriodicalIF":0.2,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49287198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paederus dermatitis' outbreak in residential hostels – A retrospective clinical study","authors":"S. Chintagunta, Priyanka S. Jaju, Sagar Kotagiri","doi":"10.4103/ijpd.ijpd_157_20","DOIUrl":"https://doi.org/10.4103/ijpd.ijpd_157_20","url":null,"abstract":"Introduction: Paederus dermatitis is an acute irritant dermatitis caused by accidental crushing of an insect belonging to the genus Paederus, releasing the vesicant pederin. It is commonly seen in the rainy season, especially in tropical regions. Methods: The aim of this study is to analyze the epidemiological and clinical findings of paederus dermatitis and factors associated with this condition in patients attending the dermatology, venereology and leprosy (DVL) department at a tertiary care hospital. This is a 3-year retrospective study from November 2016 to December 2019. This study was undertaken as a large number of cases with similar complaints attended D.V.L outpatient department during the same period (November–January) in 3 consecutive years. A total of 120 girls clinically diagnosed with paederus dermatitis residing in residential girls' hostels were included in the study. All the cases were evaluated using a standard pro forma which included a detailed history and clinical examination. All the patients were treated appropriately and control measures were advised to prevent further attacks. Patients were followed up until the lesions healed for 2 weeks. Results: Age of the children ranged from 10 to 16 years. The mean age of patients was 13.4 years. The majority of the cases were reported in November (57) and December (42) for 3 consecutive years and the remaining cases were observed randomly during the study period. Most of the patients presented within 48–96 h of lesion onset. The chief complaints were redness of the skin with itching and burning. The most common presentation was widespread erythema, edema, erosions, and desquamation involving larger areas, not localized which is uncommon with paederus dermatitis. Facial involvement is significant and observed in 99 (82.5%) cases. In addition to the face, other sites affected were the neck in 82 (68.3%), forearms in 41 (34.16%), and upper trunk in 30 (25%) patients. Constitutional symptoms although mild were reported in 3% of patients. Conclusion: An atypical variant of paederus dermatitis was observed in the majority of the cases with diffuse erythematous and desquamative lesions predominantly involving the face and neck. A careful history and awareness about varied clinical features will help in early diagnosis and to undertake preventive measures.","PeriodicalId":13275,"journal":{"name":"Indian Journal of Paediatric Dermatology","volume":"23 1","pages":"292 - 296"},"PeriodicalIF":0.2,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48309633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicoepidemiological profile of childhood leprosy in a Tertiary Care Hospital of North Karnataka","authors":"S. Parsam, Ramesh Kadi","doi":"10.4103/ijpd.ijpd_47_21","DOIUrl":"https://doi.org/10.4103/ijpd.ijpd_47_21","url":null,"abstract":"Background: Childhood leprosy is an indicator of ongoing transmission of the disease. The prevalence rate of pediatric leprosy is considered an important epidemiological index for determining the level of transmission of the disease. Our aim was to estimate the proportion of leprosy cases among children aged 0–14 years in our tertiary care hospital. Methods: A retrospective study was carried out for a period of 4 years from January 2017 to December 2020. Secondary data were collected from leprosy records pertaining to childhood leprosy (aged between 0 and 14 years). Only new cases presented during the period were included. Details of the patients such as age, sex, family history, number and site of lesions, nerve involvement, reactions, and deformities were noted. Slit-skin smear and biopsy findings were tabulated and descriptive analysis was done. Results: Fifty-five cases (9.54%) of childhood leprosy were diagnosed. Majority of the cases were in the age group of 10–14 years. The most common leprosy type was borderline tuberculoid found in 42 patients (76.36%). Forty-nine patients (89.09%) had paucibacillary (PB) and 6 (10.91%) had a multibacillary type. The most common presenting symptom was patch (61.8%). Eleven patients had a family history. Clinicopathological correlation was observed in 50 (90%) patients. Lepra reactions were seen in six (10.9%) patients and two deformities in three patients. Conclusion: The proportion of pediatric leprosy cases was 11.61% in 2017 and decreased to 6.45% in 2020. PB type is the most common type. To achieve zero childhood leprosy cases, thorough follow-up and contact tracing of adult leprosy patients, early diagnosis of childhood leprosy to prevent disabilities is the need of the hour.","PeriodicalId":13275,"journal":{"name":"Indian Journal of Paediatric Dermatology","volume":"23 1","pages":"288 - 291"},"PeriodicalIF":0.2,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42671385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chikungunya Rickettsial Coinfection","authors":"P. Sookaromdee, V. Wiwanitkit","doi":"10.4103/ijpd.ijpd_164_21","DOIUrl":"https://doi.org/10.4103/ijpd.ijpd_164_21","url":null,"abstract":"","PeriodicalId":13275,"journal":{"name":"Indian Journal of Paediatric Dermatology","volume":"23 1","pages":"265 - 265"},"PeriodicalIF":0.2,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43889637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mixed Type I and II Pigmented Fungiform Papillae of the Tongue: A Scary-Looking Innocuous Condition","authors":"S. Mani","doi":"10.4103/ijpd.ijpd_11_22","DOIUrl":"https://doi.org/10.4103/ijpd.ijpd_11_22","url":null,"abstract":"","PeriodicalId":13275,"journal":{"name":"Indian Journal of Paediatric Dermatology","volume":"23 1","pages":"249 - 250"},"PeriodicalIF":0.2,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44071320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful use of acitretin in an indian child with lipoid proteinosis","authors":"Shraddha Kote, Apoorva D. Chopkar, B. Supekar, J. Mukhi","doi":"10.4103/ijpd.ijpd_95_21","DOIUrl":"https://doi.org/10.4103/ijpd.ijpd_95_21","url":null,"abstract":"Introduction: Lipoid proteinosis is a rare autosomal recessive disease, characterized by deposition of Periodic Acid‒Schiff-positive hyaline material in the skin, mucous membrane of the upper aerodigestive tract, and different organs of the body, resulting in varied clinical manifestations. Case Report: We report a case of lipoid proteinosis in a 7-year-old boy who responded well to oral acitretin therapy. Discussion: Lipoid proteinosis is a rare disease entity, and very few reports have been mentioned in the literature based on its treatment modalities, with each treatment showing varied success rates. Oral acitretin can prove useful in cases of failure or inadequate response to other treatment, as seen in our case.","PeriodicalId":13275,"journal":{"name":"Indian Journal of Paediatric Dermatology","volume":"23 1","pages":"238 - 241"},"PeriodicalIF":0.2,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47820979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}