Sudan journal of medical sciences最新文献_第3页

Expression of Programmed Death Ligand-1 and Correlation with Clinicopathological Features and CD8 Infiltration in Breast Cancer 程序性死亡配体-1在乳腺癌中的表达及其与临床病理特征和CD8浸润的关系

Sudan journal of medical sciences Pub Date : 2023-06-30 DOI: 10.18502/sjms.v18i2.13602

S. Salih, M. Abdelaziz, Altaf S. Mosad, Ibtihal M. Abdelhag, Elmassry Re, Nadia Eldawi

{"title":"Expression of Programmed Death Ligand-1 and Correlation with Clinicopathological Features and CD8 Infiltration in Breast Cancer","authors":"S. Salih, M. Abdelaziz, Altaf S. Mosad, Ibtihal M. Abdelhag, Elmassry Re, Nadia Eldawi","doi":"10.18502/sjms.v18i2.13602","DOIUrl":"https://doi.org/10.18502/sjms.v18i2.13602","url":null,"abstract":"Background: Breast cancer (BC) is considered one of the most diversified types of tumors, characterized by a high mutational burden in the tumor milieu and a lack of immune cell makeup. The programmed death receptor-1 (PD -1)/programmed death ligand-1 (PD -L1) axis has been identified as a new target in the field of immunotherapy because, when activated, they worsen the future scenarios of the disease by helping tumor cells (TC) to escape immune surveillance. This study aims to investigate the expression of PD-L1 in BC tissues from Sudanese women and correlate the expression with clinicopathological features and the infiltration of CD8+T lymphocytes by immunohistochemistry (IHC). \u0000Methods: One hundred and fifty archived BC blocks were collected from the National Public Health Laboratory from January 2019 to August 2020. Data regarding age, TNM staging, grade, and hormonal status were considered. Tissue sections were examined using IHC to determine the expression of PD-L1 and CD8. \u0000Results: Among one hundred and fifty BC samples, 73 (48.7%) were TNBCs, and 77 (51.3%) were hormone-positive BCs. PDL-1 was significantly associated with BC subtypes, especially TNBCs (P = 0.001), a similar significant association was shown with CD8 infiltration (P = 0.006). None of the clinicopathological features was associated with PD-L1 expression. \u0000Conclusion: PD-L1 expression is strongly associated with TNBC’s and linked to CD8+ cells infiltration to the tumor milieu. Moreover, no correlation has been observed between the expression of PD-L1 and clinicopathological features in this study.","PeriodicalId":132580,"journal":{"name":"Sudan journal of medical sciences","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124629823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inappropriate Prescribing of Cefixime 400 mg Every 12 Hours Dose 头孢克肟每12小时400mg处方不当

Sudan journal of medical sciences Pub Date : 2023-06-30 DOI: 10.18502/sjms.v18i2.13609

Durr-e-Shahwar Siddiqui

引用次数: 0

Exploring Work-related Anxiety Among Newly Graduated Nurses in the Riyadh Region 利雅得地区新毕业护士工作相关焦虑调查

Sudan journal of medical sciences Pub Date : 2023-06-30 DOI: 10.18502/sjms.v18i2.13604

Kholoud Alrashedi, Amira Boshra

{"title":"Exploring Work-related Anxiety Among Newly Graduated Nurses in the Riyadh Region","authors":"Kholoud Alrashedi, Amira Boshra","doi":"10.18502/sjms.v18i2.13604","DOIUrl":"https://doi.org/10.18502/sjms.v18i2.13604","url":null,"abstract":"Background: Work-related anxiety among nurses has been linked to various issues, including a heavy workload, work-related conflict, a lack of resources, and stress. This research aims to explore work-related anxiety among recently graduated nurses in Saudi Arabia’s Riyadh region. \u0000Methods: A descriptive, cross-sectional, and relational research design examined work-related anxiety among newly graduated nurses. A sample of 400 nurses was recruited from five Saudi hospitals in the Riyadh region. This study used the job anxiety scale ( JAS) as a study tool. The tool is a self-rating scale of 70 items for assessing job anxiety but only 25 items were applied to this research. A self-administered questionnaire was used to gather demographic information. \u0000Results: This study revealed that there was, overall, low work-related anxiety among the nurse participants. On the one hand, age, gender, educational qualification, job experience, workplace, and work scheduling (hours per week) were found to impact work-related anxiety substantially. On the other hand, work position, nationality, unit of care, and marital status were found to play no significant role in work-related anxiety. \u0000Conclusion: The study’s findings indicate the importance of paying more attention to workplace anxiety. As anxiety may affect nurses’ ability to attend to the needs of patients in their care units, addressing it can reduce burnout and the desire to quit. Changes in work processes, care models, and leadership may be effective in creating a supportive environment that decreases stress and anxiety, promote learning, and provides patients with optimal and safe nursing care. Health policymakers and nurse managers in Saudi Arabia should develop particular intervention programs to reduce work-related anxiety among newly graduated nurses. Managers must seek techniques that help to adapt the present environment to the needs of nurses, as well as approaches that offer newly graduating nurses essential assistance, such as clinical supervision.","PeriodicalId":132580,"journal":{"name":"Sudan journal of medical sciences","volume":"120 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126937630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronotype, Daytime Sleepiness, and Related Factors Effects on Skipping Classroom among Medical Students in Tabuk 时间类型、日间嗜睡及相关因素对Tabuk医科学生逃课的影响

Sudan journal of medical sciences Pub Date : 2023-06-30 DOI: 10.18502/sjms.v18i2.13601

Turki Aqahtani, A. Albalawi, J. Alotaibi, Atheer K. Alshareef, Tariq Alrasheed, H. Mirghani, Iman Mirza, Amerah Alatawi, H. Albalawi, Mohammed Sheik

{"title":"Chronotype, Daytime Sleepiness, and Related Factors Effects on Skipping Classroom among Medical Students in Tabuk","authors":"Turki Aqahtani, A. Albalawi, J. Alotaibi, Atheer K. Alshareef, Tariq Alrasheed, H. Mirghani, Iman Mirza, Amerah Alatawi, H. Albalawi, Mohammed Sheik","doi":"10.18502/sjms.v18i2.13601","DOIUrl":"https://doi.org/10.18502/sjms.v18i2.13601","url":null,"abstract":"Background: Lecture attendance is very critical in medical practice. Good sleep hygiene is crucial for academic performance. Therefore, this research aimed to assess the relationship between daytime sleepiness and the chronotype, and skipping the classroom. \u0000Methods: A cross-sectional study was conducted among medical Students in Tabuk from April 2022 to July 2022. Three hundred and thirty-four medical students were randomly selected. A standardized questionnaire based on the daytime sleepiness scale, morningness–eveningness questionnaire, and risk for skipping classrooms was used. The students detailed their sleeping habits for two weeks and then responded to the questionnaire distributed directly by the researchers who attended to solve any difficulties. \u0000Results: Out of the 334 students,74.7% skipped the classroom last month. The most common reason for absence was the lecturer directly reading from the slide show (72.8%), followed by late lectures (67.8%), lecturers’ presentation skills (65.6%), and lack of interest (57.9%). Daytime sleepiness was evident in 40.1% of the students and was associated with skipping lectures (Wald, 3.86, P-value, 0.049, and 95% CI, 0.19–0.91). The majority were intermediate chronotypes (66.4%), followed by evening chronotypes (24.2%) with no association with skipping classrooms. \u0000Conclusion: Skipping lectures is common among medical students in Tabuk City, Saudi Arabia; the causes were lecture timing, daytime sleepiness, and lecturers’ presentation skills. Most students were an intermediate chronotype that was not associated with classroom absence. Further larger multi-center studies are needed.","PeriodicalId":132580,"journal":{"name":"Sudan journal of medical sciences","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116954481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum Cytokine Levels As Critical Parameters in Early Diagnosis of Disease Progression in COVID-19: A Pilot Study 血清细胞因子水平作为COVID-19疾病进展早期诊断的关键参数:一项初步研究

Sudan journal of medical sciences Pub Date : 2023-06-30 DOI: 10.18502/sjms.v18i2.13603

Walaa Mohammedsaeed, Z. Alahmadey, N. Manzoor

{"title":"Serum Cytokine Levels As Critical Parameters in Early Diagnosis of Disease Progression in COVID-19: A Pilot Study","authors":"Walaa Mohammedsaeed, Z. Alahmadey, N. Manzoor","doi":"10.18502/sjms.v18i2.13603","DOIUrl":"https://doi.org/10.18502/sjms.v18i2.13603","url":null,"abstract":"Background: The severity of Coronavirus disease 2019 (COVID-19) has been proposed to be associated with cytokine dysregulation. A significant number of patients become serious and need intensive care in hospitals. \u0000Methods: The concentrations of cytokines interleukin (IL-6, IL-10) and tumor necrosis factor (TNF) were estimated using enzyme-linked immunosorbent assay (ELISA) in serum samples of 60 adult patients infected with SARS-CoV-2 along with 50 healthy controls of the same age. The mean age of the subjects was 50-52 years and included an equal number of males and females. The patients were further grouped as severe (38 patients) and non-severe cases (22 patients). \u0000Results: The mean serum cytokine levels were significantly higher in the COVID-19 patients than in the healthy controls. IL-6 was excessively elevated in comparison to IL-10 and TNF. Comparative analysis of severe versus non-severe cases revealed only slight alterations in the cytokine levels: IL-6 being the most elevated in severe cases. The concentration of the liver enzyme ALT was higher than AST in both severe and non-severe cases. The mean concentration of serum electrolytes (Na, K, and Ca) did not vary much between the patients and healthy controls. \u0000Conclusion: There was a significant positive correlation between the levels of cytokines serum biomarkers in COVID-19 patients. It may be suggested that early detection of cytokines, especially IL-6 and serum biomarkers can help predict disease prognosis and severity in COVID-19 patients.","PeriodicalId":132580,"journal":{"name":"Sudan journal of medical sciences","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124131177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial – The Importance of Peer Review and Guidelines for Becoming a Reviewer 编辑-同行评议的重要性和成为评审员的指导方针

Sudan journal of medical sciences Pub Date : 2023-06-30 DOI: 10.18502/sjms.v18i2.13597

Emily Choynowski

引用次数: 0

Review of Plastic and Reconstructive Surgery in a General Hospital Setting: Experience from a Developing Country 综合医院整形和重建手术综述:来自发展中国家的经验

Sudan journal of medical sciences Pub Date : 2023-03-31 DOI: 10.18502/sjms.v18i1.12868

M. Bakhiet, Elbadwai Hassan-Mohamed HabibAlla, Sami Mahmoud Assil, Mohamed Daffalla Awadalla Gismalla

{"title":"Review of Plastic and Reconstructive Surgery in a General Hospital Setting: Experience from a Developing Country","authors":"M. Bakhiet, Elbadwai Hassan-Mohamed HabibAlla, Sami Mahmoud Assil, Mohamed Daffalla Awadalla Gismalla","doi":"10.18502/sjms.v18i1.12868","DOIUrl":"https://doi.org/10.18502/sjms.v18i1.12868","url":null,"abstract":"Background: Plastic and reconstructive surgery in developing countries and underserved areas are significantly limited and face changes to start a proper service. This study presents a review of plastic surgery services and experiences in a district hospital located in an underserved area.Methods: This descriptive, retrospective, hospital-based study was conducted to review patients who presented to the plastic and reconstruction departments from January 2014 to January 2015. All patients seen in the outpatient clinic or emergency departments for plastic surgical consultation or management were included in the study.Results: The total of 403 cases fulfilled the inclusion criteria. The emergency surgical operation performed in our unit were distributed in the following descending order; fingertip injury (32%), cut wrist (12.7%), cut extensor tendon (9.9%), gunshot injuries (9.4%), fracture of a small bone of the hand (8.3%), and lower limb trauma. Surgery for congenital deformities constituted the most elective operation done in our unit (31.6 %), followed by tumor surgery (18.7%), burn surgery (17.3%), aesthetic surgery procedure (12.2%), and other miscellaneous cases (12.2%).Conclusion: This report demonstrates the efficacy of secondary hospital setting to accommodate a large volume of patients during the first year of establishment, and further predicting development needs, staff training, and governmental support.","PeriodicalId":132580,"journal":{"name":"Sudan journal of medical sciences","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114976404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Tale of 5Ms: Massive Uterine Leiomyoma Mimicking Ovarian Malignancy along with Multiple Fibroids Displaying Multiple Degenerations 5Ms的故事:巨大的子宫平滑肌瘤，类似卵巢恶性肿瘤，并伴有多发性肌瘤，表现为多发性变性

Sudan journal of medical sciences Pub Date : 2023-03-31 DOI: 10.18502/sjms.v18i1.12870

A. Koul, A. Shetty, Nidha Gaffoor, N. Murali, N. Prasad

引用次数: 0

The Confusing Tale of Foreign Body Gastric Outlet Obstruction 令人困惑的异物胃出口梗阻

Sudan journal of medical sciences Pub Date : 2023-03-31 DOI: 10.18502/sjms.v18i1.12869

Nader Mutwakel Osman

引用次数: 0

COVID-19 Vaccine and Role of Community Pharmacists COVID-19疫苗及社区药师的作用

Sudan journal of medical sciences Pub Date : 2023-03-31 DOI: 10.18502/sjms.v18i1.12873

Mayyda Asif Bajwa, K. Ashiq

引用次数: 0