Epilia: Epilepsy and Community最新文献_第2页

A Case of Left Temporal Lobe Epilepsy with Transient Neologism 左颞叶癫痫伴暂时性新词1例

Epilia: Epilepsy and Community Pub Date : 2022-03-31 DOI: 10.35615/epilia.2022.00340

Hye-Rim Shin

{"title":"A Case of Left Temporal Lobe Epilepsy with Transient Neologism","authors":"Hye-Rim Shin","doi":"10.35615/epilia.2022.00340","DOIUrl":"https://doi.org/10.35615/epilia.2022.00340","url":null,"abstract":"측두엽뇌전증(temporal lobe epilepsy)은 가장 흔한 종류의 뇌전 증으로, 발작 초점에 따라 다양한 증상을 나타낸다. 발작 초점 의 편측화(lateralization)는 우성 반구가 초점인 경우 실어증, 비 우성 반구가 초점인 경우 구토, 기침 등의 증상으로 발작이 나타 날 수 있다. 이중 전신강직간대발작(generalized tonic-clonic seizure)이나 의식장애 없이 언어장애만 보이는 경우 측두엽뇌전증의 진단에 어려움이 있다. 이에 저자는 의식장애 없이 일시적인 신어조작증 (neologism)으로 발현한 좌측 측두엽뇌전증 증례를 경험하였기 에 이를 보고하자 한다. Temporal lobe epilepsy causes seizures, the semiology of which varies depending on lateralization, including aphasic seizures in the dominant hemisphere. Herein, the author report a rare case of isolated aphasia in a patient with left temporal lobe epilepsy. An 85-year-old man visited the emergency room, presenting with aphasia for 15 hours. He did not have any past medical history of neurologic diseases, but had diabetes and hypertension. Brain magnetic resonance imaging revealed no structural lesion capable of causing language dysfunction. The symptoms improved spontaneously after 1 day, but recurrent episodes of aphasia and neologism occurred. The author performed 24-hour video electroencephalography monitoring, which suggested aphasic seizures, and intermittent rhythmic delta activities were observed in the left temporal area. Therefore, the author initiated treatment with an antiseizure medication, and the patient was discharged without neurologic complications.","PeriodicalId":132321,"journal":{"name":"Epilia: Epilepsy and Community","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115183214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retrospective Study of the Serum Level of Levetiracetam in Focal Epilepsy Related to Seizure Frequency and Side Effects in a Single Center: A Preliminary Study 单中心局灶性癫痫患者血清左乙拉西坦水平与发作频率和副作用的回顾性研究:初步研究

Epilia: Epilepsy and Community Pub Date : 2022-03-24 DOI: 10.35615/epilia.2022.00333

Hyoshin Son, S. Hwang, Kyung-Il Park, K. Jung, Sang Kun Lee

{"title":"Retrospective Study of the Serum Level of Levetiracetam in Focal Epilepsy Related to Seizure Frequency and Side Effects in a Single Center: A Preliminary Study","authors":"Hyoshin Son, S. Hwang, Kyung-Il Park, K. Jung, Sang Kun Lee","doi":"10.35615/epilia.2022.00333","DOIUrl":"https://doi.org/10.35615/epilia.2022.00333","url":null,"abstract":"Antiepileptic drugs (AEDs) are the basic treatment for epilepsy, and more than 20 kinds of drugs have been developed. Despite recent efforts for new drug discovery, approximately 30% of epilepsy patients suffer from drug-resistant, intractable seizures, even with multiple uses of AEDs. Other treatments, including surgical resection, ketogenic diet, and vagus nerve stimulation, Antiepileptic drugs (AEDs) are the basic treatment for epilepsy. Levetiracetam is known to affect the synaptic vesicle protein Sv2A, and its therapeutic range has been determined by experimental data and the literature. Considering the variability in clinical situations of each patient, or center-dependent, affecting seizure-free rate or adverse drug reactions, the subdivided therapeutic range of levetiracetam in epilepsy patients in a single center and their clinical characteristics were retrospectively analyzed in this study. Data were collected and retrospectively reviewed for patients who were diagnosed with epilepsy and visited the neurology outpatient center or were admitted to the Seoul National University Hospital from January 19, 2016 (when laboratory results for the concentration of levetiracetam began) to December 31, 2020. In this study, seizure freedom was achieved in >60% of all three groups with levetiracetam. Seizure-free rates tended to be higher with increasing levetiracetam concentrations; however, the statistical significance was not clear. The frequency of adverse drug reactions tended to be higher in the moderateand high-dose groups than in the low-dose group, although this difference was not statistically significant. Further studies with multiple factors and situations with a larger number of patients will guarantee the detailed implications of levetiracetam concentration related to drug efficacy and adverse drug reactions in real clinical situations.","PeriodicalId":132321,"journal":{"name":"Epilia: Epilepsy and Community","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124189625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Growing Need for a Transitional Age Program for Adolescents with Epilepsy in Korea 对韩国青少年癫痫过渡年龄规划的需求日益增长

Epilia: Epilepsy and Community Pub Date : 2022-02-21 DOI: 10.35615/epilia.2022.00319

Soonhak Kwon

{"title":"The Growing Need for a Transitional Age Program for Adolescents with Epilepsy in Korea","authors":"Soonhak Kwon","doi":"10.35615/epilia.2022.00319","DOIUrl":"https://doi.org/10.35615/epilia.2022.00319","url":null,"abstract":"일반적으로 소아는 정체된 상태로 있거나 혹은 퇴행하는 성인과 Epilepsy is one of the most common chronic neurological conditions in adolescents and young adults. The transition from the pediatric to the adult health care system can be a major challenge for most adolescents with epilepsy and their families. An unsuccessful transition can have a detrimental effect on them as individuals, as well as on their families. Generally speaking, pediatric epileptologists often feel uncomfortable when they deal with adolescents and young adults with epilepsy due to unfamiliarity with the common psychosocial problems and diseases of adulthood, while adult epileptologists are unfamiliar with childhood-specific epilepsy syndromes and, in many cases, patients’ previous history. Therefore, a transitional age program (TAP) is imperative to remediate the care gap and facilitate a smooth transition from the pediatric to the adult care system. A TAP is a set of processes that cover all the areas of the transition, including an assessment of transition readiness, rethinking the diagnosis using currently available tests, a reevaluation for neurobehavioral comorbidities, education, setting goals, and providing recommendations. Furthermore, the TAP should start as early as possible and must be comprehensive, flexible, and patient-centered. The cost-benefit effectiveness of TAPs requiring a multidisciplinary team has not been fully evaluated, but TAPs are becoming ubiquitous, especially in developed countries. I think that TAPs must be implemented in practical ways for adolescents and young adults with epilepsy at tertiary epilepsy centers as soon as possible in Korea.","PeriodicalId":132321,"journal":{"name":"Epilia: Epilepsy and Community","volume":"216 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134062661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epilepsy and COVID-19: Recent Findings and Considerations 癫痫和COVID-19:最近的发现和考虑

Epilia: Epilepsy and Community Pub Date : 2022-02-21 DOI: 10.35615/epilia.2022.00312

Hyun Kyung Kim

{"title":"Epilepsy and COVID-19: Recent Findings and Considerations","authors":"Hyun Kyung Kim","doi":"10.35615/epilia.2022.00312","DOIUrl":"https://doi.org/10.35615/epilia.2022.00312","url":null,"abstract":"2019년 12월 중국 후베이성 우한시에서 발생한 27명의 원인불 명 폐렴의 원인이 신종 코로나바이러스(severe acute respiratory syndrome coronavirus 2, SARS-CoV-2)로 밝혀진 후 2021년 11 월 현재까지도 coronavirus disease-2019 (COVID-19)의 확산은 전 세계적으로 지속되고 있다. 코로나바이러스는 단일 가닥 (single-stranded)의 RNA 바이러스로, 주로 호흡기를 침범하여 다양한 호흡기 질환을 일으킨다. 또한 코로나바이러스는 중추 신경계 및 말초 신경계에서의 신 경친화성(neurotropism)으로도 알려져 있다. COVID-19와 관 련된 신경학적 임상 증상에 대해 2020년 4월 우한에서의 첫 보 고 이후 수많은 연구들이 발표되고 있다. 이러한 신경학적 증상 에는 두통, 어지럼증, 근육통, 후각 저하와 같은 비교적 경한 증 As the coronavirus disease 2019 (COVID-19) outbreak enters its third year, it continues to impact social life and medical practice. Although respiratory symptoms are the most important clinical manifestations of COVID-19, COVID-19 can also cause various neurologic manifestations and disorders through neurotropism and collateral injuries. The effects of COVID-19 on seizures and epilepsy have been studied. The COVID-19 pandemic has led to changes in epilepsy care. In addition, concerns regarding the effectiveness and safety of the COVID-19 vaccine in patients with epilepsy are increasing. Epileptologists need to keep up with daily updates in the evidence regarding interactions between COVID-19 and epilepsy.","PeriodicalId":132321,"journal":{"name":"Epilia: Epilepsy and Community","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129396455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The History of Neuroscience 5: Discovery of the Neuron and Its Connections 神经科学的历史5:神经元及其连接的发现

Epilia: Epilepsy and Community Pub Date : 2022-02-11 DOI: 10.35615/epilia.2022.00326

S. K. Lee

{"title":"The History of Neuroscience 5: Discovery of the Neuron and Its Connections","authors":"S. K. Lee","doi":"10.35615/epilia.2022.00326","DOIUrl":"https://doi.org/10.35615/epilia.2022.00326","url":null,"abstract":"미경을 만든 것이다(무색 렌즈 자체는 1730년에 이미 개발되었 다). 이러한 현미경의 발달과 더불어 알코올과 기타 물질을 이용 Thanks to the invention of the microscope equipped with an achromatic lens, research on the histology of the nervous system flourished during the 19th century. Jan Evangelista Purkinje, together with Gabriel Valentin, first depicted individual nerve cells. Robert Remak, one of the most remarkable microscopists of the 19th century, made the pivotal discovery that the cell body (globule) and fibers arising from the globule formed a single unit. In addition to improvements in microscopes, a new method of visualizing nervous tissue was developed—namely, the silver staining method introduced by Camillo Golgi. Golgi could identify the types and delicate branches of axons. However, he believed that axons always directly merged with other axons, which was the basis of the reticular or nerve net theory. Santiago Ramón y Cajal, the founder of modern neuroscience, finally established the cornerstone of the neuron doctrine, according to which the nerve cell is the basic unit of the nervous system and information flows from unit to unit without direct fusion. This structure is called the synapse.","PeriodicalId":132321,"journal":{"name":"Epilia: Epilepsy and Community","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124645247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

National Epilepsy Care Center: Comprehensive National Support System for Epilepsy 国家癫痫护理中心:国家癫痫综合支持系统

Epilia: Epilepsy and Community Pub Date : 2022-02-04 DOI: 10.35615/epilia.2022.00305

Ji Yun, Yu Jeong Park, Mi Seon Lee, Ji-Eun Yoo, Yu Jeong Seo, S. Hong

{"title":"National Epilepsy Care Center: Comprehensive National Support System for Epilepsy","authors":"Ji Yun, Yu Jeong Park, Mi Seon Lee, Ji-Eun Yoo, Yu Jeong Seo, S. Hong","doi":"10.35615/epilia.2022.00305","DOIUrl":"https://doi.org/10.35615/epilia.2022.00305","url":null,"abstract":"뇌전증지원센터는 보건복지부 예산 지원으로 한국의 36만 뇌 The National Epilepsy Care Center (NECC) designated and supported by the Ministry of Health and Welfare, Korea was first established in July 2020 to improve the quality of life of epilepsy patients across the medical and welfare fields in Korea. The NECC provides more direct social services to patients by conducting the projects of creating a treatment environment, supporting research, providing social services, and improving awareness. Counseling and consultation are provided through the first in Asia ‘Epilepsy Help Line’ 1670-5775, and projects such as educational leaflet and video production, e-learning education, suicide prevention project, self-help group program, volunteer activity, and awareness improvement activity are underway. Epilepsy Help Line and programs are provided with the goal of improving the quality of medical care Epilepsy foundations in the United States, United Kingdom, and Australia have advanced epilepsy help system ahead of Korea and have established a network of regional help centers, and various patient support programs, donations and fundraising are active. In the future, the NECC will more activate epilepsy surgery and neurostimulation, and it is to be expanded as a level-4 regional epilepsy treatment center project so that epilepsy patients across the country can receive the same level of epilepsy treatment. In addition, social welfare services such as epilepsy education for each subject, public awareness improvement activities, customized welfare information arrangement for epilepsy patients, and community resource development will be gradually expanded.","PeriodicalId":132321,"journal":{"name":"Epilia: Epilepsy and Community","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121739070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Headache and Epilepsy 头痛和癫痫

Epilia: Epilepsy and Community Pub Date : 2021-09-30 DOI: 10.35615/epilia.2021.00248

D. W. Kim

引用次数: 0

Epilepsy and Academic Achievement 癫痫与学业成就

Epilia: Epilepsy and Community Pub Date : 2021-09-30 DOI: 10.35615/epilia.2021.00263

Hunmin Kim

引用次数: 0

The History of Neuroscience 4: What is the Mechanism of the Brain? Localization Theory versus Holistic Theory 神经科学的历史4:大脑的机制是什么?本土化理论与整体理论

Epilia: Epilepsy and Community Pub Date : 2021-09-30 DOI: 10.35615/epilia.2021.00241

S. Lee

{"title":"The History of Neuroscience 4: What is the Mechanism of the Brain? Localization Theory versus Holistic Theory","authors":"S. Lee","doi":"10.35615/epilia.2021.00241","DOIUrl":"https://doi.org/10.35615/epilia.2021.00241","url":null,"abstract":"Luigi Galvani exposed the nerves of the frog leg and demonstrated twitching of the attached muscles by electrical stimulation. He could also elicit twitching of the corresponding muscles by simple me-tallic tapping of the nerve. This Giovanni Aldini performed a theatrical demonstration of reanima-tion of a dead body by electrical stimulation, which also supported this view. At the start of the 19th century, Franz Joseph Gall and Johann Spurzheim proposed that the brain could be divided func-tionally into many parts. They also argued that the functional dominance of each individual human produced different patterns of brain development, resulting in different skull features. The basic idea that the brain was not one functional unit, but a collection of many anatomical units with different functions, was remarkable. A holistic view of brain function was reemphasized by Marie-Jean-Pierre Flourens. Flourens, who deeply believed in laboratory science, found no apparent functional chang-es after ablation or electrical stimulation of parts of the brain, mainly in birds. Through these experiments, Flourens harshly rebuked the idea of phrenology. Beyond this anti-phrenological role, Flourens conducted important experiments revealing the functions of the cerebellum, pons, and semicir-cular canals. The first widely accepted localized human brain function was language. Paul Broca pre-sented his famous case who had developed motor aphasia with a left inferior frontal focal lesion. Eduard Hitzig and Gustav Fritsch performed an important experiment in which they identified the motor cortex of the dog brain. Finally, the excitability of the human cerebral cortex was confirmed by Roberts Bartholow.","PeriodicalId":132321,"journal":{"name":"Epilia: Epilepsy and Community","volume":"56 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116424670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epilepsy Care in the Precision Medicine Era 精准医疗时代的癫痫护理

Epilia: Epilepsy and Community Pub Date : 2021-09-30 DOI: 10.35615/epilia.2021.00284

J. Moon

引用次数: 0