Hpb最新文献

{"title":"Using cell-free DNA tumor methylation score to detect and monitor cholangiocarcinoma","authors":"Salar Javanshir,&nbsp;Isabella Angeli-Pahim,&nbsp;Pavan Iyengar,&nbsp;Anastasia Chambers,&nbsp;Iulia M. Smarandache,&nbsp;Rishiraj Ganguli,&nbsp;Abhishek Shrestha,&nbsp;Jessica Squadrito,&nbsp;Adriana Abreu,&nbsp;Gabrielle Suchan,&nbsp;Carl Rizk,&nbsp;Fahreddin Palaz,&nbsp;Steven J. Hughes,&nbsp;Ilyas Sahin,&nbsp;Joseph R. Grajo,&nbsp;Sergio Duarte,&nbsp;Ali Zarrinpar","doi":"10.1016/j.hpb.2026.05.004","DOIUrl":"10.1016/j.hpb.2026.05.004","url":null,"abstract":"<div><h3>Background</h3><div>Cholangiocarcinoma (CCA) is characterized by late or unclear diagnosis, high recurrence rates, and limited options for noninvasive disease monitoring. The widely used serum biomarker CA 19-9 has suboptimal sensitivity and specificity, underscoring the need for more accurate and reliable quantitative measures of tumor burden. Cell-free DNA (cfDNA) methylation represents a promising approach for longitudinal disease monitoring.</div></div><div><h3>Methods</h3><div>In this single-center cohort study, we evaluated a cfDNA methylation-based Tumor Methylation Score (TMS) for detecting and monitoring CCA. Twenty-five patients with histologically confirmed CCA and twelve controls with benign hepatobiliary conditions were enrolled, yielding 100 plasma samples and 26 tissue samples. cfDNA methylation was quantified across 537 cancer-associated CpG loci by qPCR method, and TMS was calculated from the difference in methylation in paired plasma and buffy coat samples. For tissue samples, TMS was calculated by quantifying methylation in tumor and background liver separately. Response to treatment was assessed using blinded radiographic review. Tissue-based validation was performed using The Cancer Genome Atlas and 4 additional GEO cohorts. Finally, cellular pathways associated with the panel genes were explored using the Ingenuity Pathway Analysis (IPA).</div></div><div><h3>Results</h3><div>TMS was significantly elevated in CCA samples compared with controls in both tissue (P = 0.007) and plasma (P &lt; 0.0001). Plasma TMS distinguished CCA from controls with a sensitivity of 74.3% and specificity of 80% (AUC = 0.823), while CA 19-9 showed no discriminatory value. TMS decreased consistently following curative resection. Longitudinal changes in TMS (ΔTMS) robustly distinguished radiographic progression from non-progression during systemic therapy (AUC = 0.968), outperforming ΔCA 19–9. Tissue-based analyses across independent cohorts confirmed cancer specificity and association with adverse outcomes. IPA identified HOXA9 as a significantly altered gene implicated in CCA carcinogenesis.</div></div><div><h3>Conclusions</h3><div>Quantitative cfDNA methylation monitoring using TMS is feasible and accurately reflects dynamic tumor burden in CCA. TMS may serve as a complementary adjunct to imaging and CA 19–9 for diagnosis, prognosis, and longitudinal disease monitoring, warranting validation in larger prospective studies.</div></div>","PeriodicalId":13229,"journal":{"name":"Hpb","volume":"28 8","pages":"Pages 1125-1135"},"PeriodicalIF":3.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148204567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board / Aims and Scope","authors":"","doi":"10.1016/S1365-182X(26)00704-5","DOIUrl":"10.1016/S1365-182X(26)00704-5","url":null,"abstract":"","PeriodicalId":13229,"journal":{"name":"Hpb","volume":"28 8","pages":"Page IFC"},"PeriodicalIF":3.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148666666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpretation of the predictive value of drain fluid amylase in patients with trans-anastomotic stents.","authors":"Takehiko Hanaki","doi":"10.1016/j.hpb.2026.07.010","DOIUrl":"https://doi.org/10.1016/j.hpb.2026.07.010","url":null,"abstract":"","PeriodicalId":13229,"journal":{"name":"Hpb","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148761249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IHPBA news 1","authors":"","doi":"10.1016/S1365-182X(26)00708-2","DOIUrl":"10.1016/S1365-182X(26)00708-2","url":null,"abstract":"","PeriodicalId":13229,"journal":{"name":"Hpb","volume":"28 8","pages":"Page IBC"},"PeriodicalIF":3.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148666832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The E-AHPBA – ESSO – Innsbruck consensus recommendations on peri- and postoperative management following liver resection","authors":"Eva Maier,&nbsp;Stefan Stättner,&nbsp;Lucia Carrion-Alvarez,&nbsp;Marcello Di Martino,&nbsp;Pim Olthof,&nbsp;Florian Primavesi,&nbsp;Dana Sochorova,&nbsp;Stijn van Laarhoven,&nbsp;Anita Balakrishnan,&nbsp;Robert Breitkopf,&nbsp;Carlijn I. Buis,&nbsp;Federica Cipriani,&nbsp;Joris Erdmann,&nbsp;Adam Frampton,&nbsp;David Fuks,&nbsp;Stefan Gilg,&nbsp;Aiste Gulla,&nbsp;Francesco Lancellotti,&nbsp;Christian Margreiter,&nbsp;Emmanuel Melloul,&nbsp;Manuel Maglione","doi":"10.1016/j.hpb.2025.10.008","DOIUrl":"10.1016/j.hpb.2025.10.008","url":null,"abstract":"<div><h3>Background</h3><div>Liver surgery carries a high risk of complications due to the interplay of patient-related factors, disease characteristics and liver function. This European consensus provides evidence-based guidance on selected aspects of perioperative care.</div></div><div><h3>Methods</h3><div>A modified Delphi process was used to achieve consensus, with a 70 % agreement threshold. The expert panel comprised hepatobiliary surgeons, anaesthetists, hepatologists, a nurse and physiotherapist. Systematic literature search was conducted in PubMed/Medline, EMBASE, Web of Science, and Cochrane databases. Evidence appraisal and statement development followed Scottish Intercollegiate Guidelines Network methodology.</div></div><div><h3>Results</h3><div>Six topics were addressed: (i) thromboprophylaxis, (ii) antibiotics, (iii) prehabilitation-nutrition-mobilisation, (iv) bile leaks, including bilio-enteric anastomosis, (v) post-hepatectomy haemorrhage, (vi) post-hepatectomy liver failure (PHLF). Screening yielded <em>204</em> included publications (initial <em>6514) and</em> thirty-two statements were formulated (median evidence-level:2). Evidence strength varied by topic with lower evidence-levels in complex surgery settings and subcohorts. Study heterogeneity and specific inclusion criteria resulted in some topics in conditional recommendations despite high-level evidence. Weakest evidence was found for thromboprophylaxis and PHLF managment. Strong recommendations were formulated for prehabilitation, mobilisation, and avoidance of routine drainage. Several evidence gaps warranting multicentre studies were identified.</div></div><div><h3>Conclusion</h3><div>Optimising perioperative care after hepatectomy remains challenging. Standardising key practices and addressing evidence gaps through collaborative research are vital to improve outcomes.</div></div>","PeriodicalId":13229,"journal":{"name":"Hpb","volume":"28 8","pages":"Pages 1005-1033"},"PeriodicalIF":3.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145523277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Omitted variable bias and validation circularity: a computational audit of the APHPBA score","authors":"Xiangbo Ma,&nbsp;Wei Li","doi":"10.1016/j.hpb.2026.04.449","DOIUrl":"10.1016/j.hpb.2026.04.449","url":null,"abstract":"","PeriodicalId":13229,"journal":{"name":"Hpb","volume":"28 8","pages":"Page 1147"},"PeriodicalIF":3.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148042173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practice patterns and implementation of combined ablation and resection (CARe) strategies for colorectal liver metastases: a pan-European survey","authors":"Gabriela Pilz da Cunha,&nbsp;Hannah H. Schulz,&nbsp;Niels F.M. Kok,&nbsp;Martijn R. Meijerink,&nbsp;Rutger-Jan Swijnenburg","doi":"10.1016/j.hpb.2026.03.007","DOIUrl":"10.1016/j.hpb.2026.03.007","url":null,"abstract":"<div><h3>Background</h3><div>Combined ablation and resection (CARe) is a parenchymal sparing alternative to more extensive liver resection in selected patients with colorectal liver metastases (CRLM). This study aims to characterize the degree of implementation of CARe and approaches across Europe.</div></div><div><h3>Methods</h3><div>An online survey was conducted among members of the European-African Hepato-Pancreato-Biliary Association, between June and August 2025, to assess current CARe practice patterns, including implementation, strategies, and clinician perspectives.</div></div><div><h3>Results</h3><div>Overall, 91 responses from 77 centres across 23 countries were analysed. The majority of respondents worked at university hospitals (81%). 91% of centres indicated that CARe is available at their institution, though most centres (65%) report using CARe in ≤20% of resections. Neither high institutional ablation nor high resection volumes were significantly associated with CARe implementation, although a trend was observed for ablation volume (p = 0.068). Minimally invasive CARe approaches are adopted in the majority (89%) of centres performing CARe, including both ultrasound guided (percutaneous (59%) or laparoscopic (73%)) and CT-guided techniques (54%), performed intraoperatively or in sequential sessions. Notably, despite the parenchymal sparing potential of CARe, 20% of respondents indicated a preference for major hepatectomy when both strategies could achieve complete tumour clearance.</div></div><div><h3>Conclusion</h3><div>Although widely available among responding centres, substantial variation in institutional implementation and strategies for CARe, highlight the need for evidence-based best practice recommendations and training programs for ablation.</div></div>","PeriodicalId":13229,"journal":{"name":"Hpb","volume":"28 8","pages":"Pages 1052-1063"},"PeriodicalIF":3.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147959931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current status of split liver transplantation using machine perfusion in the United States","authors":"Toshihiro Nakayama,&nbsp;Ryo Ito,&nbsp;Antony Attia,&nbsp;Daniel J. Ahn,&nbsp;Hirofumi Ichida,&nbsp;Shinnosuke Shiraki,&nbsp;Kazunari Sasaki","doi":"10.1016/j.hpb.2026.04.465","DOIUrl":"10.1016/j.hpb.2026.04.465","url":null,"abstract":"","PeriodicalId":13229,"journal":{"name":"Hpb","volume":"28 8","pages":"Pages 1143-1146"},"PeriodicalIF":3.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147972130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board / Aims and Scope","authors":"","doi":"10.1016/S1365-182X(26)00704-5","DOIUrl":"10.1016/S1365-182X(26)00704-5","url":null,"abstract":"","PeriodicalId":13229,"journal":{"name":"Hpb","volume":"28 8","pages":"Page IFC"},"PeriodicalIF":3.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148666672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IHPBA news 2","authors":"","doi":"10.1016/S1365-182X(26)00709-4","DOIUrl":"10.1016/S1365-182X(26)00709-4","url":null,"abstract":"","PeriodicalId":13229,"journal":{"name":"Hpb","volume":"28 8","pages":"Page OBC"},"PeriodicalIF":3.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148666675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}