Histopathology最新文献

{"title":"Haematolymphoid malignancies: beyond the current classifications","authors":"Daphne de Jong, Torsten Haferlach","doi":"10.1111/his.15368","DOIUrl":"10.1111/his.15368","url":null,"abstract":"","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":"86 1","pages":"3-5"},"PeriodicalIF":3.9,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological features and prognosis of alpha-fetoprotein-producing colorectal adenocarcinoma","authors":"Yuqing Cheng,&nbsp;Xinwen Zhang,&nbsp;Ting Li,&nbsp;Chongfang He,&nbsp;Haojun Yang,&nbsp;Xiaoli Zhou,&nbsp;Qin Huang","doi":"10.1111/his.15379","DOIUrl":"10.1111/his.15379","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>Alpha-fetoprotein (AFP)-producing colorectal adenocarcinoma (AFPCRA) is uncommon, with obscure clinicopathological features and prognosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods and Results</h3>\u0000 \u0000 <p>In this retrospective comparison study on surgically resected colorectal adenocarcinomas (CRA, <i>n</i> = 2389), we investigated and compared clinicopathological and prognostic features between AFPCRA cases with elevated pre-operative serum AFP levels, as the AFPCRA study group (<i>n</i> = 49, 2.1%), and the exact sex-, age- and stage-matched CRA cases as the control group at a 1:2 ratio during the study period from 2011 to 2021. The AFPCRA group was further divided into low and high serum AFP-level subgroups at the cut-off of 8.4 ng/ml. Compared to the control group, the AFPCR group showed a significantly higher frequency in extramural venous invasion, intermediate/high tumour budding grade, poor tumour differentiation, liver and distant metastases, mixed and hepatoid adenocarcinomas. The 5-year overall survival rate was significantly lower in the AFPCRA group (69.2%) than in the control (87.2%) (<i>P</i> = 0.002). The high AFP-level AFPCRA subgroup displayed a significantly higher prevalence of the left colon location than the low AFP-level subgroup. Risk factors of overall survival for the AFPCRA group included lymphovascular, perineural and extramural venous invasion, poor tumour differentiation, tumour budding grade, distant metastasis, pN, pM and pathological summary stages, while distant metastasis was the only independent prognostic risk factor.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>AFPCRA was rare and may be associated with aggressive behaviour and poor prognosis. These preliminary findings in this single-centre study remain to be validated by future studies with larger samples.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":"86 5","pages":"715-727"},"PeriodicalIF":3.9,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding and overcoming the pitfalls in the diagnosis of pleomorphic and carcinoma ex-pleomorphic adenoma of salivary glands","authors":"Ziyad Alsugair,&nbsp;Charles Lépine,&nbsp;Maxime Fieux,&nbsp;Françoise Descotes,&nbsp;Daniel Pissaloux,&nbsp;Jonathan Lopez,&nbsp;Juliette Russel,&nbsp;Philippe Céruse,&nbsp;Pierre Philouze,&nbsp;Emmanuelle Uro-Coste,&nbsp;Aurore Siegfried,&nbsp;Valérie Costes-Martineau,&nbsp;Anne Champagnac,&nbsp;Nazim Benzerdjeb,&nbsp;the REFCOR network","doi":"10.1111/his.15392","DOIUrl":"10.1111/his.15392","url":null,"abstract":"<p>The study illustrates a recurrent pitfall in the diagnosis of pleomorphic adenoma and carcinoma ex pleomorphic adenoma.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":"86 6","pages":"1013-1016"},"PeriodicalIF":3.9,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serous-like breast carcinomas: immunophenotypic, genetic, and clinicopathologic characterization of a morphologically distinct group of tumours","authors":"Gregor Krings,&nbsp;Eliah R. Shamir,&nbsp;Marick Laé,&nbsp;Gregory R. Bean,&nbsp;Miriam D. Post,&nbsp;Stuart J. Schnitt,&nbsp;Yunn-Yi Chen","doi":"10.1111/his.15385","DOIUrl":"10.1111/his.15385","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>Unusual morphologic patterns of breast carcinomas can raise diagnostic consideration for metastasis or special breast cancer subtypes with management implications. We describe rare invasive breast cancers that mimic serous carcinoma of the gynaecologic tract (serous-like breast carcinomas, SLBC) and characterize their clinicopathologic, immunophenotypic, and genetic features.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods and Results</h3>\u0000 \u0000 <p>All patients were female (<i>n</i> = 15, median age 49 years) without a history of gynaecologic malignancy. SLBC were characterized histologically by angulated, branched, sometimes anastomosing glands with micropapillary and/or pseudopapillary luminal projections in desmoplastic stroma. Most SLBC were triple-negative (TN, <i>n</i> = 10) or HER2-positive (<i>n</i> = 2) and grade 2 or 3, while some were oestrogen receptor (ER) low-positive/HER2-negative and low-grade (<i>n</i> = 3). CK5/6 was positive irrespective of grade or receptor status (10/10). All SLBC expressed GATA3 (14/15), TRPS1 (7/7), and/or mammaglobin (4/13). SOX10 was positive in most TN (9/10) and all ER low-positive (3/3) cases, but negative in HER2-positive tumours. WT1 was universally negative, and PAX8 was focal in one mammaglobin-positive tumour. All ER-negative SLBC were p53-aberrant and 9/11 were p16-aberrant, whereas ER-positive tumours were wildtype for both markers (3/3). <i>TP53</i> was the only frequently mutated gene, altered in all ER-negative (10/10) but no ER-positive (0/4) tumours. Clinical behaviour was variable. Only 1/6 patients achieved pathologic complete response to neoadjuvant chemotherapy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>SLBC is a rare morphologic pattern of invasive breast carcinoma that mimics metastatic serous gynaecologic carcinoma, a potential diagnostic pitfall. SLBC are heterogeneous with respect to grade, receptor profile, and oncogenic driver alterations, without specific genetic underpinnings identified. Additional studies are warranted to further evaluate the clinical behaviour of these tumours.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":"86 5","pages":"779-792"},"PeriodicalIF":3.9,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-grade myxoid spindle cell neoplasm with novel gene fusions involving MAP3K3 and MAP3K8 kinases: a report of two cases","authors":"Azfar Neyaz,&nbsp;Mana Mohebnasab,&nbsp;Elan Hahn,&nbsp;Joel Rosenbaum,&nbsp;Lucas da Gama Lobo,&nbsp;Arivarasan Karunamurthy,&nbsp;Ivy John,&nbsp;Kurt R. Weiss,&nbsp;Karen Schoedel,&nbsp;Simion I Chiosea,&nbsp;Rana Naous","doi":"10.1111/his.15388","DOIUrl":"10.1111/his.15388","url":null,"abstract":"","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":"86 5","pages":"832-836"},"PeriodicalIF":3.9,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpretation of testicular biopsy for infertility: a practical guide","authors":"Turki Al-Hussain,&nbsp;Walaa M Borhan","doi":"10.1111/his.15366","DOIUrl":"10.1111/his.15366","url":null,"abstract":"<p>Testicular biopsies are often performed in men with unexplained infertility and azoospermia to ascertain the status of spermatogenesis. Testicular pathology is one of the primary causes of male infertility. However, infrequent exposure among pathologists and a lack of uniform reporting terminology pose diagnostic challenges and variability in interpretation. These issues may lead to inaccurate evaluations, potentially impacting clinical management. The goal of this review is to offer a straightforward, practical approach to interpreting testicular biopsies, thereby assisting pathologists who handle such rare samples. Accurate interpretation of testicular biopsy for infertility plays a crucial role in management of infertile men. In this review, we present a practical guide for reporting testicular biopsies.</p>","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":"86 7","pages":"1025-1031"},"PeriodicalIF":3.9,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nuclear morphological characterisation of lobular carcinoma variants: a morphometric study","authors":"Ayaka Katayama,&nbsp;Shorouk Makhlouf,&nbsp;Michael S Toss,&nbsp;Tetsunari Oyama,&nbsp;Emad A Rakha","doi":"10.1111/his.15390","DOIUrl":"10.1111/his.15390","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background and aims</h3>\u0000 \u0000 <p>Lobular carcinoma (LC) of the breast exhibits diverse morphology and clinical behaviour. The pleomorphic variant (pLC) displays distinct cytonuclear features and aggressiveness compared to the classic variant (cLC). However, diagnosing pLC remains subjective. This study aims to refine LC's cytonuclear features, focusing on pLC.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Whole slide images of 59 LCs, including both <i>in situ</i> (LCIS) and invasive (ILC) lesions, were analysed. Nuclear measurements, including nuclear size and variability, were scored using QuPath image analysis software. For comparison, selected features were scored in normal cells (<i>n</i> = 10) and pleomorphism score-matched invasive breast carcinoma (IBC) of NST type (<i>n</i> = 33). Additional visual assessment of the pleomorphic ILC (pILC) cohort (<i>n</i> = 90) was conducted for cytomorphological features characterisation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>pILC demonstrated larger nuclear area and higher nuclear variability with abundance of cytoplasm than cILC. Compared to lymphocytes, pILC demonstrated a median area ranging from 2.7 to 4.7 times larger. Cut-off values for differentiating pILC from other ILC subtypes included median nuclear area &gt; 48.2 μm² and interquartile range (IQR) &gt; 19.4, nuclear perimeter median &gt; 25.2 μm and IQR &gt; 5.3 and maximum diameter &gt; 9.1 μm and IQR &gt; 2.2. Multivariable logistic regression confirmed these parameters as independent predictors of pILC, with the maximum diameter being the most significant (<i>P</i> &lt; 0.001). Visual assessment recognised two pILC subtypes: apocrine and non-apocrine. Apocrine variant showed nuclear roundness, pale vesicular chromatin patterns and prominent nucleoli, while non-apocrine variant exhibited greater nuclear size and shape variation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Objective nuclear measurements, combined with cytoplasmic and architectural features, provide a robust framework for diagnosing LC subtypes, improving diagnostic accuracy and reproducibility.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":"86 5","pages":"813-823"},"PeriodicalIF":3.9,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/his.15390","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is it time to acknowledge intramucosal colorectal carcinoma?","authors":"Elisa Vink-Börger,&nbsp;Nikki Knijn,&nbsp;Adriaan de Bruine,&nbsp;Jeroen Stavast,&nbsp;Rachel Sophia van der Post,&nbsp;Iris Nagtegaal","doi":"10.1111/his.15389","DOIUrl":"10.1111/his.15389","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The term ‘intramucosal carcinoma’ in the colorectum is controversial when used as a synonym for high-grade dysplasia. However, setting clear definitions for this diagnosis (i.e. <i>unequivocal infiltrative growth in the lamina propria, which might be most easily recognized in cases with overt poor differentiation or formation of signet ring cells or tumour budding</i>) allow us to investigate its relevance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods and Results</h3>\u0000 \u0000 <p>We reviewed cases from our archive (1990–2024) and selected 14 true intramucosal carcinomas using our strict histological criteria, excluding high-grade dysplasia and invasive carcinomas. These occur primarily in conventional adenomas and are frequently associated with microsatellite instability (50%). Our study shows a low estimated incidence of intramucosal carcinoma (0.01%) in population screening and highlights the low lymph node risk and the good outcome of patients with intramucosal carcinoma.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The rare diagnosis of intramucosal colorectal carcinoma aids in identifying patients at increased colorectal cancer risk, notably those with hereditary syndromes. Standardizing this diagnosis is critical to prevent overdiagnosis and unnecessary treatment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":"86 5","pages":"805-812"},"PeriodicalIF":3.9,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/his.15389","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in vascular anomalies: refining classification in the molecular era","authors":"Juan Putra,&nbsp;Alyaa Al-Ibraheemi","doi":"10.1111/his.15374","DOIUrl":"10.1111/his.15374","url":null,"abstract":"<p>The classification and understanding of vascular anomalies have significantly evolved since the initial framework by Mulliken and Glowacki, distinguishing between vascular tumours and malformations. Recent advancements in molecular diagnostics have enhanced the accuracy of identifying and managing these complex lesions. This review provides an updated analysis of select vascular anomalies, focusing on Kaposiform hemangioendothelioma (KHE), Kaposiform lymphangiomatosis (KLA), and intramuscular fast-flow vascular anomalies. It highlights the similarities and differences between these lesions, their histopathological features, and molecular underpinnings, including key genetic mutations in the RAS/PI3K/mTOR signalling pathways. Moreover, the role of <i>PIK3CA</i> mutations in vascular overgrowth syndromes is explored, alongside emerging targeted therapies, such as PI3K and MEK inhibitors, that promise improved outcomes for patients with these challenging conditions. The integration of histology, molecular diagnostics, and multidisciplinary care remains critical for the accurate diagnosis and optimal treatment of vascular anomalies in the era of precision medicine.</p>","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":"86 7","pages":"1032-1043"},"PeriodicalIF":3.9,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variability in the diagnosis and reporting of metaplastic breast carcinoma: results of an international survey","authors":"Ellen Yang,&nbsp;Susan Fineberg,&nbsp;Anas Mohamed,&nbsp;Edi Brogi,&nbsp;Hannah Wen","doi":"10.1111/his.15381","DOIUrl":"10.1111/his.15381","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>Metaplastic breast carcinoma (MBC) is a heterogeneous group of invasive breast carcinoma with squamous, spindle cell, or mesenchymal elements. It may be monophasic or biphasic, and often coexists with invasive breast carcinoma of no special type (IBC-NST). Currently, there are no standardized guidelines for reporting MBC, and a diagnostic threshold for the metaplastic component is not established by the WHO classification.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods and Results</h3>\u0000 \u0000 <p>A survey conducted from April–July 2023 gathered responses from 44 pathologists worldwide. Most respondents were academic breast pathologists, and attended weekly breast tumour boards. The criteria for diagnosing MBC were highly varied, with cutoffs ranging from any/&lt;10% to &gt;90% metaplastic component. Although 90% was the most common threshold used, only 25% of respondents applied it. Pathologists generally preferred diagnosing invasive carcinoma with mixed features when the metaplastic component was ≤50% and MBC when the metaplastic component &gt;50%. Most pathologists reported both the type and percentage of metaplastic component. In all, 43% reported core biopsy and resection specimen with different approaches. Diagnostic guidelines reportedly used (if any) were highly varied.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The study underscores the need for standardized guidelines for MBC. Without clear and established diagnostic criteria, current data on MBC remains inconsistent and hinders further research into the clinical significance and prognostic implications of the metaplastic component.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":"86 5","pages":"742-749"},"PeriodicalIF":3.9,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}