Histopathology最新文献

{"title":"Further evidence of EWSR1::GFI1B fusion in soft tissue angiofibroma: two new cases.","authors":"Azfar Neyaz, Simon Chiosea, Isabella Giovannoni, Alessandro Mazzocca, Lucas da Gama Lobo, John M Skaugen, Rita Alaggio, Ivy John","doi":"10.1111/his.15447","DOIUrl":"https://doi.org/10.1111/his.15447","url":null,"abstract":"","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Professor Raymond McMahon: an obituary","authors":"Neil A. Shepherd","doi":"10.1111/his.15440","DOIUrl":"10.1111/his.15440","url":null,"abstract":"","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":"86 5","pages":"663-664"},"PeriodicalIF":3.9,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic pitfall: GATA3 expression in mesonephric/mesonephric-like adenocarcinoma involving the breast.","authors":"Hala Alnuaim, Anjelica Hodgson","doi":"10.1111/his.15441","DOIUrl":"https://doi.org/10.1111/his.15441","url":null,"abstract":"","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of a GATA6::FOXO1 fusion in a case of cutaneous epithelioid angiomatous nodule: further evidence supporting its classification as an epithelioid haemangioma variant?","authors":"Irena Antonia Ungureanu, Nathalene Truffaut, Rihab Azmani, Francois Le Loarer, Raul Perret","doi":"10.1111/his.15439","DOIUrl":"https://doi.org/10.1111/his.15439","url":null,"abstract":"","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interobserver reproducibility of a hybrid three-tier grading system of papillary nonmuscle invasive urothelial carcinoma: an international Uropathology study.","authors":"Michelle R Downes, Katherine Lajkosz, Ferran Algaba, Yves Allory, Mahul B Amin, Liang Cheng, Sangeeta Desai, Markus Eckstein, Arndt Hartmann, Antonio Lopez-Beltran, Sebastian Mannweiler, Maurits L van Montfoort, Jon Oxley, Gladell P Paner, Hemamali Samaratunga, Steven Shen, Joshua Warrick, Sean R Williamson, Sara E Wobker, Theodorus H van der Kwast","doi":"10.1111/his.15438","DOIUrl":"https://doi.org/10.1111/his.15438","url":null,"abstract":"<p><strong>Aims: </strong>A hybrid-three tier system with low grade (LG), high grade- G2 (HG-G2), high grade- G3 (HG-G3) has been proposed in recognition of, and to help address, the clinical heterogeneity within high grade WHO 2004/2022. We assessed interobserver reproducibility amongst international uropathologists using this three-tier approach.</p><p><strong>Methods and results: </strong>Papillary Ta nonmuscle invasive bladder cancer (NMIBC) specimens (n = 30) were selected and graded by two uropathologists and assessed using WHO 2004/2022 and WHO 1973 and categorized as LG (n = 15), HG-G2 (n = 8), HG-G3 (n = 7), and photographed at 10× and 20× magnification. Images were circulated via Survey Monkey to invited uropathologists who determined: (1) that image was LG or HG, and (2) if HG, assigned to G2 or G3. Model-based kappa measure of association was used to assess interrater agreement. Eighteen uropathologists:(eight North American, eight European, two other) assessed 60 images with 1076 gradings for analysis. The kappa value amongst Europeans versus North Americans was 0.663 versus 0.647 for 10× images and 0.682 versus 0.623 for 20× images. At 10×, agreement for LG, HG-G2, and HG-G3 was 74.6%, 63.6%, and 92.0%, and at 20× was 64.3%, 63.9%, and 95.2% respectively.</p><p><strong>Conclusion: </strong>Three-tier grading of papillary Ta NMIBC had substantial interobserver agreement amongst international uropathologists. The recognition of the HG-G3 case reached the highest concordance. North American uropathologists had comparable kappa scores (substantial agreement) to Europeans, despite being unaccustomed to separating HG cases into G2 and G3, demonstrating three-tier grading could be \"quickly\" adopted by genitourinary experts if endorsed and required by the relevant bodies in their jurisdiction of practice.</p>","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ketamine cholangiopathy: clinical features and liver biopsy findings.","authors":"Jihyun Chun, Sreelakshmi Kotha, Jeremy Nayagam, Charles Gallaher, Rosa Miquel, Seung-Mo Hong, Mary Cannon, Philip Berry, Deepak Joshi, Yoh Zen","doi":"10.1111/his.15435","DOIUrl":"https://doi.org/10.1111/his.15435","url":null,"abstract":"<p><strong>Aims: </strong>To reveal clinical, imaging and pathological features of ketamine cholangiopathy.</p><p><strong>Methods and results: </strong>Eight cases, who had a history of long-term ketamine use, abnormal liver function tests and histological or radiological evidence of cholangiopathy, were retrospectively reviewed. Cases consisted of six men and two women with a median age of 36 years. Ketamine was clinically prescribed in one case for pain control or used recreationally in the remaining seven for 3-24 years (median = 12 years) until the diagnosis of cholangiopathy. Six cases had a prior diagnosis of ketamine-induced cystitis ('ketamine bladder') or urinary symptoms at the time of referral. No patient had inflammatory bowel disease, and autoantibodies were negative in all but one case. Common cholangiographic abnormalities included diffuse irregular narrowing of the intrahepatic bile ducts (n = 5) and mild dilatation of the extrahepatic bile ducts with a smooth contour (n = 5). Liver biopsies showed features of chronic cholangiopathy. Portal and lobular inflammation was mild or absent, and degrees of fibrosis were also relatively mild (Ludwig's stages 1-2). Periductal concentric fibrosis or fibrous duct obliteration was observed in four cases. Abstinence from ketamine was successful in three cases, and one showed normalisation of liver blood tests.</p><p><strong>Conclusion: </strong>Ketamine cholangiopathy mimics primary sclerosing cholangitis (PSC) biochemically, radiologically and histologically, and it seems to be less inflammatory and less progressive compared to PSC. The association with cystitis, the lack of inflammatory bowel disease and mild extrahepatic duct dilatation without irregularity are potential diagnostic clues.</p>","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary cutaneous sarcomatoid squamous cell carcinoma: a comprehensive clinicopathological and immunohistochemical study focusing on diagnostic pitfalls.","authors":"Jose A Plaza, Alejandro A Gru","doi":"10.1111/his.15437","DOIUrl":"https://doi.org/10.1111/his.15437","url":null,"abstract":"<p><strong>Aims: </strong>Primary cutaneous sarcomatoid squamous cell carcinoma (PCSSCC) is an uncommon variant of squamous cell carcinoma. Histologically, these tumours are composed of deeply infiltrative spindled and pleomorphic cells arranged in fascicles or cohesive nests and usually lacking keratinisation. Its distinction from other malignant spindle cell lesions is a difficult task that requires ancillary immunohistochemical studies to make a definitive diagnosis. A retrospective analysis of 74 cases of PCSSCC, obtained from large academic institutions, was performed, and is summarised below.</p><p><strong>Methods and results: </strong>Immunohistochemical studies were performed with antibodies against pan-cytokeratin monoclonal antibody (AE1/AE3), anti-cytokeratin (CAM 5.2) mouse monoclonal primary antibody, MNF-116, p63, p40, high-molecular-weight kininogen (HMWK), cytokeratin (CK)7, CK5/6, smooth muscle actin (SMA), desmin and H-caldesmon. All cases were poorly differentiated; however, there were some histopathological clues to the diagnosis of PCSSCC; namely, the presence of a well-differentiated component in 13 cases. Using immunohistochemistry, all cases were positive for at least one epithelial marker (AE1/AE3, MNF116, CAM5.2, p63, p40, HMWK and CK5/6). Eighteen cases had aberrant expression of SMA.</p><p><strong>Conclusions: </strong>PCSSCC can be a difficult neoplasm to diagnose, as it can appear histologically similar to other malignant spindle cell neoplasms. We describe 74 cases of PCSSCC, highlighting their salient clinical, histopathological and immunohistochemical features, and discuss the potential diagnostic pitfalls in distinguishing this entity from other malignant neoplasms. Our results indicate that a combination of thorough histological inspection coupled with an adequate battery of immunohistochemical stains is necessary to support the diagnosis of PCSSCC.</p>","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic accuracy and clinical outcomes of patients diagnosed with clear cell papillary renal cell tumour at renal mass biopsy.","authors":"Alexander Oberc, Carol C Cheung, Satheesh Krishna, Antonio Finelli, Susan Prendeville","doi":"10.1111/his.15436","DOIUrl":"https://doi.org/10.1111/his.15436","url":null,"abstract":"<p><strong>Background: </strong>Clear cell papillary renal cell tumour (CCPRCT) is a clinically indolent neoplasm. The diagnosis of CCPRCT at renal mass biopsy (RMB) may facilitate conservative management; however, this can be challenging in small samples and there are limited data on the outcome of patients managed conservatively. This study aimed to: (1) evaluate concordance between RMB and nephrectomy for the diagnosis of CCPRCT, and (2) determine the clinical outcomes of patients with CCPRCT, particularly those who have undergone conservative management.</p><p><strong>Methods and results: </strong>We reviewed all cases at our institution where CCPRCT was diagnosed or included in the differential diagnosis at RMB. In all, 65 RMB with a diagnosis/differential diagnosis of CCPRCT were identified, including 25 patients who had subsequent surgical resection. Of cases where CCPRCT was the likely or favoured diagnosis on RMB (n = 19), the final diagnosis was concordant in 16/19 (84%). Discordant cases comprised clear cell renal cell carcinoma (ccRCC) (n = 1) and RCC with fibromyomatous stroma (n = 2). In all, 15 patients were managed with active surveillance (median follow-up 34 months) and 26 were treated with ablation (median follow-up 37 months). There was no recurrence, metastasis, or death in the cohort.</p><p><strong>Conclusion: </strong>CCPRCT can be reliably diagnosed at RMB in most cases if strict morphologic and immunohistochemical (IHC) criteria are applied. Furthermore, there was no adverse behaviour among patients managed nonsurgically in our cohort. It is important, however, to recognize the limitations of RMB, particularly given that occasional examples of ccRCC can show foci resembling CCPRCT. Pathologists and treating clinicians should be aware of the limitations of RMB when considering conservative management.</p>","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Data set for reporting of paediatric rhabdomyosarcoma: recommendations from the International Collaboration on Cancer Reporting (ICCR).","authors":"Anna Kelsey, Rita Alaggio, Fleur Webster, Kelly M Bailey, Gianni Bisogno, Jessica L Davis, Sarah M Dry, Dmitry Konovalov, Alexander J Lazar, Maureen J O'Sullivan, Erin R Rudzinski, Rajkumar Venkatramani, Christian Vokuhl, Eduardo Zambrano, Marta Cohen, Miguel Reyes-Múgica","doi":"10.1111/his.15431","DOIUrl":"https://doi.org/10.1111/his.15431","url":null,"abstract":"<p><strong>Aims: </strong>Rhabdomyosarcoma (RMS) is rare, but it is the most common sarcoma in childhood. The World Health Organisation classifies RMS into four main categories, sharing the same terminology of RMS, but the subtypes have different morphology, clinical behaviour and underlying molecular characterisation. Although the main diagnostic categories have remained the same there have been changes in the histological criteria, together with integration of both immunohistochemical and molecular data in the reporting of RMS. Integrated histology reporting provides valuable information for the management of children with RMS, is important for patients enrolled into clinical trials, supports tissue-based biological research and contributes to data required in cancer registries. Consistent, comprehensive and reproducible reporting of RMS is imperative.</p><p><strong>Methods and results: </strong>In this article we provide the International Collaboration on Cancer Reporting (ICCR) process for the development of the first international Paediatric RMS data set for the reporting of biopsy and resection specimens. An international expert panel consisting of pathologists and paediatric oncologists produced a set of core and non-core elements to be included in the histopathology reporting of paediatric RMS, inclusive of clinical, macroscopic, microscopic and ancillary testing required for a comprehensive report. The selection of data items was based on review of current evidence, taking into account items that are recognised as essential for patient treatment stratification and that are currently in use in the clinical trial setting. Commentary was provided for each data item to detail the rationale for selecting it as core or non-core element, and to highlight their clinical relevance.</p><p><strong>Conclusions: </strong>The first international data set for the reporting of paediatric RMS aims to promote standardised, high-quality reporting and supports uniform data collection, which is critical for clinical data comparison on a global level, ultimately improving patient outcome.</p>","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Data set for reporting of peripheral neuroblastic tumours: recommendations from the international collaboration on cancer reporting (ICCR).","authors":"Jason A Jarzembowski, Fleur Webster, Klaus Beiske, Susan L Cohn, Ronald R de Krijger, Meredith S Irwin, Samuel Navarro, Hajime Okita, Hiroyuki Shimada, Jens Stahlschmidt, Christian Vokuhl, Larry L Wang, Marta Cohen, Miguel Reyes-Mugica","doi":"10.1111/his.15424","DOIUrl":"https://doi.org/10.1111/his.15424","url":null,"abstract":"<p><p>Peripheral neuroblastic tumours are the most common extracranial solid neoplasms occurring in children. Proper classification is critical for directing therapy and predicting prognosis. Nonetheless, their relative rarity makes accurate pathological assessment challenging, even for experienced pathologists. Here we report on a new international data set for the pathology reporting of biopsy and resection specimens with peripheral neuroblastic tumours. The data set was produced under the auspices of the International Collaboration on Cancer Reporting (ICCR), a global alliance of major (inter-)national pathology and cancer organisations. According to the ICCR's process for data set development, an international expert panel consisting of paediatric pathologists and oncologists produced a set of core and non-core data items for biopsy and resection specimens based on a critical review and discussion of current evidence. All professionals involved were neuroblastic tumour experts affiliated with tertiary referral centres. Commentary was provided for each data item to explain the rationale for selecting it as a core or non-core element, its clinical relevance and to highlight potential areas of disagreement or lack of evidence, in which case a consensus position was formulated. Following international public consultation, the documents were finalised and ratified, and the data sets, including a synoptic reporting guide, were published on the ICCR website. This first international data set for paediatric peripheral neuroblastic tumours is intended to promote high-quality, standardised pathology reporting. Its widespread adoption will improve the consistency of reporting, facilitate multidisciplinary communication and enhance comparability of data, all of which will help to improve management of children with peripheral neuroblastic tumours.</p>","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}