Histopathology最新文献

Anaplastic thyroid carcinoma with liposarcomatous foci: a novel heterologous differentiation. 间变性甲状腺癌伴脂肪肉瘤灶：一种新的异源分化。

IF 4.1 2区医学

Histopathology Pub Date : 2025-10-22 DOI: 10.1111/his.70035

Simonetta Piana, Angelina Filice, Federico Zoino, Davide Giordano

引用次数: 0

Pathologists' nightmare or challenge accepted? Soft tissue tumours of the genitourinary tract. 接受病理学家的噩梦或挑战？泌尿生殖道的软组织肿瘤。

IF 4.1 2区医学

Histopathology Pub Date : 2025-10-21 DOI: 10.1111/his.70014

Minh Anh Nguyen, Fiona M Maclean

引用次数: 0

An ignored diagnosis for initial complete hydatidiform mole: biparental complete hydatidiform mole. 一种被忽视的诊断最初完全葡萄胎：双亲本完全葡萄胎。

IF 4.1 2区医学

Histopathology Pub Date : 2025-10-20 DOI: 10.1111/his.70011

Lingling Tong, Wei Wang, Min Feng, Juan Zou

引用次数: 0

In reply to: 'Prostate cancer with favorable histology is not synonymous with prostate cancer indolence'. 回复：“具有良好组织学的前列腺癌不等同于前列腺癌不痛”。

IF 4.1 2区医学

Histopathology Pub Date : 2025-10-16 DOI: 10.1111/his.70023

Jesse K McKenney, James D Brooks, Jane K Nguyen, C K Cornelia Ding, Lisa F Newcomb, Jonathan L Myles, Reza Alaghehbandan, Christopher G Przybycin, Emily Chan, Jeffry P Simko, Nancy Y Greenland, Zeyad Schwen, Christopher J Weight, Matthew R Cooperberg, Peter R Carroll

引用次数: 0

Frequent BRAF V600E and TERT promoter-mutated renal epithelial-predominant Wilms tumours with metanephric features: a distinct subset within the Wilms tumour spectrum? 频繁的BRAF V600E和TERT启动子突变的肾上皮显性肾母细胞肿瘤具有后肾特征：肾母细胞肿瘤谱中的一个独特子集？

IF 4.1 2区医学

Histopathology Pub Date : 2025-10-16 DOI: 10.1111/his.70022

Yuemei Xu, Qiuyuan Xia, Xiaotong Wang, Ru Fang, Qi Tong, Ya Wang, Jin Chen, Jieyu Chen, Yao Fu, Jiong Shi, Qiu Rao

{"title":"Frequent BRAF V600E and TERT promoter-mutated renal epithelial-predominant Wilms tumours with metanephric features: a distinct subset within the Wilms tumour spectrum?","authors":"Yuemei Xu, Qiuyuan Xia, Xiaotong Wang, Ru Fang, Qi Tong, Ya Wang, Jin Chen, Jieyu Chen, Yao Fu, Jiong Shi, Qiu Rao","doi":"10.1111/his.70022","DOIUrl":"https://doi.org/10.1111/his.70022","url":null,"abstract":"Aims: The molecular characteristics and intricate relationships between tumours exhibiting overlapping features of metanephric adenoma (MA) and epithelial Wilms tumour (WT), as well as their pure forms, remain largely enigmatic.Methods and results: Herein, we conducted a comprehensive genetic analysis of nine epithelial-predominant Wilms tumours, focusing on genetic alterations through expanded targeted sequencing and RNA sequencing (RNA-seq) methodologies. The patients ranged in age from 13 to 61 years, with a mean and median age of 43 and 48 years, respectively. The cohort included seven males and two females. These tumours exhibited immune reactivity for BRAF, WT1, and CD57, and harboured frequent TERT promoter mutations (7/9) and BRAF V600E mutations (8/9). RNA sequencing-based clustering revealed a close similarity between the tumours and MAs, suggesting that they may represent a distinct subset within the Wilms tumour spectrum. Two patients were lost to follow-up, while the remaining seven (7/7) were alive without tumour recurrences or metastases at the time of analysis, with a mean follow-up duration of 78.1 months.Conclusions: Our research supports the notion previously described that epithelial-predominant Wilms tumours, characterized by frequent TERT promoter and BRAF V600E mutations, represent a distinct subset within the Wilms tumour spectrum. These tumours display an expression profile closely resembling that of metanephric adenomas and are associated with a favourable prognosis.","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Featured Cover 了封面

IF 4.1 2区医学

Histopathology Pub Date : 2025-10-15 DOI: 10.1111/his.70005

Katherina Baranova, Jacob A Houpt, Deaglan Arnold, Andrew A House, Laura Lockau, Lindsay Ninivirta, Stephen Pautler, Haiying Chen, Madeleine Moussa, Rola Saleeb, Jose A Gomez, Asli Yilmaz, Farshid Siadat, Adrian Box, Douglas J Mahoney, Franz J Zemp, Manal Gabril, Kiril Trpkov

引用次数: 0

CDKN2A deletion in p16-negative/HPV-positive head and neck squamous cell carcinoma: Highlighting the molecular basis behind the limitation of relying on p16 immunohistochemistry as a surrogate marker for HPV involvement. CDKN2A缺失在p16阴性/HPV阳性的头颈部鳞状细胞癌：强调依赖p16免疫组织化学作为HPV浸润的替代标志物的局限性背后的分子基础。

IF 4.1 2区医学

Histopathology Pub Date : 2025-10-09 DOI: 10.1111/his.70021

Trevor Teich, Rong Hu, Anita Nagy, Mary Shago, Yen Chen Kevin Ko, Carl Ren, Raja R Seethala, Bibianna Purgina, Elan Hahn

{"title":"CDKN2A deletion in p16-negative/HPV-positive head and neck squamous cell carcinoma: Highlighting the molecular basis behind the limitation of relying on p16 immunohistochemistry as a surrogate marker for HPV involvement.","authors":"Trevor Teich, Rong Hu, Anita Nagy, Mary Shago, Yen Chen Kevin Ko, Carl Ren, Raja R Seethala, Bibianna Purgina, Elan Hahn","doi":"10.1111/his.70021","DOIUrl":"https://doi.org/10.1111/his.70021","url":null,"abstract":"Aims: Immunohistochemistry (IHC) for p16 is widely used as a surrogate marker for HPV involvement in oropharyngeal squamous cell carcinoma (OPSCC), among other tumours. Confirming HPV status in OPSCC is critical, as HPV-positive tumours have better overall survival and may require de-escalated therapy compared to HPV-independent OPSCC in the future. However, discordance exists between p16 and HPV, and direct HPV testing is occasionally required to ensure an accurate diagnosis. The aim of this study is to highlight the genomic basis behind the limitation of relying on p16 IHC as a surrogate marker for HPV involvement.Methods and results: Through a multi-institutional collaboration, this case series compiled four patients with a 'false' negative p16 staining pattern in HPV-positive non-keratinizing head and neck squamous cell carcinoma. All cases demonstrated minimal to no p16 IHC staining and were positive for HPV by direct RNA in situ hybridization. Through CDKN2A fluorescence in situ hybridization testing, three patients demonstrated a homozygous deletion of CDKN2A and one demonstrated a heterozygous deletion.Conclusions: This series highlights the genomic basis for the 'false' negative p16 results, raising awareness of a significant diagnostic pitfall while emphasizing the importance of careful consideration of clinicopathologic parameters in the clinical workup of these cases.","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular profile of atypical Leydig cell tumours. 非典型间质细胞肿瘤的分子特征。

IF 4.1 2区医学

Histopathology Pub Date : 2025-10-09 DOI: 10.1111/his.70018

Muhammad F K Choudhry, Diogo Caires, Yaser Gamallat, Asli Yilmaz, Fadi Brimo, Bob Argiropoulos, Tarek A Bismar

{"title":"Molecular profile of atypical Leydig cell tumours.","authors":"Muhammad F K Choudhry, Diogo Caires, Yaser Gamallat, Asli Yilmaz, Fadi Brimo, Bob Argiropoulos, Tarek A Bismar","doi":"10.1111/his.70018","DOIUrl":"https://doi.org/10.1111/his.70018","url":null,"abstract":"Aims: To investigate histological and copy number variations (CNVs) in Leydig cell tumours (LCTs) of the testis. Although usually benign, a small minority of cases can be associated with a poor prognosis and metastasis.Methods: We performed whole copy number analysis to compare the genomic profile of atypical (defined by the presence of any atypical features) versus benign LCTs. Our sample consisted of one malignant (with biopsy-proven metastasis), five atypical and five benign cases.Results: We found increased genomic instability in the malignant tumour and within two out of five (40%) atypical cases. One benign case revealed a likely pathogenic mutation in the neurofibromatosis type 2 gene, but all benign cases lacked genomic instability. Apart from the malignant case (which had metastatic spread to the scrotal skin), all remaining atypical cases did not reveal evidence of recurrence or metastatic spread.Conclusion: CNVs by themselves are not sufficient to discriminate between cases that are benign versus those with malignant potential, without the use of histomorphological parameters. Genomic instability was only detected in the malignant and atypical cases, and not in any of the benign tumours. Thus, genomic instability may represent an early step in malignant progression. The presence of metastasis remains the only malignant criterion for LCTs.","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular profiling in paediatric hepatocellular adenomas: phenotypic correlations and clinical significance. 儿童肝细胞腺瘤的分子分析：表型相关性和临床意义。

IF 4.1 2区医学

Histopathology Pub Date : 2025-10-09 DOI: 10.1111/his.70019

Yan Zhou, Antonio R Perez-Atayde, Xuchen Zhang, Allison F O'Neill, Alanna J Church, Juan Putra

{"title":"Molecular profiling in paediatric hepatocellular adenomas: phenotypic correlations and clinical significance.","authors":"Yan Zhou, Antonio R Perez-Atayde, Xuchen Zhang, Allison F O'Neill, Alanna J Church, Juan Putra","doi":"10.1111/his.70019","DOIUrl":"https://doi.org/10.1111/his.70019","url":null,"abstract":"Aims: Hepatocellular adenomas (HCAs) are rare in children and often arise in distinct clinical contexts, despite sharing classification frameworks with adult cases. This series evaluates the clinicopathologic features of HCAs in patients 21 years or younger, highlighting phenotype-genotype correlations and the clinical relevance of molecular testing.Methods and results: 27 HCAs from 26 patients (69% female; mean age: 16.2 years) were analyzed. Based on morphology and immunohistochemistry (IHC), most cases were unclassified (46%), followed by inflammatory (35%), HNF1A-inactivated (15%) and β-catenin-activated (4%) subtypes. Most patients (69%) had multifocal disease. In addition to classic risk factors such as oral contraceptive use and obesity, 35% had a history of neoplasm and 15% had glycogen storage disease. Next-generation sequencing was performed on 13 HCAs; germline testing was available in 1 patient with familial adenomatous polyposis. While molecular testing had limited impact on reclassification, it was valuable in cases with ambiguous IHC profiles and in guiding management of patients with atypical or syndromic presentations by excluding variants associated with malignant potential.Conclusions: Paediatric HCAs arise in diverse clinical contexts and may require individualized treatment planning. While histologic and immunophenotypic evaluation is sufficient in most cases, molecular profiling adds value in diagnostically challenging scenarios and may help guide management decisions.","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tumour-infiltrating lymphocytes, tertiary lymphoid structures and myxoid stroma predict upstaging of ductal carcinoma in situ in breast biopsies. 肿瘤浸润淋巴细胞，三级淋巴结构和黏液样间质在乳腺活检中预测导管原位癌的分期。

IF 4.1 2区医学

Histopathology Pub Date : 2025-10-02 DOI: 10.1111/his.70009

Chung-Yen Huang, Yu-Jui Wang, Min-Shu Hsieh, Pin-Yu Lin, Yi-Hsuan Lee

{"title":"Tumour-infiltrating lymphocytes, tertiary lymphoid structures and myxoid stroma predict upstaging of ductal carcinoma in situ in breast biopsies.","authors":"Chung-Yen Huang, Yu-Jui Wang, Min-Shu Hsieh, Pin-Yu Lin, Yi-Hsuan Lee","doi":"10.1111/his.70009","DOIUrl":"https://doi.org/10.1111/his.70009","url":null,"abstract":"Aims: We aimed to evaluate tumour-infiltrating lymphocytes (TILs), tertiary lymphoid structures (TLSs) and myxoid stroma in breast biopsies diagnosed with atypical ductal hyperplasia (ADH) and ductal carcinoma in situ (DCIS). We hypothesized that these stromal features may help identify patients at high risk for upstaging to invasive carcinoma.Methods and results: Analysis included 592 patients diagnosed with ADH or DCIS via breast biopsy. TILs, TLSs and myxoid stroma were correlated with high-risk features, including larger lesion size, higher BIRADS scores, higher nuclear grade, comedonecrosis, oestrogen receptor (ER) negativity and HER2 overexpression, and were associated with an increased risk of upstaging. In a multivariate logistic regression model incorporating stromal TILs or TLSs, myxoid stroma and basic pathological factors, both stromal TILs or TLSs and myxoid stroma showed independent predictive value, with an AUC of 0.77. The AUC further increased to 0.87 when clinical factors and immunohistochemistry (ER and HER2) were included. Both stromal TILs or TLSs and myxoid stroma demonstrated predictive power exceeding that of comedonecrosis and comparable with nuclear grade. The two pathologists showed moderate to high interobserver agreement in evaluating these stromal and immune features. A simplified scoring system based on six clinicopathological variables retained strong discriminative ability (AUC 0.84).Conclusions: Stromal TILs, TLSs and myxoid stroma are robust predictors of upstaging to invasive carcinoma in patients diagnosed with ADH/DCIS on biopsy. These features can be readily assessed by pathologists using only H&E staining and should be considered in future risk stratification models to inform clinical decision-making.","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0