Histopathology最新文献

{"title":"Breast biomarkers evolution between primary and distant metastasis: incidence and significance.","authors":"Maha Khedr, Shipra Gandhi, Arya Mariam Roy, Malak Alharbi, Anthony George, Kristopher Attwood, Thaer Khoury","doi":"10.1111/his.15387","DOIUrl":"https://doi.org/10.1111/his.15387","url":null,"abstract":"<p><strong>Aims: </strong>To evaluate the evolution when breast cancer (BC) is classified as three clinical profiles and five clinical profiles by incorporating human epidermal growth factor 2 (HER2)-low to the biomarkers' profile.</p><p><strong>Methods and results: </strong>BC with distant metastasis that has document hormonal receptors (HR) (positive, negative) and HER2 (positive, low, zero) results were included (n = 161). Cases were categorised into three clinical profiles (HR-positive/HER2-negative, HER2-positive and TNBC) and five (HR-positive/HER2-zero, HR-positive/HER2-low, HR-negative/HER2-zero, HR-negative/HER2-low, HR-positive or negative/HER2-positive). Evolution occurred in 22.4% cases when three clinical profiles were analysed and 36.6% considering five clinical profiles. There were no statistically significant differences among the three clinical profiles in overall survival (OS). When five clinical profiles were analysed, HR-negative/HER2-zero had the worst OS with HzR = 6.82 and 95% confidence interval (CI) =1.19, 39.23, P = 0.031. In the multivariable analysis, ER-positive was associated with HER2 discordance less than oestrogen receptor (ER)-negative with odds ratio (OR) = 0.354 and 95% CI = 0.14-0.88, P = 0.025. In the multivariable analysis, patients with Eastern Cooperative Oncology Group 2+ had worse OS with hazard ratio (HzR) = 5.54 and 95% CI = 2.4-12.79, P < 0.0001. HR concordant had better OS with HzR = 0.34 and 95% CI = 0.2-0.63, P = 0.0004. HER2 conversion from low to zero had worse OS than HER2 concordance with HzR 2.66 and 95% CI = 1.21-5.83, P = 0.015.</p><p><strong>Conclusions: </strong>Five-profile classification provides a more accurate idea about the rate of potential change in treating BC in the metastatic setting.</p>","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142835537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Featured Cover","authors":"Piers Blombery,&nbsp;Daphne de Jong,&nbsp;Judith A Ferry,&nbsp;Eric D Hsi,&nbsp;Sarah L Ondrejka,&nbsp;John F Seymour,&nbsp;Alberto Zamò,&nbsp;Alexandar Tzankov,&nbsp;Wencke Walter,&nbsp;Ilaria Iacobucci,&nbsp;Manja Meggendorfer,&nbsp;Ana C Xavier,&nbsp;Andishe Attarbaschi,&nbsp;Dita Gratzinger,&nbsp;Olga Balagué","doi":"10.1111/his.15391","DOIUrl":"https://doi.org/10.1111/his.15391","url":null,"abstract":"<p>The cover image is based on the articles <i>Closing the gap between biology and classification in splenic B-cell lymphomas</i> by Piers Blombery et al., https://doi.org/10.1111/his.15323; <i>Diagnosis of acute lymphoblastic leukaemia: an overview of the current genomic classification, diagnostic approaches, and future directions</i> by Wencke Walter et al., https://doi.org/10.1111/his.15338 and <i>Dedicated diagnostic approaches for mature B-cell non-Hodgkin lymphomas occurring in children, adolescents, and young adults</i> by Ana C Xavier et al., https://doi.org/10.1111/his.15362.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":"86 1","pages":"i"},"PeriodicalIF":3.9,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/his.15391","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142868649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in peripheral T cell lymphomas: pathogenesis, genetic landscapes and emerging therapeutic targets","authors":"Alexander S Pichler,&nbsp;Catalina Amador,&nbsp;Ayumi Fujimoto,&nbsp;Kengo Takeuchi,&nbsp;Daphne de Jong,&nbsp;Javeed Iqbal,&nbsp;Philipp B Staber","doi":"10.1111/his.15376","DOIUrl":"10.1111/his.15376","url":null,"abstract":"<p>Peripheral T cell lymphomas (PTCLs) are a biologically diverse and aggressive group of non-Hodgkin lymphomas that originate from mature T cells, often presenting with complex clinical and morphological features. This review explores the challenges in diagnosing and classifying PTCLs, focusing on the intricate biology of the more common nodal entities. Advances in molecular diagnostics, such as mutational and gene expression profiling, have improved our understanding. However, the rarity and morphological variability of PTCLs continue to complicate the definition of biologically and clinically meaningful entities, as well as the application of current diagnoses in daily practice; these advancements have not yet translated into improved clinical outcomes. Standard therapies fail in most cases and lead to poor prognoses, highlighting the urgent need for improved therapeutic strategies. Precise characterisation of PTCL advances refined classification and supports the development of more targeted and effective treatments. Recent approaches have focused on biology-based risk stratification, either within specific entities or in an entity-agnostic manner. This development aims for improved treatment selection or even personalised treatment based on genetic, epigenetic and functional profiles.</p>","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":"86 1","pages":"119-133"},"PeriodicalIF":3.9,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/his.15376","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Haematolymphoid malignancies: beyond the current classifications","authors":"Daphne de Jong,&nbsp;Torsten Haferlach","doi":"10.1111/his.15368","DOIUrl":"10.1111/his.15368","url":null,"abstract":"","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":"86 1","pages":"3-5"},"PeriodicalIF":3.9,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological features and prognosis of alpha-fetoprotein-producing colorectal adenocarcinoma.","authors":"Yuqing Cheng, Xinwen Zhang, Ting Li, Chongfang He, Haojun Yang, Xiaoli Zhou, Qin Huang","doi":"10.1111/his.15379","DOIUrl":"https://doi.org/10.1111/his.15379","url":null,"abstract":"<p><strong>Aims: </strong>Alpha-fetoprotein (AFP)-producing colorectal adenocarcinoma (AFPCRA) is uncommon, with obscure clinicopathological features and prognosis.</p><p><strong>Methods and results: </strong>In this retrospective comparison study on surgically resected colorectal adenocarcinomas (CRA, n = 2389), we investigated and compared clinicopathological and prognostic features between AFPCRA cases with elevated pre-operative serum AFP levels, as the AFPCRA study group (n = 49, 2.1%), and the exact sex-, age- and stage-matched CRA cases as the control group at a 1:2 ratio during the study period from 2011 to 2021. The AFPCRA group was further divided into low and high serum AFP-level subgroups at the cut-off of 8.4 ng/ml. Compared to the control group, the AFPCR group showed a significantly higher frequency in extramural venous invasion, intermediate/high tumour budding grade, poor tumour differentiation, liver and distant metastases, mixed and hepatoid adenocarcinomas. The 5-year overall survival rate was significantly lower in the AFPCRA group (69.2%) than in the control (87.2%) (P = 0.002). The high AFP-level AFPCRA subgroup displayed a significantly higher prevalence of the left colon location than the low AFP-level subgroup. Risk factors of overall survival for the AFPCRA group included lymphovascular, perineural and extramural venous invasion, poor tumour differentiation, tumour budding grade, distant metastasis, pN, pM and pathological summary stages, while distant metastasis was the only independent prognostic risk factor.</p><p><strong>Conclusions: </strong>AFPCRA was rare and may be associated with aggressive behaviour and poor prognosis. These preliminary findings in this single-centre study remain to be validated by future studies with larger samples.</p>","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding and overcoming the pitfalls in the diagnosis of pleomorphic and carcinoma ex-pleomorphic adenoma of salivary glands.","authors":"Ziyad Alsugair, Charles Lépine, Maxime Fieux, Françoise Descotes, Daniel Pissaloux, Jonathan Lopez, Juliette Russel, Philippe Céruse, Pierre Philouze, Emmanuelle Uro-Coste, Aurore Siegfried, Valérie Costes-Martineau, Anne Champagnac, Nazim Benzerdjeb","doi":"10.1111/his.15392","DOIUrl":"https://doi.org/10.1111/his.15392","url":null,"abstract":"<p><p>The study illustrates a recurrent pitfall in the diagnosis of pleomorphic adenoma and carcinoma ex pleomorphic adenoma.</p>","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serous-like breast carcinomas: immunophenotypic, genetic, and clinicopathologic characterization of a morphologically distinct group of tumours.","authors":"Gregor Krings, Eliah R Shamir, Marick Laé, Gregory R Bean, Miriam D Post, Stuart J Schnitt, Yunn-Yi Chen","doi":"10.1111/his.15385","DOIUrl":"https://doi.org/10.1111/his.15385","url":null,"abstract":"<p><strong>Aims: </strong>Unusual morphologic patterns of breast carcinomas can raise diagnostic consideration for metastasis or special breast cancer subtypes with management implications. We describe rare invasive breast cancers that mimic serous carcinoma of the gynaecologic tract (serous-like breast carcinomas, SLBC) and characterize their clinicopathologic, immunophenotypic, and genetic features.</p><p><strong>Methods and results: </strong>All patients were female (n = 15, median age 49 years) without a history of gynaecologic malignancy. SLBC were characterized histologically by angulated, branched, sometimes anastomosing glands with micropapillary and/or pseudopapillary luminal projections in desmoplastic stroma. Most SLBC were triple-negative (TN, n = 10) or HER2-positive (n = 2) and grade 2 or 3, while some were oestrogen receptor (ER) low-positive/HER2-negative and low-grade (n = 3). CK5/6 was positive irrespective of grade or receptor status (10/10). All SLBC expressed GATA3 (14/15), TRPS1 (7/7), and/or mammaglobin (4/13). SOX10 was positive in most TN (9/10) and all ER low-positive (3/3) cases, but negative in HER2-positive tumours. WT1 was universally negative, and PAX8 was focal in one mammaglobin-positive tumour. All ER-negative SLBC were p53-aberrant and 9/11 were p16-aberrant, whereas ER-positive tumours were wildtype for both markers (3/3). TP53 was the only frequently mutated gene, altered in all ER-negative (10/10) but no ER-positive (0/4) tumours. Clinical behaviour was variable. Only 1/6 patients achieved pathologic complete response to neoadjuvant chemotherapy.</p><p><strong>Conclusion: </strong>SLBC is a rare morphologic pattern of invasive breast carcinoma that mimics metastatic serous gynaecologic carcinoma, a potential diagnostic pitfall. SLBC are heterogeneous with respect to grade, receptor profile, and oncogenic driver alterations, without specific genetic underpinnings identified. Additional studies are warranted to further evaluate the clinical behaviour of these tumours.</p>","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-grade myxoid spindle cell neoplasm with novel gene fusions involving MAP3K3 and MAP3K8 kinases: a report of two cases.","authors":"Azfar Neyaz, Mana Mohebnasab, Elan Hahn, Joel Rosenbaum, Lucas da Gama Lobo, Arivarasan Karunamurthy, Ivy John, Kurt R Weiss, Karen Schoedel, Simion I Chiosea, Rana Naous","doi":"10.1111/his.15388","DOIUrl":"https://doi.org/10.1111/his.15388","url":null,"abstract":"","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpretation of testicular biopsy for infertility: a practical guide.","authors":"Turki Al-Hussain, Walaa M Borhan","doi":"10.1111/his.15366","DOIUrl":"https://doi.org/10.1111/his.15366","url":null,"abstract":"<p><p>Testicular biopsies are often performed in men with unexplained infertility and azoospermia to ascertain the status of spermatogenesis. Testicular pathology is one of the primary causes of male infertility. However, infrequent exposure among pathologists and a lack of uniform reporting terminology pose diagnostic challenges and variability in interpretation. These issues may lead to inaccurate evaluations, potentially impacting clinical management. The goal of this review is to offer a straightforward, practical approach to interpreting testicular biopsies, thereby assisting pathologists who handle such rare samples. Accurate interpretation of testicular biopsy for infertility plays a crucial role in management of infertile men. In this review, we present a practical guide for reporting testicular biopsies.</p>","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nuclear morphological characterisation of lobular carcinoma variants: a morphometric study.","authors":"Ayaka Katayama, Shorouk Makhlouf, Michael S Toss, Tetsunari Oyama, Emad A Rakha","doi":"10.1111/his.15390","DOIUrl":"https://doi.org/10.1111/his.15390","url":null,"abstract":"<p><strong>Background and aims: </strong>Lobular carcinoma (LC) of the breast exhibits diverse morphology and clinical behaviour. The pleomorphic variant (pLC) displays distinct cytonuclear features and aggressiveness compared to the classic variant (cLC). However, diagnosing pLC remains subjective. This study aims to refine LC's cytonuclear features, focusing on pLC.</p><p><strong>Methods: </strong>Whole slide images of 59 LCs, including both in situ (LCIS) and invasive (ILC) lesions, were analysed. Nuclear measurements, including nuclear size and variability, were scored using QuPath image analysis software. For comparison, selected features were scored in normal cells (n = 10) and pleomorphism score-matched invasive breast carcinoma (IBC) of NST type (n = 33). Additional visual assessment of the pleomorphic ILC (pILC) cohort (n = 90) was conducted for cytomorphological features characterisation.</p><p><strong>Results: </strong>pILC demonstrated larger nuclear area and higher nuclear variability with abundance of cytoplasm than cILC. Compared to lymphocytes, pILC demonstrated a median area ranging from 2.7 to 4.7 times larger. Cut-off values for differentiating pILC from other ILC subtypes included median nuclear area > 48.2 μm² and interquartile range (IQR) > 19.4, nuclear perimeter median > 25.2 μm and IQR > 5.3 and maximum diameter > 9.1 μm and IQR > 2.2. Multivariable logistic regression confirmed these parameters as independent predictors of pILC, with the maximum diameter being the most significant (P < 0.001). Visual assessment recognised two pILC subtypes: apocrine and non-apocrine. Apocrine variant showed nuclear roundness, pale vesicular chromatin patterns and prominent nucleoli, while non-apocrine variant exhibited greater nuclear size and shape variation.</p><p><strong>Conclusions: </strong>Objective nuclear measurements, combined with cytoplasmic and architectural features, provide a robust framework for diagnosing LC subtypes, improving diagnostic accuracy and reproducibility.</p>","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}