Histopathology最新文献

{"title":"TERT promoter mutations are useful to distinguish phyllodes tumours with a fibroadenoma-like morphology from cellular fibroadenomas.","authors":"Alex Fortun, Hilde Vernaeve, Anne-France Dekairelle, Ophélie Simon, Tanja Schraepen, Christine Galant, Mieke R Van Bockstal","doi":"10.1111/his.15552","DOIUrl":"https://doi.org/10.1111/his.15552","url":null,"abstract":"","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144992444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastric biopsies with prominent eosinophils: Clinicopathologic features and response to therapy.","authors":"Nigar Anjuman Khurram, Sanjay Kakar, Dana Balitzer","doi":"10.1111/his.15549","DOIUrl":"https://doi.org/10.1111/his.15549","url":null,"abstract":"<p><strong>Aims: </strong>The use of the term 'histologic eosinophilic gastritis' (EoG) has been proposed for cases with ≥30 eosinophils/high power field (HPF) in five separate HPF and with no known associated causes of eosinophilia. This study evaluates the clinical presentation, pathologic characteristics of 'histologic eosinophilic gastritis'.</p><p><strong>Methods and results: </strong>Gastric biopsies with prominent mucosal eosinophils over 23 years were retrieved yielding 87 qualifying cases. Clinical information and follow-up data were retrieved from medical records. Of the 72 cases with no discernible aetiology, 56 satisfied the criteria for 'histologic eosinophilic gastritis' (Group 1), while 16 had prominent eosinophils without satisfying these criteria (Group 2). There were no differences in clinical presentation, endoscopic findings, morphologic features or treatment response between these groups. The cases with a secondary aetiology (Group 3), included Crohn disease (n = 5), concurrent or prior history of Helicobacter pylori gastritis (n = 5), strongyloidiasis (n = 1), collagenous gastritis (n = 1), hyper-eosinophilic syndrome (n = 1), autoimmune atrophic gastritis (n = 1) and systemic mastocytosis (n = 1). Of the 10 patients with histologic eosinophilic gastritis who were treated with steroids (with or without a combination of other therapies), seven (70%) had documented response to steroid-based therapy, with three (30%) patients who were symptomatically steroid non-responsive. No histologic differences were identified in patients with steroid-responsive disease. Two patients developed relapsing disease characterized by severe abdominal pain dependent on steroid therapy.</p><p><strong>Conclusions: </strong>The criteria for 'histologic eosinophilic gastritis' can miss cases with clinically significant eosinophilia and our study results argue against using this term for pathology diagnosis. The majority of patients with increased gastric mucosal eosinophils present with non-specific GI symptoms and endoscopic findings. While a significant proportion of patients improve symptomatically without treatment or with anti-acid therapy, a small proportion of patients develop steroid-dependent, relapsing idiopathic disease that warrants additional clinical follow-up.</p>","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144992413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of oncologic outcomes in high-grade organ-confined prostate cancer after prostatectomy","authors":"Reem Youssef,&nbsp;Omer AM Saeed,&nbsp;Ezra Baraban,&nbsp;Mohammad Salimian,&nbsp;Kenneth A Iczkowski,&nbsp;Lorene J Chung,&nbsp;Nicholas Baniak,&nbsp;Eva M Compérat,&nbsp;Ying Wang,&nbsp;Geert JLH van Leenders,&nbsp;Ankur R Sangoi,&nbsp;Douglas Jian-Xian Wu,&nbsp;Adeboye O Osunkoya,&nbsp;Shivani Kandukuri,&nbsp;Alicia Cuber,&nbsp;Kvetoslava Michalova,&nbsp;Andrea Strakova-Peterikova,&nbsp;Guido Martignoni,&nbsp;Anna Caliò,&nbsp;Lisa Marcolini,&nbsp;Hiroshi Miyamoto,&nbsp;Angela Pecoraro,&nbsp;Toyonori Tsuzuki,&nbsp;Andres Martin Acosta","doi":"10.1111/his.15547","DOIUrl":"10.1111/his.15547","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>In radical prostatectomy (RP), Grade Group (GG) 4/5 prostate cancer [high-grade prostate cancer (HGPC) hereafter] is often associated with extension beyond the prostate and positive surgical margins. Hence, there is limited information on post-RP outcomes of patients with completely resected HGPC confined to the prostate (pT2).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and methods</h3>\u0000 \u0000 <p>Clinical outcomes were assessed in a cohort of patients with pT2 HGPC and negative surgical margins using Kaplan-Meier statistics and Cox regression analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results and conclusion</h3>\u0000 \u0000 <p>Four hundred and seven RPs were initially assessed: 236 (58%) with GG 4 and 171 (42%) with GG 5 prostate cancer (PCa). Survival analysis was performed on subsets of patients with available follow-up (BCR: <i>n</i> = 343, metastases: <i>n</i> = 347) to identify clinicopathologic variables associated with the risk of biochemical recurrence and metastasis. The size of the dominant nodule (cut-off 15 mm) (HR 1.654, 95% CI 1.026–2.667; <i>P</i> = 0.04) and the preoperative PSA level (HR 1.052, 95% CI 1.009–1.097; <i>P</i> = 0.02) were associated with a higher likelihood of BCR on univariate regression analysis, with only preoperative PSA remaining significant when both variables were assessed concurrently (HR 1.051, 95% CI 1.007–1.098; <i>P</i> = 0.02). On univariate Cox regression analysis, the size of the dominant nodule (cut-off: 15 mm; HR 6.315, 95% CI 2.021–19.725; <i>P &lt;</i> 0.01), the presence of large cribriform components (HR 4.375, 95% CI 0.999–19.159; <i>P</i> = 0.05), and LVI (HR 3.808, 95% CI 1.086–13.354; <i>P</i> = 0.04) were associated with the risk of metastasis, but only size remained an independent predictor on multivariate analysis (HR 5.66, 95% CI 1.761–18.191; <i>P</i> &lt; 0.01In p for cut-off of 15 mm).</p>\u0000 </section>\u0000 </div>","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":"87 5","pages":"736-744"},"PeriodicalIF":4.1,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/his.15547","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifocal extramural venous invasion is a powerful predictor of adverse oncological outcomes in stages I-III colorectal cancer.","authors":"Aysegul Sari, David P Cyr, Cherry Pun, Sameer Shivji, Deanna Ng, Kai Duan, Amanpreet Brar, Siham Zerhouni, Rossi Tomin, Carol J Swallow, Erin D Kennedy, Mantaj S Brar, James R Conner, Richard Kirsch","doi":"10.1111/his.15519","DOIUrl":"https://doi.org/10.1111/his.15519","url":null,"abstract":"<p><strong>Aims: </strong>This study aimed to determine the impact of venous invasion (VI) characteristics on oncological outcomes in colorectal cancer (CRC).</p><p><strong>Methods and results: </strong>Resection specimens from 368 patients with TNM stages I-III CRC were assessed for VI including its presence/absence, location [intramural (IMVI) or extramural (EMVI)], number and size of the largest VI focus. VI and EMVI were identified in 55% and 32% of cases, respectively. EMVI, but not IMVI, was significantly associated with decreased 5-year recurrence-free survival (RFS) and disease-specific survival (DSS) (hazard ratio [HR] 4.2, 95% confidence interval CI [2.6-6.9] and 3.7 [95% CI 1.9-6.9], p < 0.0001, respectively). Multifocal EMVI (mEMVI), defined as 2 or more EMVI foci, was identified in 67% of EMVI-positive cases. In multivariable analysis, EMVI (HR 2.4 [95% CI 1.3-4.3], P = 0.003) and mEMVI (HR 2.4 [95% CI: 1.3-4.4], P = 0.02) were independently associated with RFS and demonstrated stronger associations than all other examined features, including T and N stage. These associations were maintained when the cohort was expanded to include 113 patients who received neoadjuvant therapy in addition to the original 368 patients who had not ('expanded cohort', n = 481). An increasing number of EMVI foci was significantly associated with decreased RFS and DSS (P < 0.0001). Patients with >5 EMVI foci (n = 31) had a particularly poor prognosis with 5-year RFS and DSS of 29% and 56%, respectively. EMVI dimensions were not associated with oncological outcomes.</p><p><strong>Conclusions: </strong>Extramural location and multifocality are features of VI strongly associated with adverse oncological outcomes. If externally validated, incorporation of EMVI multifocality into future reporting protocols merits consideration.</p>","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathologic, immunohistochemical and genomic characterization of urothelial carcinoma with myxoid and chordoid features","authors":"Ting Zhao,&nbsp;Mahmut Akgul,&nbsp;Stephanie E Siegmund","doi":"10.1111/his.15545","DOIUrl":"10.1111/his.15545","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To comprehensively characterize the clinicopathologic, immunohistochemical and genomic features of urothelial carcinoma with myxoid and chordoid features (UCMC), a rare histologic subtype of urothelial carcinoma with fewer than 50 reported cases in the literature.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods and results</h3>\u0000 \u0000 <p>We retrospectively identified and analysed eight cases of UCMC using clinicopathologic information, immunohistochemistry and molecular profiling by DNA next-generation sequencing. Genomic analysis revealed a heterogeneous molecular profile, with alterations previously implicated in urothelial carcinoma, including p53/Rb/cell cycle pathway genes (6/7 cases), histone modification genes (6/7 cases) and FGFR3/PIK3CA signalling pathway genes (5/7 cases). Actionable variants were present in 6/7 cases. Classification utilizing immunohistochemical surrogates for basal and luminal subtypes of urothelial carcinoma demonstrated mixed subtypes: three cases with a luminal profile, one case with a basal profile, two cases which were double negative and two cases with a non-specific profile. One case demonstrated a molecular and immunohistochemical profile consistent with plasmacytoid urothelial carcinoma, suggesting that myxoid and chordoid features may overlap with previously recognized histologic subtypes. The five-year overall survival rate was 75%, with varying stages at presentation (pT1–pT3).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>UCMC represents a rare histologic finding, which can be associated with multiple molecular subtypes of urothelial carcinoma and can pose a diagnostic dilemma when identifying potentially aggressive histologic subtypes. It is uncertain whether UCMC represents a distinct histologic subtype, or (more likely) a histologic pattern acquired during tumour evolution. Further investigation is needed to fully understand the biological and clinical significance of this histologic pattern.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":"87 5","pages":"757-767"},"PeriodicalIF":4.1,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Superficial plexiform schwannoma of the skin and subcutis: Clinicopathological study of 48 cases.","authors":"David I Suster, John M Gross, Steven D Billings, Jennifer S Ko, Saul M Suster, Shira Ronen","doi":"10.1111/his.15544","DOIUrl":"https://doi.org/10.1111/his.15544","url":null,"abstract":"<p><strong>Aims: </strong>To study the clinicopathological characteristics of a large cohort of cutaneous plexiform schwannoma.</p><p><strong>Methods and results: </strong>A total of 48 cases of plexiform schwannoma were collected. Clinical and pathological features including age, location, location within the dermis, histology, immunohistochemical features, treatment and clinical follow-up were collected by reviewing glass slides or abstracted from the medical record. The patients were 22 women and 26 men aged 6-84 years (mean: 43). The tumours arose in the extremities in 17 patients, trunk in 17, head and neck in 12, and buttock in 2. The tumours were all superficially located and confined to the dermis, subcutis, or both and measured from 0.3 to 6.0 cm (mean: 2.0 cm). The tumours were all well-circumscribed and showed a multinodular, plexiform pattern of growth. Histologically they showed features of Antoni type A in 30 cases, Antoni type B in 3, and a combination of type A and type B in 15. Immunohistochemical stains in all cases were positive for S100 and SOX10 and showed peripheral condensation of EMA and CD34 positive perineurial cells. The Ki-67 index was low in all cases (1%-2%). Seven patients (12.5%) had type 2 neurofibromatosis (NF2). All patients were treated by complete surgical excision. Clinical follow-up from 13 months to 5 years was available in 16 patients; there was no evidence of recurrence or metastases.</p><p><strong>Conclusions: </strong>Plexiform schwannomas arising in the skin and subcutis are indolent. A subset shows an association with neurofibromatosis type 2.</p>","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two similar but distinct types of breast acinar cell carcinoma: evidence from histological, immunohistochemical and molecular features.","authors":"Mingfang Sun, Lin Fu, Hongjiu Ren, Jian Wang, Xuyong Lin, Qingfu Zhang","doi":"10.1111/his.15543","DOIUrl":"https://doi.org/10.1111/his.15543","url":null,"abstract":"<p><strong>Aims: </strong>Breast acinar cell carcinoma (AciCC) is a rare breast cancer subtype that exhibits morphological similarities to salivary gland AciCC. However, the molecular profile of breast AciCC differs significantly from that of salivary gland AciCC, suggesting that they may not be related. Whether breast AciCC represents a distinct breast cancer subtype remains controversial.</p><p><strong>Methods and results: </strong>This study analysed two groups of breast AciCCs. Using comprehensive morphological, immunohistochemical, fluorescence in situ hybridisation and next-generation sequencing analyses, we elucidated the similarities and differences between these two distinct types of 'breast AciCCs' and their salivary gland counterpart. The first, based on morphological and immunohistochemical features, satisfied the 2019 World Health Organization diagnostic criteria for breast AciCC. Notably, NR4A3, a specific marker for salivary gland AciCC, was not expressed in these cases. We propose designating this tumour type as 'carcinoma with acinar cell differentiation'. In contrast, the second group included a case of AciCC in situ, which demonstrated morphological, immunohistochemical and molecular features identical to those of salivary gland AciCC, including NR4A3 protein overexpression and NR4A3 gene rearrangement. This case was considered a precursor of true salivary gland-type AciCC originating in the breast.</p><p><strong>Conclusions: </strong>This study provides new insights into breast AciCC nomenclature: the widely recognised AciCC name, 'carcinoma with acinar cell differentiation' might be more appropriate. Although true salivary gland-type AciCC requires additional cases for confirmation, our case has clarified that true salivary gland-type AciCC can indeed exist in the breast.</p>","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urothelial carcinoma reporting: more grade categories improve risk stratification","authors":"Murali Varma","doi":"10.1111/his.15546","DOIUrl":"10.1111/his.15546","url":null,"abstract":"","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":"87 5","pages":"647-648"},"PeriodicalIF":4.1,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathology reporting of hepatoblastoma resections: recommendations from the international collaboration on cancer reporting.","authors":"Dolores H López-Terrada, Fleur Webster, Rita Alaggio, Jonathan W Bush, Soo-Jin Cho, Ronald R de Krijger, Takeshi Inoue, Allison F O'Neill, Antonio R Perez-Atayde, Sarangarajan Ranganathan, Jens Stahlschmidt, Yukichi Tanaka, Marta Cohen, Miguel Reyes-Múgica","doi":"10.1111/his.15536","DOIUrl":"10.1111/his.15536","url":null,"abstract":"<p><strong>Aims: </strong>Hepatoblastoma is the most common primary malignant tumour of the liver diagnosed in children and its incidence is increasing worldwide. Ongoing international clinical trials and scientific collaborative efforts are attempting to standardize the diagnosis, risk stratification and management of young patients diagnosed with this rare cancer, which includes surgical resection of the tumour. Here we report the international consensus-based dataset for the pathology reporting of hepatoblastoma resection specimens. The dataset was developed under the auspices of the International Collaboration on Cancer Reporting (ICCR), a global alliance of international pathology and cancer organizations.</p><p><strong>Methods and results: </strong>According to the ICCR's guidelines for dataset development, an international expert panel including paediatric pathologists and a paediatric oncologist specialized in liver tumours developed a set of core and non-core data items for hepatoblastoma resection specimens based on critical review and discussion of current evidence available. Members of the panel were specialists working in tertiary paediatric hospitals, central reviewers for international paediatric liver tumours consortia and/or involved in paediatric liver tumour trials expert committees. Commentaries were provided to support each data item, explaining the rationale for selecting them as a 'core' or 'non-core' elements, their clinical relevance and highlighting potential areas of lack of evidence, including clinical, macroscopic, microscopic and ancillary testing considerations. The hepatoblastoma dataset was finalized and ratified following international public consultation and is published on the ICCR website for wide implementation.</p><p><strong>Conclusion: </strong>This is the first international dataset developed by an international expert panel for reporting hepatoblastoma resection specimens aimed to promote high-quality, standardized pathology reporting of these rare paediatric liver tumours. The adoption and implementation of this hepatoblastoma data set, freely available worldwide on the ICCR website (www.iccr-cancer.org/data-sets), will facilitate accurate reporting and enhance the consistency of data collection, support retrospective and inform prospective research and ultimately help to improve clinical outcomes of children with hepatoblastoma.</p>","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropathology","authors":"","doi":"10.1111/his.15495","DOIUrl":"https://doi.org/10.1111/his.15495","url":null,"abstract":"","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":"87 S1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/his.15495","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144861761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}