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Open Journal of Radiology and Medical Imaging最新文献

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Designing a Simple Electromechanical Device for Using to Automatically and Non–Invasively Diagnose Deep Tissue Pathology Such as Psoriasis 设计一种用于自动无创诊断牛皮癣等深层组织病理的简易机电装置
Open Journal of Radiology and Medical Imaging Pub Date : 2021-12-20 DOI: 10.36811/ojrmi.2021.110030
Alireza Heidari, Ricardo Gobato, Abhijit Mitra
{"title":"Designing a Simple Electromechanical Device for Using to Automatically and Non–Invasively Diagnose Deep Tissue Pathology Such as Psoriasis","authors":"Alireza Heidari, Ricardo Gobato, Abhijit Mitra","doi":"10.36811/ojrmi.2021.110030","DOIUrl":"https://doi.org/10.36811/ojrmi.2021.110030","url":null,"abstract":"By placing a soft, sensitive device on the skin, you may be able to quickly detect non-invasive skin disorders in real time. A research team led by a scientist from California South University (CSU) has designed a simple electromechanical device that can be used to automatically and non-invasively diagnose deep tissue pathology such as psoriasis. These findings form the basis for future applications in the clinical evaluation of skin cancers or skin diseases.\u0000\u0000Keywords: Cancer; Cells; Tissues; Tumors; Prevention; Prognosis; Diagnosis; Imaging; Screening, Treatment; Management","PeriodicalId":132118,"journal":{"name":"Open Journal of Radiology and Medical Imaging","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129960735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Searching Cytotoxic T Cells for Destroying Target Invading Cells 寻找细胞毒性T细胞摧毁目标入侵细胞
Open Journal of Radiology and Medical Imaging Pub Date : 2021-12-20 DOI: 10.36811/ojrmi.2021.110033
Alireza Heidari, Ricardo Gobato, Abhijit Mitra
{"title":"Searching Cytotoxic T Cells for Destroying Target Invading Cells","authors":"Alireza Heidari, Ricardo Gobato, Abhijit Mitra","doi":"10.36811/ojrmi.2021.110033","DOIUrl":"https://doi.org/10.36811/ojrmi.2021.110033","url":null,"abstract":"A groundbreaking study led by engineering and medical researchers at the California South University (CSU) shows how immune cells engineered in new cancer therapies can overcome physical barriers so that the patient's own immune system can fight tumors. This research could improve the future of millions of cancer patients worldwide. Immunotherapy, instead of using chemicals or radiation, is a type of cancer treatment that helps the patient's immune system fight cancer. T cells are a type of white blood cell that is essential for the body's immune system. Cytotoxic T cells are like soldiers searching for and destroying target invading cells. Although there has been success in using immunotherapy for some types of cancer in the blood or blood-producing organs, T cell work is much more difficult in solid tumors\u0000\u0000Keywords: Cancer; Cells; Tissues; Tumors; Prevention; Prognosis; Diagnosis; Imaging; Screening, Treatment; Management","PeriodicalId":132118,"journal":{"name":"Open Journal of Radiology and Medical Imaging","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124864772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Indication of a Type of DNA Damage Called "Alkylation" as High Levels of Tumor Alkylation Damage 一种被称为“烷基化”的DNA损伤是肿瘤高水平烷基化损伤的迹象
Open Journal of Radiology and Medical Imaging Pub Date : 2021-12-20 DOI: 10.36811/ojrmi.2021.110028
Ricardo Gobato, Abhijit Mitra
{"title":"Indication of a Type of DNA Damage Called \"Alkylation\" as High Levels of Tumor Alkylation Damage","authors":"Ricardo Gobato, Abhijit Mitra","doi":"10.36811/ojrmi.2021.110028","DOIUrl":"https://doi.org/10.36811/ojrmi.2021.110028","url":null,"abstract":"In this recent study, DNA data from 900 patients with colorectal cancer were reviewed. Analysis of the data showed a distinct mutation signature, a pattern that had never been identified before but indicated a type of DNA damage called \"alkylation.\" Red meat contains chemicals that can cause alkylation. High levels of tumor alkylation damage are seen only in patients who consume an average of more than 150 grams of meat per day, roughly equivalent to two or more meals. On the other hand, a group of researchers in 2019 in a controversial conclusion stated that they do not have much confidence in reducing deaths from colon cancer by avoiding red meat.\u0000\u0000Keywords: Cancer; Cells; Tissues; Tumors; Prevention; Prognosis; Diagnosis; Imaging; Screening, Treatment; Management","PeriodicalId":132118,"journal":{"name":"Open Journal of Radiology and Medical Imaging","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130474699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of a Mimicry of the Protein that Potentially Isolates the Mutated p53 Material and Prevents Further Protein Accumulation 鉴定一种可能分离突变p53物质并阻止进一步蛋白质积累的蛋白质拟态
Open Journal of Radiology and Medical Imaging Pub Date : 2021-12-20 DOI: 10.36811/ojrmi.2021.110024
Ricardo Gobato, Abhijit Mitra
{"title":"Identification of a Mimicry of the Protein that Potentially Isolates the Mutated p53 Material and Prevents Further Protein Accumulation","authors":"Ricardo Gobato, Abhijit Mitra","doi":"10.36811/ojrmi.2021.110024","DOIUrl":"https://doi.org/10.36811/ojrmi.2021.110024","url":null,"abstract":"The team first screened a set of protein mimics originally designed to target Alzheimer's disease and type 2 diabetes. The results identify a mimicry of the protein that potentially isolates the mutated p53 material and prevents further protein accumulation. The researchers then showed that segregation of mutated p53 grains by protein mimicking restored the suppressive function of the p53 tumor, leading to the death of a wide range of cancer cells. Importantly, protein mimicry therapy effectively reduces tumors that contain mutated p53 while showing no significant toxins for healthy tissue, resulting in significantly longer survival. \"As the prevalence of cancer increases worldwide, there is an urgent need for new cancer therapies to complement or replace existing therapies,\" said the study's lead author. Here we show the first successful use of a small molecule amyloid inhibitor as an anticancer agent. We believe that this will have a far-reaching impact, as it effectively bridges the gap between amyloid disease and cancer and is the basis for passing on information approaches in the design of new and robust cancer mutation therapies for the p53 mutation.\u0000\u0000Keywords: Cancer; Cells; Tissues; Tumors; Prevention; Prognosis; Diagnosis; Imaging; Screening, Treatment; Management","PeriodicalId":132118,"journal":{"name":"Open Journal of Radiology and Medical Imaging","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114594650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Removing the Breast from the Body, Cryoectomy or Cryopreservation of Tumors Preserve Breast Size, Reduce the Risk of Infection and Prevent Scarring 切除乳房，冷冻切除或冷冻保存肿瘤保持乳房大小，减少感染的风险，防止疤痕
Open Journal of Radiology and Medical Imaging Pub Date : 2021-12-20 DOI: 10.36811/ojrmi.2021.110034
Ricardo Gobato, Abhijit Mitra
{"title":"Removing the Breast from the Body, Cryoectomy or Cryopreservation of Tumors Preserve Breast Size, Reduce the Risk of Infection and Prevent Scarring","authors":"Ricardo Gobato, Abhijit Mitra","doi":"10.36811/ojrmi.2021.110034","DOIUrl":"https://doi.org/10.36811/ojrmi.2021.110034","url":null,"abstract":"Unprecedented studies have shown that slow-growing breast cancers can be treated with highly targeted tumor cryopreservation technology without the need for surgery. Experiments show that this method is effective in women with low-risk breast cancer over the age of 60. Cryoablation is a solution that eliminates breast tumors safely, quickly and painlessly or without the need for surgery. Takes. This method exposes the patient's tissues to severe cold to remove them without the need for anesthesia in the clinic. The new study, which involved about 200 women, found that after eliminating low-risk breast cancer, patients were left without cancer for three years. This treatment can be used to treat cancers of the bone, kidney, prostate and other types. Unlike lumpectomy or mastectomy, which involves removing the breast from the body, cryoectomy or cryopreservation of tumors preserve breast size, reduce the risk of infection and prevent scarring, and allow patients to function normally quickly, the researchers said. Resume yourself.\u0000\u0000Keywords: Cancer; Cells; Tissues; Tumors; Prevention; Prognosis; Diagnosis; Imaging; Screening, Treatment; Management","PeriodicalId":132118,"journal":{"name":"Open Journal of Radiology and Medical Imaging","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123311035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Overcoming Immune Depletion is the Main Goal of Developing New Therapies 克服免疫衰竭是开发新疗法的主要目标
Open Journal of Radiology and Medical Imaging Pub Date : 2021-12-20 DOI: 10.36811/ojrmi.2021.110023
Ricardo Gobato, Abhijit Mitra
{"title":"Overcoming Immune Depletion is the Main Goal of Developing New Therapies","authors":"Ricardo Gobato, Abhijit Mitra","doi":"10.36811/ojrmi.2021.110023","DOIUrl":"https://doi.org/10.36811/ojrmi.2021.110023","url":null,"abstract":"In recent years, immunotherapy has revolutionized the treatment of cancer; However, inflammatory reactions in healthy tissues often have side effects that can be serious and lead to permanent discontinuation of treatment. This toxicity is not yet well understood and is a major obstacle to the use of immunotherapy. When the immune system is so severely activated, the resulting inflammatory reaction can have detrimental effects and sometimes serious damage to healthy tissue. We wanted to know if there was a difference between an optimal immune response that aims to kill cancer and an unwanted response that could affect healthy tissue. Identifying the distinctive elements between these two immune responses allows the development of new, more effective and less toxic therapeutic approaches.\u0000\u0000Keywords: Cancer; Cells; Tissues; Tumors; Prevention; Prognosis; Diagnosis; Imaging; Screening, Treatment; Management","PeriodicalId":132118,"journal":{"name":"Open Journal of Radiology and Medical Imaging","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129236750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
T–Cell Engineering for Chimeric Antigen Receptor T–Cell Therapy in Cancer 嵌合抗原受体t细胞治疗肿瘤的t细胞工程
Open Journal of Radiology and Medical Imaging Pub Date : 2021-12-20 DOI: 10.36811/ojrmi.2021.110037
Ricardo Gobato, Abhijit Mitra
{"title":"T–Cell Engineering for Chimeric Antigen Receptor T–Cell Therapy in Cancer","authors":"Ricardo Gobato, Abhijit Mitra","doi":"10.36811/ojrmi.2021.110037","DOIUrl":"https://doi.org/10.36811/ojrmi.2021.110037","url":null,"abstract":"Through T-cell engineering, researchers at the California South University (CSU) Cancer Research Institute (CRI) have shown that tumor growth can be stopped in a variety of cancers and prevented from spreading to other tissues. Findings from this study are the result of decades of research by Professor Alireza Haidari, a member of the Cancer Biology Research Program at the California South University (CSU), who discovered a protein called AH that can inhibit the growth and spread of cancer cells in several different ways. They become in the tissues of the body.\u0000\u0000Keywords: Cancer; Cells; Tissues; Tumors; Prevention; Prognosis; Diagnosis; Imaging; Screening, Treatment; Management","PeriodicalId":132118,"journal":{"name":"Open Journal of Radiology and Medical Imaging","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128161733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Significant Role of Nanoparticles as a Drug Delivery System for Cancer Treatment 纳米颗粒作为癌症治疗药物传递系统的重要作用
Open Journal of Radiology and Medical Imaging Pub Date : 2021-12-20 DOI: 10.36811/ojrmi.2021.110029
Alireza Heidari, Ricardo Gobato, Abhijit Mitra
{"title":"Significant Role of Nanoparticles as a Drug Delivery System for Cancer Treatment","authors":"Alireza Heidari, Ricardo Gobato, Abhijit Mitra","doi":"10.36811/ojrmi.2021.110029","DOIUrl":"https://doi.org/10.36811/ojrmi.2021.110029","url":null,"abstract":"According to the results of a global phase 2 clinical trial, the new drug sotorasib reduces tumor size and promises to improve and increase survival in patients with lung tumors caused by specific DNA mutations. It is designed to counteract the effects of mutations that are seen in about 13% of patients with non-small cell lung adenocarcinoma (a common type of lung cancer). The Food and Drug Administration (FDA) on May 28 approved the drug as a targeted treatment for patients with small cell lung cancer whose tumors express a specific mutation called G12C in the KRAS gene. Small cell lung cancer accounts for more than 80% of lung cancers. More than 200,000 new cases of non-small cell lung cancer are diagnosed in the United States each year.\u0000\u0000Keywords: Cancer; Cells; Tissues; Tumors; Prevention; Prognosis; Diagnosis; Imaging; Screening, Treatment; Management","PeriodicalId":132118,"journal":{"name":"Open Journal of Radiology and Medical Imaging","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122485505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding the Relationship between Microbiome, Diet and Cancer Risk 了解微生物群、饮食和癌症风险之间的关系
Open Journal of Radiology and Medical Imaging Pub Date : 2021-12-20 DOI: 10.36811/ojrmi.2021.110032
Ricardo Gobato, Abhijit Mitra
{"title":"Understanding the Relationship between Microbiome, Diet and Cancer Risk","authors":"Ricardo Gobato, Abhijit Mitra","doi":"10.36811/ojrmi.2021.110032","DOIUrl":"https://doi.org/10.36811/ojrmi.2021.110032","url":null,"abstract":"When it comes to the microbiome, people usually think of the gut, but there is also the breast microbiome, and its role in the health and risk of breast cancer is not fully understood. A microbiome is a collection of microorganisms that live in a specific environment in the body. Diet can affect the breast microbiome, which shows that like the gut microbiome, breast microbiomes can respond to diet. New research now shows that diet, including fish oil supplements, can alter not only the breast microbiome but also its cancerous tumors.\u0000\u0000Keywords: Cancer; Cells; Tissues; Tumors; Prevention; Prognosis; Diagnosis; Imaging; Screening, Treatment; Management","PeriodicalId":132118,"journal":{"name":"Open Journal of Radiology and Medical Imaging","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131315635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Overcoming Immune Depletion is the Main Goal of Developing New Therapies for Cancer or Severe Viral Infections 克服免疫耗竭是开发癌症或严重病毒感染新疗法的主要目标
Open Journal of Radiology and Medical Imaging Pub Date : 2021-12-20 DOI: 10.36811/ojrmi.2021.110022
Ricardo Gobato, Abhijit Mitra
{"title":"Overcoming Immune Depletion is the Main Goal of Developing New Therapies for Cancer or Severe Viral Infections","authors":"Ricardo Gobato, Abhijit Mitra","doi":"10.36811/ojrmi.2021.110022","DOIUrl":"https://doi.org/10.36811/ojrmi.2021.110022","url":null,"abstract":"It is widely known that severe viral infections and cancer disrupt the immune system, including T cells, a process called \"immune fatigue.\" Overcoming immune depletion is the main goal of developing new therapies for cancer or severe viral infections. Called Apex cells, they can maintain their function for a long time.\u0000\u0000Keywords: Cancer; Cells; Tissues; Tumors; Prevention; Prognosis; Diagnosis; Imaging; Screening, Treatment; Management","PeriodicalId":132118,"journal":{"name":"Open Journal of Radiology and Medical Imaging","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128571873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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