HIV Medicine最新文献

{"title":"HIV in Latin American migrants in the UK: A neglected population in the 95-95-95 targets.","authors":"Natalie Elkheir, Catherine Dominic, Amy Price, Jessica Carter, Nadia Ahmed, David A J Moore","doi":"10.1111/hiv.70007","DOIUrl":"https://doi.org/10.1111/hiv.70007","url":null,"abstract":"<p><strong>Background: </strong>The UK has reached the UNAIDS 2025 targets (of 95% of those living with HIV to be diagnosed, 95% to be on treatment and 95% of those on treatment to be virally suppressed). However, it is not known whether this target is met in subgroups such as migrant populations. Latin Americans are a fast-growing migrant group in the UK and have low engagement with healthcare services, yet little is known about the HIV profile in this population. This study aimed to explore the profile of Latin American migrants under HIV care in the UK, and to identify any gaps in the 95-95-95 target in this population.</p><p><strong>Methods: </strong>Country of birth- and gender- stratified prevalence of HIV in Latin American migrants in the UK (as of December 2022) was estimated using data from the HIV and AIDS Reporting System and the Office for National Statistics. UNAIDS (2024) estimates from Latin American countries were used as proxies for expected prevalences and applied to Latin American demography in England to calculate expected cases. The ratio of the observed (or diagnosed) cases to the expected cases was calculated to estimate potential underdiagnosis.</p><p><strong>Results: </strong>A total of 2482 migrants born in Latin American countries were diagnosed with (and under care for) HIV in the UK (observed prevalence 841 per 100 000 population) by the end of 2022. The highest observed prevalence was in men born in Brazil (2431 per 100 000 population) and the lowest in women born in Mexico (30 per 100 000 population). Some 89% (n = 2219) of Latin American migrants under care for HIV were men, with 263 women under care with HIV in the whole of the UK. For women born in Mexico, Argentina, Chile, Venezuela and Uruguay it was estimated that only 14%, 17%, 25%, 26% and 33% of women living with HIV were under care, respectively.</p><p><strong>Conclusions: </strong>There may be a significant burden of underdiagnosis of HIV among Latin American women in the UK. Although based on some assumptions (notably the application of national HIV estimates to migrant populations which have a different risk profile), the gender disparity is striking. Community engagement and culturally appropriate targeted awareness raising and testing campaigns are recommended.</p>","PeriodicalId":13176,"journal":{"name":"HIV Medicine","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of training healthcare professionals in the detection and management of neuropsychiatric comorbidities in people with HIV: The CONECTAR project in Spain.","authors":"Jordi Blanch, Esteban Martinez, Álvaro Mena, Carlos Dueñas, Enrique Bernal, Alfonso Cabello, Marcelino Hayek, Rafael Mican, Ramón Morillo-Verdugo, María Sainz, Cristina González Conde, Ignacio Perez-Valero","doi":"10.1111/hiv.70002","DOIUrl":"https://doi.org/10.1111/hiv.70002","url":null,"abstract":"<p><strong>Introduction: </strong>Although anxiety, depression and insomnia in people with HIV (PWH) are prevalent and have a major impact on clinical outcomes and quality of life, physicians fail to evaluate them routinely. The CONECTAR Project [Neuropsychiatric Comorbidity (NPC): Key to Antiretroviral Treatment] aimed to improve NPC clinical care in PWH in Spain by upskilling healthcare professionals (HCPs).</p><p><strong>Methods: </strong>A group of HCPs developed a training programme, supported by national and international guidelines, to improve expertise on detecting and managing NPCs in PWH. The programme was conducted through workshops for physicians and nurses in various Spanish regions from April to November 2023; survey questionnaires were administered to physicians before the commencement of training and 15 days after. Later, a workshop was held for nurses who manage NPCs in PWH.</p><p><strong>Results: </strong>The programme was completed by 64 physicians (22 had completed both questionnaires) and 11 nurses (no feedback obtained). Feedback from physicians reflected that the programme boosted awareness and self-perception of being more qualified, knowledgeable and able to use management tools and resources. Physicians also reported improved perception of time available for visits and more frequent enquiries about patients' NPC symptoms. Despite their satisfaction with the workshops, half of the physicians recognized the need for more training.</p><p><strong>Conclusion: </strong>The CONECTAR Project was a successful training programme that was well received and valued by HCPs who routinely manage NPCs in PWH. Institutions involved in HCP training to manage anxiety, depression and insomnia more effectively in PWH should consider similar proposals to reinforce clinical practices.</p>","PeriodicalId":13176,"journal":{"name":"HIV Medicine","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial and temporal trends in HIV/AIDS burden among South Asian countries from 1990 to 2021: A systematic examination of the Global Burden of Disease study 2021.","authors":"Akashanand, Mahalaqua Nazli Khatib, Hashem Abu Serhan, Diptismita Jena, G PadmaPriya, Pawan Sharma, Pradeep Soothwal, Amit Barwal, M Ravi Kumar, Pranchal Rajput, Lara Jain, Abhay M Gaidhane, Ganesh Bushi, Muhammed Shabil, Rachana Mehta, Kiran Bhopte, Manika Gupta, Sanjit Sah","doi":"10.1111/hiv.70003","DOIUrl":"https://doi.org/10.1111/hiv.70003","url":null,"abstract":"<p><strong>Background: </strong>HIV/AIDS remains a significant public health concern in South Asia, and trends in disease burden vary across the region. This study analyzed spatial and temporal trends in HIV/AIDS from 1990 to 2021 using data from the Global Burden of Disease (GBD) study 2021, focusing on incidence, prevalence, mortality, and disability-adjusted life-years (DALYs).</p><p><strong>Methods: </strong>We conducted a secondary analysis of GBD 2021 data, applying Joinpoint regression and auto-regressive integrated moving average models to assess trends in HIV/AIDS burden across South Asian countries. We calculated metrics such as average annual percentage change (AAPC), and estimated APC (EAPC) to evaluate temporal trends.</p><p><strong>Results: </strong>We found significant variations in HIV/AIDS trends across South Asia. India had the highest burden, with a sharp increase in DALYs between 1990 and 2000 with a percentage change (PC) of 184.09, followed by a decline (-0.73 in 2010-2021). Pakistan experienced the highest growth in DALYs and mortality (average PC 36.46; estimated PC 38.65), indicating severe ongoing public health challenges. In contrast, Nepal and Maldives showed notable reductions in both DALYs and mortality rates, reflecting successful intervention efforts. Afghanistan and Bangladesh exhibited fluctuating trends, with slight increases in the initial years followed by stabilization or modest declines. Auto-regressive integrated moving average projections suggested a slight increase in HIV/AIDS incidence by 2031, with mortality rates expected to decline more significantly.</p><p><strong>Conclusion: </strong>The burden of HIV/AIDS in South Asia varies significantly, with some countries achieving reductions and others, particularly Pakistan, facing rising challenges. Continued and targeted public health interventions are crucial for managing and reducing the burden of HIV/AIDS across South Asia.</p>","PeriodicalId":13176,"journal":{"name":"HIV Medicine","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between country of birth, migration status and engagement in HIV care among gay and bisexual men living with HIV in Australia, 2019-2022.","authors":"Simin Yu, James MacGibbon, Benjamin Bavinton, Anthony K J Smith, John Rule, Limin Mao, Timothy R Broady, Martin Holt","doi":"10.1111/hiv.13769","DOIUrl":"https://doi.org/10.1111/hiv.13769","url":null,"abstract":"<p><strong>Background: </strong>In the last decade, while HIV diagnoses have declined among Australian-born gay and bisexual men (GBM), they have declined much less among migrant GBM, with recently arrived GBM facing particular challenges, such as access to HIV treatment. This study assessed HIV care cascade (treatment) outcomes among GBM living with HIV in Australia by migration status.</p><p><strong>Methods: </strong>Data were collected in national cross-sectional behavioural surveillance surveys during 2019-2022. HIV cascade outcomes were stratified by country of birth and length of residency in Australia, examining HIV clinical appointments in the previous year, being on antiretroviral treatment (ART) and achieving an undetectable viral load. Percentages were calculated with the previous cascade step as the corresponding denominator.</p><p><strong>Results: </strong>Between 2019 and 2022, 32 236 GBM completed surveys, including 2533 (7.9%) people living with HIV (PLWH). Among 2188 PLWH reporting migration/residency status, 72.2% were Australian-born, 13.3% were from high-income English-speaking countries, 13.0% were non-recently arrived migrant GBM from other countries and 1.5% were recently arrived in Australia (<2 years). Median ages for the four groups were 50, 51, 41 and 34 years, respectively. Recently arrived PLWH were the most likely to be recently diagnosed (<2 years, 15.2% vs. <5% in the other groups). The HIV cascade of care, treatment, and viral suppression differed by migration status (p < 0.001): Australian-born, 92.5%, 96.9% and 94.6%, respectively; born in high-income-English-speaking countries, 91.8%, 97.4%,9 8.9%; non-recently arrived, 93.7%, 95.1%, 96.8%; and recently-arrived, 90.9%, 90.0%, 100%. Recently-arrived PLWH were less likely to be on treatment, but all those on treatment achieved viral suppression.</p><p><strong>Conclusions: </strong>Engaging and supporting recently arrived PLWH in Australia to access ART and relinking PLWH disengaged from care remains crucial.</p>","PeriodicalId":13176,"journal":{"name":"HIV Medicine","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patients re-engaging with HIV care in Guatemala: Prioritizing CD4 counting and screening for histoplasmosis and tuberculosis.","authors":"Narda Medina, Ana Alastruey-Izquierdo, Oscar Bonilla, Danicela Mercado, Eduardo Arathoon, Juan Luis Rodriguez-Tudela","doi":"10.1111/hiv.70000","DOIUrl":"https://doi.org/10.1111/hiv.70000","url":null,"abstract":"<p><strong>Background: </strong>Discontinuation of antiretroviral therapy (ART) significantly contributes to the development of advanced HIV disease (AHD) and opportunistic infections. This study analyzed data from patients who re-engaged in care after ART interruption and compared the cohort with patients with newly diagnosed HIV, focusing on the burden of tuberculosis and histoplasmosis.</p><p><strong>Methods: </strong>A diagnostic package for opportunistic infections was implemented in Guatemala in 2017, encompassing tuberculosis and histoplasmosis. From 2017 to 2019, we enrolled 1379 adults re-engaging in care and 3412 patients with newly diagnosed HIV across 13 healthcare facilities. Data collection included demographic information, laboratory test results, and patient outcomes.</p><p><strong>Results: </strong>Among patients re-engaging in care, 54% (491 of 903) had AHD, which was comparable to the 50.1% (1349 of 2692) in newly diagnosed patients. Among the re-engaging cohort, 34.5% had not undergone CD4 testing, compared with 21.1% in the newly diagnosed group. This highlights a significant gap in assessing advanced HIV status through an objective, unbiased test. Among patients re-engaging in care, the incidence rates of tuberculosis and histoplasmosis were 9.7% and 8.3%, respectively, regardless of immune status. This indicated a high burden of opportunistic infections in this group, with newly diagnosed patients showing similar incidence rates of 8.5% for tuberculosis and 8.3% for histoplasmosis.</p><p><strong>Conclusion: </strong>Patients re-engaging in care should follow a similar process to newly diagnosed patients. There is an urgent need for routine and immediate CD4 testing to identify AHD and implement the recommended comprehensive diagnostic and care package. Early detection and targeted interventions are crucial for reducing AIDS-related mortality.</p>","PeriodicalId":13176,"journal":{"name":"HIV Medicine","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weight and mortality in people living with HIV and heart failure: Obesity paradox in the era of glucagon-like peptide 1 (GLP-1) receptor agonists and sodium-glucose cotransporter-2 (SGLT-2) inhibitors","authors":"Natalia Nazarenko,&nbsp;Yi-Yun Chen,&nbsp;Pawel Borkowski,&nbsp;Luca Biavati,&nbsp;Matthew Parker,&nbsp;Coral Vargas-Pena,&nbsp;Ishmum Chowdhury,&nbsp;Joshua Bock,&nbsp;Vibhor Garg,&nbsp;Shivang Bhakta,&nbsp;Maisha Maliha,&nbsp;Dimitrios Raptis,&nbsp;Mandar Kalpesh Shah,&nbsp;Robert Faillace,&nbsp;Leonidas Palaiodimos","doi":"10.1111/hiv.13760","DOIUrl":"10.1111/hiv.13760","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Obesity is a recognized risk factor for heart failure (HF) in people living with HIV. However, among patients with HF, being overweight or having mild to moderate obesity has been associated with significantly improved survival rates compared with those at normal weight—a phenomenon known as the obesity paradox. This paradox has not yet been evaluated in patients with both HIV and HF in the era of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT-2is). Our study aimed to assess the mortality risk associated with body mass index (BMI) in patients with both HIV and HF and evaluate the impact of GLP-1 RAs and SGLT-2is on mortality across different weight categories.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Method&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study analyzed data from the New York City Health + Hospitals Corporation (NYC HHC) cohort (NYC 4H), which included records from 11 major New York City Health + Hospitals facilities. The dataset combined retrospective baseline data with ongoing prospective follow-up. The cohort consisted of adults with confirmed HIV and HF who had inpatient or clinic visits between July 2017 and June 2022. HIV infection and HF were initially identified using relevant &lt;i&gt;International Classification of Diseases and Related Health Problems, 10th Revision&lt;/i&gt; codes and were further confirmed through laboratory results and echocardiograms. Medication data were verified through electronic health records and cross-referenced with pharmacy records. The primary outcome was the hazard ratio (HR) of overall mortality across different BMI categories in patients with both HIV and HF, assessed using proportional hazard regression models adjusted for age, sex, race, comorbidities, smoking status, and functional status. Secondary analyses included re-hospitalization within 6 months of discharge and the association between GLP-1 RAs/SGLT-2is and overall mortality in patients with HIV and HF. Additional analyses were conducted to assess the efficacy of these medications within different BMI categories.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A total of 1044 patients were analyzed, including 657 males (62.9%) and 387 females (37.1%), with an average age of 61.6 years at baseline and an average follow-up of 3.8 years. A low BMI (&lt;18.5) was associated with a 57% increase in mortality (HR 1.57; 95% confidence interval [CI] 1.03–2.39; &lt;i&gt;p&lt;/i&gt; = 0.04), whereas class I obesity (BMI 30.0–35.9) was associated with a 35% reduction in mortality (HR 0.65; 95% CI 0.42–0.99; &lt;i&gt;p&lt;/i&gt; = 0.04) compared with normal BMI, after adjusting for covariates. Class II obesity was associated with a lower rate of re-hospitalization within 6 months of dischar","PeriodicalId":13176,"journal":{"name":"HIV Medicine","volume":"26 4","pages":"581-591"},"PeriodicalIF":2.8,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of atherosclerosis in HIV-associated vasculopathy in young South African stroke patients","authors":"Eitzaz Sadiq,&nbsp;Angela Woodiwiss,&nbsp;Grace Tade,&nbsp;Jeremy Nel,&nbsp;Gavin Norton,&nbsp;Girish Modi","doi":"10.1111/hiv.13764","DOIUrl":"10.1111/hiv.13764","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>HIV-associated vasculopathy is known to cause stroke in people living with HIV (PLWH). The role of atherosclerosis is unclear. We assessed the aetiology of vasculopathy in PLWH and tested the utility of markers of subclinical atherosclerosis to distinguish atherosclerotic (AV) from non-atherosclerotic vasculopathy (NAV).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This cross-sectional study recruited PLWH with stroke at a hospital in Johannesburg, South Africa, from 2014 to 2017. Patients with meningitis were excluded. Cerebrospinal fluid (CSF) was tested for multi-viral polymerase chain reaction, including varicella zoster virus (VZV). Once an aetiological category was assigned, carotid intima-media thickness (cIMT) and aortic pulse wave velocity (PWV) were compared in AV and NAV, and to predetermined thresholds for subclinical atherosclerosis (cIMT≥0.70 mm, PWV≥10.00 m/s).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Some 28/85 PLWH (32.9%) vs. 9/109 (8.3%, <i>p</i> &lt; 0.0001) people-without-HIV had vasculopathy on computed tomography angiography. Only four PLWH had AV. Compared with NAV (<i>n</i> = 11), those with AV were older (50.0 ± 4.1 vs. 39.2 ± 9.2 years, <i>p</i> = 0.04) and had more cardiovascular risk factors (median 2.0 [IQR 1.5–2.5] vs. 0.0 [IQR 0.0–1.0], <i>p</i> = 0.02). cIMT in AV was higher than in NAV (1.01 ± 0.07 mm [<i>n</i> = 4] vs. 0.63 ± 0.04 mm [<i>n</i> = 9], <i>p</i> &lt; 0.001). All with AV had cIMT and PWV above the predetermined thresholds, while all except one with NAV were below. We found evidence of VZV in eight PLWH and HIV-associated vasculitis in six.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Vasculopathy in PLWH in our region appears to be predominantly non-atherosclerotic. cIMT and PWV were useful adjuncts in distinguishing AV from NAV. Despite excluding meningitis, VZV was implicated in a large proportion, emphasizing the likely underdiagnosis of this treatable infection. We thus recommend CSF VZV testing in all PLWH with stroke.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13176,"journal":{"name":"HIV Medicine","volume":"26 4","pages":"633-642"},"PeriodicalIF":2.8,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/hiv.13764","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing the quality of life and social skills of children living with HIV: A case–control study","authors":"Qiuyi Yang,&nbsp;Jiechao Zhou,&nbsp;Guanghua Lan,&nbsp;Qi Qin,&nbsp;Hongyan Lu,&nbsp;Wei Chen,&nbsp;Jinming Su,&nbsp;Xiaoliang Zeng","doi":"10.1111/hiv.13758","DOIUrl":"10.1111/hiv.13758","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Our objective was to understand the current status of and factors influencing the quality of life and social skills of children living with HIV and to provide a reference for improving medical service management and formulating support policies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 183 children aged 7–14 years, living with HIV, and admitted to the Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention from March 2022 to February 2024 were included retrospectively. We used the children's basic information and their scores from the Quality of Life Scale for Children and Adolescents (QLSCA) and Normal Development of Social Skills From Infant to Junior High School Children (S-M scale) to explore their the status of their quality of life and social skills and the factors influencing both.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Four factors (life satisfaction, socio-psychological functioning, physical and mental health, and living environment) and QLSCA T-scores in the case group were significantly lower than those in the control group (<i>p</i> &lt; 0.01). S-M scale scores (self-help, locomotion, operation, communication, socialization, self-direction) in the case group were significantly lower than those in the control group (<i>p</i> &lt; 0.001). The main factors affecting the social skills of children living with HIV were side effects from antiretroviral therapy (odds ratio [OR] 7.365, <i>p</i> &lt; 0.003), comorbidities (OR 12.948, <i>p</i> &lt; 0.006), intellectual development (OR 6.045, <i>p</i> &lt; 0.027), and awareness of HIV infection status (OR 0.261, <i>p</i> &lt; 0.014).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Children living with HIV have low quality of life and poor social skills. Clinicians should pay attention to side effects from antiretroviral therapy, comorbidities, children's intellectual development, and their awareness of their HIV infection status.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13176,"journal":{"name":"HIV Medicine","volume":"26 4","pages":"569-580"},"PeriodicalIF":2.8,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on 'Exploring the cascade of mental healthcare among people with HIV experiencing depressive symptoms in the UK and Ireland: The POPPY study'.","authors":"Shubham Kumar, Rachana Mehta, Ranjana Sah, Amogh Verma","doi":"10.1111/hiv.13767","DOIUrl":"https://doi.org/10.1111/hiv.13767","url":null,"abstract":"","PeriodicalId":13176,"journal":{"name":"HIV Medicine","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of HBV serological status on HIV virological efficacy of two-drug antiretroviral regimens: A retrospective observational study on virologically suppressed people with HIV switching to lamivudine/dolutegravir","authors":"Pierluigi Francesco Salvo,&nbsp;Arturo Ciccullo,&nbsp;Elena Visconti,&nbsp;Francesca Lombardi,&nbsp;Carlo Torti,&nbsp;Simona Di Giambenedetto,&nbsp;Gianmaria Baldin","doi":"10.1111/hiv.13765","DOIUrl":"10.1111/hiv.13765","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study aimed to evaluate the HIV virological efficacy of two-drug regimens (2DR) with lamivudine (3TC) and dolutegravir (DTG) in people with HIV (PWH), classified by their hepatitis B virus (HBV) serological status. Specifically, it explored whether isolated anti-hepatitis B core (anti-HBc) positivity impacts virological outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective observational study was conducted at Fondazione Policlinico Universitario Agostino Gemelli IRCCS, enrolling 606 virologically suppressed (HIV-RNA &lt; 50 copies/mL) PWH who switched to a 2DR regimen with 3TC/DTG. Participants were categorized into four groups based on their HBV serological status: hepatitis B surface antibody (HBsAb)-positive/hepatitis B core antibody (HBcAb)-positive, HBsAb-negative/HBcAb-negative, HBsAb-positive/HBcAb-negative, and isolated HBcAb positivity. Viral failure (VF) was defined as two consecutive HIV viral loads above 50 copies/mL or a single HIV viral load above 1000 copies/mL, and viral blips (VBs) as a single HIV-RNA measurement between 50 and 200 copies/mL followed by suppression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>During 2216.4 patient-years of follow-up (PYFU), we observed 30 VFs (1.3 per 100 PYFU) and 63 VBs (2.9 per 100 PYFU). No statistically significant differences in VF or VB were noted between the serological groups. Additionally, no significant alanine aminotransferase (ALT) flares or HBV-DNA breakthroughs were observed, with HBV-DNA remaining undetectable throughout.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The study supports the virological efficacy of 3TC/DTG-based 2DR in PWH, regardless of HBV serological status. Isolated anti-HBc positivity did not influence virological outcomes independently. Larger studies are warranted to further investigate HIV–HBV interactions in this context.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13176,"journal":{"name":"HIV Medicine","volume":"26 4","pages":"650-653"},"PeriodicalIF":2.8,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/hiv.13765","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}