HIV Medicine最新文献

{"title":"Comparison of treatment-emergent resistance-associated mutations and discontinuation due to adverse events among integrase strand transfer inhibitor-based single-tablet regimens and cabotegravir + rilpivirine for the treatment of virologically suppressed people with HIV: A systematic literature review and network meta-analysis.","authors":"Ishfaq Rashid, Nathan R Unger, Connor Willis, Teerapon Dhippayom, Moti Ramgopal, Elizabeth M Sherman, Nicholas Yared, Rachel Safran, Edwin Swiatlo, Amy R Weinberg, Soodi Navadeh, Howard Weston Schmutz, Nathorn Chaiyakunapruk","doi":"10.1111/hiv.70050","DOIUrl":"https://doi.org/10.1111/hiv.70050","url":null,"abstract":"<p><strong>Objective: </strong>This study evaluated rates of treatment-emergent resistance-associated mutations (TE-RAMs) and discontinuation due to adverse events (DC-AEs) across integrase strand transfer inhibitor (INSTI)-based single-tablet regimens and injectable cabotegravir + rilpivirine (CAB + RPV) in virologically suppressed people with HIV.</p><p><strong>Methods: </strong>A systematic literature review was conducted for phase 2-4 randomized controlled trials with ≥48 weeks of follow-up involving virologically suppressed people with HIV aged ≥12 years and published January 2003-March 2024. A random-effects network meta-analysis estimated comparative rates of TE-RAMs and DC-AEs among regimens at 48 weeks. Risk of bias and strength of evidence were assessed using Cochrane RoB and CINeMA, respectively.</p><p><strong>Results: </strong>Fourteen (7509 participants) and nine (4656 participants) studies were included in the TE-RAMs and DC-AEs analyses, respectively. No significant differences in rates of TE-RAMs were observed; risk ratios (RRs) for TE-RAMs for bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF), dolutegravir/abacavir/lamivudine (DTG/ABC/3TC) and CAB + RPV every 4 weeks (Q4W) versus CAB + RPV every 8 weeks (Q8W) were 0.22 (95% CI, 0.02-2.04), 0.22 (95% CI, 0.00-19.85) and 0.40 (95% CI, 0.14-1.09). Compared with CAB + RPV Q4W and Q8W, DC-AEs were significantly lower with B/F/TAF (RR, 0.15 [95% CI, 0.03-0.75] and RR, 0.16 [95% CI, 0.04-0.67], respectively) and DTG/ABC/3TC (RR, 0.05 [95% CI, 0.01-0.48] and RR, 0.05 [95% CI, 0.01-0.46], respectively).</p><p><strong>Conclusions: </strong>In virologically suppressed people with HIV, switching to CAB + RPV Q8W yielded a non-significant increased risk of TE-RAMs compared with INSTI-based 2- and 3-drug regimens and CAB + RPV Q4W. Both CAB + RPV Q4W and Q8W had significantly higher risks of DC-AEs than B/F/TAF and DTG/ABC/3TC. Findings highlight the importance of considering both resistance and tolerability when switching regimens.</p>","PeriodicalId":13176,"journal":{"name":"HIV Medicine","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The silent crisis: Vertical HIV transmission and the struggle for antiretroviral access.","authors":"Pérez-Cavazos Samantha, Pérez-Alba Eduardo, Camacho-Ortiz Adrián","doi":"10.1111/hiv.70052","DOIUrl":"https://doi.org/10.1111/hiv.70052","url":null,"abstract":"<p><strong>Introduction: </strong>Vertical transmission of HIV remains a critical and preventable aspect of the global HIV epidemic. Despite significant advancements in antiretroviral therapy (ART) and prevention strategies reducing mother-to-child transmission (MTCT) worldwide, a concerning disparity persists between what is medically achievable and the reality experienced in many communities.</p><p><strong>Methods: </strong>This manuscript reviews the current landscape of MTCT of HIV, drawing on documented successes in elimination and identifying persistent barriers. It analyzes challenges related to therapeutic options for neonates, pharmaceutical supply chains, regulatory approval processes for neonatal ART, and the socio-ethical dimensions. Based on this analysis, a comprehensive five-point action plan is proposed to address these multifaceted issues.</p><p><strong>Results: </strong>The review highlights that 19 countries and territories have successfully eliminated MTCT of HIV, demonstrating the feasibility of this goal. However, significant barriers impede universal success. These include: 1) Limited availability of neonatal-specific ART formulations. 2) Pharmaceutical market dynamics driven by high-income countries. 3) Ethical and regulatory hurdles in conducting clinical trials for ART in neonates, hindering the generation of safety data. 4) MTCT is not just a medical problem but a profound social justice issue, exacerbated by stigma and discrimination.</p><p><strong>Conclusions: </strong>Elimination of vertical HIV transmission is an attainable goal. The proposed action plan-encompassing strengthened antenatal screening, prompt ART initiation for pregnant women, guaranteed neonatal prophylaxis, robust supply chain management, and dedicated research and advocacy-offers a pathway to extend the possibility of an HIV-free start in life to every child, regardless of geographic or economic circumstance.</p>","PeriodicalId":13176,"journal":{"name":"HIV Medicine","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"They didn't think we'd live this long\": A qualitative exploration of older adults living with HIV perspectives on geriatric care in Ontario.","authors":"Kristina M Kokorelias, Dean Valentine, Andrew D Eaton, Erica Dove, Esther Su, Christine L Sheppard, Stuart McKinlay, Paige Brown, Hardeep K Singh, Marina B Wasilewski, Ashley Flanagan, Alice Zhabokritsky, Reham Abdelhalim, Rabea Parpia, Rahel Zewude, Laura Jamieson, Sharon Walmsley, Luxey Sirisegaram","doi":"10.1111/hiv.70047","DOIUrl":"https://doi.org/10.1111/hiv.70047","url":null,"abstract":"<p><strong>Introduction: </strong>Advances in human immunodeficiency virus (HIV) care have increased life expectancy, leading to more older adults living with HIV. This study examines older adults' perspectives on geriatric healthcare needs.</p><p><strong>Methods: </strong>A community-based qualitative study in Ontario, Canada, recruited some adults aged 50+ years living with HIV through quota and purposive sampling. Quota sampling was used to include individuals of different ages, genders and ethno-racial backgrounds to capture a range of experiences. Data were collected via semi-structured interviews and focus groups, analyzed using the Qualitative Analysis Guide of Leuven.</p><p><strong>Results: </strong>Participants included interviewees (n = 14) and focus group attendees (n = 12). Four themes emerged: (1) lack of knowledge and access to geriatric care, highlighting service challenges; (2) healthcare providers' understanding of HIV and ageing, with stigma concerns; (3) role of social support networks for emotional/practical support; and (4) requirements for improved geriatric care, advocating provider education and greater social care access.</p><p><strong>Conclusions: </strong>Gaps in geriatric care for older adults with HIV highlight stigma, access issues and the need for education, virtual care and tailored, inclusive healthcare solutions.</p>","PeriodicalId":13176,"journal":{"name":"HIV Medicine","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic syndrome and Pathobiological Determination of Atherosclerosis in Youth risk score in adolescents with and without perinatally acquired HIV in the Cape Town Adolescent and Antiretroviral Cohort (CTAAC)-Heart study.","authors":"Sahera Dirajlal-Fargo, Mothabisi Nyathi, Shan Sun, Lauren Balmert Bonner, Morné Kahts, Nana Akua Asafu-Agyei, Nomawethu Jele, Emma Carkeek, Justine Legbedze, Grace A McComsey, Matthew Feinstein, Landon Myer, Ntobeko A B Ntusi, Heather J Zar, Jennifer Jao","doi":"10.1111/hiv.70049","DOIUrl":"https://doi.org/10.1111/hiv.70049","url":null,"abstract":"<p><strong>Background: </strong>Limited data exist describing metabolic syndrome (MetS) and Pathobiological Determinants of Atherosclerosis in Youth (PDAY) coronary arteries (CA) and abdominal aorta (AA) risk scores in youth with HIV in sub-Saharan Africa.</p><p><strong>Methods: </strong>This cross-sectional analysis assessed MetS and PDAY CA and AA risk scores among youth with perinatally acquired HIV, youth with non-perinatally acquired HIV, and HIV-seronegative youth. Elevated PDAY score was defined as ≥1. Cluster heat map analysis was used, and logistic regression models were fit to assess the association of HIV status with MetS and PDAY CA and AA risk scores separately after adjusting for covariates.</p><p><strong>Results: </strong>We enrolled 237 youth with perinatally acquired HIV, 56 youth with non-perinatally acquired HIV and 71 HIV-seronegative youth; median (interquartile range = IQR) age was 18 (17, 20) years, 58% females. Youth with non-perinatally acquired HIV had the highest proportion with MetS (34%), while HIV-seronegative youth had 23%, and youth with perinatally acquired HIV 12%. Forty-seven percent of youth with perinatally acquired HIV, 63% of youth with non-perinatally acquired HIV and 41% of HIV-seronegative youth had elevated PDAY CA score; 30% of youth with perinatally acquired HIV, 39% of youth with non-perinatally acquired HIV and 23% of HIV-seronegative youth had elevated PDAY AA score. A non-overweight but hyperlipidaemic phenotype predominantly comprised of youth with perinatally acquired HIV was observed by cluster analysis. Youth with perinatally acquired HIV had lower adjusted odds of MetS compared with HIV-seronegative youth (odds ratio = 0.35, 95% confidence interval: 0.16, 0.79) but HIV status (either youth with perinatally acquired HIV or youth with non-perinatally acquired HIV vs. HIV-seronegative) was not associated with an elevated PDAY CA or AA risk score.</p><p><strong>Conclusion: </strong>Youth with perinatally acquired HIV have a lower odd of MetS, reflecting an overall non-overweight, but hyperlipidaemic phenotype highlighting the need for further cardiometabolic research in this ageing population in South Africa.</p>","PeriodicalId":13176,"journal":{"name":"HIV Medicine","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HIV seroconversions and genotypic viral resistance profiles in the PrEP impact trial.","authors":"Andrea Cartier, Ana Milinkovic, Lisa Goodall, Borja Mora-Peris, Dana Ogaz, Adrian Palfreeman, Branca Pereira, Iain Reeves, John Saunders, Ann K Sullivan","doi":"10.1111/hiv.70045","DOIUrl":"https://doi.org/10.1111/hiv.70045","url":null,"abstract":"<p><strong>Objectives: </strong>Here we describe HIV seroconversion events in participants of the PrEP Impact trial.</p><p><strong>Methods: </strong>Of 24 268 participants, we reviewed data for the 54 who were diagnosed with HIV during the trial; 11 at baseline.</p><p><strong>Results: </strong>Incidence was low for those diagnosed pre-pandemic at 0.13 per 100 person-years, and mainly linked to low self-reported adherence. The emergence of drug resistance in participants reporting recent oral PrEP (tenofovir disoproxil maleate with emtricitabine (TDF/FTC)) exposure was low (where analysis results are available, 21% of participants who seroconverted during trial participation showed drug resistance).</p><p><strong>Conclusions: </strong>Oral PrEP TDF/FTC is an effective HIV prevention intervention. Further data are needed to assess the prevalence and impact of increasing oral PrEP TDF/FTC use on HIV resistance.</p>","PeriodicalId":13176,"journal":{"name":"HIV Medicine","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in prevalence of anaemia among people living with HIV in the UK: 20 cross-sectional analyses using population-based electronic primary healthcare records.","authors":"George B Freer, Jennifer Cooper, Krishnarajah Nirantharakumar, G Neil Thomas, Tiffany E Gooden","doi":"10.1111/hiv.70044","DOIUrl":"https://doi.org/10.1111/hiv.70044","url":null,"abstract":"<p><strong>Background: </strong>People living with HIV have a greater prevalence of anaemia compared with people without HIV, which increases the risk of associated morbidity and premature mortality. Risk factors for anaemia among people living with HIV have changed in recent decades due to new antiretroviral therapy (ART), increased uptake of ART and increasing chronic conditions among people living with HIV; thus, anaemia prevalence may have changed over time. We aimed to identify the prevalence and trends of anaemia among people living with HIV over a 20-year period.</p><p><strong>Methods: </strong>A series of 20 annual cross-sectional analyses were performed from 2002 to 2021. Data on people living with HIV aged ≥18 years from Clinical Practice Research Datalink (CPRD) Aurum was used, a population-based UK primary healthcare database. Overall and annual prevalence of all-cause anaemia, defined as any clinical code indicative of having anaemia, was calculated using multivariable logistic regression models and adjusted for age, sex, ethnicity, smoking status and deprivation. Trends were determined by investigating the change in prevalence across the 20 annual analyses using linear regression. Prevalence and trends of anaemia were also calculated among the following sub-groups of people living with HIV: age, sex, ethnicity, body mass index, smoking and socioeconomic deprivation.</p><p><strong>Results: </strong>Data for 41 990 people living with HIV were included. Overall adjusted prevalence of anaemia was 6.89%; however, this significantly increased from 4.6% (95% CI: 4.72%, 5.06%) in 2002 to 7.42% (95% CI: 7.33%, 7.51%) in 2021. A significant positive trend for anaemia was found (adjusted coefficient + 0.123; 95% CI: 0.107, 0.139; p < 0.001) and this was consistent among all sub-groups. Females, older age (≥50 years), non-smokers, Black ethnicity, overweight/obese and higher deprivation had an increased prevalence of anaemia.</p><p><strong>Conclusion: </strong>Anaemia among people living with HIV is increasing, with certain groups of people living with HIV experiencing a greater burden. Efforts should be made to prevent and reduce anaemia among people living with HIV to mitigate further morbidity, premature mortality and additional inequalities.</p>","PeriodicalId":13176,"journal":{"name":"HIV Medicine","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge about biomedical HIV prevention among healthcare workers: A cross-sectional study in Europe and Central Asia.","authors":"Ana Mendez-Lopez, Fiona Burns, Ann Sullivan, Charlotte Deogan, Katharine E A Darling, Daniel Simoes, Alex Garner, Julia Del Amo, Sini Pasanen, Elena Vaughan, Joelle Verluyten, Sanjay Bhagani, Esteban Martinez, Teymur Noori","doi":"10.1111/hiv.70048","DOIUrl":"10.1111/hiv.70048","url":null,"abstract":"<p><strong>Background: </strong>Knowledge of HIV prevention among healthcare workers, such as undetectable equals untransmittable (U=U), post-exposure prophylaxis (PEP) and pre-exposure prophylaxis (PrEP) can hold implications for patient care and the HIV epidemic. Understanding the level of knowledge about HIV prevention among healthcare workers can provide information to enhance the effectiveness and equity of HIV prevention, treatment and care.</p><p><strong>Methods: </strong>An online survey was conducted to collect data on HIV knowledge among clinical and non-clinical healthcare workers in 54 countries in Europe and Central Asia between September and December of 2023. Knowledge was measured using questions asking respondents to agree or disagree with correct statements about HIV transmission and prevention. Four main outcome variables assessed knowledge among healthcare workers about U=U, PrEP, PEP and a combined outcome measuring overall knowledge level. Fixed-effects logistic and Poisson regression models assessed whether sociodemographic factors, professional characteristics and experiences with people living with HIV were associated with knowledge about these topics. Additionally, we assessed the impact of having ever received training on infection control and training on HIV stigma and discrimination on healthcare workers' knowledge of U=U, PEP and PrEP.</p><p><strong>Results: </strong>Among 18 348 healthcare workers, correct knowledge of U=U was reported by 61.25%, PEP by 55.70% and PrEP by 40.74%. A composite of correct knowledge across all topics was achieved by 31.29% of participants. Key sociodemographic and professional determinants influencing increased knowledge included being a man, of younger age and a medical doctor. Increased knowledge was also associated with having more experience caring for people with HIV, including working in an HIV care or infectious diseases department, and having cared for a higher number of people living with HIV in the past year. Having ever received training on infection control that included PEP and training on HIV stigma and discrimination was associated with increased knowledge in all areas. Across all determinants, respondents living in Western Europe reported higher knowledge about biomedical HIV prevention.</p><p><strong>Interpretation: </strong>Substantial knowledge gaps in HIV prevention were found among healthcare workers in Europe and Central Asia. Suboptimal knowledge and sociodemographic and professional differences warrant targeted training initiatives and interventions for improving healthcare workers' knowledge of HIV. The non-representative nature of the sample limits the generalizability of the findings.</p>","PeriodicalId":13176,"journal":{"name":"HIV Medicine","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual cross-sectional and longitudinal perspective on the continuum of HIV care to disentangle natural epidemic evolution from real progress, Belgium 2014-2022.","authors":"D Van Beckhoven, B Serrien, R Demeester, J Van Praet, P Messiaen, G Darcis, S Henrard, P De Munter, A Libois, J Deblonde","doi":"10.1111/hiv.70027","DOIUrl":"https://doi.org/10.1111/hiv.70027","url":null,"abstract":"<p><strong>Introduction: </strong>This study provides a comprehensive overview of HIV care by combining cross-sectional and longitudinal continuum of care (CoC) analyses.</p><p><strong>Methods: </strong>Using national surveillance data 2014-2022, a five-stage cross-sectional CoC was calculated among people living with HIV (incl. undiagnosed): diagnosed, linked to care, retained in care, on antiretroviral therapy (ART) and virally suppressed. For the longitudinal CoC, cumulative incidences (CI) were calculated for each transition.</p><p><strong>Results: </strong>The study included 26 191 people living with HIV. By the end of 2022, an estimated 18 302 persons were living with HIV in Belgium. Of these, 92.1% were diagnosed, 90.9% linked to care, 89.2% retained in care, 87.9% on ART and 85.6% virally suppressed. One-year post-infection diagnosis rates were 38% (2014-2016), 33% (2017-2019) and 31% (2020-2022), with differences disappearing after correction for immigration timing. Time from diagnosis to care entry remained stable at 82% within 3 months. Time to ART initiation and to viral load suppression reduced substantially, with 3-month CIs rising from 69% and 71%, respectively (2014-2016), to 91% and 77% (2020-2022). Transitions between all stages of care were the fastest among Belgian men who have sex with men. People who inject drugs had the lowest CI for care entry and viral suppression. Cumulative incidences of ART initiation increased substantially for all key populations, exceeding 90% within 3 months in 2020-2022, except for non-Belgian heterosexuals (87%).</p><p><strong>Conclusion: </strong>A steady improvement in the CoC places Belgium close to the joint united nations programme on HIV/AIDS 95-95-95 targets, although populations like people who inject drugs and migrants still face significant barriers to care. Timely diagnosis by supporting existing and innovative testing strategies should be prioritized.</p>","PeriodicalId":13176,"journal":{"name":"HIV Medicine","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge and HIV-related stigma among Portuguese healthcare professionals: A cross-sectional analysis.","authors":"F Cota Medeiros, A Méndez-López, R Correia de Abreu, R Sarmento E Castro, F Maltez, F Antunes","doi":"10.1111/hiv.70039","DOIUrl":"https://doi.org/10.1111/hiv.70039","url":null,"abstract":"<p><strong>Introduction: </strong>Stigma and discrimination against people living with human immunodeficiency virus (PLHIV) within healthcare settings remain significant barriers to effective care. Stigmatizing attitudes persist among healthcare professionals, potentially undermining care quality. This study aimed to assess HIV-related knowledge and attitudes among healthcare professionals in Portugal, focusing on identifying factors associated with stigma.</p><p><strong>Methods: </strong>This study was part of a European survey by the European Centre for Disease Prevention and Control (ECDC) and the European AIDS Clinical Society (EACS). Data were collected via an online self-administered questionnaire between September and December 2023, targeting healthcare professionals in Portugal. Descriptive statistics, chi-square tests and multivariate logistic regression were used to assess associations between sociodemographic characteristics, HIV knowledge and stigma.</p><p><strong>Results: </strong>A total of 807 healthcare professionals participated in the study, with a majority being women (78%), and a mean age of 43.5 years. Most respondents were nurses (38%) and doctors (28%), worked in hospitals (54%) or primary healthcare centres (31%). The analysis showed that healthcare professionals working in HIV-dedicated departments, hospitals or community centres exhibited significantly higher levels of HIV-related knowledge. In contrast, female professionals, those over 40 years old and non-doctor professionals were less likely to demonstrate high HIV-related knowledge. Regarding stigma, professionals with limited HIV training and lower HIV knowledge were more likely to display higher levels of stigma.</p><p><strong>Conclusions: </strong>These findings highlight the need for targeted educational interventions to reduce stigma. Strengthening HIV-specific training, especially in stigma reduction, is crucial for improving care for PLHIV and fostering an inclusive healthcare environment.</p>","PeriodicalId":13176,"journal":{"name":"HIV Medicine","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What services, interventions and support are available for People with HIV in England to manage their overall health and wellbeing? A scoping review.","authors":"Howell T Jones, Lucy Lynch, Tristan J Barber, Meriel Rattue, Laura J Waters, David Asboe, Angeline Walker, Ian Williams","doi":"10.1111/hiv.70041","DOIUrl":"https://doi.org/10.1111/hiv.70041","url":null,"abstract":"<p><strong>Objectives: </strong>The average age of a person living with HIV in high-income countries is increasing, as are rates of multimorbidity and frailty. To meet these needs, existing services must adapt. This review aimed to identify the existing literature on what services are available to undertake long-term condition management (LTCM) for People with HIV in England.</p><p><strong>Methods: </strong>A scoping review employing the Arksey & O'Malley's methodological framework was performed. Seven databases were searched most recently in October 2024 for studies describing services, interventions, or support for People with HIV in England to manage their overall health and wellbeing. Study inclusion was not limited by year of publication. Narrative reviews were excluded. Two reviewers independently performed data extraction using predetermined criteria, followed by a descriptive analysis.</p><p><strong>Results: </strong>Forty publications were identified with six key areas where LTCM was addressed: HIV services, secondary care services, primary care, palliative care, peer support, self-management, and specialist services, suggesting that currently no service can undertake LTCM alone.</p><p><strong>Conclusions: </strong>If LTCM for People with HIV is to expand outside of HIV services, then additional HIV training is required for healthcare professionals with a focus on reducing stigma. Peer support should be at the forefront, and People with HIV should be involved in the assessment of need, design, and evaluation of services. There is a scarcity of high-level evidence, which justifies the need for further research and ongoing service evaluation to identify the optimal model(s) to ensure effective, equitable, and cost-effective care.</p>","PeriodicalId":13176,"journal":{"name":"HIV Medicine","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}