Human Vaccines & Immunotherapeutics最新文献_第8页

YouTube and COVID-19 vaccines: A mini scoping review. YouTube和COVID-19疫苗:一个小型范围审查。

IF 4.8 4区医学

Human Vaccines & Immunotherapeutics Pub Date : 2023-12-31 Epub Date: 2023-04-27 DOI: 10.1080/21645515.2023.2202091

Sandhya Narayanan, Corey H Basch

引用次数: 0

The relative prevalence of the Omicron variant within SARS-CoV-2 infected cohorts in different countries: A systematic review. 不同国家SARS-CoV-2感染人群中基因组变体的相对流行率:一项系统综述

IF 4.8 4区医学

Human Vaccines & Immunotherapeutics Pub Date : 2023-12-31 DOI: 10.1080/21645515.2023.2212568

Aparajita Sarkar, Sara Omar, Aya Alshareef, Kareem Fanous, Shaunak Sarker, Hasan Alroobi, Fahad Zamir, Mahmoud Yousef, Dalia Zakaria

{"title":"The relative prevalence of the Omicron variant within SARS-CoV-2 infected cohorts in different countries: A systematic review.","authors":"Aparajita Sarkar, Sara Omar, Aya Alshareef, Kareem Fanous, Shaunak Sarker, Hasan Alroobi, Fahad Zamir, Mahmoud Yousef, Dalia Zakaria","doi":"10.1080/21645515.2023.2212568","DOIUrl":"10.1080/21645515.2023.2212568","url":null,"abstract":"The Omicron variant of SARS-CoV-2 was detected in October 2021 and exhibited high transmissibility, immune evasion, and reduced severity when compared to the earlier variants. The lesser vaccine effectiveness against Omicron and its reduced severity created vaccination hesitancy among the public. This review compiled data reporting the relative prevalence of Omicron as compared to the early variants to give an insight into the existing variants, which may shape the decisions regarding the targets of the newly developed vaccines. Complied data revealed more than 90% prevalence within the infected cohorts in some countries. The BA.1 subvariant predominated over the BA.2 during the early stages of the Omicron wave. Moreover, BA.4/BA.5 subvariants were detected in South Africa, USA and Italy between October 2021 and April 2022. It is therefore important to develop vaccines that protect against Omicron as well as the early variants, which are known to cause more severe complications.","PeriodicalId":13058,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"19 1","pages":"2212568"},"PeriodicalIF":4.8,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d4/ec/KHVI_19_2212568.PMC10234134.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9573222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomarkers for predicting tumor response to PD-1 inhibitors in patients with advanced pancreatic cancer. 预测晚期胰腺癌患者对PD-1抑制剂反应的生物标志物

IF 4.8 4区医学

Human Vaccines & Immunotherapeutics Pub Date : 2023-12-31 Epub Date: 2023-02-21 DOI: 10.1080/21645515.2023.2178791

Xin Qiu, Zhan Shi, Fan Tong, Changchang Lu, Yahui Zhu, Qiaoli Wang, Qing Gu, Xiaoping Qian, Fanyan Meng, Baorui Liu, Juan Du

{"title":"Biomarkers for predicting tumor response to PD-1 inhibitors in patients with advanced pancreatic cancer.","authors":"Xin Qiu, Zhan Shi, Fan Tong, Changchang Lu, Yahui Zhu, Qiaoli Wang, Qing Gu, Xiaoping Qian, Fanyan Meng, Baorui Liu, Juan Du","doi":"10.1080/21645515.2023.2178791","DOIUrl":"10.1080/21645515.2023.2178791","url":null,"abstract":"Pancreatic cancer is among the most lethal malignant neoplasms, and few patients with pancreatic cancer benefit from immunotherapy. We retrospectively analyzed advanced pancreatic cancer patients who received PD-1 inhibitor-based combination therapies during 2019-2021 in our institution. The clinical characteristics and peripheral blood inflammatory markers (neutrophil-to-lymphocyte ratio [NLR], platelet-to-lymphocyte ratio [PLR], lymphocyte-to-monocyte ratio [LMR], and lactate dehydrogenase [LDH]) were collected at baseline. Chi-squared and Fisher's exact tests were used to evaluate relationships between the above parameters and tumor response. Cox regression analyses were employed to assess the effects of baseline factors on patients' survival and immune-related adverse events (irAEs). Overall, 67 patients who received at least two cycles of PD-1 inhibitor were considered evaluable. A lower NLR was independent predictor for objective response rate (38.1% vs. 15.2%, P = .037) and disease control rate (81.0% vs. 52.2%, P = .032). In our study population, patients with lower LDH had superior progression-free survival (PFS) and overall survival(OS) (mPFS, 5.4 vs. 2.8 months, P < .001; mOS, 13.3 vs. 3.6 months, P < .001). Liver metastasis was verified to be a negative prognostic factor for PFS (2.4 vs. 7.8 months, P < .001) and OS (5.7 vs. 18.0 months, P < .001). The most common irAEs were hypothyroidism (13.4%) and rash (10.5%). Our study demonstrated that the pretreatment inflammatory markers were independent predictors for tumor response, and the baseline LDH level and liver metastasis were potential prognostic markers of survival in patients with pancreatic cancer treated with PD-1 inhibitors.","PeriodicalId":13058,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"19 1","pages":"2178791"},"PeriodicalIF":4.8,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/dc/54/KHVI_19_2178791.PMC10026926.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9203465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Penta- and hexavalent vaccination of extremely and very-to-moderate preterm infants born at less than 34 weeks and/or under 1500 g: A systematic literature review. 34周以下和/或1500克以下出生的极重度和极中度早产儿的五价和六价疫苗接种：一项系统文献综述。

IF 4.8 4区医学

Human Vaccines & Immunotherapeutics Pub Date : 2023-12-31 DOI: 10.1080/21645515.2023.2191575

Markus Knuf, Marie-Laure Charkaluk, Phung Nguyen The Nguyen, Ignacio Salamanca de la Cueva, Petra Köbrunner, Lauren Mason, Maurine Duchenne, Valérie Berlaimont

{"title":"Penta- and hexavalent vaccination of extremely and very-to-moderate preterm infants born at less than 34 weeks and/or under 1500 g: A systematic literature review.","authors":"Markus Knuf, Marie-Laure Charkaluk, Phung Nguyen The Nguyen, Ignacio Salamanca de la Cueva, Petra Köbrunner, Lauren Mason, Maurine Duchenne, Valérie Berlaimont","doi":"10.1080/21645515.2023.2191575","DOIUrl":"10.1080/21645515.2023.2191575","url":null,"abstract":"Debate regarding vaccinating high-risk infants with penta- and hexavalent vaccines persists, despite their good immunogenicity and acceptable safety profile in healthy full-term infants. We report the findings of a systematic literature search that aimed to present data on the immunogenicity, efficacy, effectiveness, safety, impact, compliance and completion of penta- and hexavalent vaccination in high-risk infants, including premature newborns. Data from the 14 studies included in the review showed that the immunogenicity and the safety profile of penta- and hexavalent vaccines in preterm infants was generally similar to those seen in full-term infants, with the exception of an increase in cardiorespiratory adverse events such as apnea, bradycardia and desaturation following vaccination in preterm infants. Despite recommendations of vaccinating preterm infants according to their actual age, and the relatively high completion rate of the primary immunization schedule, vaccination was often delayed, increasing the vulnerability of this high-risk population to vaccine-preventable diseases.","PeriodicalId":13058,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"19 1","pages":"2191575"},"PeriodicalIF":4.8,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/09/b3/KHVI_19_2191575.PMC10120554.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9930496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of the pre-Omicron COVID-19 vaccines against Omicron in reducing infection, hospitalization, severity, and mortality compared to Delta and other variants: A systematic review. 与Delta和其他变体相比，预Omicron COVID-19疫苗在减少感染、住院、严重程度和死亡率方面的有效性:一项系统综述。

IF 4.8 4区医学

Human Vaccines & Immunotherapeutics Pub Date : 2023-12-31 Epub Date: 2023-03-13 DOI: 10.1080/21645515.2023.2167410

Pradipta Paul, Ahmed El-Naas, Omar Hamad, Mohammad A Salameh, Nada Mhaimeed, Ibrahim Laswi, Ali A Abdelati, Jamal AlAnni, Bushra Khanjar, Dana Al-Ali, Krishnadev V Pillai, Abdallah Elshafeey, Hasan Alroobi, Zain Burney, Omar Mhaimeed, Mohammad Bhatti, Pratyaksha Sinha, Muna Almasri, Ahmed Aly, Khalifa Bshesh, Reem Chamseddine, Omar Khalil, Ashton D'Souza, Thanu Shree, Narjis Mhaimeed, Lina Yagan, Dalia Zakaria

{"title":"Effectiveness of the pre-Omicron COVID-19 vaccines against Omicron in reducing infection, hospitalization, severity, and mortality compared to Delta and other variants: A systematic review.","authors":"Pradipta Paul, Ahmed El-Naas, Omar Hamad, Mohammad A Salameh, Nada Mhaimeed, Ibrahim Laswi, Ali A Abdelati, Jamal AlAnni, Bushra Khanjar, Dana Al-Ali, Krishnadev V Pillai, Abdallah Elshafeey, Hasan Alroobi, Zain Burney, Omar Mhaimeed, Mohammad Bhatti, Pratyaksha Sinha, Muna Almasri, Ahmed Aly, Khalifa Bshesh, Reem Chamseddine, Omar Khalil, Ashton D'Souza, Thanu Shree, Narjis Mhaimeed, Lina Yagan, Dalia Zakaria","doi":"10.1080/21645515.2023.2167410","DOIUrl":"10.1080/21645515.2023.2167410","url":null,"abstract":"Despite widespread mass rollout programs, the rapid spread of the SARS-CoV-2 Omicron variant called into question the effectiveness of the existing vaccines against infection, hospitalization, severity, and mortality compared to previous variants. This systematic review summarizes and compares the effectiveness of the COVID-19 vaccines, with respect to the above outcomes in adults, children, and adolescents. A comprehensive literature search was undertaken on several databases. Only 51 studies met our inclusion criteria, revealing that the protection from primary vaccination against Omicron infection is inferior to protection against Delta and Alpha infections and wanes faster over time. However, mRNA vaccine boosters were reported to reestablish effectiveness, although to a lower extent against Omicron. Nonetheless, primary vaccination was shown to preserve strong protection against Omicron-associated hospitalization, severity, and death, even months after last dose. However, boosters provide more robust and longer-lasting protection against hospitalizations due to Omicron as compared to only primary series.","PeriodicalId":13058,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"19 1","pages":"2167410"},"PeriodicalIF":4.8,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ec/3b/KHVI_19_2167410.PMC10054360.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9210285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preclinical safety evaluation of a bivalent inactivated EV71-CA16 vaccine in mice immunized intradermally. 皮内免疫小鼠双价灭活疫苗EV71-CA16的临床前安全性评价

IF 4.8 4区医学

Human Vaccines & Immunotherapeutics Pub Date : 2023-12-31 DOI: 10.1080/21645515.2023.2209472

Yun Liao, Qinfang Jiang, Xinqian Huo, Li Yu, Jinling Yang, Heng Zhao, Dandan Li, Xingli Xu, Guorun Jiang, Caixing Zhang, Cong Li, Yun Li, Ying Zhang, Mingxiang Shao, Baofeng Liu, Lianzhong Shen, Shengtao Fan, Qihan Li

{"title":"Preclinical safety evaluation of a bivalent inactivated EV71-CA16 vaccine in mice immunized intradermally.","authors":"Yun Liao, Qinfang Jiang, Xinqian Huo, Li Yu, Jinling Yang, Heng Zhao, Dandan Li, Xingli Xu, Guorun Jiang, Caixing Zhang, Cong Li, Yun Li, Ying Zhang, Mingxiang Shao, Baofeng Liu, Lianzhong Shen, Shengtao Fan, Qihan Li","doi":"10.1080/21645515.2023.2209472","DOIUrl":"10.1080/21645515.2023.2209472","url":null,"abstract":"Hand, foot and mouth disease is a common acute viral infectious disease that poses a serious threat to the life and health of young children. With the development of an effective inactivated EV71 vaccine, CA16 has become the main pathogen causing HFMD. Effective and safe vaccines against this disease are urgently needed. In our previous study, a bivalent inactivated vaccine was shown to have good immunogenicity and to induce neutralizing antibodies in mice and monkeys. Repeated administration toxicity is a critical safety test in the preclinical evaluation of vaccines. In this study, BALB/c mice were used to evaluate the toxicity of the bivalent vaccine after multiple intradermal administrations. Clinical observation was performed daily, and body weight, food intake, hematological characteristics, serum biochemical parameters, antinuclear antibodies, CD4+/CD8a+ T-cell proportions, bone marrow smear results and pathology results were recorded. The results showed that there was no significant change at the injection site and no adverse reactions related to the vaccine. The bivalent inactivated EV71-CA16 vaccine exhibits good safety in mice, and these results provide a sufficient basis for further clinical trials.","PeriodicalId":13058,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"19 1","pages":"2209472"},"PeriodicalIF":4.8,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7b/fb/KHVI_19_2209472.PMC10208166.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9514112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of rotavirus vaccine introduction in Abidjan, Côte d'Ivoire. 在阿比让引入轮状病毒疫苗的影响Côte科特迪瓦。

IF 4.8 4区医学

Human Vaccines & Immunotherapeutics Pub Date : 2023-12-31 Epub Date: 2023-01-31 DOI: 10.1080/21645515.2022.2156231

Alice Britoh Mlan, Rachel M Burke, Hamidou Koné, Catherine Boni-Cisse, Rebecca N'Guessan, Flore Zaba, Lepri Nicaise Aka, Kofi N'Zue, San Koffi Adom, Sié Kabran Kouadio, Armel Bhérat Kouadio, Syndou Meité, Stephane Koffi, Hortense Faye-Kette, Keith Shaba, Bernard Ntsama, Joseph Biey, Negar Aliabadi, Jason M Mwenda, Umesh D Parashar, Jacqueline E Tate

{"title":"Impact of rotavirus vaccine introduction in Abidjan, Côte d'Ivoire.","authors":"Alice Britoh Mlan, Rachel M Burke, Hamidou Koné, Catherine Boni-Cisse, Rebecca N'Guessan, Flore Zaba, Lepri Nicaise Aka, Kofi N'Zue, San Koffi Adom, Sié Kabran Kouadio, Armel Bhérat Kouadio, Syndou Meité, Stephane Koffi, Hortense Faye-Kette, Keith Shaba, Bernard Ntsama, Joseph Biey, Negar Aliabadi, Jason M Mwenda, Umesh D Parashar, Jacqueline E Tate","doi":"10.1080/21645515.2022.2156231","DOIUrl":"10.1080/21645515.2022.2156231","url":null,"abstract":"Côte d'Ivoire introduced rotavirus vaccine in March 2017. Rotavirus surveillance is conducted at Centre Hospitalier Universitaire de Yopougon in Abidjan, the capital city. Children <5 years of age are enrolled in rotavirus surveillance if admitted to the hospital with acute gastroenteritis. We used sentinel surveillance data from 2014 through mid-2019 to compare trends in rotavirus pediatric gastroenteritis hospitalizations before and after rotavirus vaccine introduction. We used Poisson regression to analyze changes in rotavirus prevalence, adjusting for calendar month and accounting for total monthly admissions; January 2014 - December 2016 was considered \"pre-vaccine,\" and January 2017 - June 2019 was considered \"post-vaccine.\" Age distribution and severity were compared between periods using the Mann-Whitney U test. Rotavirus-positive admissions declined 51% (95% CI: 28%-67%), from 31.5% pre-vaccine to 14.9% afterward. The median age of rotavirus-positive children increased from 7 months (interquartile range [IQR]: 5-11) in the pre-vaccine period to 11 months (IQR: 7-18, p = .005) in the post-vaccine period. The median severity score decreased from 11 to 9 (p = .008) among all children, and from 12 pre- to 10.5 post-vaccine (p = .35) among rotavirus-positive children. Our findings suggest that rotavirus vaccine introduction contributed to reduced rotavirus hospitalization in Abidjan and possibly more broadly.","PeriodicalId":13058,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"19 1","pages":"2156231"},"PeriodicalIF":4.8,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9110567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-lasting complete response to SHR-1701 plus famitinib in refractory advanced gallbladder cancer: A case report SHR-1701 加法米替尼治疗难治性晚期胆囊癌的持久完全反应：病例报告

IF 4.8 4区医学

Human Vaccines & Immunotherapeutics Pub Date : 2023-12-21 DOI: 10.1080/21645515.2023.2294575

Lixia Yi, Xiaoyan Zhu, Jing Xie, Zhiqiang Meng

引用次数: 0

A bibliometric and knowledge-map study of CAR-T cell-related cytokine release syndrome (CRS) from 2012 to 2023 2012年至2023年CAR-T细胞相关细胞因子释放综合征（CRS）的文献计量和知识图谱研究

IF 4.8 4区医学

Human Vaccines & Immunotherapeutics Pub Date : 2023-12-19 DOI: 10.1080/21645515.2023.2291900

Huimin Li, Qing Huang, Yuan Zhang

引用次数: 0

Potential motivators affecting parental intention in COVID-19 vaccination for children aged 6 months to 4 years: Implications for targeted vaccine interventions in Japan 影响家长为 6 个月至 4 岁儿童接种 COVID-19 疫苗意向的潜在动机：对日本有针对性的疫苗干预措施的影响

IF 4.8 4区医学

Human Vaccines & Immunotherapeutics Pub Date : 2023-12-19 DOI: 10.1080/21645515.2023.2296737

Yukiko Kato, Tomohiro Shinozaki, Daisuke Sugiyama, Atsuko Taguchi, Satoko Nagata

引用次数: 0