Adhi Marihot Pardamean Pulungan, A. Hariyanto, Candra Adi Nugroho, Dede Sulaeman Farisi, Franky Sandjaja, M.Farisan Auzan, M. Yudistira, Nellyn Angela, Widyanti Djaali, Gregorius Ben Prajogi
{"title":"Hubungan antara Perilaku Merokok dengan Kejadian Mukositis Berat pada Pasien Keganasan Kepala dan Leher yang Menjalani Radioterapi","authors":"Adhi Marihot Pardamean Pulungan, A. Hariyanto, Candra Adi Nugroho, Dede Sulaeman Farisi, Franky Sandjaja, M.Farisan Auzan, M. Yudistira, Nellyn Angela, Widyanti Djaali, Gregorius Ben Prajogi","doi":"10.32532/JORI.V9I1.62","DOIUrl":"https://doi.org/10.32532/JORI.V9I1.62","url":null,"abstract":"Tujuan: Mukositis akibat radiasi adalah reaksi yang paling mengganggu yang terjadi ketika pasien kanker kepala leher menjalani radiasi. Telah diketahui bahwa merokok dapat mengganggu aktivitas sitotoksik Natural Killer cells dengan meningkatkan produksi sitokin pro-inflamasi dan proliferasi sel T terhadap mitogen. Kasus berbasis bukti ini mengevaluasi dampak riwayat merokok sebelumnya terhadap kejadian mukositis pada pasien kanker kepala leher yang menjalani pengobatan radiasi.Metode: Pencarian bukti-bukti dari literatur dilakukan di PubMed dan EBSCOhost. Seluruh penelitian yang memenuhi kriteria inklusi dan eksklusi dinilai aspek validitas, kepentingan dan aplikabilitasnya dengan menggunakan kuesioner penilaian kritis dari Oxford Center of Evidence-Based MedicineHasil: Dari 104 penelitian yang sudah ditemukan, 6 penelitian dipilih untuk ditelaah lebih lanjut. Hanya terdapat satu studi, Tao dkk., yang menunjukkan hubungan yang signifikan antara riwayat merokok dan reaksi mukosa oral akibat radiasi meskipun dengan Interval Kepercayaan yang rendah (1.258-58.23). Lima penelitian lainnya gagal menunjukkan hubungan yang signifikan.Kesimpulan: Tidak ada penelitian yang menunjukkan dampak riwayat merokok sebelumnya dengan kejadian mukositis pada pasien kanker kepala leher yang menjalani radiasi. Namun, lima dari enam penelitian menunjukkan insiden mukositis yang lebih tinggi pada kelompok pasien yang memiliki riwayat merokok sebelumnya.","PeriodicalId":130312,"journal":{"name":"Radioterapi & Onkologi Indonesia","volume":"130 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128297401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Kompresi Medulla Spinalis akibat Metastasis","authors":"Aurika Sinambela, Irwan Ramli","doi":"10.32532/JORI.V9I1.65","DOIUrl":"https://doi.org/10.32532/JORI.V9I1.65","url":null,"abstract":"Sebanyak 5 – 10% pasien kanker akan mengalami kompresi medulla spinalis akibat metastasis (KMSM). Penyakit ini terjadi saat tumor atau fragmen tulang menggeser dan menekan kedudukan medulla dalam kanalis spinalis. Gejala utama adalah nyeri punggung (83-95% pasien), dengan atau tanpa deficit motorik (82% pasien) dan sensorik (50-80% pasien). Saat ini pencitraan terpilih untuk diagnosis kompresi medulla spinalis adalah MRI dengan kontras. Kondisi ini merupakan salah satu kegawatdaruratan onkologi, yang harus ditatalaksana segera setelah diagnosisnya ditentukan. Modalitas terapi yang tersedia saat ini adalah operasi, radioterapi, dan kortikosteroid. Sepertiga pasien dengan KMSM memiliki kesempatan hidup lebih dari 1 tahun setelah terapi, sehingga tatalaksana yang dipilih harus mempertimbangkan toksisitas dan morbiditas pasca terapi agar tercapai kualitas hidup yang optimal.","PeriodicalId":130312,"journal":{"name":"Radioterapi & Onkologi Indonesia","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128244007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Perbandingan Protokol Terapi Radiasi pada Glioblastoma Multiforme","authors":"Febryono Basuki Raharjo, Nana Supriana","doi":"10.32532/JORI.V8I1.61","DOIUrl":"https://doi.org/10.32532/JORI.V8I1.61","url":null,"abstract":"Peran radioterapi dalam penatalaksanaan Glioblastoma Multiforme (GBM) terus berkembang, mulai dari teknik Whole Brain Radiotherapy (WBRT), 3D-Conformal Radiotherapy (3D-CRT) hingga teknik Intensity Modulated Radiotherapy (IMRT). Perkembangan teknologi radiodiagnostik CT-scan dan MRI juga berkontribusi besar dalam peningkatan akurasi dalam lokalisasi gross tumor. Seiring peningkatan teknologi tersebut, penentuan volume target radiasi menjadi hal yang terus menjadi perdebatan dan terdapat beberapa perbedaan panduan protokol delineasi. Dalam tinjauan pustaka ini, kami akan membandingkan serta mempelajari kelemahan dan keuntungan dari berbagai protokol delineasi yang ada.","PeriodicalId":130312,"journal":{"name":"Radioterapi & Onkologi Indonesia","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129081674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sarkoma Ewing","authors":"Fenny Gozal, H.M Djakaria","doi":"10.32532/jori.v8i1.58","DOIUrl":"https://doi.org/10.32532/jori.v8i1.58","url":null,"abstract":"Sarkoma Ewing/ Ewing Sarcoma (ES) merupakan keganasan tulang tersering nomor dua pada anak setelah osteosarkoma. Sebagai tumor dengan derajat keganasan tinggi, seringkali ES terdiagnosis dengan kondisi lesi yang ekstensif serta tidak jarang sudah mengalami metastasis sehingga prognosis pasien menjadi buruk. Tata laksana yang tepat untuk ES menjadi tantangan bagi klinisi dalam menangani pasien. Terapi multimodalitas berupa kombinasi antara kemoterapi, pembedahan dan radioterapi menjadi pilihan terbaik dalam tatalaksana ES yang dapat meningkatkan angka 5 year survival dari pasien ES. Radioterapi dalam hal ini memiliki peranan sebagai terapi definitif, pre operatif maupun sebagai terapi adjuvan post operatif.","PeriodicalId":130312,"journal":{"name":"Radioterapi & Onkologi Indonesia","volume":"171 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132442691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Kraniofaringioma","authors":"M. Silalahi, H. M. Djakaria","doi":"10.32532/jori.v8i1.60","DOIUrl":"https://doi.org/10.32532/jori.v8i1.60","url":null,"abstract":"Kraniofaringioma merupakan tumor jinak regio sella yang jarang terjadi dan penanganannya memiliki kesulitan yang tinggi karena lokasinya dan morbiditasnya, serta tingginya laju rekurensi. Di Amerika Serikat, sekitar 1,2-4,6% dari seluruh tumor intrakranial adalah kraniofaringioma. Gambaran khas untuk kraniofaringioma adalah tumor suprasella dengan komponen padat dan kistik yang dapat disertai dengan gambaran kalsifikasi. Reseksi komplit lewat pembedahan diyakini merupakan pilihan tatalaksana terbaik, walaupun sayangnya sulit tercapai. Radiasi eksterna diberikan pada reseksi subtotal dan sebagai terapi utama pada kraniofaringioma rekuren. Teknik radiasi konformal yang diberikan setelah reseksi subtotal baik dengan menggunakan dosis konvensional ataupun dengan teknik stereotactic radiosurgery (SRS) memberikan kontrol lokal yang baik dan mengurangi risiko morbiditas dibandingkan terapi pembedahan yang agresif untuk mencapai reseksi total.","PeriodicalId":130312,"journal":{"name":"Radioterapi & Onkologi Indonesia","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132192794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Kanker Vulva","authors":"Wahyu Nurhidayat, Irwan Ramli","doi":"10.32532/jori.v8i1.57","DOIUrl":"https://doi.org/10.32532/jori.v8i1.57","url":null,"abstract":"Kanker vulva adalah keganasan ginekologi yang jarang terjadi pada wanita (1% dari seluruh keganasan pada wanita). Sekitar 80-90% jenis histopatologi kanker vulva adalah karsinoma sel skuamosa. Faktor risiko terjadinya kanker vulva adalah usia lanjut, adanya lesi prekanker, infeksi HPV, imunodefisiensi, merokok dan lichen sclerosis. Keterlibatan kelenjar getah bening merupakan faktor prognosis terpenting yang dapat menurunkan overall survival. Modalitas terapi pada kanker vulva adalah kombinasi antara operasi, kemoterapi dan radioterapi. Preservasi anatomi dan fungsi organ menjadi menjadi pertimbangan penting dalam menentukan tatalaksana kanker vulva. Pada makalah ini akan dibahas peran radiasi pada kanker vulva.","PeriodicalId":130312,"journal":{"name":"Radioterapi & Onkologi Indonesia","volume":"85 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115690531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Keganasan Primer Vagina","authors":"Anak Agung Dewi Lestari, N. Supriana","doi":"10.32532/JORI.V8I1.59","DOIUrl":"https://doi.org/10.32532/JORI.V8I1.59","url":null,"abstract":"Keganasan primer vagina adalah keganasan yang jarang ditemukan, berkisar 1-2% dari seluruh keganasan ginekologi. Keganasan primer vagina sebagian besar berupa karsinoma sel skuamosa yang erat berhubungan dengan adanya infeksi Human Papillomavirus (HPV). Radioterapi memegang peranan penting dalam tatalaksana keganasan vagina dengan mengkombinasikan radiasi eksterna dengan brakiterapi. Operasi memiliki peran yang sangat sedikit pada kasus ini karena letak anatomis vagina yang sangat dekat dengan kandung kencing dan rektum. Kemoradiasi masih diperdebatkan penggunaannya dalam terapi keganasan vagina.","PeriodicalId":130312,"journal":{"name":"Radioterapi & Onkologi Indonesia","volume":"150 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124196296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ayu Santika Santaningrum, Fenny Tjuatja, G. A. Pradana, Hari Murti Wijaya, J. Anton, Regina Wulandari, S. Dewi, Sudibio, Wahyu Diyana
{"title":"Short-course versus Long-Course Preoperative Radiotherapy in Rectal Cancer: an Evidence Based Case report","authors":"Ayu Santika Santaningrum, Fenny Tjuatja, G. A. Pradana, Hari Murti Wijaya, J. Anton, Regina Wulandari, S. Dewi, Sudibio, Wahyu Diyana","doi":"10.32532/jori.v8i2.70","DOIUrl":"https://doi.org/10.32532/jori.v8i2.70","url":null,"abstract":"Background Surgery is the mainstay therapy for colorectal carcinoma with curative intent, while radiotherapy and chemotherapy act as adjuvant or neoadjuvant therapy. The desicion for surgery depends on tumor resectability. Neoadjuvant radiotherapy, both short-course radiotherapy (SRT) or long-course radiotherapy (LRT) with or without concurent chemtherapy, is aimed to increase tumor resectability. This article compares advantages of SRT and LRT. Method We designed a search filter using relevant synonyms for the domain: “rectal carcinoma”, “resectable”, “preoperative radiotherapy”, and “short-course”. Publications are retrieved from PubMed, Cochrane Library, and EBSCO using MESH terms and search terms in title and abstract fields. Articles’ titles and abstracts from search result are screened for relevance. Eligible articles are selected based on inclusion and exclusion criterias. Selected articles are critically appraised for methods validity. Result Six articles are included in our study, consists of four randomized clinical trials and four metaanalyses. Conclusion SRT is as effective as LRT with or without chemotherapy in terms of overall survival, disease free survival, local recurrence rate, disease metastasis rate, free resection rate, and grade 3-4 toxicity. LRT with or without chemotherapy showed superiority in increasing pathological complete response rate and sphincter preservation rate. SRT is a better choice in centers with a long waiting list.","PeriodicalId":130312,"journal":{"name":"Radioterapi & Onkologi Indonesia","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124446527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David Andi Wijaya, Agung Tri Cahyono, Aslim Taslim, Eka Indah Pratiwi, Fahmi Radityamurti, F. Herdian, Ida Ayu Trisna Kumaladewi, Narissa Dewi Maulany, T. P. Putri, G. B. Prajogi
{"title":"Effect of Delayed Adjuvant Radiotherapy in Early Breast Cancer on Local Control, Distant Metastasis and Overall Survival: an Evidence-Based Case Report","authors":"David Andi Wijaya, Agung Tri Cahyono, Aslim Taslim, Eka Indah Pratiwi, Fahmi Radityamurti, F. Herdian, Ida Ayu Trisna Kumaladewi, Narissa Dewi Maulany, T. P. Putri, G. B. Prajogi","doi":"10.32532/JORI.V8I2.69","DOIUrl":"https://doi.org/10.32532/JORI.V8I2.69","url":null,"abstract":"Breast cancer is the second most common cancer in the world and, by far, the most frequent cancer among women with an estimated 1,67 million new cancer diagnosed in 2012 (25% of all cancers). In principle, radiation therapy is indicated in early breast cancer after breast conserving surgery or after radical mastectomy-with-positive-or-near-margin. Unfortunately, not all aforementioned indicated patients could receive immediate treatment, often due to limited radiation therapy facility. We constructed this report to investigate comprehensively, whether delayed radiation therapy for indicated-post-surgical-early breast cancer case has a significant effect to survival (either locoregional or distant metastasis-free survival). Searching was conducted on PubMed ® , Cochrane ® , and Scopus ® . After screening for titles and abstracts, we found 25 articles, 15 of which we finally included for performing full reading. From this systematic searching, we found that time to radiation is inconsistently related to locoregional survival, overall survival, and distant metastasis-free survival.","PeriodicalId":130312,"journal":{"name":"Radioterapi & Onkologi Indonesia","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123049285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Peran Radiasi dalam Tatalaksana Retinoblastoma","authors":"Aurika Sinambela, H. M. Djakaria","doi":"10.32532/JORI.V8I2.64","DOIUrl":"https://doi.org/10.32532/JORI.V8I2.64","url":null,"abstract":"Retinoblastoma merupakan keganasan orbita tersering pada anak. Leukokoria merupakan tanda utama pada 80% pasien, diikuti strabismus, penurunan visus, hingga perdarahan vitreus pada penyakit stadium lanjut. Retinoblstoma dapat bersifat unilateral maupun bilateral, herediter maupun non-herediter, di mana terjadi mutasi pada kedua alel gen RB1 pada lengan panjang kromosom 13 (13q14). Tujuan utama terapi retinoblastoma adalah penyelamatan hidup pasien dan tujuan sekundernya adalah penyelamatan bola mata dan fungsi penglihatan. Agar tujuan ini tercapai, diagnosis dini dan tatalaksana multimodalitas yang terdiri atas kemoterapi, terapi fokal, operasi, dan radiasi oleh tim multidisiplin diperlukan. Laju sintasan retinoblastoma pada negara berkembang mencapai >95% namun pada negara sedang berkembang, mortalitas retinoblastoma masih tinggi, mencapai 40-70% karena keterlambatan diagnosis dan terapi.","PeriodicalId":130312,"journal":{"name":"Radioterapi & Onkologi Indonesia","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133625284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}