Hospital Pharmacy最新文献

{"title":"Impact of a Pharmacist Driven Penicillin Allergy De-labeling Protocol on Rates of Reported Allergy in the Intensive Care Unit.","authors":"Mujtaba Mahmud, Shahristan R Kokoy, Joanna L Stollings, Allison B McCoy, Grace Koo, Mary Lynn Dear, Todd W Rice, Elizabeth J Phillips, Cosby A Stone","doi":"10.1177/00185787251337625","DOIUrl":"10.1177/00185787251337625","url":null,"abstract":"<p><p>Inaccurate penicillin allergy labels (PALs) results in use of broader, less optimized antibiotics. Studies have shown challenging low-risk PALs is safe and effective. We assessed the proportion of PALs among critically ill patients after a pharmacist driven allergy de-labeling program was implemented in the medical intensive care unit (MICU) between November 2017 and March 2023. There was a notable reduction in the proportion of PALs pre-intervention (14.0%) and post-intervention (12.8%). Persistent reductions in the proportion of PALs among readmitted patients was seen in both MICU (21.4% to 15.9%) and non-MICU patients (13.8% to 11.1%). This study further emphasizes the potential for proactive surveillance and intervention on low-risk PALs by pharmacists to reduce the burden of broad-spectrum antibiotics, which may optimize antibiotic usage and possibly impact institutional antimicrobial spectrum.</p>","PeriodicalId":13002,"journal":{"name":"Hospital Pharmacy","volume":" ","pages":"00185787251337625"},"PeriodicalIF":0.7,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacovigilance and Stevens-Johnson Syndrome (SJS)/Toxic Epidermal Necrolysis (TEN): 55 Years of Retrospective Analysis of the FDA Adverse Event Reporting System (FAERS) Database.","authors":"Eleonora Castellana, Patricia Madalina Budau, Maria Rachele Chiappetta","doi":"10.1177/00185787251337610","DOIUrl":"https://doi.org/10.1177/00185787251337610","url":null,"abstract":"<p><p><b>Purpose:</b> This study investigates Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN), severe and rare cutaneous adverse reactions often linked to drug use, utilizing data from the Food and Drug Administration Adverse Event Reporting System (FAERS) database collected between 1969 and 2024. The objective is to identify the drugs most frequently associated with these conditions and to analyze trends in reporting over time. <b>Methods:</b> A retrospective analysis was conducted on 29 661 136 total adverse event reports, including 39 398 cases (0.13%) related to SJS/TEN. The drugs most commonly associated were classified using the Anatomical Therapeutic Chemical (ATC) system. The analysis included the severity, outcomes, gender, and age distribution of affected patients, focusing on drugs with the highest number of reports and their association with SJS/TEN. Regarding outcomes, their total number exceeds the number of SJS/TEN cases, as a single adverse drug reaction (ADR) can be associated with multiple outcomes. <b>Results:</b> Of the SJS/TEN cases, 97.79% were classified as severe, and 20.86% were fatal. Reports of SJS/TEN have increased significantly over the decades, peaking during the 2018 to 2020 period. The most frequently implicated drugs were Lamotrigine (9.17% of cases), Sulfamethoxazole/Trimethoprim (6.12%), and Allopurinol (5.88%). Other significant drugs included Phenytoin (5.05%), Acetaminophen (4.97%), and Ibuprofen (4.13%). Valdecoxib showed the highest percentage of SJS/TEN cases relative to its total adverse event reports (10.71%). Women were slightly more affected (51.03%) than men (39.30%). The most impacted age group was 18 to 64 years (45.12%), followed by 65 to 85 years (23.16%). Most reports were submitted by healthcare professionals (70.38%). <b>Conclusion:</b> The 55-year retrospective analysis highlights a rising trend in SJS/TEN reporting, attributed to increased awareness and vigilance in pharmacovigilance. These findings emphasize the importance of monitoring high-risk drugs, such as antiepileptics, analgesics, and antibacterials, and implementing strategies to mitigate associated risks. This study underscores the need for ongoing surveillance and education to enhance patient safety.</p>","PeriodicalId":13002,"journal":{"name":"Hospital Pharmacy","volume":" ","pages":"00185787251337610"},"PeriodicalIF":0.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of a Self-Service Data Exploration Tool Within an Academic Medical Center Department of Pharmacy.","authors":"Thomas S Achey, Holly R Griffin","doi":"10.1177/00185787251337613","DOIUrl":"https://doi.org/10.1177/00185787251337613","url":null,"abstract":"<p><p><b>Purpose:</b> The validation and implementation of a self-service data exploration and reporting tool in an academic medical center is described. <b>Summary:</b> Macro-level data is abundant within hospitals and health systems. In the absence of a data scientist, other solutions were explored within Medical University of South Carolina (MUSC) Health pharmacy's technology. A data exploration tool within the electronic health record was validated for widespread use. Based on limited experiences, an educational session was conducted to satisfy Practice Advancement Initiative (PAI) 2030 recommendations for staff competence and personnel professional development desires. Epic SlicerDicer was leveraged by frontline staff for data-driven decision-making in operational and clinical arenas. The MUSC Health Department of Pharmacy incorporated the tool into a data-driven culture. The tool had widespread use upon implementation. After disseminating the tool, impact was measured and evaluated. Its utility impacted operations, drug distribution, formulary management, resident research, quality improvement, and staff satisfaction. There now exists an accessible tool for staff to utilize on-demand for data-driven recommendations and interventions. <b>Conclusion:</b> A data exploration tool within the electronic health record improved operational efficiency, cost savings, and research productivity. It offers elevated decision-making and enhanced professional development for staff.</p>","PeriodicalId":13002,"journal":{"name":"Hospital Pharmacy","volume":" ","pages":"00185787251337613"},"PeriodicalIF":0.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of Pharmacist Resources at a Community Internal Medicine Teaching Hospital: Development of a Tool Through Pharmacist and Physician Expert Panels.","authors":"Rachel K Russ, Marjorie V Neidecker, Ariane Schieber, Robert J Weber, Charlotte Forshay","doi":"10.1177/00185787251337599","DOIUrl":"https://doi.org/10.1177/00185787251337599","url":null,"abstract":"<p><p><b>Purpose:</b> Expansion of acute care clinical pharmacist roles requires pharmacy departments to optimize allocation of pharmacist resources. This study aimed to develop an objective resource optimization tool to rank clinical service needs to assign internal medicine pharmacist resources at a community hospital within an academic medical center health system. Additionally, this study aimed to collect and analyze physician expert opinion to supplement the pharmacist-developed tool. <b>Method:</b> A pharmacist expert panel was convened to determine patient characteristics necessitating additional pharmacist services. Retrospective electronic health record data were aggregated by patient characteristic categories and ranked by clinical services. Separately, a survey of attending physicians rated patient cases on the need for additional pharmacy services and provided rationale. Results of both panels were analyzed and compared to develop and strengthen the tool. <b>Results:</b> The pharmacist-developed tool included three patient characteristic categories: Patient Acuity, Critical Drug Monitoring, and Transitions of Care. An internal medicine teaching service scored highest for needing additional pharmacy services; surgery and urology resulted in lowest scores. Highest ranked cases surveyed by physicians were patients with more complex transitions of care, inpatient medication management, and disease state optimization. Comparing panels, 92.5% of physician comments were related to one of the three categories included in the pharmacist developed tool. Remaining comments fell within a new category, Patient Allergies. <b>Conclusion:</b> Pharmacists and physicians identified similar patient characteristic categories requiring more robust pharmacist services across internal medicine patients. Alignment of the two panels confirms the inputs used to develop the tool and increases confidence in its application for pharmacist resource optimization.</p>","PeriodicalId":13002,"journal":{"name":"Hospital Pharmacy","volume":" ","pages":"00185787251337599"},"PeriodicalIF":0.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacist Preparation of 4F-PCC in the Emergency Department: Implications for Hemorrhage Management.","authors":"Yalcin Golcuk","doi":"10.1177/00185787251337593","DOIUrl":"https://doi.org/10.1177/00185787251337593","url":null,"abstract":"","PeriodicalId":13002,"journal":{"name":"Hospital Pharmacy","volume":" ","pages":"00185787251337593"},"PeriodicalIF":0.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Switching from Nusinersen to Risdiplam in Spinal Muscular Atrophy: A Comparative Analysis of Safety, Efficacy, and Economic Impact.","authors":"Eleonora Castellana","doi":"10.1177/00185787241282213","DOIUrl":"10.1177/00185787241282213","url":null,"abstract":"","PeriodicalId":13002,"journal":{"name":"Hospital Pharmacy","volume":" ","pages":"103-104"},"PeriodicalIF":0.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11559751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacy-Physiotherapy Interprofessional Education and Practice.","authors":"Seif El Hadidi","doi":"10.1177/00185787241280240","DOIUrl":"10.1177/00185787241280240","url":null,"abstract":"<p><p>Interprofessional education (IPE) is an educational technique in which tutors and students from several healthcare disciplines, such as pharmacy and physiotherapy, collaborate to achieve a common goal. IPE has been shown to increase patient outcomes and professional growth among healthcare teams. Pharmacists and physiotherapists have different knowledge bases and skills, both of which are integral to the effectiveness of a collaborative healthcare team. By bringing their respective expertise together in an interprofessional context these healthcare professionals can work to develop increased understanding, respect for each other's roles, and the ability to collaborate more effectively.</p>","PeriodicalId":13002,"journal":{"name":"Hospital Pharmacy","volume":" ","pages":"101-102"},"PeriodicalIF":0.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11559938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Four Decades of Progress: Evaluating Saudi Arabia's Research Publications in Pharmaceutical Sciences.","authors":"Dileep K Rohra, Ismail Memon","doi":"10.1177/00185787251326821","DOIUrl":"10.1177/00185787251326821","url":null,"abstract":"<p><p><b>Objectives:</b> This study aims to analyze the quantity and quality of pharmaceutical science publications originating from Saudi Arabia and compare research publications retrieved from Scopus over the past 40 years (1980-2019). <b>Methods:</b> Data was collected from Scopus, with each publication assigned a unique identifier. Information such as the journal's name, year of publication, and publication type were recorded. The Journal Impact Factor (JIF) for the year 2018, obtained from ISI Web of Science, was used for all publications. The mean impact factor (MIF) for each year was calculated by dividing the cumulative IF by the total number of publications in that year. All data was entered into Microsoft Excel and analyzed using numbers, means, and percentages. <b>Results:</b> A total of 12 299 papers were published from Saudi Arabia in the field of pharmaceutical sciences. A modest growth trend in publication was observed from 1980 to 2008. However, starting in 2009, there was a notable increase in annual publication counts, reaching 1400 by 2016, and maintaining a range of 1200 to 1400 annually until 2019. A highly statistically significant upward trajectory in the JIF was observed from 1980 to 2018, with annual variations. The SCImago Journal Rank also exhibited a similar pattern of increased research growth. <b>Conclusion:</b> This study indicates a consistent growth in both the quantity of publications and the presence in quality journals indexed with Scopus published in the field of pharmaceutical sciences from Saudi Arabia.</p>","PeriodicalId":13002,"journal":{"name":"Hospital Pharmacy","volume":" ","pages":"00185787251326821"},"PeriodicalIF":0.8,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thrombotic Thrombocytopenic Purpura-Induced Cardiomyopathy and Troponin Clearance with Plasmapheresis: True or False Reassurance?","authors":"Soomal Rafique, Yara Deeb, Fares Ghanem, Mukul Bhattarai","doi":"10.1177/00185787251328593","DOIUrl":"10.1177/00185787251328593","url":null,"abstract":"<p><p>Thrombotic thrombocytopenic purpura (TTP) is a rare microangiopathic hemolytic anemia caused by a deficiency in the von Willebrand factor-cleaving protease ADAMTS13, resulting in the formation of microthrombi. TTP is associated with severe cardiovascular complications, such as myocardial infarction, congestive heart failure, arrhythmias, and cardiogenic shock, which can lead to a poor prognosis. Although plasmapheresis is the cornerstone of TTP treatment, it complicates the interpretation of cardiac biomarkers due to the rapid clearance of these markers from the bloodstream. We present the case of a 19-year-old African American female diagnosed with TTP who had critically elevated levels of high-sensitivity troponin (HS troponin). Notably, her HS troponin levels declined rapidly with ongoing plasmapheresis, underscoring the difficulties in interpreting cardiac biomarkers in TTP and the effects of treatment on these values. This case highlights the challenges in diagnosing and managing cardiovascular complications associated with TTP and their impact on patient prognosis.</p>","PeriodicalId":13002,"journal":{"name":"Hospital Pharmacy","volume":" ","pages":"00185787251328593"},"PeriodicalIF":0.8,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926812/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Awareness, Perception and Opinions Toward Artificial Intelligence Among Pharmacy Students.","authors":"Mohammad Abobakr Al-Ghazali","doi":"10.1177/00185787251326227","DOIUrl":"https://doi.org/10.1177/00185787251326227","url":null,"abstract":"<p><p><b>Background:</b> Artificial intelligence (AI) helps to develop personalized medication therapy and regimens. It improves the patient care system. A cross-sectional study used and included pharmacy students, using validated survey questions. <b>Objective:</b> This study aimed to evaluate awareness, perception and opinion toward AI among pharmacy students. <b>Design:</b> This is a cross-sectional study (survey-based). <b>Methods:</b> A cross-sectional survey distribution among students in different levels of the college of pharmacy at National University (NU). The questions were classified to measure the variation of demographics, awareness, perceptions and opinions toward Artificial Intelligence (AI). <b>Results:</b> The results showed that more than 50% of pharmacy students are familiar with the uses of AI and know it's important in scientific research, 46.4% have a basic understanding of AI technologies. However more than 75% don't know the applications of AI used in pharmacy practice, 50.6 % don't know AI can support therapeutic diagnosis and 57 % don't know its importance in pharmacy education. A high perception was shown toward AI in facilitating pharmacy access to information (84.2%) and patients' access to the service (80.8%). In addition, 92% suggested that AI training is needed and 86.1 % recommended using AI in scientific research. The conclusion of this study identified the needs for awareness toward AI, and the important role of AI for education in pharmacy and health communities.</p>","PeriodicalId":13002,"journal":{"name":"Hospital Pharmacy","volume":" ","pages":"00185787251326227"},"PeriodicalIF":0.8,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}