Impact of a Pharmacist Driven Penicillin Allergy De-labeling Protocol on Rates of Reported Allergy in the Intensive Care Unit.

IF 0.8 Q4 PHARMACOLOGY & PHARMACY

Hospital Pharmacy Pub Date : 2025-05-06 DOI:10.1177/00185787251337625

Mujtaba Mahmud, Shahristan R Kokoy, Joanna L Stollings, Allison B McCoy, Grace Koo, Mary Lynn Dear, Todd W Rice, Elizabeth J Phillips, Cosby A Stone

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Abstract

Inaccurate penicillin allergy labels (PALs) results in use of broader, less optimized antibiotics. Studies have shown challenging low-risk PALs is safe and effective. We assessed the proportion of PALs among critically ill patients after a pharmacist driven allergy de-labeling program was implemented in the medical intensive care unit (MICU) between November 2017 and March 2023. There was a notable reduction in the proportion of PALs pre-intervention (14.0%) and post-intervention (12.8%). Persistent reductions in the proportion of PALs among readmitted patients was seen in both MICU (21.4% to 15.9%) and non-MICU patients (13.8% to 11.1%). This study further emphasizes the potential for proactive surveillance and intervention on low-risk PALs by pharmacists to reduce the burden of broad-spectrum antibiotics, which may optimize antibiotic usage and possibly impact institutional antimicrobial spectrum.

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药剂师驱动的青霉素过敏脱标方案对重症监护病房报告过敏率的影响。

不准确的青霉素过敏标签（PALs）导致使用范围更广，优化程度较低的抗生素。研究表明，具有挑战性的低风险pal是安全有效的。2017年11月至2023年3月期间，在医疗重症监护病房（MICU）实施了药剂师驱动的过敏去标签计划后，我们评估了重症患者中PALs的比例。干预前pal比例（14.0%）和干预后pal比例（12.8%）显著降低。再入院患者中PALs比例持续下降在MICU患者（21.4%至15.9%）和非MICU患者（13.8%至11.1%）中均可见。本研究进一步强调了药剂师对低风险pal进行主动监测和干预的潜力，以减轻广谱抗生素的负担，这可能会优化抗生素的使用，并可能影响机构的抗菌药物谱。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hospital Pharmacy PHARMACOLOGY & PHARMACY-

CiteScore

1.70

自引率

0.00%

发文量

期刊介绍： Hospital Pharmacy is a monthly peer-reviewed journal that is read by pharmacists and other providers practicing in the inpatient and outpatient setting within hospitals, long-term care facilities, home care, and other health-system settings The Hospital Pharmacy Assistant Editor, Michael R. Cohen, RPh, MS, DSc, FASHP, is author of a Medication Error Report Analysis and founder of The Institute for Safe Medication Practices (ISMP), a nonprofit organization that provides education about adverse drug events and their prevention.