Heart, Lung and Circulation最新文献

{"title":"Hypertension and lipid clinical guidelines – a new approach","authors":"","doi":"10.1016/j.hlc.2024.12.005","DOIUrl":"10.1016/j.hlc.2024.12.005","url":null,"abstract":"","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"34 1","pages":"Page 102"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143143560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronobiological Patterns and Risk of Acute Aortic Dissection: A Clinical Retrospective and Two-Sample Mendelian Randomisation Study.","authors":"Xiangyang Xu, Yizhi Yu, Jiefu Fan, Shuaikang Shen, Zhimin Zhao, Sufan Ding, Jiajun Zhang, Zhiyun Xu, Yangkai Wang, Lin Han, Yangfeng Tang","doi":"10.1016/j.hlc.2024.10.010","DOIUrl":"https://doi.org/10.1016/j.hlc.2024.10.010","url":null,"abstract":"<p><strong>Aim: </strong>Acute aortic dissection (AAD) represents a cardiovascular ailment characterised by a notable mortality rate. Chronobiological patterns can offer a predictive framework for anticipating the onset of AAD.</p><p><strong>Method: </strong>Data were gathered from 1,151 patients diagnosed with AAD at Changhai Hospital in Shanghai, China, spanning 2000-2023. The χ² test was used to assess whether specific periods exhibited significantly different seasonal/weekly distributions compared with others. Fourier models were utilised for the analysis of rhythmicity in monthly/circadian distribution. Publicly available genome-wide association studies datasets were used to establish the causal relationship between chronotype and AAD. Two sets of genetics instruments were used for analysis, derived from publicly available genetic summary data: 75 single-nucleotide polymorphisms (SNPs) significantly associated with chronotype; and SNPs associated with AAD in the FinnGen consortium.</p><p><strong>Results: </strong>The mean age was 51.5±13.8 years, with 665 patients (57.8%) aged <55 years. Among the 1,151 patients, 80.9% were male. The distribution of DeBakey types was 73.2% (843) for DeBakey I, 21% (242) for DeBakey II, and 5.7% (66) for DeBakey III. Comorbidities included hypertension in 58.5% (673 cases) and diabetes in 7.8% (90 cases). A peak occurred during colder periods (winter/December), and a trough was noted in warmer periods (summer/June). Weekly distribution exhibited no significant variation. Fourier analysis revealed a statistically significant circadian variation (p<0.0001) with a trough between 23:00 and 00:00, a prominent peak from 07:00 to 08:00, and a minor peak between 20:00 and 21:00. Subgroup analyses identified circadian rhythmicity in all subgroups, except for the DeBakey III group and the female group. Using the 75 chronotype-related SNPs, evidence was found of a potential causal effect of chronotype on the risk of AAD, as the inverse-variance weighting analysis showed that self-report chronotype of morningness was associated with a decreased risk of AAD.</p><p><strong>Conclusion: </strong>The findings substantiate that the initiation of AAD displays noteworthy seasonal, monthly, and circadian patterns. The Mendelian randomisation analysis also indicated that the onset of acute aortic dissection is related to circadian rhythm. These findings offer a fresh perspective, facilitating the identification of triggering factors for AAD and bolstering preventive measures for this catastrophic event.</p>","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor “Addressing Gaps in Post-MI Medication Use Study” regarding: “Patterns of 12-Month Post-Myocardial Infarction Medication Use According to Revascularisation Strategy: Analysis of 15,339 Admissions in Victoria, Australia” by Livori et al. Heart Lung Circ. 2024;33:1439–1449","authors":"Stephan Mayntz MD, MPH, PhD ,&nbsp;Rose Peronard MD","doi":"10.1016/j.hlc.2024.10.006","DOIUrl":"10.1016/j.hlc.2024.10.006","url":null,"abstract":"","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"33 12","pages":"Pages e75-e76"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sudden Unexpected Death—COVID-19, Cardiac Rhythm or Conundrum?","authors":"Andreas Pflaumer MD, FRACP ,&nbsp;Elizabeth D. Paratz BMedSc, FRACP, PhD","doi":"10.1016/j.hlc.2024.11.006","DOIUrl":"10.1016/j.hlc.2024.11.006","url":null,"abstract":"","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"33 12","pages":"Pages 1614-1615"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac Society of Australia and New Zealand","authors":"","doi":"10.1016/S1443-9506(24)01896-1","DOIUrl":"10.1016/S1443-9506(24)01896-1","url":null,"abstract":"","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"33 12","pages":"Pages 1700-1701"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143158507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Hospitalised COVID-19 Patients Arriving With Hypoxic Respiratory Failure","authors":"William Giesing MD ,&nbsp;Hywel Soney DO ,&nbsp;Lucas Wang MD ,&nbsp;Lawrence Hoang MD ,&nbsp;Mingyang Cui MSc ,&nbsp;Sri Prathivada MD ,&nbsp;Manavjot Sidhu MD","doi":"10.1016/j.hlc.2023.10.023","DOIUrl":"10.1016/j.hlc.2023.10.023","url":null,"abstract":"<div><h3>Background</h3><div>Hypoxia is a common complication seen in people with COVID-19 and can often be the presenting symptom.</div></div><div><h3>Methods</h3><div><span>Using a multi-centre observational database, we analysed 3,624 hospitalised COVID-19 PCR-positive patients at Methodist Health System, Dallas, Texas, USA from March 2020 to December 2020. We compared in-hospital death or hospice referral rates and major adverse cardiovascular events (MACE) between patients with four levels of oxygen (O</span>₂<span><span><span><span>) requirements (0–1 L/min, 2–10 L/min, 11–20 L/min, 21–100 L/min). MACE included </span>congestive heart failure (CHF) exacerbations, myocardial infarctions (MI), strokes, </span>pulmonary embolism (PE) / </span>deep venous thrombosis<span><span> (DVT), and shock. </span>Logistic regression analysis was used to determine comorbidities and demographics associated with mortality. Multinomial regression analysis was used to find which of these variables were associated with hypoxia.</span></span></div></div><div><h3>Results</h3><div>Patients who arrived needing 0–1 L/min of O₂ had reduced risk of mortality compared to those requiring 2–10 L/min (OR=1.54, 95% CI=1.207–1.976, p&lt;0.0001), 11–20 L/min (OR=4.55, 95% CI=3.169–6.547, p&lt;0.0001), or 21–100 L/min (OR=12.06, 95% CI=8.548–17.016, p&lt;0.0001). In addition, patients who arrived needing 0–1 L/min of O₂<span> showed reduced risk of MACE compared to those requiring 2–10 L/min (OR=1.20, 95% CI=1.029–1.409, p&lt;0.0001), 11–20 L/min (OR=2.76, 95% CI 2.06–3.696, p&lt;0.0001), or 21–100 L/min (OR=6.74, 95% CI 4.966–9.155, p&lt;0.0001).</span></div></div><div><h3>Conclusion</h3><div>Hypoxia on arrival is associated with a significantly increased risk of mortality and MACE among hospitalised patients with COVID-19. This data will promote better prognostication and help reduce negative outcomes in an inpatient setting.</div></div>","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"33 12","pages":"Pages 1688-1692"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141616190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inspiratory Muscle Training in Cardiac Rehabilitation of Patients With Heart Failure: Optional or Fundamental?","authors":"Jéssica Malek Silva MSc ,&nbsp;Carlos Augusto Camillo PhD ,&nbsp;Luiz Carlos Marques Vanderlei PhD","doi":"10.1016/j.hlc.2024.04.313","DOIUrl":"10.1016/j.hlc.2024.04.313","url":null,"abstract":"","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"33 12","pages":"Pages e73-e74"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Use of the Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio in Predicting Transcatheter Aortic Valve Implantation Mortality","authors":"Sachin Nair MD ,&nbsp;Francis J. Ha MBBS ,&nbsp;Arul Baradi MBBS ,&nbsp;Shane Nanayakkara MBBS, PhD ,&nbsp;Lucy Soden MD ,&nbsp;David Jin MD ,&nbsp;Robert Whitbourn MBBS ,&nbsp;Andrew Wilson MBBS, PhD ,&nbsp;Sonny Palmer MBBS, DMedSci","doi":"10.1016/j.hlc.2024.07.006","DOIUrl":"10.1016/j.hlc.2024.07.006","url":null,"abstract":"<div><h3>Aim</h3><div>Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) are simple biomarkers that reflect systemic inflammation and are associated with adverse cardiovascular disease outcomes. The utility of NLR and PLR for risk prediction following transcatheter aortic valve implantation (TAVI) is not clear.</div></div><div><h3>Method</h3><div>We retrospectively analysed a prospectively maintained database of patients who underwent TAVI at a tertiary hospital from 2009 to 2022. Baseline demographics, NLR, PLR and Society of Thoracic Surgeons Predicted Risk of Mortality (STS-PROM) scores were obtained. The 30-day and 1-year survival rates were analysed using a logistic regression model while overall survival was analysed using the Kaplan–Meier method. Predictors of survival were calculated using a Cox-hazards regression model and presented as odds ratio (OR) with 95% confidence interval (CI).</div></div><div><h3>Results</h3><div>Overall, 367 patients were included in this study (mean age 84 years, 51% male). Median follow-up was 19 months (interquartile range 8.8–40 months) with a median survival of 7.2 years (interquartile range 3.5–10.3 years). NLR was associated with 30-day mortality (OR 1.75; 95% CI 1.25–2.68; p&lt;0.01). PLRs marginally predicted 1-year mortality (OR 1.01; 95% CI 1.00–1.02). However, only the STS-PROM score significantly predicted overall survival (hazard ratio 1.07; 95% CI 1.02–1.12; p=0.03) after adjustment for NLR and PLR.</div></div><div><h3>Conclusions</h3><div>NLR is associated with 30-day mortality following TAVI. PLR was not a clinically significant predictor of mortality after TAVI. Only the STS-PROM score remained a significant predictor of overall survival.</div></div>","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"33 12","pages":"Pages 1680-1687"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142390139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Way to Study the Effect of Bushfire Smoke on Cardiorespiratory Health","authors":"","doi":"10.1016/j.hlc.2024.11.001","DOIUrl":"10.1016/j.hlc.2024.11.001","url":null,"abstract":"","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"33 12","pages":"Page 1699"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143158016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to: Abstract 369, “Cardiovascular Outcomes in Patients Treated With Ibrutinib and Related Therapies” [Heart, Lung and Circulation, Volume 33, Supplement 4, August 2024, Pages S296–S297, (Abstracts for the 72nd Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand, 1–4 August 2024, Perth, Australia)].","authors":"S. Aroney ,&nbsp;S. Roberts ,&nbsp;A. Sitharthan ,&nbsp;J. Jan ,&nbsp;H. Kim ,&nbsp;M. Honeysett ,&nbsp;J. Yu ,&nbsp;N. Collins ,&nbsp;D. Ngo ,&nbsp;A. Sverdlov","doi":"10.1016/j.hlc.2024.11.007","DOIUrl":"10.1016/j.hlc.2024.11.007","url":null,"abstract":"","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"33 12","pages":"Page e79"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143158018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}