Heart, Lung and Circulation最新文献

{"title":"Surgical Management for Primary Malignant Cardiac Tumors: Contemporary Trends and Outcomes","authors":"Kanhua Yin MD, MPH , Yesh Datar BA , J. Dylan Pate DO, MS , Michael J. Reardon MD , Nikola Dobrilovic MD, MBA","doi":"10.1016/j.hlc.2025.02.103","DOIUrl":"10.1016/j.hlc.2025.02.103","url":null,"abstract":"","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"34 7","pages":"Pages 733-735"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translating Global Heart Failure Guidelines into the Australian Reality","authors":"Ahthavan Narendren MBBS, MMed, GradCertDigitHlth , Kate Rankin MBBS, FRACP, FCSANZ , Prasanna Venkataraman MBBS, LLB, FRACP, PhD, FCSANZ , Naveen Sharma MBBS, FRACP, FCSANZ , Gautam Vaddadi MBBS, BMedSci, FRACP, PhD, FCSANZ , John Amerena MBBS, FRACP, FCSANZ","doi":"10.1016/j.hlc.2025.06.002","DOIUrl":"10.1016/j.hlc.2025.06.002","url":null,"abstract":"","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"34 7","pages":"Pages 654-661"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Defining Gaps in the Management of Familial Hypercholesterolaemia Using Electronic Health Records in Rural General Practice","authors":"Kyle Selga BTech, MD , Maverick Daniel BPharm, MD , Samuel Moffatt BClinSci, MD , Louis Steyn BMSc, MD, FRACGP , Benjamin Whittaker MD , Jennene Greenhill BA, GradDip Nsg, PhD , Ian Hamilton-Craig PhD, FRACP, FCSANZ, FLS","doi":"10.1016/j.hlc.2025.03.004","DOIUrl":"10.1016/j.hlc.2025.03.004","url":null,"abstract":"","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"34 7","pages":"Pages 730-732"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Just Because We Can, Does It Mean We Should? Conservative Management of Penetrating Missile Injury to the Heart","authors":"Kanhua Yin MD, MPH, Garima Thakkar MD, John M. Forman MD, Sumaiya Sarwar MD, Heather R. Klepacz MD, MBA, FACS, Dustin R. Neel MD, FACS, Michael Moncure MD, FACS, Stanley M. Augustin MD, FACS","doi":"10.1016/j.hlc.2025.04.083","DOIUrl":"10.1016/j.hlc.2025.04.083","url":null,"abstract":"","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"34 7","pages":"Pages 736-738"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Desmopressin in Terms of Bleeding and Transfusion in Cardiac Surgery With Cardiopulmonary Bypass: A Systematic Review and Meta-Analysis","authors":"Marion Picchio MD ,&nbsp;Carlo Marcucci MD ,&nbsp;Cécile Jaques ,&nbsp;Sylvain Mauron MD ,&nbsp;Mael Zuercher MD","doi":"10.1016/j.hlc.2025.01.003","DOIUrl":"10.1016/j.hlc.2025.01.003","url":null,"abstract":"<div><div>Bleeding and transfusion during cardiac surgery are major sources of complications. Surgery and cardiopulmonary bypass can induce coagulopathy, including platelet dysfunction. Desmopressin has been shown to reduce bleeding and transfusion requirements, although with conflicting results. This study aimed to systematically evaluate the available evidence regarding the efficacy and safety of desmopressin in cardiac surgery with cardiopulmonary bypass.</div><div>The Embase, MEDLINE, Cochrane Central, Web of Science, and <span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> databases were searched for prospective studies comparing desmopressin with placebo in cardiac surgery with cardiopulmonary bypass. A meta-analysis with bleeding at 24 hours as the primary outcome and the amount and incidence of blood product transfusions as secondary outcomes was performed. Safety outcomes included re-exploration rate, thromboembolic events, and mortality.</div><div>Thirty-four (34) studies comprising 2,523 patients were included. Bleeding at 24 hours was reduced in the desmopressin group (weighted mean difference, 96.20 mL; 95% confidence interval [CI] −148.44 to −43.96; p=0.0003 with heterogeneity [I²]=76%). The amount of blood products transfused (red blood cells) was reduced in the desmopressin group (standardised mean difference [SMD], −0.32; 95% CI −0.58 to −0.05). No significant difference was found for transfusion of platelets (SMD, −0.16; 95% CI −0.58 to 0.26) or fresh frozen plasma (SMD, −0.30; 95% CI −0.67 to −0.06). No significant differences were observed between the two groups with respect to safety outcomes.</div><div>Results of the present meta-analysis demonstrated that desmopressin reduced blood loss and the amount of red blood cell transfusions after cardiac surgery. However, this result should be interpreted with caution, given the considerable heterogeneity among the studies.</div></div>","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"34 7","pages":"Pages 674-692"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Piezo1/Extracellular Signal-Regulated Kinase Signal Pathway Regulates Proliferation and Migration of Aortic Vascular Smooth Muscle Cells and Participates in Thoracic Aortic Aneurysm","authors":"Weihong Nie MD ,&nbsp;Wenxuan Cao MM ,&nbsp;Yingzhu Zhuang MM ,&nbsp;Sumin Yang MD ,&nbsp;Hui Zhang MM ,&nbsp;Haoyu Hu MM ,&nbsp;Chunying Shi PhD ,&nbsp;Hong Zhang MD, PhD","doi":"10.1016/j.hlc.2025.03.012","DOIUrl":"10.1016/j.hlc.2025.03.012","url":null,"abstract":"<div><h3>Background</h3><div>Vascular smooth muscle cell (VSMC) proliferation and migration contribute to vascular remodelling in thoracic aortic aneurysms (TAA). An increase in cytosolic Ca²⁺ concentration triggers VSMC proliferation and migration. Piezo1, a mechanosensitive cation channel, may be involved in the proliferation and migration of VSMCs, and potentially in the development of TAA.</div></div><div><h3>Method</h3><div>This study analysed Piezo1 and its potential downstream protein extracellular signal-regulated kinases (ERK) in aortic surgical specimens from six patients with TAA and six controls. In in vitro experiments, Yoda1, a Piezo1 agonist, SCH772984, an ERK inhibitor, si-Piezo1, used for silencing the piezo1 gene, and LM22B-10, an ERK activator, were used to regulate the expression of Piezo1 and ERK in rat thoracic aortic VSMCs. The effects of these treatments on cell proliferation, migration, apoptosis, and phenotypic switch were measured.</div></div><div><h3>Results</h3><div>Through the comparison of human samples, it was discovered that the expressions of Piezo1 and ERK in the aortic media of TAA were higher than in normal samples. Additionally, the levels of VSMC proliferation and apoptosis were higher in TAA samples. This confirmed that upregulation of Piezo1 can induce cell proliferation and migration by activating the ERK pathway. It was also found that Piezo1/ERK signalling does not affect cell apoptosis. Additionally, it was discovered that inhibiting Piezo1/ERK signalling can induce a phenotypical switch in cells.</div></div><div><h3>Conclusions</h3><div>These data indicate that Piezo1 is significantly activated in aortic VSMCs from patients with TAA, which may be involved in TAA by promoting VSMC proliferation and migration through the ERK signalling pathway. This study provides a new insight into the biological action of the Piezo1/ERK signalling pathway in the pathogenesis of TAA.</div></div>","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"34 7","pages":"Pages 704-718"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paid MBP advert: ANZSCTS ASM advert","authors":"","doi":"10.1016/S1443-9506(25)00488-3","DOIUrl":"10.1016/S1443-9506(25)00488-3","url":null,"abstract":"","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"34 7","pages":"Page 745"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144632100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time is Muscle: Closing the Rural STEMI Care Gap in Australia","authors":"Ahthavan Narendren MBBS, MMed, GradCertDigitHlth ,&nbsp;Kate Rankin MBBS, FRACP, FCSANZ ,&nbsp;Adam Hutchison MBBS, MPH, PhD, FRACP ,&nbsp;Chin Hiew MBBS, FRACP, FCSANZ, FSCAI ,&nbsp;John Amerena MBBS, FRACP, FCSANZ","doi":"10.1016/j.hlc.2025.06.004","DOIUrl":"10.1016/j.hlc.2025.06.004","url":null,"abstract":"","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"34 7","pages":"Pages 665-669"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"iCARDIO Alliance Global Implementation Guidelines on Heart Failure 2025","authors":"Vijay Chopra (India),&nbsp;Muhammad Shahzeb Khan (USA),&nbsp;Magdy Abdelhamid (Egypt),&nbsp;William T. Abraham (USA),&nbsp;Offer Amir (Israel),&nbsp;Stefan D. Anker (Germany),&nbsp;John J. Atherton (Australia),&nbsp;Fernando Bacal (Brazil),&nbsp;Ralph Stephen von Bardeleben (Germany),&nbsp;Dulce Brito (Portugal),&nbsp;Lucrecia Maria Burgos (Argentina),&nbsp;Javed Butler (USA),&nbsp;Maria Rosa Costanzo (USA),&nbsp;Albertino Damasceno (Mozambique),&nbsp;Justin A. Ezekowitz (Canada),&nbsp;Ishaque Hameed (USA),&nbsp;Sivadasanpillai Harikrishnan (India),&nbsp;Tiny Jaarsma (Sweden),&nbsp;Anuradha Lala (USA),&nbsp;Ileana L. Piña (USA),&nbsp;Shelley Zieroth (Canada)","doi":"10.1016/j.hlc.2025.05.094","DOIUrl":"10.1016/j.hlc.2025.05.094","url":null,"abstract":"<div><div>Inconsistencies in healthcare access, varying infrastructure, resource constraints and diverse local practices as well as practical and political issues restrict the global applicability of currently available guidelines. There is a need for universal recommendations that address the unique challenges faced by patients and healthcare providers worldwide. Our iCARDIO Alliance Global Implementation Guidelines emphasize the incorporation of novel therapies, while integrating standard of care with the most up-to-date evidence to enable clinicians to optimize patient care. This document is about heart failure (HF), including acute and chronic heart failure, heart failure with reduced ejection fraction and heart failure with preserved ejection fraction as well as cardiomyopathies. Context-specific recommendations tailored to individual patient needs are highlighted providing a thorough evaluation of the risks, benefits, and overall value of each therapy, aiming to establish a standard of care that improves patient outcomes and reduces the burden of hospitalization in this susceptible population. These guidelines provide evidence-based recommendations that represent a group consensus considering the many other published guidelines that have reviewed many of the issues discussed here, but they also make new recommendations where new evidence has recently emerged. Most importantly these guidelines also provide recommendations on a number of issues where resource limitations may put constraints on the care provided to HF patients. Such “economic adjustment” recommendations aim to provide guidance for situations when “Resources are somewhat limited” or when “Resources are severely limited”. Hence, this document presents not only a comprehensive but also concise update to HF management guidelines thereby aiming to provide a unified strategy for the pharmacological, non-pharmacological, invasive and interventional management of this significant global health challenge that is applicable to the needs of healthcare around the globe.</div></div>","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"34 7","pages":"Pages e55-e82"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transforming the Future of Heart Health","authors":"","doi":"10.1016/j.hlc.2025.06.001","DOIUrl":"10.1016/j.hlc.2025.06.001","url":null,"abstract":"","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"34 7","pages":"Pages 743-744"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144632099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}