ACS Chemical Health & Safety最新文献_第4页

Shifting Culture from Blame to Gain: Challenges and Encouragements 从责备到收获的文化转变:挑战与鼓励

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ACS Chemical Health & Safety Pub Date : 2023-07-24 DOI: 10.1021/acs.chas.3c00058

Amanda B. Chung, Austin B. Moyle, Monica M. S. Nyansa* and Joshua A. Powell,

引用次数: 0

Chemical Lab Safety Education by Massive Open Online Course 大规模开放在线课程开展化学实验室安全教育

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ACS Chemical Health & Safety Pub Date : 2023-07-24 DOI: 10.1021/acs.chas.3c00018

Hongyan Feng*, Yilun Ding, Pingping Zhu, Yuan Zheng, Quan Lan, Wei Huang, Mingli Gao and Hongyu Liu,

引用次数: 0

Lesson Learned from a Case of Radioactive Contamination 一起放射性污染事件的教训

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ACS Chemical Health & Safety Pub Date : 2023-07-20 DOI: 10.1021/acs.chas.3c00034

Daopeng Sheng, Kai Li, Lanhua Chen, Hailong Zhang, Juan Diwu, Zhifang Chai, Shuao Wang and Yaxing Wang*,

引用次数: 1

Toxic Release Damage Distance Assessment Based on the Short-Cut Method: A Case Study for the Transport of Chlorine and Hydrochloric Acid in Densely Urbanized Areas in the Mediterranean Region 基于捷径法的毒性释放损害距离评估——以地中海地区城市密集区氯和盐酸的迁移为例

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ACS Chemical Health & Safety Pub Date : 2023-07-12 DOI: 10.1021/acs.chas.2c00095

Angela M. Tomasoni*, Abdellatif Soussi and Roberto Sacile,

{"title":"Toxic Release Damage Distance Assessment Based on the Short-Cut Method: A Case Study for the Transport of Chlorine and Hydrochloric Acid in Densely Urbanized Areas in the Mediterranean Region","authors":"Angela M. Tomasoni*, Abdellatif Soussi and Roberto Sacile, ","doi":"10.1021/acs.chas.2c00095","DOIUrl":"https://doi.org/10.1021/acs.chas.2c00095","url":null,"abstract":"The transportation of dangerous goods by road is the most accident-prone mode of transportation, even if accidents involving road transportation of dangerous goods are considered as a Low Probability and High Consequence event (LPHC event). However, several dangerous goods are transported by road networks, such as petroleum products and chemicals, which can generate major dangerous consequences such as spills, explosions, fires, or toxic clouds. In this context, this article presents a method to calculate and quickly quantify the sizes of impact zones characterized by high lethality and irreversible injuries to people in the case of a hazardous materials transport accident. This method is used as a module for the analysis of the consequences of different potential accident scenarios, for the Web-GIS platform proposed by LOSE+LAB, that implements appropriate ICT tools and systems for monitoring the flow of goods that would enable a continuous monitoring system at the cross-border level and transmit data and information to the territory actors involved in the management of dangerous goods according to the ADR standard. The proposed method provides the user with a visualization of the possible outcomes of an event by reproducing the impact area for different accident scenarios, which can provide quick maps of the hazard and represents a decision support system for territorial governance in terms of intervention and response protocols for emergency management in the cases of dangerous goods accidents.","PeriodicalId":12,"journal":{"name":"ACS Chemical Health & Safety","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acs.chas.2c00095","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"661673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Skin Absorption Potential of Chemicals Relevant to Painting Trades 涂料行业相关化学品皮肤吸收电位的评价

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ACS Chemical Health & Safety Pub Date : 2023-07-03 DOI: 10.1021/acs.chas.3c00026

Nishith Ghosh*, Pallavee Vitti Krushna, Jagdish D. Sharma and Alok Srivastava,

{"title":"Evaluation of Skin Absorption Potential of Chemicals Relevant to Painting Trades","authors":"Nishith Ghosh*, Pallavee Vitti Krushna, Jagdish D. Sharma and Alok Srivastava, ","doi":"10.1021/acs.chas.3c00026","DOIUrl":"https://doi.org/10.1021/acs.chas.3c00026","url":null,"abstract":"Painters experience occupational exposure through inhalation and skin absorption to various chemicals that are used as ingredients of paint mixtures and other related painting trades. Although several investigations indicated significant contribution of exposure via skin absorption to exhibit harmful effects on health among painters, assessment of the skin absorption hazards of the paint chemicals is limited. Here, we evaluated the skin absorption of a number of organic chemicals relevant to painting trades using mathematical models. For this purpose, we estimated the skin permeability coefficient of the chemicals using the Potts and Guy correlation equation. The estimated permeability coefficients were further utilized to estimate the maximum flux of the non-volatile chemicals across the skin. The skin permeability coefficient and maximum flux of the chemicals across the skin were compared to those of the chemicals to which the American Conference of Governmental Industrial Hygienists (ACGIH) assigned a “skin” notation. We critically analyzed the estimated maximum fluxes and the acute toxicity data of the chemicals available in the literature that helped to identify the chemicals posing a significant skin absorption hazard. The analyses suggest that triethanolamine and m-phenylenediamine pose significant skin absorption hazards, though these chemicals have not yet been assigned a “skin” notation in the ACGIH TLV book. The ratio of dermal uptake directly from air to inhalation intake of volatile solvents used in paint mixtures was estimated for a typical occupational setting. N-Methyl-2-pyrrolidone showed significant dermal uptake fraction compared to its intake via inhalation route.","PeriodicalId":12,"journal":{"name":"ACS Chemical Health & Safety","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"718164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Importance of Maintaining Laboratory Emergency Equipment─Showers and Eyewashes 维护实验室应急设备──淋浴器和洗眼器的重要性

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ACS Chemical Health & Safety Pub Date : 2023-06-27 DOI: 10.1021/acs.chas.3c00028

Joshua A. Powell*,

引用次数: 0

Toxicity of Polymeric Nanodrugs as Drug Carriers 聚合物纳米药物作为药物载体的毒性

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ACS Chemical Health & Safety Pub Date : 2023-06-23 DOI: 10.1021/acs.chas.3c00008

Ananda Babu Sairam*, Anandhavelu Sanmugam*, Ashwini Pushparaj, Gaayathri Mahesh Kumar, Nithila Sundarapandian, Sulakshuna Balaji, Muthuchamy Nallal* and Kang Hyun Park*,

{"title":"Toxicity of Polymeric Nanodrugs as Drug Carriers","authors":"Ananda Babu Sairam*, Anandhavelu Sanmugam*, Ashwini Pushparaj, Gaayathri Mahesh Kumar, Nithila Sundarapandian, Sulakshuna Balaji, Muthuchamy Nallal* and Kang Hyun Park*, ","doi":"10.1021/acs.chas.3c00008","DOIUrl":"https://doi.org/10.1021/acs.chas.3c00008","url":null,"abstract":"The ambiguity of certain diseases and the potential toxicity of many medications have sparked demand for the incorporation and enhancement of drug delivery systems (DDSs). Nanomedicine has received renewed attention in modern medical advancements with therapeutic uses. Therefore, the development of nanomedicines for enhanced bioaccessibility, long drug administration, and dose reduction has advanced as a unique concept. Nanocapsules, nanoemulsions, drug nanocrystals, micelles, solid lipid nanoparticles (SLNs), and polymeric nanoparticles (poly-NPs) are among the most effective nanomedicine techniques. Poly-NPs have emerged as a potential method to enhance drug pharmacokinetics. Pharmaceutical potency can be increased by using nanocarriers and medication formulations. The potential of poly-NPs to alter contemporary medicine has attracted significant interest; polymer adaptability makes them suitable for site-specific drug delivery requirements. However, little is known about their safety in long-term studies using high-pitched doses. These cells exhibit some extrapyramidal symptoms (EPS) because of the reactivity and size reduction of the polymers chosen by using living cells other than the target. With an increased understanding of polymers and their properties, it is equally important to emphasize the safety and toxicity of DDSs. Some of the toxic effects of polymeric nanodrugs include an increase in the cytotoxicity of the cell, reduction in the feasibility of the cell, increase in the rate of programmed cell death (apoptosis), precursors for tumor formation, DNA destruction, gene toxicity, rupture of the cell membrane, and lipid peroxidation reactions. In this article, we discuss the toxicity of nanoparticles (NPs) used in DDSs, including polylactide-co-glycolide, polylactic acid, polycaprolactone, and poly(alkyl cyanoacrylates), used in DDSs.","PeriodicalId":12,"journal":{"name":"ACS Chemical Health & Safety","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2023-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41079034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrogen or Helium Conservation in Gas Chromatography Mass Spectrometry: How We Chose What Was Right for Our Laboratory 气相色谱质谱法中的氢或氦守恒:我们如何选择适合我们实验室的

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ACS Chemical Health & Safety Pub Date : 2023-06-23 DOI: 10.1021/acs.chas.3c00020

Jeramie Ellis*, and , Kristy Kounovsky-Shafer,

引用次数: 0

Characterization of Emissions from Carbon Dioxide Laser Cutting Acrylic Plastics 二氧化碳激光切割丙烯酸塑料排放物的表征

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ACS Chemical Health & Safety Pub Date : 2023-06-22 DOI: 10.1021/acs.chas.3c00013

Alejandro Munoz, Jacob Schmidt, I. H. Mel Suffet and Candace Su-Jung Tsai*,

{"title":"Characterization of Emissions from Carbon Dioxide Laser Cutting Acrylic Plastics","authors":"Alejandro Munoz, Jacob Schmidt, I. H. Mel Suffet and Candace Su-Jung Tsai*, ","doi":"10.1021/acs.chas.3c00013","DOIUrl":"https://doi.org/10.1021/acs.chas.3c00013","url":null,"abstract":"Carbon dioxide laser cutters are used to cut and engrave on various types of materials, including metals, wood, and plastics. Although many are equipped with fume extractors for removing airborne substances generated during laser cutting, gases and particulate matter can be released upon opening the lid after completion. This study focused on investigating laser cutting acrylic sheets and associated emissions. Real-time instruments were utilized to monitor both particulate concentrations and size distributions, while the patented Tsai diffusion sampler was used to collect particulate samples on a polycarbonate membrane and transmission electron microscopy (TEM) grid. Identification of released gases consisted of the use of gas sampling with Teflon gas bags followed by analysis using gas chromatography-mass spectrometry (GC-MS). A portable ambient infrared air analyzer was used to quantify the concentrations of the chemicals released by laser cutting activities. The results of the study found that a significant concentration of particulate matter, including nanoplastic particles ranging 15.4–86 nm in particle sizes, and microplastics with agglomerates were released each time the laser cutter lid was opened and were observed to gradually increase in concentration for a period of at least 20 min after the completion of a cut. The GC-MS gaseous samples primarily contained methyl methacrylate at a low level close to the detection limit of the infrared air analyzer.","PeriodicalId":12,"journal":{"name":"ACS Chemical Health & Safety","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2023-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acs.chas.3c00013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"818965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spotlights: Safety Anecdotes and In-Depth Analyses 焦点:安全轶事和深入分析

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ACS Chemical Health & Safety Pub Date : 2023-06-22 DOI: 10.1021/acs.chas.3c00059

Mary Beth Mulcahy, Lauren Goulding* and Stephen R. Larson,

引用次数: 0