Hormone and Metabolic Research最新文献_第9页

Prediction of Prognosis in Patients with Sepsis Based on Platelet-Related Genes. 基于血小板相关基因预测败血症患者的预后。

IF 2 4区医学

Hormone and Metabolic Research Pub Date : 2024-12-01 Epub Date: 2024-06-13 DOI: 10.1055/a-2331-1362

Jing Jiang, Juan Zhang, Ting Wang, Daihua Yu, Xiu Ren

{"title":"Prediction of Prognosis in Patients with Sepsis Based on Platelet-Related Genes.","authors":"Jing Jiang, Juan Zhang, Ting Wang, Daihua Yu, Xiu Ren","doi":"10.1055/a-2331-1362","DOIUrl":"10.1055/a-2331-1362","url":null,"abstract":"The study aimed to develop a risk prognostic model using platelet-related genes (PRGs) to predict sepsis patient outcomes. Sepsis patient data from the Gene Expression Omnibus (GEO) database and PRGs from the Molecular Signatures Database (MSigDB) were analyzed. Differential analysis identified 1139 differentially expressed genes (DEGs) between sepsis and control groups. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses revealed enrichment in functions related to immune cell regulation and pathways associated with immune response and infectious diseases. A risk prognostic model was established using LASSO and Cox regression analyses, incorporating 10 PRGs selected based on their association with sepsis prognosis. The model demonstrated good stratification and prognostic effects, confirmed by survival and receiver operating characteristic (ROC) curve analyses. It served as an independent prognostic factor in sepsis patients. Further analysis using the CIBERSORT algorithm showed higher infiltration of activated natural killer (NK) cells and lower infiltration of CD8 T cells and CD4 T cells naïve in the high-risk group compared to the low-risk group. Additionally, expression levels of human leukocyte antigen (HLA) genes were significantly lower in the high-risk group. In conclusion, the 10-gene risk model based on PRGs accurately predicted sepsis patient prognosis and immune infiltration levels. This study provides valuable insights into the role of platelets in sepsis prognosis and diagnosis, offering potential implications for personalized treatment strategies.","PeriodicalId":12999,"journal":{"name":"Hormone and Metabolic Research","volume":" ","pages":"900-909"},"PeriodicalIF":2.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141319503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Prognostic Impact of Radioiodine Therapy in Patients with Papillary Thyroid Cancer. 放射性碘疗法对甲状腺乳头状癌患者预后的影响

IF 2 4区医学

Hormone and Metabolic Research Pub Date : 2024-11-01 Epub Date: 2024-11-07 DOI: 10.1055/a-2423-4849

Matthias Schott, Patricia Schott-Ohly, Sarah Krieg, Cora Thomaschky, Jan-Hendrik Wieltsch, Alexander Petrovitch, Andreas Krieg

{"title":"The Prognostic Impact of Radioiodine Therapy in Patients with Papillary Thyroid Cancer.","authors":"Matthias Schott, Patricia Schott-Ohly, Sarah Krieg, Cora Thomaschky, Jan-Hendrik Wieltsch, Alexander Petrovitch, Andreas Krieg","doi":"10.1055/a-2423-4849","DOIUrl":"https://doi.org/10.1055/a-2423-4849","url":null,"abstract":"Radioiodine (RAI) therapy after surgery, is an important component for the treatment of patients with papillary thyroid cancer (PTC), the most common thyroid cancer. In this study we sought to evaluate the cancer-specific survival (CSS) impact of RAI in specific thyroid cancer subgroups. The Surveillance, Epidemiology, and End Results (SEER) database were used to identify patients with PTC who underwent surgery between 2000 and 2019. Patients not treated with RAI were compared to those treated with RAI using propensity score matching (PSM) on the basis of identical inclusion criteria. A total of 106 333 patients were identified from the SEER database. RAI therapy was associated with improved CSS in the matched cohort (HR: 0.83; 95% CI: 0.72-0.96, p=0.01) but not in the unmatched data set (HR: 1.46; 95% CI: 1.30-1.64, p<0.001) among all PTC patients regardless of disease stage. Detailed analyses, however, showed that only patients with high-risk disease (pT3N1, pT4N1) experienced the greatest benefit in CSS. In the lower disease stages, no significant differences were recognized in the group of PTC patients with or without RAI therapy. One exception: in the group of PTC patients in stage pT1bN0, a significant difference was seen towards RAI. This is, however, most likely due to the large number of patients investigated. In summary, RAI therapy should not be used in low-risk PTC patients and might be used to some extent in intermediate-risk PTC patients. The histological suptype of the tumor needs to be considered in this context.","PeriodicalId":12999,"journal":{"name":"Hormone and Metabolic Research","volume":"56 11","pages":"770-778"},"PeriodicalIF":2.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification and Verification of a Glycolysis-Related lncRNA Prognostic Signature for Hepatocellular Carcinoma. 肝细胞癌糖酵解相关lncRNA预后特征的鉴定与验证

IF 2 4区医学

Hormone and Metabolic Research Pub Date : 2024-11-01 Epub Date: 2024-05-21 DOI: 10.1055/a-2314-0988

Fakai Qiu, Guozheng Yu, Mei Li, Zhubin Li, Qinyang Zhang, Xudong Mu, Yuan Cheng, Pengtao Zhai, Qunyi Liu

{"title":"Identification and Verification of a Glycolysis-Related lncRNA Prognostic Signature for Hepatocellular Carcinoma.","authors":"Fakai Qiu, Guozheng Yu, Mei Li, Zhubin Li, Qinyang Zhang, Xudong Mu, Yuan Cheng, Pengtao Zhai, Qunyi Liu","doi":"10.1055/a-2314-0988","DOIUrl":"10.1055/a-2314-0988","url":null,"abstract":"Hepatocellular carcinoma (HCC) is a primary liver cancer with a high mortality rate. The search for a new biomarker could help the prognosis of HCC patients. We identified the glycolytic gene set associated with HCC and the glycolytic lncRNA based on TCGA and MsigDB databases. According to these lncRNAs, K-means clustering, and regression analysis were performed on the patients. Two groups of HCC patients with different lncRNA expression levels were obtained based on K-means clustering results. The results of difference analysis and enrichment analysis showed that DEmRNA in the two HCC populations with significant survival differences was mainly enriched in transmembrane transporter complex, RNA polymerase II specificity, cAMP signaling pathway, and calcium signaling pathway. In addition, a prognostic model of HCC with 4 DElncRNAs was constructed based on regression analysis. ROC curve analysis showed that the model had good predictive performance. Drug predictionresults showed that the efficacy of JQ1, niraparib, and teniposide was higher in the low-risk group than in the high-risk group. In conclusion, this study preliminarily identified glycolytic-related prognostic features of lncRNAs in HCC and constructed a risk assessment model. The results of this study are expected to guide the prognosis assessment of clinical HCC patients.","PeriodicalId":12999,"journal":{"name":"Hormone and Metabolic Research","volume":" ","pages":"827-834"},"PeriodicalIF":2.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141075893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Construction and Validation of a Prognostic Model Based on Mitochondrial Genes in Prostate Cancer. 构建并验证基于线粒体基因的前列腺癌预后模型

IF 2 4区医学

Hormone and Metabolic Research Pub Date : 2024-11-01 Epub Date: 2024-06-13 DOI: 10.1055/a-2330-3696

Dan Wang, Hui Pan, Shaoping Cheng, Zhigang Huang, Zhenlei Shi, Hao Deng, Junwu Yang, Chenghua Jin, Jin Dai

{"title":"Construction and Validation of a Prognostic Model Based on Mitochondrial Genes in Prostate Cancer.","authors":"Dan Wang, Hui Pan, Shaoping Cheng, Zhigang Huang, Zhenlei Shi, Hao Deng, Junwu Yang, Chenghua Jin, Jin Dai","doi":"10.1055/a-2330-3696","DOIUrl":"10.1055/a-2330-3696","url":null,"abstract":"This study attempted to build a prostate cancer (PC) prognostic risk model with mitochondrial feature genes. PC-related MTGs were screened for Cox regression analyses, followed by establishing a prognostic model. Model validity was analyzed via survival analysis and receiver operating characteristic (ROC) curves, and model accuracy was validated in the GEO dataset. Combining risk score with clinical factors, the independence of the risk score was verified by using Cox analysis, followed by generating a nomogram. The Gleason score, microsatellite instability (MSI), immune microenvironment, and tumor mutation burden were analyzed in two risk groups. Finally, the prognostic feature genes were verified through a q-PCR test. Ten PC-associated MTGs were screened, and a prognostic model was built. Survival analysis and ROC curves illustrated that the model was a good predictor for the risk of PC. Cox regression analysis revealed that risk score acted as an independent prognostic factor. The Gleason score and MSI in the high-risk group were substantially higher than in the low-risk group. Levels of ESTIMATE Score, Immune Score, Stromal Score, immune cells, immune function, immune checkpoint, and immunopheno score of partial immune checkpoints in the high-risk group were significantly lower than in the low-risk group. Genes with the highest mutation frequencies in the two groups were SPOP, TTN, and TP53. The q-PCR results of the feature genes were consistent with the gene expression results in the database. The 10-gene model based on MTGs could accurately predict the prognosis of PC patients and their responses to immunotherapy.","PeriodicalId":12999,"journal":{"name":"Hormone and Metabolic Research","volume":" ","pages":"807-817"},"PeriodicalIF":2.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141319502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Supplementation with NAD + Precursors on Metabolic Syndrome Parameters: A Systematic Review and Meta-Analysis. 补充 NAD+ 前体对代谢综合征参数的影响：系统回顾与元分析》。

IF 2 4区医学

Hormone and Metabolic Research Pub Date : 2024-11-01 Epub Date: 2024-08-07 DOI: 10.1055/a-2382-6829

Amanda Oliveira-Cruz, Alessa Macedo-Silva, Débora Silva-Lima, Julia Sanchez-Almeida, Lívia Cruz-Coutinho, Matheus Paiva Santos Tavares, David Majerowicz

{"title":"Effects of Supplementation with NAD + Precursors on Metabolic Syndrome Parameters: A Systematic Review and Meta-Analysis.","authors":"Amanda Oliveira-Cruz, Alessa Macedo-Silva, Débora Silva-Lima, Julia Sanchez-Almeida, Lívia Cruz-Coutinho, Matheus Paiva Santos Tavares, David Majerowicz","doi":"10.1055/a-2382-6829","DOIUrl":"10.1055/a-2382-6829","url":null,"abstract":"Intracellular levels of NAD + regulate metabolism, among other ways, through enzymes that use NAD + as a substrate, capable of inducing catabolic processes, such as lipid oxidation, glucose uptake, and mitochondrial activity. In several model organisms, administering precursor compounds for NAD + synthesis increases its levels, improves lipid and glucose homeostasis, and reduces weight gain. However, evidence of the effects of these precursors on human patients needs to be better evaluated. Therefore, we carried out a systematic review and meta-analysis of randomized clinical trials that assessed the effects of NAD + precursors on Metabolic Syndrome parameters in humans. We based our methods on PRISMA 2020. Our search retrieved 429 articles, and 19 randomized controlled trials were included in the meta-analysis. We assessed the risk of bias with the Rob 2 algorithm and summarized the quality of evidence with the GRADE algorithm. Supplementation with NAD + precursors reduced plasma levels of total cholesterol and triglycerides in volunteers, but the intervention did not significantly affect the other outcomes analyzed. Three of the included articles presented a high risk of bias. The quality of evidence varied between very low and low due to the risk of bias, imprecision, and indirectness. The number of participants in outcomes other than lipidemia is still generally tiny; therefore, more clinical trials evaluating these parameters will increase the quality of the evidence. On the other hand, quality randomized studies are essential to assess better the effects of NAD + precursors on lipidemia.","PeriodicalId":12999,"journal":{"name":"Hormone and Metabolic Research","volume":" ","pages":"818-826"},"PeriodicalIF":2.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Growth Hormone on Osteoarthritis Development. 生长激素对骨关节炎发展的影响

IF 2 4区医学

Hormone and Metabolic Research Pub Date : 2024-11-01 Epub Date: 2024-11-07 DOI: 10.1055/a-2411-9344

Lin Sun, Xiaokun Gang, Fei Li, Weiying Guo, Mengzhao Cui, Guixia Wang

引用次数: 0

Dysregulation of miR-335-5p in People with Obesity and its Predictive Value for Metabolic Syndrome. 肥胖症患者体内 miR-335-5p 的失调及其对代谢综合征的预测价值

IF 2 4区医学

Hormone and Metabolic Research Pub Date : 2024-10-01 Epub Date: 2024-03-06 DOI: 10.1055/a-2261-8115

Liting Lu, Yufeng He

{"title":"Dysregulation of miR-335-5p in People with Obesity and its Predictive Value for Metabolic Syndrome.","authors":"Liting Lu, Yufeng He","doi":"10.1055/a-2261-8115","DOIUrl":"10.1055/a-2261-8115","url":null,"abstract":"The epidemic of obesity and metabolic syndrome has become the most serious global public health problem. The part played by microRNA (miRNA) in the onset and progression of obesity and metabolic syndrome has been increasingly focused upon. The goal of this study was to explore miR-335-5p as a potential predictive biomarker or therapeutic target for obesity and metabolic syndrome. The expression level of miR-335-5p was detected by qRT-PCR. The diagnostic value of miR-335-5p was evaluated by ROC curve. The association between serum miR-335-5p levels and various clinical parameters was assessed using the chi-square test. Logistic regression analysis was used to evaluate the risk factors of metabolic syndrome in obese population. The biological processes and molecular mechanisms are studied through GO and KEGG enrichment analysis. The ROC curve analysis revealed that miR-335-5p could serve as a predictive indicator for the development of obesity accompanied by metabolic syndrome. Logistic regression analysis revealed that BMI, TG, FBG, HOMA-IR, and miR-335-5p expression represent independent risk factors of metabolic syndrome occurrence. Chi-square test analysis revealed that patients with higher values of BMI, SBP, DBP, TG, FBG, and HOMA-IR exhibited a more significantly increased expression of miR-335-5p in their serum. In conclusion, miR-335-5p holds predictive and diagnostic value for obesity and metabolic syndrome and has potential to serve as a biomarker for these conditions.","PeriodicalId":12999,"journal":{"name":"Hormone and Metabolic Research","volume":" ","pages":"749-755"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140049340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Pathophysiological Associations Between Obesity, NAFLD, and Atherosclerotic Cardiovascular Diseases. 肥胖症、非酒精性脂肪肝和动脉粥样硬化性心血管疾病之间的病理生理学关联。

IF 2 4区医学

Hormone and Metabolic Research Pub Date : 2024-10-01 Epub Date: 2024-03-12 DOI: 10.1055/a-2266-1503

Meng Li, Man Cui, Guoxia Li, Yueqiu Liu, Yunsheng Xu, Seyed Parsa Eftekhar, Moein Ala

{"title":"The Pathophysiological Associations Between Obesity, NAFLD, and Atherosclerotic Cardiovascular Diseases.","authors":"Meng Li, Man Cui, Guoxia Li, Yueqiu Liu, Yunsheng Xu, Seyed Parsa Eftekhar, Moein Ala","doi":"10.1055/a-2266-1503","DOIUrl":"10.1055/a-2266-1503","url":null,"abstract":"Obesity, non-alcoholic fatty liver disease (NAFLD), and atherosclerotic cardiovascular diseases are common and growing public health concerns. Previous epidemiological studies unfolded the robust correlation between obesity, NAFLD, and atherosclerotic cardiovascular diseases. Obesity is a well-known risk factor for NAFLD, and both of them can markedly increase the odds of atherosclerotic cardiovascular diseases. On the other hand, significant weight loss achieved by lifestyle modification, bariatric surgery, or medications, such as semaglutide, can concomitantly improve NAFLD and atherosclerotic cardiovascular diseases. Therefore, certain pathophysiological links are involved in the development of NAFLD in obesity, and atherosclerotic cardiovascular diseases in obesity and NAFLD. Moreover, recent studies indicated that simultaneously targeting several mechanisms by tirzepatide and retatrutide leads to greater weight loss and markedly improves the complications of metabolic syndrome. These findings remind the importance of a mechanistic viewpoint for breaking the association between obesity, NAFLD, and atherosclerotic cardiovascular diseases. In this review article, we mainly focus on shared pathophysiological mechanisms, including insulin resistance, dyslipidemia, GLP1 signaling, inflammation, oxidative stress, mitochondrial dysfunction, gut dysbiosis, renin-angiotensin-aldosterone system (RAAS) overactivity, and endothelial dysfunction. Most of these pathophysiological alterations are primarily initiated by obesity. The development of NAFLD further exacerbates these molecular and cellular alterations, leading to atherosclerotic cardiovascular disease development or progression as the final manifestation of molecular perturbation. A better insight into these mechanisms makes it feasible to develop new multi-target approaches to simultaneously unhinge the deleterious chain of events linking obesity and NAFLD to atherosclerotic cardiovascular diseases.","PeriodicalId":12999,"journal":{"name":"Hormone and Metabolic Research","volume":" ","pages":"683-696"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140109848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glucocorticoid Sensitivity Among Young Survivors of Childhood Acute Lymphoblastic Leukemia: What Does It Matter? 儿童急性淋巴细胞白血病年轻幸存者的糖皮质激素敏感性：这有什么关系？

IF 2 4区医学

Hormone and Metabolic Research Pub Date : 2024-10-01 Epub Date: 2024-08-05 DOI: 10.1055/a-2363-4823

Adriana Aparecida Siviero-Miachon, Ana Virgínia Lopes de Sousa, Bruno Moreira Simião, Elisangela Oliveira Araújo, Renato Alvarenga, Angela Maria Spinola-Castro, Carlos Alberto Longui

{"title":"Glucocorticoid Sensitivity Among Young Survivors of Childhood Acute Lymphoblastic Leukemia: What Does It Matter?","authors":"Adriana Aparecida Siviero-Miachon, Ana Virgínia Lopes de Sousa, Bruno Moreira Simião, Elisangela Oliveira Araújo, Renato Alvarenga, Angela Maria Spinola-Castro, Carlos Alberto Longui","doi":"10.1055/a-2363-4823","DOIUrl":"10.1055/a-2363-4823","url":null,"abstract":"The aim of the study was to assess glucocorticoid sensitivity in survivors of childhood acute lymphoblastic leukemia using in vivo and in vitro tests. Thirty leukemia survivors of both sexes aged ≥18 years participated in the study and at least two years after therapy withdrawal. In vivo tests comprised: a) a very low dose intravenous dexamethasone suppression test for measurement of serum cortisol before, after, and % suppression, compared with 32 age-matched controls; and b) 0.25 mg overnight oral dexamethasone suppression test for assessment of salivary cortisol before, after, and % suppression. In vitro methods comprised: c) glucocorticoid receptor polymorphisms: BcI1-NR3C1 and A3669G; and d) splicing variant of glucocorticoid receptor GR-α mRNA by real-time quantitative polymerase chain reaction, compared with 32 controls. There was a reduction in salivary cortisol, and 73.3% of leukemia survivors showed high sensitivity according to % suppression after oral dexamethasone (p<0.05). Serum cortisol at baseline, after the test, % suppression after intravenous dexamethasone, and the percentage of high sensitivity were reduced in the leukemia group (%F=36.7; p<0.05). The BcI1-NR3C1 and A3669G polymorphisms were present in 11/30 (36.7%) and 5/30 (16.7%) patients, respectively. GR-α mRNA levels were lower in the leukemia group than in the controls (p<0.05). Survivors of acute lymphoblastic leukemia presented with reduced glucocorticoid sensitivity. Glucocorticoid sensitivity allows individualized treatment to avoid adverse effects and may be involved in cardiovascular disease risk among this particular group of cancer survivors.","PeriodicalId":12999,"journal":{"name":"Hormone and Metabolic Research","volume":" ","pages":"718-726"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meta-Analysis and Network Analysis Differentially Detect Various Pro-Inflammatory Mediators and Risk Factors for Type 2 Diabetes in the Elderly. 元分析和网络分析可差异化检测各种促炎介质和老年人 2 型糖尿病的风险因素。

IF 2 4区医学

Hormone and Metabolic Research Pub Date : 2024-10-01 Epub Date: 2024-01-09 DOI: 10.1055/a-2241-5281

Linlin Gu, Yue Du, Fang Liang

{"title":"Meta-Analysis and Network Analysis Differentially Detect Various Pro-Inflammatory Mediators and Risk Factors for Type 2 Diabetes in the Elderly.","authors":"Linlin Gu, Yue Du, Fang Liang","doi":"10.1055/a-2241-5281","DOIUrl":"10.1055/a-2241-5281","url":null,"abstract":"Type 2 diabetes (T2D) has a pathophysiological component that includes inflammation. Inflammation-sensitive marker measurement may be helpful in determining the risk of complications for both older T2D patients and the public. This study aimed to investigate the association between blood pro-inflammatory mediators and the characteristics of elderly patients with T2D using meta and network analyses. The Web of Science, Scopus, PubMed, and Cochrane Library databases were selected as study methodology. The Quality in Prognosis Studies (QUIPS) tool in the meta-analysis assessed the studies' methodological quality. The selected studies were statistically analyzed using the META-MAR tool based on the standardized mean difference (SMD). The selected studies included nine examinations involving 6399 old people [+>+55 years old, 65.9+±+4.09 (mean+±+SD)]. The meta-analysis showed that pro-inflammatory mediators (SMD 0.82) and patient-related variables [risk factors (SMD 0.71)] were significantly associated with T2D (p+<+0.05). Subgroup analysis revealed that tumor necrosis factor alpha (TNF-α; SMD 1.08), body mass index (SMD 0.64), high-density lipoprotein (HDL; SMD -0.61), body weight (SMD 0.50), and blood pressure (SMD 1.11) were factors significantly associated with T2D (p+<+0.05). Network analysis revealed that among patient characteristics, diastolic blood pressure and, among inflammatory mediators, leptin were the most closely associated factors with T2D in older adults. Moreover, network analysis showed that TNF-α and systolic blood pressure were most closely associated with leptin. Overall, alternate techniques, such as meta-analysis and network analysis, might identify different markers for T2D in older people. A therapeutic decision-making process needs to consider these differences in advance.","PeriodicalId":12999,"journal":{"name":"Hormone and Metabolic Research","volume":" ","pages":"727-736"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139402541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0