Hormone and Metabolic Research最新文献

Evaluating the Role of Galectin-1, Adiponectin, Leptin, and Adiponectin/Leptin Ratio as Risk Factors for Cardiovascular Diseases. 评价半乳糖凝集素-1、脂联素、瘦素和脂联素/瘦素比值作为心血管疾病危险因素的作用

IF 1.8 4区医学

Hormone and Metabolic Research Pub Date : 2025-09-30 DOI: 10.1055/a-2714-1556

Lizan Arkawazi, Darya Abdulateef, Trifa Mahmood

{"title":"Evaluating the Role of Galectin-1, Adiponectin, Leptin, and Adiponectin/Leptin Ratio as Risk Factors for Cardiovascular Diseases.","authors":"Lizan Arkawazi, Darya Abdulateef, Trifa Mahmood","doi":"10.1055/a-2714-1556","DOIUrl":"https://doi.org/10.1055/a-2714-1556","url":null,"abstract":"Cardiovascular diseases (CVDs) are a leading cause of death globally. Early identification of individuals at elevated risk is essential for improving preventive measures and patient outcomes. Biomarkers like Galectin-1, leptin, and adiponectin are known to play roles in metabolic processes, with a low adiponectin/leptin ratio indicating a heightened cardiometabolic risk. However, the association between Galectin-1, leptin, adiponectin, and the adiponectin/leptin ratio with CVD risk scores is not well understood. This study aims to assess these markers' correlation with CVD risk and their potential utility as predictors. This cross-sectional study assessed 135 healthy adults through questionnaires and blood pressure measurements. Each participant's cardiovascular (CV) risk was estimated, with serum Galectin-1, adiponectin, and leptin levels measured. Comparisons of adipokines levels between age-groups were conducted. The associations between variables were assessed, and linear regression was applied with cardiovascular risk score as the outcome. Statistical significance was set at p < 0.05. After excluding fifteen individuals, 122 subjects (62 males, 60 females; mean age 43.8 years) were included in the study. Leptin levels correlated positively with CV risk score and LDL levels in younger individuals, while the adiponectin/leptin ratio showed a negative correlation with LDL and CV risk scores across age groups. Smoking was a strong predictor of CV risk in younger participants, whereas diabetes, cholesterol/HDL ratio, and leptin were significant predictors in the middle-aged group (p < 0.05). Among measured adipokines, leptin is as a key predictor of cardiovascular risk, alongside established factors like smoking, diabetes, and cholesterol/HDL ratio.","PeriodicalId":12999,"journal":{"name":"Hormone and Metabolic Research","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impaired Thyroid Hormone Sensitivity is Associated with Increased Risk of Liver Fibrosis in Euthyroid Population: A Cross-Sectional Analysis of NHANES. 甲状腺功能正常人群中甲状腺激素敏感性受损与肝纤维化风险增加相关：NHANES的横断面分析

IF 1.8 4区医学

Hormone and Metabolic Research Pub Date : 2025-09-11 DOI: 10.1055/a-2700-6797

Xingyu Yao, Kaiwen Xiao, Hein Ko Oo

{"title":"Impaired Thyroid Hormone Sensitivity is Associated with Increased Risk of Liver Fibrosis in Euthyroid Population: A Cross-Sectional Analysis of NHANES.","authors":"Xingyu Yao, Kaiwen Xiao, Hein Ko Oo","doi":"10.1055/a-2700-6797","DOIUrl":"https://doi.org/10.1055/a-2700-6797","url":null,"abstract":"The interplay between liver fibrosis and thyroid function remains incompletely understood, particularly regarding thyroid hormone sensitivity. Thus, this study aims to explore the relationship between liver fibrosis and thyroid hormone sensitivity in euthyroid U.S. individuals. This study involved 4678 euthyroid participants from the National Health and Nutrition Examination Survey 2007-2012. Key clinical parameters were extracted, including thyroid-stimulating hormone (TSH), free and total thyroxine, and liver function related data. Thyroid hormone sensitivity was assessed by three indices: the Thyroid Feedback Quantile-based Index (TFQI), TSH index (TSHI), and thyrotrophic thyroxine resistance index (TT4RI). Multiple regression analyses and machine learning models were performed to evaluate the relationships between liver fibrosis and thyroid sensitivity indices. Participants with advanced liver fibrosis indicated by fibrosis index 4 (FIB-4) demonstrated significantly impaired thyroid hormone sensitivity indicated by TFQI, TT4RI, and TSHI. Then the logistic regression and restricted cubic spline analysis indicated that TFQI, TT4RI, and TSHI were risk factors for liver fibrosis (OR>1, p < 0.05). Furthermore, we developed machine learning models using random forest and Boruta's algorithm identifying thyroid hormone sensitivity indices, TSHI, TT4RI, and TFQI as key predictors for liver fibrosis. Mediation analysis indicates that uric acid is a weak mediator between thyroid hormone sensitivity and liver fibrosis. This study reveals that impaired thyroid hormone sensitivity is a risk factor is a risk factor for liver fibrosis progression in euthyroid individuals. These findings uncover a potential molecular link between thyroid hormone signaling and the development of liver fibrosis, warranting further investigation.","PeriodicalId":12999,"journal":{"name":"Hormone and Metabolic Research","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-Center Study of Therapeutic Apheresis in 24 Male Patients from the MENA Region: Reduction of Lipids, Inflammatory Markers, Autoantibodies, and Implications for Fatigue, Genetics, and Aging. 来自中东和北非地区24名男性患者的治疗性单中心研究：脂质、炎症标志物、自身抗体的降低，以及疲劳、遗传和衰老的影响。

IF 1.8 4区医学

Hormone and Metabolic Research Pub Date : 2025-09-11 DOI: 10.1055/a-2678-7739

Charlotte Steenblock, Romy Walther, Yannick Kok, Philip Mavberg, Mohamad Yaman, Rupert Handgretinger, Yandy Marx Castillo-Aleman, Maysoon Al Karam, Stefan R Bornstein

{"title":"Single-Center Study of Therapeutic Apheresis in 24 Male Patients from the MENA Region: Reduction of Lipids, Inflammatory Markers, Autoantibodies, and Implications for Fatigue, Genetics, and Aging.","authors":"Charlotte Steenblock, Romy Walther, Yannick Kok, Philip Mavberg, Mohamad Yaman, Rupert Handgretinger, Yandy Marx Castillo-Aleman, Maysoon Al Karam, Stefan R Bornstein","doi":"10.1055/a-2678-7739","DOIUrl":"https://doi.org/10.1055/a-2678-7739","url":null,"abstract":"Cardiovascular and metabolic disorders, particularly diabetes and obesity, are highly prevalent in the Middle East and North Africa (MENA) region, exhibiting some of the highest global incidence rates. These conditions significantly increase the severity of infectious diseases, notably COVID-19, leading to a rise in long-COVID cases among affected individuals. Furthermore, the MENA region's extreme temperatures exacerbate cardiovascular issues by elevating heart rates and blood pressure, increasing dehydration and blood viscosity. Extracorporeal therapies, such as apheresis, effectively reduces plasma lipids and inflammatory markers. Furthermore, apheresis has shown promise in reducing autoantibodies associated to long-COVID. Our previous research indicated that apheresis alleviates symptoms in patients with long-COVID and chronic fatigue syndrome. In this study, we treated 24 male patients from the MENA region suffering from chronic fatigue and/or different metabolic diseases such as diabetes, dyslipidemia, or obesity, using double filtration plasmapheresis. Comprehensive plasma analyses were performed before and after apheresis to assess lipid profiles, inflammatory markers, and autoantibodies, revealing significant changes following the procedure. Genetic analyses on a subgroup of the patients showed no mutations in the LDLR, APOB, APOE, PCSK9, LIPA, and LDLRAP1 genes known to be associated with predispositions to monogenic lipid disorders. However, all patients in this subgroup demonstrated an intermediate to high likelihood that their elevated lipid levels have a polygenic basis. These findings suggest that implementing apheresis in the MENA region could significantly improve health outcomes and life expectancy for affected individuals.","PeriodicalId":12999,"journal":{"name":"Hormone and Metabolic Research","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

68Ga-Pentixafor PET/CT in Primary Aldosteronism: Preliminary Analysis on CECT Concordance and PET/CT Avidity Patterns. 68ga - pentxaat在原发性醛固酮增多症中的应用：CECT一致性和PET/CT贪婪型的初步分析。

IF 1.8 4区医学

Hormone and Metabolic Research Pub Date : 2025-09-11 DOI: 10.1055/a-2700-7598

Anuj Ban, Anurag Ranjan Lila, Manjiri Karlekar, Rohit Barnabas, Saba Samad Memon, Vijaya Sarathi, Gaurav Malhotra, Krantikumar Rathod, Sameer Rege, Padma Badhe, C V Harinarayan, Tushar Bandgar

{"title":"68Ga-Pentixafor PET/CT in Primary Aldosteronism: Preliminary Analysis on CECT Concordance and PET/CT Avidity Patterns.","authors":"Anuj Ban, Anurag Ranjan Lila, Manjiri Karlekar, Rohit Barnabas, Saba Samad Memon, Vijaya Sarathi, Gaurav Malhotra, Krantikumar Rathod, Sameer Rege, Padma Badhe, C V Harinarayan, Tushar Bandgar","doi":"10.1055/a-2700-7598","DOIUrl":"https://doi.org/10.1055/a-2700-7598","url":null,"abstract":"68Ga-Pentixafor positron emission tomography/computed tomography (PET/CT) has shown potential in primary aldosteronism (PA) subtyping, but analysis of its diagnostic accuracy based on contrast-enhanced CT (CECT) concordance and PET/CT avidity patterns is lacking. The objective of this study was to evaluate the diagnostic accuracy of 68Ga-Pentixafor PET/CT for subtyping PA, and to assess its performance based on concordance with CECT and PET/CT avidity patterns. Clinical, biochemical, radiological, functional imaging, treatment, histopathological and follow-up details of 30 patients with PA who underwent PET/CT over two years at a tertiary centre in India were retrospectively analysed. Diagnostic accuracy of PET/CT for PA subtyping was evaluated in the whole cohort and in subgroups based on CECT-PET/CT concordance and PET/CT avidity patterns. Out of the 30 patients, final subtype classification was achieved in 15 (9 unilateral and 6 bilateral) based on surgical outcomes and/or AVS. PET/CT correctly subtyped 14/15 (93.3%) patients. CECT and PET/CT concordance was seen in 10 patients and PET/CT accuracy was 100% (10/10) in this subgroup. CECT and PET/CT discordance (CECT bilateral and PET/CT unilateral) was seen in 5 patients and PET/CT accuracy in this subgroup was 80% (4/5). PET/CT avidity patterns in the 15 patients having final subtype classification were unilateral avid(n=10), bilateral avid(n=2), and bilateral non-avid(n=3). Diagnostic accuracy of PET/CT was 90% (9/10) in patients with unilateral avidity, and 100% in those with bilateral avidity or non-avidity. Preliminary analysis of CECT-PET/CT scan concordance and PET/CT avidity patterns suggests that PET/CT demonstrates higher accuracy in certain subgroups, potentially guiding the triage for AVS.","PeriodicalId":12999,"journal":{"name":"Hormone and Metabolic Research","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thyroid Hormones and Aging: Modulators of Mitochondrial Health, Metabolic Flexibility, and Longevity Pathways. 甲状腺激素与衰老：线粒体健康、代谢灵活性和长寿途径的调节剂。

IF 1.8 4区医学

Hormone and Metabolic Research Pub Date : 2025-09-08 DOI: 10.1055/a-2698-0521

Angela D Mazza

{"title":"Thyroid Hormones and Aging: Modulators of Mitochondrial Health, Metabolic Flexibility, and Longevity Pathways.","authors":"Angela D Mazza","doi":"10.1055/a-2698-0521","DOIUrl":"https://doi.org/10.1055/a-2698-0521","url":null,"abstract":"Thyroid hormones (TH), primarily triiodothyronine (T3) and thyroxine (T4), are critical regulators of metabolic rate, mitochondrial function, and cellular repair mechanisms. Emerging evidence suggests that thyroid status may significantly influence aging trajectories and longevity through modulation of key cellular pathways. Objective: This review explores the role of thyroid hormones in aging biology, with a focus on their interaction with longevity-associated signaling pathways and the hallmarks of aging. Both physiological and subclinical thyroid states in the context of healthspan, cognitive preservation, metabolic resilience, and mitochondrial integrity are explored. A narrative synthesis of human and animal studies was conducted, including mechanistic, epidemiologic, and clinical data, to evaluate how thyroid hormone levels affect aging pathways such as mTOR, AMPK, IGF-1, sirtuins, FOXO transcription factors, and mitochondrial biogenesis. Thyroid hormones modulate several hallmarks of aging, including mitochondrial dysfunction, genomic instability, epigenetic drift, and deregulated nutrient sensing. T3 enhances mitochondrial respiration and autophagy while interacting with mTOR and AMPK to regulate energy balance. Altered thyroid function-particularly subclinical hypothyroidism, has been paradoxically associated with increased longevity in some centenarian cohorts, possibly due to reduced oxidative metabolism. However, overt thyroid dysfunction is linked to increased metabolic risk in aging populations. Thyroid hormones serve as metabolic gatekeepers that influence both cellular aging and organismal longevity. A deeper understanding of their role in aging pathways may inform novel strategies for promoting healthy aging, including thyroid hormone modulation, and personalized endocrine optimization.","PeriodicalId":12999,"journal":{"name":"Hormone and Metabolic Research","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms of Action of Umbilical Cord Mesenchymal Stem Cells in Type 2 Diabetes Mellitus Treatment. 脐带间充质干细胞在2型糖尿病治疗中的作用机制

IF 1.8 4区医学

Hormone and Metabolic Research Pub Date : 2025-09-04 DOI: 10.1055/a-2695-7019

Qiqiang Tao, Pinlei Lv, Xiao Dong, Wenrui Li, Yanyu Luo, Guojun Huang

{"title":"Mechanisms of Action of Umbilical Cord Mesenchymal Stem Cells in Type 2 Diabetes Mellitus Treatment.","authors":"Qiqiang Tao, Pinlei Lv, Xiao Dong, Wenrui Li, Yanyu Luo, Guojun Huang","doi":"10.1055/a-2695-7019","DOIUrl":"https://doi.org/10.1055/a-2695-7019","url":null,"abstract":"Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease involving multiple organs. It affects the quality of life of patients significantly. Traditional treatments have certain limitations, such as side effects caused by long-term intake, complications owing to prolonged pathogenesis, and limited therapeutic effects. However, cellular therapy has demonstrated remarkable positive effects, such as improved blood glucose and lipid levels, repaired pancreatic and renal structure, and improvements in diabetic complications. We constructed a T2DM rat model in this study. Rats were divided into six groups to assess the best injection method. Four groups were further formed to evaluate the anti-inflammatory effects of umbilical cord mesenchymal stem cells (UC-MSCs). The anti-inflammatory effects of human UC-MSCs were demonstrated using inflammatory factors and M2 macrophages, a type of anti-inflammatory macrophage. Western blotting and terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick-end labeling (TUNEL) staining were performed to further elaborate the mechanism of action of hUC-MSCs in T2DM treatment. In this study, we confirmed that hUC-MSCs could efficiently treat T2DM. We conducted an ameliorative fasting blood glucose (FBG) test and an oral glucose tolerance test (OGTT). We assessed the recovery of liver and renal function using biochemical factors (such as TC, TG, BUN, and Ccr, among others). The anti-inflammatory effect of the treatment was demonstrated by the increased expression of biomarkers in M2 macrophages and reduced secretion of inflammatory cytokines, such as TNF-a. The regulatory mechanism involved the TLR4/NF-kB signaling pathway. The apoptosis of pancreatic tissues in T2DM was also inhibited by UC-MSCs, contributing to relief from T2DM symptoms. In conclusion, our findings confirmed that efficient T2DM treatment using hUC-MSCs treating was related to anti-inflammatory effects mediated via TLR4/NF-kB signaling inhibition and apoptosis attenuation in pancreatic tissues.","PeriodicalId":12999,"journal":{"name":"Hormone and Metabolic Research","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiology, Prevention, and Clinical Management of Allergic Rhinitis. 变应性鼻炎的流行病学、预防和临床管理。

IF 1.8 4区医学

Hormone and Metabolic Research Pub Date : 2025-08-01 Epub Date: 2025-09-08 DOI: 10.1055/a-2687-6822

Vijayshwari Mishra, Ramenani Hari Babu

{"title":"Epidemiology, Prevention, and Clinical Management of Allergic Rhinitis.","authors":"Vijayshwari Mishra, Ramenani Hari Babu","doi":"10.1055/a-2687-6822","DOIUrl":"10.1055/a-2687-6822","url":null,"abstract":"Allergic rhinitis (AR) is a widespread chronic condition caused by immune responses involving immunoglobulin E (IgE) when exposed to airborne allergens. It frequently coexists with conditions such as asthma and eye inflammation and represents a major public health issue due to its significant burden and associated disabilities across the globe. Key contributing factors include exposure to airborne or workplace-related allergens and hereditary predispositions. AR negatively impacts daily life, including social interactions, academic performance, and productivity at work, while also leading to considerable economic expenses. The ARIA (Allergic Rhinitis and its Impact on Asthma) guidelines categorize AR based on duration (intermittent or persistent) and severity (mild or moderate/severe). Diagnosis primarily relies on clinical evaluation, and in patients with uncontrolled or long-term symptoms, confirmation may involve skin prick testing or detecting specific IgE antibodies in the blood. Common treatments include oral, nasal, or eye-drop antihistamines (H1-blockers), nasal corticosteroids, or a combination of both delivered intranasally. Allergen-specific immunotherapy, administered by qualified specialists and using standardized extracts, is beneficial for individuals with ongoing symptoms. Insights from real-life data collected through mobile applications are enhancing understanding of AR types and their management. Future developments aim to improve recognition of complex overlapping conditions, utilize health technology evaluations, and promote patient-involved treatment decisions.","PeriodicalId":12999,"journal":{"name":"Hormone and Metabolic Research","volume":" ","pages":"453-463"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Application of Assay- and Age-Specific Parathyroid Hormone (PTH) Reference Intervals Decreases the Diagnosis of Normocalcaemic Primary Hyperparathyroidism and Improves Diagnostic Concordance of PTH Assays. 应用测定和年龄特异性甲状旁腺激素（PTH）参考区间降低了正常血钙血症原发性甲状旁腺功能亢进的诊断，提高了PTH测定的诊断一致性。

IF 1.8 4区医学

Hormone and Metabolic Research Pub Date : 2025-08-01 Epub Date: 2025-09-08 DOI: 10.1055/a-2690-6416

Halimah Khalil, Jonathan Fenn, Anna Sanders, Clare Ford, Rousseau Gama, Tejas Kalaria

{"title":"The Application of Assay- and Age-Specific Parathyroid Hormone (PTH) Reference Intervals Decreases the Diagnosis of Normocalcaemic Primary Hyperparathyroidism and Improves Diagnostic Concordance of PTH Assays.","authors":"Halimah Khalil, Jonathan Fenn, Anna Sanders, Clare Ford, Rousseau Gama, Tejas Kalaria","doi":"10.1055/a-2690-6416","DOIUrl":"10.1055/a-2690-6416","url":null,"abstract":"Parathyroid hormone (PTH) assays are not standardized and therefore PTH results are interpreted using manufacturer-provided assay-specific reference intervals. Assay-specific PTH reference intervals, however, do not account for between-assay differences and lead to discordance in the diagnosis of normocalcaemic primary hyperparathyroidism (NCPHPT). PTH increases with age independent of vitamin D, renal function, phosphate and ionized calcium. The observed variations in age-nonspecific PTH reference intervals may, in part, be attributed to the varying proportions of individuals from different age sub-sets included in the direct sampling reference interval studies. We assessed the impact of recently derived age-specific reference intervals for Abbott and Roche PTH assays on the diagnosis and diagnostic concordance of previously identified NCPHPT individuals. Of the 46 NCPHPT individuals identified using elevated Abbott PTH, only 16 (35%) were concordant for NCPHPT whereas 30 (65%) had normal PTH when samples were analysed by the Roche method and results were interpreted using the manufacturer-provided reference intervals for both methods. However, interpreting results using the method-specific age-related PTH reference intervals resulted in 31 (67%) individuals having a concordant normal PTH, eight (17%) having concordant NCPHPT and only seven (15%) remaining discordant (NCPHPT by Abbott and normal by Roche methods). Application of assay- and age-specific reference intervals decreases the diagnosis of NCPHPT and improves diagnostic concordance between PTH assays. We suggest that the diagnosis of NCPHPT should be based on assay- and age-specific PTH reference intervals. Until PTH assays are harmonized, subsequent PTH measurements for NCPHPT patients should ideally be performed using the same assay.","PeriodicalId":12999,"journal":{"name":"Hormone and Metabolic Research","volume":" ","pages":"471-476"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adverse Event Profile Differences Between Metyrapone and Osilodrostat: A Pharmacovigilance Study of the FDA Adverse Event Reporting System. 不良事件概况美替拉酮和奥西洛他的差异：FDA不良事件报告系统的药物警戒研究。

IF 1.8 4区医学

Hormone and Metabolic Research Pub Date : 2025-08-01 Epub Date: 2025-08-18 DOI: 10.1055/a-2685-7512

Chunyong Xia, Lanxin Hu, Ying Fan, Jie Liu, Ya Gan

{"title":"Adverse Event Profile Differences Between Metyrapone and Osilodrostat: A Pharmacovigilance Study of the FDA Adverse Event Reporting System.","authors":"Chunyong Xia, Lanxin Hu, Ying Fan, Jie Liu, Ya Gan","doi":"10.1055/a-2685-7512","DOIUrl":"10.1055/a-2685-7512","url":null,"abstract":"Metyrapone and osilodrostat are both steroidogenic inhibitors targeting the 11β-hydroxylase, yet their safety profile has not been comprehensively analyzed. The objective of this study is to compare the adverse events (AEs) associated with osilodrostat and metyrapone based on the Food and Drug Administration Adverse Event Reporting System (FAERS). AEs were classified according to the System Organ Class (SOC) in the Medical Dictionary for Regulatory Activities (MedDRA) version 26.1. Adverse event (AE) signals of osilodrostat and metyrapone were determined by calculating reporting odds ratios (ROR). A total of 1380 and 449 AE reports were retrieved from osilodrostat and metyrapone, respectively, involving 26 and 27 SOC categories. Unexpected AEs such as asthenia, decrease of blood potassium, myalgia, increase of blood pressure, abdominal distension, increase of blood testosterone, nephrolithiasis, and hunger were associated with osilodrostat. while metyrapone was linked with respiratory failure, deep vein thrombosis, interstitial lung disease, liver function test abnormal, and respiratory distress. Among osilodrostat-treated patients, those aged between 18 to 65 years old were more likely to develop adrenal insufficiency, fatigue, tachycardia, than those older than 65. Male patients treated with metyrapone have the significantly higher incidence of the increased blood corticotrophin, muscular weakness and acute respiratory distress syndrome compared to females. During treatment with osilodrostat and metyrapone, clinicians need to monitor the effects of AEs varied by gender and age and to pay more attention to new AE signals.","PeriodicalId":12999,"journal":{"name":"Hormone and Metabolic Research","volume":" ","pages":"464-470"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144872987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of METS-IR with Pregnancy Outcomes in Euthyroid Women: A Retrospective Cohort Study. METS-IR与甲状腺功能正常妇女妊娠结局的关联：一项回顾性队列研究。

IF 1.8 4区医学

Hormone and Metabolic Research Pub Date : 2025-08-01 Epub Date: 2025-09-10 DOI: 10.1055/a-2691-0428

Jiaying Lin, Qianwen Xie, Zize Guo, Xiang Lin, Qi Shen, Mengyuan Han, Juan Lin

{"title":"Association of METS-IR with Pregnancy Outcomes in Euthyroid Women: A Retrospective Cohort Study.","authors":"Jiaying Lin, Qianwen Xie, Zize Guo, Xiang Lin, Qi Shen, Mengyuan Han, Juan Lin","doi":"10.1055/a-2691-0428","DOIUrl":"10.1055/a-2691-0428","url":null,"abstract":"The non-insulin-based metabolic score for insulin resistance (METS-IR) is a recently developed index aimed at being a practical and efficient alternative biomarker of insulin resistance (IR). This study aimed to investigate the association between METS-IR in euthyroid women in the first trimester of pregnancy and pregnancy outcomes. A total of 1810 participants who gave birth at Fujian Maternity and Child Health Hospital from November 2018 to November 2019 were included in this study. Thyroid function, fasting blood glucose (FPG) levels, lipid profiles, and anthropometric parameters were collected during the first trimester of pregnancy. METS-IR was calculated by FPG, total triglyceride, high-density lipoprotein cholesterol, and body mass index. Pregnancy outcomes were collected. There were 75 (4.1%) cases of macrosomia and 433 (23.9%) cases of gestational diabetes mellitus (GDM). Participants were divided into four groups based on METS-IR, with a median and interquartile range of METS-IR levels of 23.91 (22.83, 24.67), 26.53 (25.88, 27.17), 29.13 (28.47, 30.00), and 33.59 (32.10, 36.21), respectively. The higher METS-IR quartile was significantly associated with macrosomia and GDM (p<0.05). The risk of macrosomia and GDM increased with the increased METS-IR levels when METS-IR was a continuous variable, particularly METS-IR levels reaching 27.84 and higher (overall p<0.05). We found no correlation between METS-IR and low birth weight, cesarean section, and preterm delivery (p>0.05). Increasing METS-IR in euthyroid women in the first trimester of pregnancy may predict macrosomia and GDM.","PeriodicalId":12999,"journal":{"name":"Hormone and Metabolic Research","volume":" ","pages":"486-493"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0