Hormone and Metabolic Research最新文献

Metabolic and Hormonal Profile of Insulin-Like Peptide 5 (INSL5) in Polycystic Ovary Syndrome: A Prospective Analysis. 多囊卵巢综合征中胰岛素样肽5 （INSL5）的代谢和激素特征：一项前瞻性分析

IF 2 4区医学

Hormone and Metabolic Research Pub Date : 2025-07-01 DOI: 10.1055/a-2636-9491

Deniz Cengiz, Esra Nur Ademoğlu Dilekçi, Ömür Albayrak, Özgür Mehmet Yis

{"title":"Metabolic and Hormonal Profile of Insulin-Like Peptide 5 (INSL5) in Polycystic Ovary Syndrome: A Prospective Analysis.","authors":"Deniz Cengiz, Esra Nur Ademoğlu Dilekçi, Ömür Albayrak, Özgür Mehmet Yis","doi":"10.1055/a-2636-9491","DOIUrl":"https://doi.org/10.1055/a-2636-9491","url":null,"abstract":"Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder with diverse metabolic and hormonal manifestations. Insulin-like peptide 5 (INSL5), a gut-derived hormone of the relaxin/insulin family, is expressed in the central nervous system, colonic and reproductive tissues, but its clinical significance in PCOS remains unclear. This study aimed to evaluate circulating INSL5 levels in PCOS and explore their associations with key hormonal and metabolic parameters. In this prospective cross-sectional study, 45 women with newly diagnosed PCOS and 35 age-matched healthy controls (18-35 years) were evaluated. Clinical characteristics, hormonal profiles, and metabolic markers - including serum anti-Müllerian hormone (AMH) and INSL5 - were assessed. INSL5 levels were measured using enzyme-linked immunosorbent assay (ELISA). Median serum INSL5 levels did not differ significantly between PCOS and control groups (12.5 vs. 15.5 ng/ml; p=0.103). However, within the PCOS group, INSL5 was inversely correlated with body mass index, insulin, HOMA-IR, total and LDL cholesterol, triglycerides, fat mass, and free androgen index, and positively correlated with sex hormone-binding globulin (p<0.05 for all). AMH was significantly higher in the PCOS group and demonstrated a diagnostic cut-off of 5.04 ng/ml (AUC: 0.808; sensitivity: 75.6%; specificity: 74.3%). Although INSL5 did not show diagnostic utility for PCOS, its consistent associations with insulin resistance, androgenic activity, and lipid metabolism suggest a potential role in metabolic regulation. These findings support its relevance as a candidate marker for metabolic phenotyping and warrant further investigation into its physiological role within the PCOS spectrum.","PeriodicalId":12999,"journal":{"name":"Hormone and Metabolic Research","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations of Obesity, Vitamin D, Adjusted Total Calcium, and Parathyroid Hormone in US from NHANES. 美国肥胖、维生素D、调整总钙和甲状旁腺激素的相关性

IF 2 4区医学

Hormone and Metabolic Research Pub Date : 2025-06-27 DOI: 10.1055/a-2638-1810

Ethan Frank, Eric Adjei Boakye, Brendan C Stack

{"title":"Associations of Obesity, Vitamin D, Adjusted Total Calcium, and Parathyroid Hormone in US from NHANES.","authors":"Ethan Frank, Eric Adjei Boakye, Brendan C Stack","doi":"10.1055/a-2638-1810","DOIUrl":"https://doi.org/10.1055/a-2638-1810","url":null,"abstract":"Evidence for obesity and vitamin D deficiency as components of a data phenotype for primary hyperparathyroidism (pHPT) is critical to understanding primary hyperparathyroidism. This study examined the association between vitamin D, body mass index (BMI), albumin total calcium, parathyroid hormone (PTH) and data from National Health and Nutrition Examination Survey (NHANES). Associations of 25-hydroxyvitamin D, albumin adjusted calcium, and BMI with elevated PTH were evaluated, with elevated PTH being defined as>9.02 pmol/l. Outcomes were PTH (pmol/l), 25-hydroxyvitamin D (nmol/l), albumin adjusted calcium (mmol/l), and BMI. A weighted multivariable logistic regression model estimated the associations. A total of 9740 survey respondents were included in the study, 3.5% had elevated PTH. Mean vitamin D level was 57.7 (SD=22.6) nmol/l and BMI was 28.6 (SD=6.5) kg/m2. A one unit increase in BMI was associated with higher odds of elevated PTH [adjusted odds ratio (aOR)=1.04; 95% confidence interval (CI): 1.02, 1.06] whereas a one unit increase in vitamin D (aOR=0.97; 95% CI: 0.96, 0.98) or calcium (aOR=0.51; 95% CI: 0.29, 0.89) had decreased odds of elevated PTH. Higher BMI and lower levels of 25-hydroxyvitamin D are components of the primary hyperparathyroidism data phenotype. A refined data phenotype may improve detection/management of pHPT.","PeriodicalId":12999,"journal":{"name":"Hormone and Metabolic Research","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcomes of 68Ga-NODAGA-Exendin-4 PET/CT Guided Surgical Management of Insulinomas in MEN1: A Preliminary Study. 68Ga-NODAGA-Exendin-4 PET/CT引导下MEN1胰岛素瘤手术治疗的初步研究

IF 2 4区医学

Hormone and Metabolic Research Pub Date : 2025-06-23 DOI: 10.1055/a-2620-2931

Ketki Sunil Ambulkar, Ravikumar Shah, Anurag Lila, Anima Sharma, Rohit Barnabas, Manjiri Karlekar, Saba Samad Memon, Vijaya Sarathi, Sameer Rege, Priyanka Verma, Gaurav Malhotra, Vikram Lele, Tushar Bandgar

{"title":"Outcomes of 68Ga-NODAGA-Exendin-4 PET/CT Guided Surgical Management of Insulinomas in MEN1: A Preliminary Study.","authors":"Ketki Sunil Ambulkar, Ravikumar Shah, Anurag Lila, Anima Sharma, Rohit Barnabas, Manjiri Karlekar, Saba Samad Memon, Vijaya Sarathi, Sameer Rege, Priyanka Verma, Gaurav Malhotra, Vikram Lele, Tushar Bandgar","doi":"10.1055/a-2620-2931","DOIUrl":"10.1055/a-2620-2931","url":null,"abstract":"The data on the use of 68Ga-NODAGA-exendin-4 PET/CT in localizing multiple endocrine neoplasia type 1 (MEN1)-related insulinomas is evolving; however, surgical outcomes data are not available. We describe our cohort of patients with MEN1-related endogenous hyperinsulinemic hypoglycemia (EHH), where 68Ga-NODAGA-exendin-4 PET/CT was used to guide conservative surgery. A retrospective record review of MEN1-related EHH cases managed between 2000 and 2024 was performed for clinical features, imaging, and management. Outcomes were assessed for patients whose surgical extent was determined by 68Ga-NODAGA-exendin-4 PET/CT versus conventional imaging (CECT and 68Ga-DOTATATE PET/CT). Five patients with a median age of 17 (15.5-18.5 years) with EHH underwent laparoscopic, single lesion enucleation based on 68Ga-NODAGA-exendin-4 PET/CT. On preoperative imaging, CT identified culprit lesion in four, while 68Ga-DOTATATE PET/CT localized in one, and had one false positive uptake in non-functioning NET. The median duration of hospital stay was 6 (5.5-9) days. Over a median follow-up of 48 (3.5-84.5) months, none had EHH recurrence or exocrine/endocrine pancreatic insufficiency. On follow-up, one patient had an uneventful pregnancy and delivery. In the remaining 15, who underwent surgery based on conventional imaging, 12 (80%) required extensive surgery beyond enucleation, of which two needed intraoperative ultrasound localization. This group had a postoperative hospital stay of 11 (8-23) days, one recurrence after 84 months, and pancreatic insufficiency in 5 (33%). Our center observation suggests that GLP1R-based PET/CT-guided conservative insulinoma surgery in MEN1 patients is effective and safe and needs further validation.","PeriodicalId":12999,"journal":{"name":"Hormone and Metabolic Research","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CGM-Based Real-World Data on the Transition from Glargine U100 to U300 in Children and Adolescents with Type 1 Diabetes. 基于cgm的儿童和青少年1型糖尿病患者从甘精胰岛素U100到U300转换的真实世界数据

IF 2 4区医学

Hormone and Metabolic Research Pub Date : 2025-06-12 DOI: 10.1055/a-2634-8614

Gürkan Tarçın

{"title":"CGM-Based Real-World Data on the Transition from Glargine U100 to U300 in Children and Adolescents with Type 1 Diabetes.","authors":"Gürkan Tarçın","doi":"10.1055/a-2634-8614","DOIUrl":"https://doi.org/10.1055/a-2634-8614","url":null,"abstract":"This study aimed to compare continuous glucose monitoring (CGM) parameters in children and adolescents with Type 1 diabetes (T1D) who transitioned from glargine U100 to glargine U300 to evaluate efficacy and safety. A total of 52 participants aged 6-18 years using CGM were analyzed before and after transitioning from glargine U100 to glargine U300. For each individual, a 2-week CGM data collection was conducted after optimizing the glargine U100 dose. Participants then switched to glargine U300 at the same dose, with doses adjusted based on CGM graphs every three days. One week after the final dose adjustment, a second 2-week CGM period was recorded. Additionally, nighttime (00:00-08:00) data were analyzed, with glucose fluctuations measured by coefficient of variation (CV) and root mean squared error (RMSE). All parameters were compared between glargine U100 and U300. No significant differences were observed in glucose management indicator (GMI) or time in range (TIR) between glargine U100 and U300. However, glargine U300 was associated with significantly reduced hypoglycemia frequency and duration across 24-hour and nocturnal periods. Lower CV and RMSE values during nighttime further indicated reduced glycemic variability with glargine U300. An average 10% increase in basal insulin dose was required following the transition. The study provides real-world, CGM-based evidence suggesting that glargine U300 offers a safer, more stable option for managing T1D in children, particularly in reducing hypoglycemia. These findings highlight glargine U300's potential advantages in glycemic stability, supporting its use in pediatric diabetes care.","PeriodicalId":12999,"journal":{"name":"Hormone and Metabolic Research","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144283738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Asymmetric Dimethylarginine: A Never-Aging Story. 更正：不对称二甲基精氨酸：一个永不老化的故事。

IF 2 4区医学

Hormone and Metabolic Research Pub Date : 2025-06-10 DOI: 10.1055/a-2626-3601

Natalia Jarzebska, Stefan R Bornstein, Sergey Tselmin, Ulrich Julius, Barbara Cellini, Richard Siow, Mike Martin, Rajeshwar P Mookerjee, Arduino A Mangoni, Norbert Weiss, Roman N Rodionov

引用次数: 0

Expression Profiles of Glucocorticoid Receptor α- and β-Isoforms in Diverse Physiological and Pathological Conditions. 糖皮质激素受体α-和β-亚型在不同生理和病理条件下的表达谱。

IF 2 4区医学

Hormone and Metabolic Research Pub Date : 2025-06-06 DOI: 10.1055/a-2619-5035

Xiang Chen, Hongyu He

{"title":"Expression Profiles of Glucocorticoid Receptor α- and β-Isoforms in Diverse Physiological and Pathological Conditions.","authors":"Xiang Chen, Hongyu He","doi":"10.1055/a-2619-5035","DOIUrl":"10.1055/a-2619-5035","url":null,"abstract":"Through alternative splicing, two isoforms of the glucocorticoid receptor (GR) gene are generated, termed GRα and GRβ. GRα is predominantly expressed and shows steroid binding activity, whereas GRβ is thought to be inactive as a result of its truncated ligand-binding domain. GRβ may only act as a dominant negative inhibitor when co-expressed with GRα. GRβ specifically binds RU486 and also exhibits intrinsic transcriptional activities to directly regulate the expression of a large number of genes via both GRα-dependent and GRα-independent mechanisms. Hypercortisolemia and hypocortisolemia show different effects on the expression profiles of GR isoforms. Inflammatory cytokines induce GRβ expression and lead to an increased GRβ/GRα ratio, which may be related to glucocorticoid resistance during inflammatory diseases. Because GRβ inhibits the activity of GRα, it has the potential to ameliorate glucocorticoid-induced abnormal metabolism, muscle loss or be used to treat tumors. While elevated GRβ expression has been found in some inflammatory diseases and may be relevant to glucocorticoid unresponsiveness, whether GRβ modulates glucocorticoid sensitivity in vivo is under debate because of its extremely low expression levels under physiological situations.","PeriodicalId":12999,"journal":{"name":"Hormone and Metabolic Research","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of Semaglutide Injection in the Treatment of Type 2 Diabetes Mellitus and its Impact on C-Peptide Levels. 西马鲁肽注射液治疗2型糖尿病的疗效及对c肽水平的影响。

IF 2 4区医学

Hormone and Metabolic Research Pub Date : 2025-06-05 DOI: 10.1055/a-2618-7509

Shuying Xie, Lan Ye, Anyuan Yang, Xiaoyan Li, Ying Yin

{"title":"Efficacy of Semaglutide Injection in the Treatment of Type 2 Diabetes Mellitus and its Impact on C-Peptide Levels.","authors":"Shuying Xie, Lan Ye, Anyuan Yang, Xiaoyan Li, Ying Yin","doi":"10.1055/a-2618-7509","DOIUrl":"https://doi.org/10.1055/a-2618-7509","url":null,"abstract":"Type 2 Diabetes Mellitus (T2DM) remains a significant global health challenge, necessitating more effective therapeutic strategies. This study was to observe the impact of semaglutide on the C-Peptide levels and glycemic variability. This retrospective evaluation was conducted from January 2020 to January 2023 at our hospital, involving 172 patients diagnosed with T2DM. Patients were stratified into two groups: the observation group (86 patients) received semaglutide injections plus metformin, and the control group (86 patients) received only metformin. Treatment efficacy was assessed using changes in HbA1c, fasting blood glucose (FBG), 2-hour postprandial blood glucose (2 h BG), and C-Peptide levels. Additional evaluations included changes in glycemic variability indicators such as standard deviation of blood glucose (SDBG), mean of daily differences (MODD), and mean amplitude of glycemic excursions (MAGE). The observation group showed significantly greater improvements in glycemic control and C-Peptide levels compared to the control group. Specifically, the observation group achieved a significant reduction in HbA1c from 70 mmol/mol to 53 mmol/mol, FBG from 10.91 mmol/l to 6.12 mmol/l, and increased C-Peptide levels in both fasting and postprandial states. Improvements in glycemic variability were also more pronounced in the observation group. There was no significant difference in the incidence of adverse events between the two groups. Semaglutide combined with metformin significantly enhances the efficacy of treatment in T2DM patients, with marked improvements in C-Peptide levels, glycemic control, and reduction in glycemic variability. This combination therapy not only offers superior glucose management but also appears to bolster pancreatic function.","PeriodicalId":12999,"journal":{"name":"Hormone and Metabolic Research","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Asymmetric Dimethylarginine: A Never-Aging Story. 不对称二甲基精氨酸：永不衰老的故事。

IF 2 4区医学

Hormone and Metabolic Research Pub Date : 2025-05-26 DOI: 10.1055/a-2537-4692

Natalia Jarzebska, Stefan R Bornstein, Sergey Tselmin, Ulrich Julius, Barbara Cellini, Richard Siow, Mike Martin, Rajeshwar P Mookerjee, Arduino A Mangoni, Norbert Weiss, Roman N Rodionov

{"title":"Asymmetric Dimethylarginine: A Never-Aging Story.","authors":"Natalia Jarzebska, Stefan R Bornstein, Sergey Tselmin, Ulrich Julius, Barbara Cellini, Richard Siow, Mike Martin, Rajeshwar P Mookerjee, Arduino A Mangoni, Norbert Weiss, Roman N Rodionov","doi":"10.1055/a-2537-4692","DOIUrl":"10.1055/a-2537-4692","url":null,"abstract":"Human aging is intrinsically associated with the onset and the progression of several disease states causing significant disability and poor quality of life. Although such association was traditionally considered immutable, recent advances have led to a better understanding of several critical biochemical pathways involved in the aging process. This, in turn, has stimulated a significant body of research to investigate whether reprogramming these pathways could delay the progression of human ageing and/or prevent relevant disease states, ultimately favoring healthier aging process. Cellular senescence is regarded as the principal causative factor implicated in biological and pathophysiological processes involved in aging. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase and an independent risk factor for several age-associated diseases. The selective extracorporeal removal of ADMA is emerging as a promising strategy to reduce the burden of age-associated disease states. This article discusses the current knowledge regarding the critical pathways involved in human aging and associated diseases and the possible role of ADMA as a target for therapies leading to healthier aging processes.","PeriodicalId":12999,"journal":{"name":"Hormone and Metabolic Research","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Testosterone Deprivation Impairs Cardiac Systolic Function in Orchiectomized Wistar Rats. 睾丸素剥夺损害去睾丸大鼠心脏收缩功能。

IF 2 4区医学

Hormone and Metabolic Research Pub Date : 2025-05-01 Epub Date: 2025-04-22 DOI: 10.1055/a-2569-7387

Gabriela Almeida Motta, Graziele Halmenschlager, Rachel Pinto Dornelles Dutra, Cláudia Ramos Rhoden, Ângela Maria Vicente Tavares, Alexandre Luz de Castro, Alex Sander da Rosa Araujo, Adriane Belló-Klein, Karen Breitenbach da Silva, Ernani Luis Rhoden

{"title":"Testosterone Deprivation Impairs Cardiac Systolic Function in Orchiectomized Wistar Rats.","authors":"Gabriela Almeida Motta, Graziele Halmenschlager, Rachel Pinto Dornelles Dutra, Cláudia Ramos Rhoden, Ângela Maria Vicente Tavares, Alexandre Luz de Castro, Alex Sander da Rosa Araujo, Adriane Belló-Klein, Karen Breitenbach da Silva, Ernani Luis Rhoden","doi":"10.1055/a-2569-7387","DOIUrl":"10.1055/a-2569-7387","url":null,"abstract":"Several studies have linked low levels of testosterone with increased symptoms of cardiac disease and cardiovascular mortality; however, the effects of testosterone deficiency on cardiac systolic function and morphology are still not completely elucidated. The present study aims to evaluate the influence of testosterone deprivation on cardiac systolic function and morphology. Male Wistar rats were divided into two groups: Sham operation group (Sham): animals underwent sham operation and Orchiectomized group (Orchiec): animals underwent bilateral orchiectomy. The experimental protocol lasted 60 days after the surgery. All animals were weighted and blood samples collected to serum testosterone analysis, determined by chemiluminescence, on first (before orchiectomy) and on 60th days. One day before euthanasia (on the 59th day) echocardiographic parameters were assessed to evaluate left ventricle (LV) systolic function and morphology. Statistical significant difference was set at≤0.05. Orchiec rats presented reduced LV fractional shortening (p=0.032), increased myocardial performance index (MPI) (p=0.043), prolonged mitral valve closure time (p=0.013) and decreased heart rate (p=0.049) when compared to Sham. No statistically significant difference was found in the ejection fraction (p=0.666) between groups. Besides that, heart weight was lower in Orchiec group (p=0.035) when compared to Sham group. Testosterone deprivation reduced cardiac systolic function, changing contraction and relaxation parameters. Testosterone deficiency also changed heart rate and heart weight. The present study demonstrated for the first time that castrated levels of testosterone could alter parameters such as mitral valve closing time and MPI.","PeriodicalId":12999,"journal":{"name":"Hormone and Metabolic Research","volume":" ","pages":"346-354"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Study on the Correlation Between Cortisol Secretion and Type 2 Diabetes and Hypertension in Patients with Adrenal Tumors. 肾上腺肿瘤患者皮质醇分泌与2型糖尿病及高血压相关性的临床研究

IF 2 4区医学

Hormone and Metabolic Research Pub Date : 2025-05-01 Epub Date: 2025-06-03 DOI: 10.1055/a-2586-3681

Jiao Jiao, Xianjun Cao, Xuan Yi, Guangbin Li, Feng Han, Yu Su

{"title":"Clinical Study on the Correlation Between Cortisol Secretion and Type 2 Diabetes and Hypertension in Patients with Adrenal Tumors.","authors":"Jiao Jiao, Xianjun Cao, Xuan Yi, Guangbin Li, Feng Han, Yu Su","doi":"10.1055/a-2586-3681","DOIUrl":"https://doi.org/10.1055/a-2586-3681","url":null,"abstract":"This study aimed to investigate the correlation between cortisol secretion and the prevalence of type 2 diabetes (T2D) and hypertension in patients with adrenal tumors. A total of 164 patients with benign adrenal tumors were recruited between January 2019 and December 2024. Cortisol levels were assessed using a 1 mg overnight dexamethasone suppression test, classifying patients into three groups: non-functional adrenal tumors (group A, n=73), minimal autonomous cortisol secretion (MACS, group B, n=64), and MACS with confirmed Cushing's syndrome (group C, n=27). Statistical analyses compared the prevalence of hypertension and T2D across groups. Cortisol concentrations were measured using high-performance liquid chromatography (HPLC) and ELISA. Logistic regression identified factors influencing hypertension and T2D. The prevalence of hypertension and T2D was significantly higher in group C compared to groups A and B (p<0.05). Cortisol concentrations were higher in groups C and B than in group A (p<0.05), with group C showing the highest levels. Elevated cortisol in MACS patients was associated with increased hypertension risk (p<0.05) and higher rates of T2D (p<0.05). Age was a significant predictor, with a 9% increase in risk for each additional year. Cortisol secretion in adrenal tumor patients is linked to T2D and hypertension. As cortisol levels and age increase, so does the risk of these conditions, highlighting cortisol as a potential biomarker for managing these comorbidities.","PeriodicalId":12999,"journal":{"name":"Hormone and Metabolic Research","volume":"57 5","pages":"338-345"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0