Hormone and Metabolic Research最新文献_第4页

Asymmetric Dimethylarginine: A Never-Aging Story. 不对称二甲基精氨酸：永不衰老的故事。

IF 2 4区医学

Hormone and Metabolic Research Pub Date : 2025-05-26 DOI: 10.1055/a-2537-4692

Natalia Jarzebska, Stefan R Bornstein, Sergey Tselmin, Ulrich Julius, Barbara Cellini, Richard Siow, Mike Martin, Rajeshwar P Mookerjee, Arduino A Mangoni, Norbert Weiss, Roman N Rodionov

{"title":"Asymmetric Dimethylarginine: A Never-Aging Story.","authors":"Natalia Jarzebska, Stefan R Bornstein, Sergey Tselmin, Ulrich Julius, Barbara Cellini, Richard Siow, Mike Martin, Rajeshwar P Mookerjee, Arduino A Mangoni, Norbert Weiss, Roman N Rodionov","doi":"10.1055/a-2537-4692","DOIUrl":"10.1055/a-2537-4692","url":null,"abstract":"Human aging is intrinsically associated with the onset and the progression of several disease states causing significant disability and poor quality of life. Although such association was traditionally considered immutable, recent advances have led to a better understanding of several critical biochemical pathways involved in the aging process. This, in turn, has stimulated a significant body of research to investigate whether reprogramming these pathways could delay the progression of human ageing and/or prevent relevant disease states, ultimately favoring healthier aging process. Cellular senescence is regarded as the principal causative factor implicated in biological and pathophysiological processes involved in aging. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase and an independent risk factor for several age-associated diseases. The selective extracorporeal removal of ADMA is emerging as a promising strategy to reduce the burden of age-associated disease states. This article discusses the current knowledge regarding the critical pathways involved in human aging and associated diseases and the possible role of ADMA as a target for therapies leading to healthier aging processes.","PeriodicalId":12999,"journal":{"name":"Hormone and Metabolic Research","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Testosterone Deprivation Impairs Cardiac Systolic Function in Orchiectomized Wistar Rats. 睾丸素剥夺损害去睾丸大鼠心脏收缩功能。

IF 2 4区医学

Hormone and Metabolic Research Pub Date : 2025-05-01 Epub Date: 2025-04-22 DOI: 10.1055/a-2569-7387

Gabriela Almeida Motta, Graziele Halmenschlager, Rachel Pinto Dornelles Dutra, Cláudia Ramos Rhoden, Ângela Maria Vicente Tavares, Alexandre Luz de Castro, Alex Sander da Rosa Araujo, Adriane Belló-Klein, Karen Breitenbach da Silva, Ernani Luis Rhoden

{"title":"Testosterone Deprivation Impairs Cardiac Systolic Function in Orchiectomized Wistar Rats.","authors":"Gabriela Almeida Motta, Graziele Halmenschlager, Rachel Pinto Dornelles Dutra, Cláudia Ramos Rhoden, Ângela Maria Vicente Tavares, Alexandre Luz de Castro, Alex Sander da Rosa Araujo, Adriane Belló-Klein, Karen Breitenbach da Silva, Ernani Luis Rhoden","doi":"10.1055/a-2569-7387","DOIUrl":"10.1055/a-2569-7387","url":null,"abstract":"Several studies have linked low levels of testosterone with increased symptoms of cardiac disease and cardiovascular mortality; however, the effects of testosterone deficiency on cardiac systolic function and morphology are still not completely elucidated. The present study aims to evaluate the influence of testosterone deprivation on cardiac systolic function and morphology. Male Wistar rats were divided into two groups: Sham operation group (Sham): animals underwent sham operation and Orchiectomized group (Orchiec): animals underwent bilateral orchiectomy. The experimental protocol lasted 60 days after the surgery. All animals were weighted and blood samples collected to serum testosterone analysis, determined by chemiluminescence, on first (before orchiectomy) and on 60th days. One day before euthanasia (on the 59th day) echocardiographic parameters were assessed to evaluate left ventricle (LV) systolic function and morphology. Statistical significant difference was set at≤0.05. Orchiec rats presented reduced LV fractional shortening (p=0.032), increased myocardial performance index (MPI) (p=0.043), prolonged mitral valve closure time (p=0.013) and decreased heart rate (p=0.049) when compared to Sham. No statistically significant difference was found in the ejection fraction (p=0.666) between groups. Besides that, heart weight was lower in Orchiec group (p=0.035) when compared to Sham group. Testosterone deprivation reduced cardiac systolic function, changing contraction and relaxation parameters. Testosterone deficiency also changed heart rate and heart weight. The present study demonstrated for the first time that castrated levels of testosterone could alter parameters such as mitral valve closing time and MPI.","PeriodicalId":12999,"journal":{"name":"Hormone and Metabolic Research","volume":" ","pages":"346-354"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Study on the Correlation Between Cortisol Secretion and Type 2 Diabetes and Hypertension in Patients with Adrenal Tumors. 肾上腺肿瘤患者皮质醇分泌与2型糖尿病及高血压相关性的临床研究

IF 2 4区医学

Hormone and Metabolic Research Pub Date : 2025-05-01 Epub Date: 2025-06-03 DOI: 10.1055/a-2586-3681

Jiao Jiao, Xianjun Cao, Xuan Yi, Guangbin Li, Feng Han, Yu Su

{"title":"Clinical Study on the Correlation Between Cortisol Secretion and Type 2 Diabetes and Hypertension in Patients with Adrenal Tumors.","authors":"Jiao Jiao, Xianjun Cao, Xuan Yi, Guangbin Li, Feng Han, Yu Su","doi":"10.1055/a-2586-3681","DOIUrl":"https://doi.org/10.1055/a-2586-3681","url":null,"abstract":"This study aimed to investigate the correlation between cortisol secretion and the prevalence of type 2 diabetes (T2D) and hypertension in patients with adrenal tumors. A total of 164 patients with benign adrenal tumors were recruited between January 2019 and December 2024. Cortisol levels were assessed using a 1 mg overnight dexamethasone suppression test, classifying patients into three groups: non-functional adrenal tumors (group A, n=73), minimal autonomous cortisol secretion (MACS, group B, n=64), and MACS with confirmed Cushing's syndrome (group C, n=27). Statistical analyses compared the prevalence of hypertension and T2D across groups. Cortisol concentrations were measured using high-performance liquid chromatography (HPLC) and ELISA. Logistic regression identified factors influencing hypertension and T2D. The prevalence of hypertension and T2D was significantly higher in group C compared to groups A and B (p<0.05). Cortisol concentrations were higher in groups C and B than in group A (p<0.05), with group C showing the highest levels. Elevated cortisol in MACS patients was associated with increased hypertension risk (p<0.05) and higher rates of T2D (p<0.05). Age was a significant predictor, with a 9% increase in risk for each additional year. Cortisol secretion in adrenal tumor patients is linked to T2D and hypertension. As cortisol levels and age increase, so does the risk of these conditions, highlighting cortisol as a potential biomarker for managing these comorbidities.","PeriodicalId":12999,"journal":{"name":"Hormone and Metabolic Research","volume":"57 5","pages":"338-345"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut Microbial Control of Neurotransmitters and Their Relation to Neurological Disorders: A Comprehensive Review. 肠道微生物控制神经递质及其与神经系统疾病的关系：综述。

IF 2 4区医学

Hormone and Metabolic Research Pub Date : 2025-05-01 Epub Date: 2025-03-12 DOI: 10.1055/a-2536-1421

Kajal Gurow, Deepak Chandra Joshi, Jyoti Gwasikoti, Nirmal Joshi

{"title":"Gut Microbial Control of Neurotransmitters and Their Relation to Neurological Disorders: A Comprehensive Review.","authors":"Kajal Gurow, Deepak Chandra Joshi, Jyoti Gwasikoti, Nirmal Joshi","doi":"10.1055/a-2536-1421","DOIUrl":"10.1055/a-2536-1421","url":null,"abstract":"The study explores the vital role of gut microbiota in regulating neurotransmitters and its subsequent effects on brain function and mental health. It aims to unravel the mechanisms by which microbial metabolites influence neurotransmitter synthesis and signaling. The ultimate goal is to identify potential therapeutic strategies targeting gut microbiota for the management and treatment of neurological disorders, such as depression, autism spectrum disorder (ASD), anxiety, and Parkinson's disease. The review synthesizes current research on the gut-brain axis, focusing on the influence of gut microbial metabolites on key neurotransmitters, including dopamine, serotonin, and gamma-aminobutyric acid (GABA). It incorporates a multidisciplinary approach, linking microbiology, neurobiology, and clinical research. Each section presents an in-depth review of scientific studies, clinical trials, and emerging therapeutic strategies. The findings highlight the intricate interplay between gut microbiota and the central nervous system. Gut microbes significantly impact the synthesis and signaling of crucial neurotransmitters, which play a pivotal role in neurological health. Evidence supports the hypothesis that modulating gut microbiota can alter neurotransmitter output and alleviate symptoms associated with neurological disorders. Notable therapeutic potentials include microbiota-targeted interventions for managing depression, ASD, anxiety, and Parkinson's disease. This comprehensive analysis underscores the critical connection between gut microbiota and neurological health. By bridging gaps between microbiology, neurobiology, and clinical practice, the study opens avenues for innovative therapeutic approaches. It provides a valuable resource for researchers, clinicians, and students, emphasizing the need for continued investigation into gut microbiota's role in neurological disorders and its therapeutic potential.","PeriodicalId":12999,"journal":{"name":"Hormone and Metabolic Research","volume":" ","pages":"315-325"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Testosterone Deprivation Impairs Cardiac Systolic Function in Orchiectomized Wistar Rats. 更正：睾酮剥夺损害去睾丸Wistar大鼠心脏收缩功能。

IF 2 4区医学

Hormone and Metabolic Research Pub Date : 2025-05-01 Epub Date: 2025-05-19 DOI: 10.1055/a-2597-9671

Gabriela Almeida Motta, Graziele Halmenschlager, Rachel Pinto Dornelles Dutra, Cláudia Ramos Rhoden, Ângela Maria Vicente Tavares, Alexandre Luz de Castro, Alex Sander da Rosa Araujo, Adriane Belló-Klein, Karen Breitenbach da Silva, Ernani Luis Rhoden

引用次数: 0

Thyroid Gland and Pregnancy - Clinical Update. 甲状腺与妊娠-临床更新。

IF 2 4区医学

Hormone and Metabolic Research Pub Date : 2025-05-01 Epub Date: 2025-06-03 DOI: 10.1055/a-2604-4177

Violeta Mladenovic, Ravi Shah, Sanja Medenica, Pinaki Dutta, Nikola Zankovic, Slavica Aksam, Jayaditya Ghosh, MdSadam Hussain, Zoran Gluvic

{"title":"Thyroid Gland and Pregnancy - Clinical Update.","authors":"Violeta Mladenovic, Ravi Shah, Sanja Medenica, Pinaki Dutta, Nikola Zankovic, Slavica Aksam, Jayaditya Ghosh, MdSadam Hussain, Zoran Gluvic","doi":"10.1055/a-2604-4177","DOIUrl":"https://doi.org/10.1055/a-2604-4177","url":null,"abstract":"Thyroid function undergoes significant alterations during pregnancy due to changes in hormone levels and higher metabolic demands. The thyroid gland in pregnancy enlarges by 10%; however, in iodine-deficient areas, this growth might reach 40%. Elevated levels of human chorionic gonadotropin (hCG) in early pregnancy leads to increased thyroid hormone production. While triiodothyronine (T3) and thyroid-stimulating hormone (TSH) do not cross the placenta, thyroxine (T4) does. Thyroid hormone demands peaks between weeks 16 and 20 of pregnancy and remains high until delivery. There is a rise in the levels of thyroxine-binding globulin (TBG), during the period of pregnancy, raising total T4 and T3 levels while TSH levels usually decrease. Pregnancy-related thyroid disorders, such as hypothyroidism, hyperthyroidism, and autoimmune thyroid diseases (AITD), carry the potential to impair the well-being of both the child as well as the mother. A range of 5-20% of women belonging to the reproductive age group have AITD, which can be associated with the possibility of infertility, miscarriages, and/or poor pregnancy outcomes. If improperly managed, overt hypothyroidism can cause severe complications such as developmental delay and preeclampsia. Effective management requires regular monitoring and appropriate treatment adjustment. Treatment for hypothyroidism involves levothyroxine, whereas cautious use of antithyroid medications is advised for hyperthyroidism. Postpartum thyroiditis (PPT), an autoimmune condition occurring after childbirth, requires careful management to address both hyperthyroid and hypothyroid phases. A comprehensive understanding and management of these conditions are critical for optimizing maternal and fetal health outcomes. Thyroid disorders are common in women of reproductive age group.","PeriodicalId":12999,"journal":{"name":"Hormone and Metabolic Research","volume":"57 5","pages":"303-314"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy, Safety, and Future of GLP-1 Receptor Agonists: A Systematic Literature Review and Meta-Analysis. GLP-1受体激动剂的疗效、安全性和未来：系统文献综述和荟萃分析。

IF 2 4区医学

Hormone and Metabolic Research Pub Date : 2025-05-01 Epub Date: 2025-05-23 DOI: 10.1055/a-2569-7315

Griffin Katz

{"title":"Efficacy, Safety, and Future of GLP-1 Receptor Agonists: A Systematic Literature Review and Meta-Analysis.","authors":"Griffin Katz","doi":"10.1055/a-2569-7315","DOIUrl":"10.1055/a-2569-7315","url":null,"abstract":"GLP-1 receptor agonists have emerged as important therapeutic agents for type 2 diabetes mellitus (T2DM), but their comparative efficacy and broader applications remain subjects of ongoing research. The aim of the study was to evaluate and compare the efficacy, safety, and clinical applications of three GLP-1 receptor agonists - Semaglutide, Dulaglutide, and Exenatide - through systematic review and meta-analysis. A comprehensive search of PubMed/MEDLINE, Embase, Cochrane Library, Scopus, and Web of Science (2015-2023) identified 20 randomized controlled trials and observational studies. Primary outcomes included changes in HbA1c and body weight. Risk of bias was assessed using the Cochrane Collaboration's Risk of Bias tool. Semaglutide demonstrated superior efficacy with mean HbA1c reduction of 1.45% and weight loss of 1.44 kg. Dulaglutide showed consistent reductions in HbA1c (1.1%) and weight (1.2 kg). while Exenatide exhibited moderate effects. Meta-analysis revealed a significant pooled effect estimate favoring GLP-1 receptor agonists. with a mean HbA1c difference of -0.81 (95% CI: -0.92 to -0.70). Gastrointestinal side effects were most common, with Semaglutide showing the highest incidence. This meta-analysis establishes Semaglutide as the most effective GLP-1 receptor agonist for glycemic control and weight reduction, while Dulaglutide and Exenatide offer viable alternatives with fewer side effects. These findings support evidence-based decision-making in T2DM management and highlight the potential broader therapeutic applications of GLP-1 receptor agonists beyond diabetes care.","PeriodicalId":12999,"journal":{"name":"Hormone and Metabolic Research","volume":" ","pages":"326-337"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proteomic Profiling of Age-Related Proteins Following Extracorporeal Apheresis. 体外分离后年龄相关蛋白的蛋白质组学分析。

IF 2 4区医学

Hormone and Metabolic Research Pub Date : 2025-04-15 DOI: 10.1055/a-2563-1187

Romy Walther, Bhawana Singh, Xiaoke Yin, Philip Mavberg, Anna Mücke, Roman Rodionov, Mahmoud Babir, Manuel Mayr, Stefan R Bornstein

{"title":"Proteomic Profiling of Age-Related Proteins Following Extracorporeal Apheresis.","authors":"Romy Walther, Bhawana Singh, Xiaoke Yin, Philip Mavberg, Anna Mücke, Roman Rodionov, Mahmoud Babir, Manuel Mayr, Stefan R Bornstein","doi":"10.1055/a-2563-1187","DOIUrl":"https://doi.org/10.1055/a-2563-1187","url":null,"abstract":"Lipoprotein apheresis (LA) is often the last option to adequately reduce lipoproteins in patients with familial hypercholesterolemia and lipoprotein (a) hyperlipidemia. Characterized by mild side effects, it is now the most effective method of preventing major cardiovascular events (CVEs). This benefit is due not only to the lowering of lipoprotein levels, but probably also to many other pleiotropic effects that have been extensively described in the literature. These include the reduction of inflammatory signaling substances, fibrinogen, plasminogen or components of the oxidative stress response. Here, we performed a proteomic analysis of 12 patients treated with therapeutic apheresis using two different pore size filters to quantify the effect on age-related plasma proteins. This study showed that important proteins such as α-2-macroglobulin, apolipoprotein C-III, complement C1s subcomponent, C4b-binding protein alpha chain, CD5 antigen-like and pregnancy zone protein, whose role in numerous aging processes has been well described, were significantly reduced by apheresis treatment. We conclude that therapeutic apheresis may be a promising approach to reduce these age-related proteins and that these treatments may become an essential part of managing cardiovascular risk in an aging population.","PeriodicalId":12999,"journal":{"name":"Hormone and Metabolic Research","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can Lipoprotein(a) Predict the Risk of Diabetic Nephropathy in Type 2 Diabetes Mellitus?: A Systematic Review and Meta-Analysis. 脂蛋白(a)能否预测2型糖尿病肾病的风险？：系统回顾与元分析。

IF 2 4区医学

Hormone and Metabolic Research Pub Date : 2025-04-01 Epub Date: 2025-04-10 DOI: 10.1055/a-2554-0696

Feixiang Wu, Chenmin Cui, Junping Wu, Yunqing Wang

{"title":"Can Lipoprotein(a) Predict the Risk of Diabetic Nephropathy in Type 2 Diabetes Mellitus?: A Systematic Review and Meta-Analysis.","authors":"Feixiang Wu, Chenmin Cui, Junping Wu, Yunqing Wang","doi":"10.1055/a-2554-0696","DOIUrl":"https://doi.org/10.1055/a-2554-0696","url":null,"abstract":"We aimed to examine if serum lipoprotein(a) [Lp(a)] values could be used to predict the risk of diabetic nephropathy (DN) in type 2 diabetes mellitus (T2DM). English-language observational studies available as full-texts on PubMed, Embase, Scopus, and Web of Science databases up to 28th November 2024 were included in the review. Studies were to assess the association between Lp(a) and DN and report adjusted effect size. Random-effects meta-analysis was conducted. Five cross-sectional, two case-control, and eight studies prospective cohort were included. Six studies used Lp(a) as a continuous variable while eight used it as a categorical variable. Two studies used Lp(a) as both. Meta-analysis showed that an incremental increase in Lp(a) was associated with a small increase in the risk of DN (OR: 1.03 95% CI: 1.01, 1.04 I2=86%). Meta-analysis also showed that high levels of Lp(a) were associated with a significant increase in the risk of DN (OR: 1.64 95% CI: 1.24, 2.17 I2=67%). Subgroup analysis based on study design, location, sample size, T2DM duration, baseline HbA1c, and definition of DN yielded mixed results. Lp(a) could be a potential marker for DN in T2DM. Further investigations may provide better evidence.","PeriodicalId":12999,"journal":{"name":"Hormone and Metabolic Research","volume":"57 4","pages":"242-251"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic Assessment and Analysis of Underlying Biological Mechanisms of Prostate Cancer Based on Estrogen-Related Genes. 基于雌激素相关基因的前列腺癌预后评估及潜在生物学机制分析。

IF 2 4区医学

Hormone and Metabolic Research Pub Date : 2025-04-01 Epub Date: 2025-04-10 DOI: 10.1055/a-2548-1568

Heng Zhang, Meng-Die Fan, Yang Hu, Qing Yang, Jia-Wei Jiang, Min Xu

{"title":"Prognostic Assessment and Analysis of Underlying Biological Mechanisms of Prostate Cancer Based on Estrogen-Related Genes.","authors":"Heng Zhang, Meng-Die Fan, Yang Hu, Qing Yang, Jia-Wei Jiang, Min Xu","doi":"10.1055/a-2548-1568","DOIUrl":"https://doi.org/10.1055/a-2548-1568","url":null,"abstract":"Prostate cancer (PCa) ranks among the most prevalent cancers in men, noted for its high mortality rate and unfavorable prognosis. Estrogen-related genes (ERGs) are significantly associated with the progression of PCa. This investigation aims to comprehensively assess the prognosis of PCa based on ERGs and explore its underlying biological mechanisms. Univariate, multivariate, and Least Absolute Shrinkage and Selection Operator (LASSO) regression analyses were conducted to identify prognostic signature genes and build a prognostic model. The model's predictive performance was assessed using Receiver Operating Characteristic (ROC) curve analysis. Gene Set Enrichment Analysis (GSEA), Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were employed to investigate the underlying molecular mechanisms of PCa. Antitumor drugs with high sensitivity were predicted using the CellMiner database and the pRRophitic package. Additionally, miRNAs targeting the identified signature genes were predicted using the miRNet database. This study identified six ERGs as prognostic biomarkers for PCa: POU4F1, BMP2, PGF, GAS1, GNAZ, and FGF11. The findings indicated that individuals in the low-risk category exhibited improved prognostic results. Notably, PCa progression may be closely linked to the cell adhesion molecule pathway and epigenetic regulation. Additionally, hsa-let-7a-5p and hsa-miR-34a-5p were identified as potential therapeutic regulators for PCa treatment. In conclusion, this research offers novel perspectives into the progression of PCa, providing robust scientific support for the development of personalized treatment strategies for PCa patients.","PeriodicalId":12999,"journal":{"name":"Hormone and Metabolic Research","volume":"57 4","pages":"273-285"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0