Can Lipoprotein(a) Predict the Risk of Diabetic Nephropathy in Type 2 Diabetes Mellitus?: A Systematic Review and Meta-Analysis.

IF 2 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Hormone and Metabolic Research Pub Date : 2025-04-01 Epub Date: 2025-04-10 DOI:10.1055/a-2554-0696

Feixiang Wu, Chenmin Cui, Junping Wu, Yunqing Wang

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引用次数: 0

Abstract

We aimed to examine if serum lipoprotein(a) [Lp(a)] values could be used to predict the risk of diabetic nephropathy (DN) in type 2 diabetes mellitus (T2DM). English-language observational studies available as full-texts on PubMed, Embase, Scopus, and Web of Science databases up to 28th November 2024 were included in the review. Studies were to assess the association between Lp(a) and DN and report adjusted effect size. Random-effects meta-analysis was conducted. Five cross-sectional, two case-control, and eight studies prospective cohort were included. Six studies used Lp(a) as a continuous variable while eight used it as a categorical variable. Two studies used Lp(a) as both. Meta-analysis showed that an incremental increase in Lp(a) was associated with a small increase in the risk of DN (OR: 1.03 95% CI: 1.01, 1.04 I²=86%). Meta-analysis also showed that high levels of Lp(a) were associated with a significant increase in the risk of DN (OR: 1.64 95% CI: 1.24, 2.17 I²=67%). Subgroup analysis based on study design, location, sample size, T2DM duration, baseline HbA1c, and definition of DN yielded mixed results. Lp(a) could be a potential marker for DN in T2DM. Further investigations may provide better evidence.

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脂蛋白(a)能否预测2型糖尿病肾病的风险？：系统回顾与元分析。

我们的目的是研究血清脂蛋白(a) [Lp(a)]值是否可以用于预测2型糖尿病（T2DM）患者糖尿病肾病（DN）的风险。截至2024年11月28日，在PubMed、Embase、Scopus和Web of Science数据库中可获得的英文观察性研究的全文被纳入综述。研究评估Lp(a)和DN之间的关系，并报告调整后的效应量。进行随机效应荟萃分析。包括5项横断面研究、2项病例对照研究和8项前瞻性队列研究。6项研究将Lp(a)作为连续变量，8项研究将其作为分类变量。两项研究同时使用Lp(a)。荟萃分析显示，Lp(a)的增加与DN风险的小幅增加相关（OR: 1.03 95% CI: 1.01, 1.04 I2=86%）。荟萃分析还显示，高水平的Lp(a)与DN风险显著增加相关（OR: 1.64 95% CI: 1.24, 2.17 I2=67%）。基于研究设计、地点、样本量、T2DM持续时间、基线HbA1c和DN定义的亚组分析得出了不同的结果。Lp(a)可能是T2DM患者DN的潜在标志物。进一步的调查可能会提供更好的证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hormone and Metabolic Research 医学-内分泌学与代谢

CiteScore

3.80

自引率

0.00%

发文量

125

审稿时长

3-8 weeks

期刊介绍： Covering the fields of endocrinology and metabolism from both, a clinical and basic science perspective, this well regarded journal publishes original articles, and short communications on cutting edge topics. Speedy publication time is given high priority, ensuring that endocrinologists worldwide get timely, fast-breaking information as it happens. Hormone and Metabolic Research presents reviews, original papers, and short communications, and includes a section on Innovative Methods. With a preference for experimental over observational studies, this journal disseminates new and reliable experimental data from across the field of endocrinology and metabolism to researchers, scientists and doctors world-wide.