Hepato-gastroenterology最新文献_第6页

Interferon α2b increases MMP-13 and IL-10 expression in Kupffer cells through MAPK signaling pathways. 干扰素α2b通过MAPK信号通路增加Kupffer细胞中MMP-13和IL-10的表达。

Hepato-gastroenterology Pub Date : 2015-03-01

Zheng Yu, Man Xie, Xu Fan, Jidong Jia

{"title":"Interferon α2b increases MMP-13 and IL-10 expression in Kupffer cells through MAPK signaling pathways.","authors":"Zheng Yu, Man Xie, Xu Fan, Jidong Jia","doi":"","DOIUrl":"","url":null,"abstract":"Background/aims: Kupffer cells play critical roles in both progression and resolution of liver fibrosis. Interferon α2b is an important immunoregulator which has anti-fibrotic effect in addition to its antiviral effect. It remained unclear whether the anti-fibrotic effect of interferon α2b is mediated by regulating functions of Kupffer cells.Methodology: Primary isolated Kupffer cells were cultured with interferon α2b and the expression of matrix metalloproteinase-13, interleukin-10, transforming growth factor -β1 and tumor necrosis factor-α were measured. To investigate the role of mitogen-activated protein kinase pathways in regulating cytokines production by interferon α2b-stimulated Kupffer cells, inhibitors were given before cells were treated with interferon a2b.Results: Cell purity was more than 98%. Stimulating Kupffer cells with interferon α2b led to a dramatic increase in matrix metalloproteinase-13 and interleukin-10 expression. In contrast, the values of tumor necrosis factor-α and transforming growth factor -β1 remained unchanged throughout the 24-hour observation period. Inhibited ERK1/2 pathway prevented interferon α2b-triggered matrix metalloproteinase-13 production, while inhibited p38MAPK, ERK1/2 or JNK signaling pathways all blocked interleukin-10 expression.Conclusions: Interferon α2b may exert anti-fibrotic effect by elevating the level of matrix metalloproteinase-13 and interleukin-10 in Kupffer cells, in a mitogen-activated protein kinase signaling pathways-dependent manner.","PeriodicalId":12985,"journal":{"name":"Hepato-gastroenterology","volume":"62 138","pages":"350-4"},"PeriodicalIF":0.0,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33195080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detailed analysis of extra-pancreatic nerve plexus invasion in pancreatic body carcinoma analyzed by 50 consecutive series of distal pancreatectomy with en-bloc celiac axis resection. 对50例连续行胰远端切除术联合腹腔轴切除术胰腺体癌胰腺外神经丛浸润情况进行详细分析。

Hepato-gastroenterology Pub Date : 2015-03-01

Takahiro Tsuchikawa, Satoshi Hirano, Toru Nakamura, Keisuke Okamura, Eiji Tamoto, Soichi Murakami, Yo Kurashima, Yuma Ebihara, Toshiaki Shichinohe

{"title":"Detailed analysis of extra-pancreatic nerve plexus invasion in pancreatic body carcinoma analyzed by 50 consecutive series of distal pancreatectomy with en-bloc celiac axis resection.","authors":"Takahiro Tsuchikawa, Satoshi Hirano, Toru Nakamura, Keisuke Okamura, Eiji Tamoto, Soichi Murakami, Yo Kurashima, Yuma Ebihara, Toshiaki Shichinohe","doi":"","DOIUrl":"","url":null,"abstract":"Background/aims: Advanced pancreatic body carcinoma frequently accompany extra-pancreatic nerve plexus (PL) invasion, one of the poor indicator of patient prognosis. The present study aimed to reveal the progress of the PL invasion from cancer of the pancreas body toward the root of the celiac artery (CA) and superior mesenteric artery (SMA) followed by investigation of the relevance of diagnostic accuracy.Methodology: Resected specimens from 50 consecutive patients who underwent distal pancreatectomy with en bloc celiac axis resection (DP-CAR) were pathologically analyzed for the direction of PL invasion. Diagnostic accuracy on CT imaging were also investigated.Results: Thirty seven of the 50 patients (74%) were positive for PL invasion around the CHA, SPA, CA and SMA. In terms of the diagnostic accuracy, positive predictive values for the PL invasion were 35%, 36%, 43% and 81% for the SPA, CHA, CA and SMA, respectively. Among 21 patients and 23 patients with PL invasion around CHA and SPA, 13 and 6 patients also accompanied PL invasion around CA, respectively.Conclusions: Carcinoma of the pancreatic body is found to frequently accompany PL invasion around CA. Under the limitation of low diagnostic accuracy, DP-CAR might be feasible operation that increases the possibility of R0 resection.","PeriodicalId":12985,"journal":{"name":"Hepato-gastroenterology","volume":"62 138","pages":"455-8"},"PeriodicalIF":0.0,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33252746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between chronic use of proton pump inhibitors and small- intestinal bacterial overgrowth assessed using lactulose hydrogen breath tests. 使用乳果糖氢呼吸试验评估长期使用质子泵抑制剂与小肠细菌过度生长之间的关系。

Hepato-gastroenterology Pub Date : 2015-03-01

Yasuhiro Fujiwara, Toshio Watanabe, Motoko Muraki, Hirokazu Yamagami, Tetsuya Tanigawa, Masatsugu Shiba, Kazunari Tominaga, Tetsuo Arakawa

{"title":"Association between chronic use of proton pump inhibitors and small- intestinal bacterial overgrowth assessed using lactulose hydrogen breath tests.","authors":"Yasuhiro Fujiwara, Toshio Watanabe, Motoko Muraki, Hirokazu Yamagami, Tetsuya Tanigawa, Masatsugu Shiba, Kazunari Tominaga, Tetsuo Arakawa","doi":"","DOIUrl":"","url":null,"abstract":"Background/aims: Several adverse events have been reported in patients who are chronic users of proton pump inhibitors (PPIs); however, the association between PPI use and small-intestinal bacterial overgrowth (SIBO) is controversial. We examined the prevalence of SIBO, as assessed by the lactulose hydrogen breath test (LHBT), based on the use of gastric acid-suppressive drugs in Japanese patients. METH- ODOLOGY: Ninety-four patients who were examined by the LHBT were assessed retrospectively. We used several criteria to define a positive LHBT result. Nine patients received probiotics containing Lactobacillus casei.Results: Fifty patients were PPI users, 14 were histamine-2 receptor antagonist (H2RA) users, and were 30 non-PPI and non-H2RA users (controls). There were no significant differences in prevalence of LHBT-positive cases among the three groups. Multiple-adjusted regression showed no significant association between PPI use and being LHBT-positive. Prevalence of postprandial fullness in PPI users was high (46%), but such symptoms were not related to LHBT results. Four (44%) of 9 cases became LHBT-negative and the maximal peak of H2 production decreased significantly after probiotic treatment.Conclusions: PPI treatment is not associated with SIBO in Japanese patients. Mechanisms apart from SIBO could cause the high prevalence of postprandial fullness in PPI users.","PeriodicalId":12985,"journal":{"name":"Hepato-gastroenterology","volume":"62 138","pages":"268-72"},"PeriodicalIF":0.0,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33253467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-incision laparoscopic distal gastrectomy for early gastric cancer through a homemade single port access device. 自制单孔通道装置单切口腹腔镜早期胃癌远端切除术。

Hepato-gastroenterology Pub Date : 2015-03-01

Zhi-Wei Jiang, Shu Zhang, Gang Wang, Kun Zhao, Jiang Liu, Li Ning, Jieshou Li

{"title":"Single-incision laparoscopic distal gastrectomy for early gastric cancer through a homemade single port access device.","authors":"Zhi-Wei Jiang, Shu Zhang, Gang Wang, Kun Zhao, Jiang Liu, Li Ning, Jieshou Li","doi":"","DOIUrl":"","url":null,"abstract":"Background/aims: We presented a series of single-incision laparoscopic distal gastrectomies for early gastric cancer patients through a type of homemade single port access device and some other conventional laparoscopic instruments.Methodology: A single-incision laparoscopic distal gastrectomy with D1 + α lymph node dissection was performed on a 46 years old male patient who had an early gastric cancer.Results: This single port access device has facilitated the conventional laparoscopic instruments to accomplish the surgery and we made in only 6 minutes. Total operating time for this surgery was 240 minutes. During the operation, there were about 100 milliliters of blood loss, and 17 lymph-nodes were retrieved.Conclusion: This homemade single port access device shows its superiority in economy and convenience for complex single-incision surgeries. Single-incision laparoscopic distal gastrectomy for early gastric cancer can be conducted by experienced laparoscopic surgeons. Fully take advantage of both SILS and fast track surgery plan can bring to successful surgeries with minimal postoperative pain, quicker mobilization, early recovery of intestinal function, and better cosmesis effect for the patients.","PeriodicalId":12985,"journal":{"name":"Hepato-gastroenterology","volume":"62 138","pages":"518-23"},"PeriodicalIF":0.0,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33253612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk, diagnosis and treatment to postoperative delirium in elderly patients with gastrointestinal cancers. 老年胃肠道肿瘤患者术后谵妄的危险、诊断和治疗。

Hepato-gastroenterology Pub Date : 2015-03-01

Li-Na Ma, Rui-Li Zhang

引用次数: 0

Individualized perfusion of sargent gloryvine decoction for clinical severe acute pancreatitis treatment. 格洛藤汤个体化灌注治疗临床重症急性胰腺炎。

Hepato-gastroenterology Pub Date : 2015-03-01

Ni Jun, Yuan Wenbin, Cen Feng, Yan Qiang, Zhang Guolei

{"title":"Individualized perfusion of sargent gloryvine decoction for clinical severe acute pancreatitis treatment.","authors":"Ni Jun, Yuan Wenbin, Cen Feng, Yan Qiang, Zhang Guolei","doi":"","DOIUrl":"","url":null,"abstract":"Background/aims: To observe the effects of Sargent gloryvine decoction (SGD) on severe acute pancreatitis (SAP) treatment and to evaluate its clinical value.Methodology: 112 patients of SAP in our hospital from January, 2005 to December, 2012 were recruited for retrospective analysis. They were divided into two groups, SGD group (62 patients) and control group without treated with SGD (50 patients). Inflammation factor, CT grade and Ranson grade were used to estimate the severity of SAP, and were compared in these two groups. In addition, peripancreatic infection, incidence of pseudo pancreatic cyst, time of anal exsufflation and duration of fever were used to evaluate the effect of SGD treatment. After perfusion of SGD for different time, hospitalization days and cost were recorded to evaluate clinical value of SGD.Results: After perfusion, many indexes in SGD were remarkably superior to those of control group, such as duration of fever, incidence of pseudo pancreatic cyst, peripancreatic infection and Ranson grade. Meanwhile, SGD can sharply down-regulate inflammation reaction levels of SAP patients, so that the hospitalization days and costs can be obviously saved.Conclusion: According to comparison, perfusion of SGD is a potential candidate for SAP treatment and is valuable in clinical application.","PeriodicalId":12985,"journal":{"name":"Hepato-gastroenterology","volume":"62 138","pages":"459-62"},"PeriodicalIF":0.0,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33254686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Practical prognostic index for survival in patients with unresectable pancreatic cancer treated with gemcitabine or S-1. 吉西他滨或S-1治疗不可切除胰腺癌患者生存的实用预后指数。

Hepato-gastroenterology Pub Date : 2015-03-01

Tatsuya Kurihara, Mari Kogo, Masakazu Ishii, Keiichiro Yoneyama, Katsuya Kitamura, Ken Shimada, Shunichi Shimizu, Hitoshi Yoshida, Yuji Kiuchi

{"title":"Practical prognostic index for survival in patients with unresectable pancreatic cancer treated with gemcitabine or S-1.","authors":"Tatsuya Kurihara, Mari Kogo, Masakazu Ishii, Keiichiro Yoneyama, Katsuya Kitamura, Ken Shimada, Shunichi Shimizu, Hitoshi Yoshida, Yuji Kiuchi","doi":"","DOIUrl":"","url":null,"abstract":"Background/aims: We performed this retrospective cohort study to identify prognostic factors for unresectable pancreatic cancer treated with current standard therapy using gemcitabine (GEM) or S-1 and to stratify patients prior to treatment using a prognostic index (PI).Methodology: We analyzed 182 patients with unresectable pancreatic cancer, who had received GEM or S-1 as first-line chemotherapy. Factors that contributed to the prognosis were identified by univariate and multivariate analysis using a Cox proportional hazards model. The PI was constructed using the factors identified in the multivariate analysis.Results: By multivariate analysis, performance status (PS), stage, and absolute neutrophil count (ANC) were identified as factors that independently contributed to the prognosis of unresectable pancreatic cancer (P < 0.05). The hazard ratios were 1.69, 3.33, and 1.18, respectively. In addition, PI was calculated using these three factors. Patients were classified into three groups according to the PI values. A significant difference was observed among the survival curves of these three groups (P < 0.05).Conclusions: We identified three prognostic factors in the population after the introduction of S-1, and have created a simple and useful PI. This index demonstrates the ability to accurately classify advanced pancreatic cancer patients before the start of treatment.","PeriodicalId":12985,"journal":{"name":"Hepato-gastroenterology","volume":"62 138","pages":"478-84"},"PeriodicalIF":0.0,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33254690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ovarian cancer liver metastases--should we apply the principle of optimal cytoreduction to the liver? A review. 卵巢癌肝转移——我们是否应该将最佳细胞减少原则应用于肝脏?复习一下。

Hepato-gastroenterology Pub Date : 2015-03-01

Nicolae Bacalbaşa, Irinel Popescu

引用次数: 0

Outcomes of laparoscopic colorectal surgery in patients of previous abdominal surgery: a systemic review and meta-analysis. 腹腔镜结直肠手术对既往腹部手术患者的疗效：一项系统综述和荟萃分析。

Hepato-gastroenterology Pub Date : 2015-03-01

Liang Wang, Haichao Yan, Jiangtao Li

引用次数: 0

Sorafenib after RFA in HCC patients: a pilot study. HCC患者RFA后索拉非尼:一项初步研究。

Hepato-gastroenterology Pub Date : 2015-03-01

Giorgio de Stefano, Nunzia Farella, Umberto Scognamiglio, Giulia Liorre, Giosuele Calabria, Tiziana Ascione, Antonio Giorgio, Valentina Iodice

引用次数: 0