使用乳果糖氢呼吸试验评估长期使用质子泵抑制剂与小肠细菌过度生长之间的关系。

Hepato-gastroenterology Pub Date : 2015-03-01
Yasuhiro Fujiwara, Toshio Watanabe, Motoko Muraki, Hirokazu Yamagami, Tetsuya Tanigawa, Masatsugu Shiba, Kazunari Tominaga, Tetsuo Arakawa
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引用次数: 0

摘要

背景/目的:在长期使用质子泵抑制剂(PPIs)的患者中已经报道了一些不良事件;然而,PPI的使用与小肠细菌过度生长(SIBO)之间的关系是有争议的。我们通过乳果糖氢呼气试验(LHBT)评估了SIBO的患病率,基于日本患者使用胃酸抑制药物。方法:对94例经LHBT检查的患者进行回顾性评估。我们使用了几个标准来定义LHBT阳性结果。9名患者接受了含有干酪乳杆菌的益生菌治疗。结果:50例患者为PPI使用者,14例为组胺-2受体拮抗剂(H2RA)使用者,30例为非PPI和非H2RA使用者(对照组)。三组间lhbt阳性病例的患病率无显著差异。多重调整回归显示PPI使用与lhbt阳性无显著相关性。PPI使用者的餐后饱腹感发生率很高(46%),但这些症状与LHBT结果无关。9例中有4例(44%)变为lhbt阴性,经益生菌处理后H2产峰显著降低。结论:PPI治疗与日本患者SIBO无关。SIBO以外的机制可能导致PPI使用者餐后饱腹感的高发。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between chronic use of proton pump inhibitors and small- intestinal bacterial overgrowth assessed using lactulose hydrogen breath tests.

Background/aims: Several adverse events have been reported in patients who are chronic users of proton pump inhibitors (PPIs); however, the association between PPI use and small-intestinal bacterial overgrowth (SIBO) is controversial. We examined the prevalence of SIBO, as assessed by the lactulose hydrogen breath test (LHBT), based on the use of gastric acid-suppressive drugs in Japanese patients. METH- ODOLOGY: Ninety-four patients who were examined by the LHBT were assessed retrospectively. We used several criteria to define a positive LHBT result. Nine patients received probiotics containing Lactobacillus casei.

Results: Fifty patients were PPI users, 14 were histamine-2 receptor antagonist (H2RA) users, and were 30 non-PPI and non-H2RA users (controls). There were no significant differences in prevalence of LHBT-positive cases among the three groups. Multiple-adjusted regression showed no significant association between PPI use and being LHBT-positive. Prevalence of postprandial fullness in PPI users was high (46%), but such symptoms were not related to LHBT results. Four (44%) of 9 cases became LHBT-negative and the maximal peak of H2 production decreased significantly after probiotic treatment.

Conclusions: PPI treatment is not associated with SIBO in Japanese patients. Mechanisms apart from SIBO could cause the high prevalence of postprandial fullness in PPI users.

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来源期刊
Hepato-gastroenterology
Hepato-gastroenterology 医学-外科
自引率
0.00%
发文量
1
审稿时长
1.9 months
期刊介绍: Hepato-Gastroenterology has been discontinued as of 2015. Extremely limited quantities of back issues in print available for sale.
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