Health and Quality of Life Outcomes最新文献

{"title":"Depression and psychiatric help-seeking as joint outcomes: a Bayesian multilevel analysis of household-level dependence.","authors":"Fatih Camadan, Mehmet Selim Yıldız, Hatice Büşra Şahin, Faruk Urak, Taha Berkay Börekçi, Abdulbaki Bilgiç","doi":"10.1186/s12955-026-02531-x","DOIUrl":"10.1186/s12955-026-02531-x","url":null,"abstract":"<p><p>BACKGROUND: Depression and the utilization of psychiatric services (PSU) are complex mental health outcomes shaped by a wide range of individual, familial, and socioeconomic factors. However, within the context of Türkiye, limited attention has been devoted to the simultaneous modeling of these outcomes and to the systematic examination of their shared household-level determinants. METHODS: This study conducts a concurrent analysis of two binary outcomes—self-reported depression and receipt of professional psychiatric care within the past 12 months—using data from a nationally representative household survey. The analytical sample comprises 22,742 individuals nested within 10,028 households across Türkiye. A Bayesian multilevel bivariate logistic regression model was employed to account explicitly for the hierarchical structure of the data, with individuals nested within households. Household-level random intercepts were specified for both outcomes, and the correlation between the latent processes underlying depression and PSU was directly estimated. Weakly informative priors were adopted, and model estimation was performed using the No-U-Turn Sampler (NUTS), an efficient variant of the Hamiltonian Monte Carlo algorithm. RESULTS: The results reveal pronounced clustering of both depression and PSU at the household level. A strong positive correlation between household-level random effects indicates that individuals experiencing depression are substantially more likely to utilize psychiatric services within the same family context. At the individual level, men are significantly less likely than women to report depressive symptoms or to seek psychiatric care. Tobacco and alcohol use are positively associated with depression risk, whereas adequate rest and healthier lifestyle behaviors exhibit protective effects. Increases in body mass index (BMI) are associated with a higher likelihood of depression. In contrast, active employment and higher household income are linked to reduced depression risk. Additionally, a range of sociodemographic and economic characteristics exert significant effects on both depression and PSU. CONCLUSIONS: These findings demonstrate that depression and psychiatric service utilization (PSU) are shaped not only by individual-level characteristics but also by shared familial and structural factors. The results underscore the need for mental health policies that move beyond narrowly individual-centered frameworks and instead adopt holistic strategies that incorporate household dynamics and broader socioeconomic conditions. </p>","PeriodicalId":12980,"journal":{"name":"Health and Quality of Life Outcomes","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13242676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147689863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Approaches used to model patient and carer health-related quality of life in economic models of rare disease treatments in NICE appraisals.","authors":"Lea Wiedmann, John Cairns","doi":"10.1186/s12955-026-02532-w","DOIUrl":"10.1186/s12955-026-02532-w","url":null,"abstract":"<p><p>INTRODUCTION: Providing robust health-related quality of life (HRQoL) evidence for rare disease treatments (RDTs) is difficult due to the challenges involved in generating and interpreting evidence for rare diseases. Our objective was to systematically review the approaches used to model patient and carer HRQoL in economic models in RDT appraisals published by the National Institute for Health and Care Excellence (NICE). METHODS: We identified appraisals completed between 2011 and 2023 and recorded HRQoL modelling characteristics from appraisal documents, including the approach used to derive the patient health state utility values (HSUVs) used in the final appraisal, and whether and how carer HRQoL was included. We mapped the approaches to estimating patient and carer HRQoL against NICE’s hierarchy of preferred HRQoL methods. RESULTS: We identified a total of 111 indications. Overall, we found heterogeneity in the approaches used to model patient and carer HRQoL. Regarding patient HRQoL, EQ-5D data was not available from a relevant study in 59.5% of indications in the final appraisal, and EQ-5D was not deemed appropriate by the committee in 6.3% of indications. EQ-5D from a relevant study was available and used in 34.2% of indications. Various sources of patient utilities were used, including EQ-5D values from a relevant study, estimates from the published literature (EQ-5D or non-EQ-5D), values derived from statistical mapping, vignette studies, or proxy conditions, combinations of several types, or values based on assumptions. Approaches to modelling patient utilities were also discussed in three-quarters of final appraisal documents, suggesting a considerable influence on the final recommendation. The impact on carer HRQoL was included quantitatively in the final appraisal in 26.1% of indications; for 3.6% of indications, the committee considered it qualitatively; and for one indication (0.9%) both quantitatively and qualitatively. CONCLUSION: Our findings suggest that, given the NICE hierarchy, patient and carer HRQoL was not very well captured in RDT appraisals. If the NICE hierarchy is viewed as a taxonomy of possible approaches, our findings also suggest that it does not accommodate some of the approaches used to estimate HRQoL in RDT appraisals. These issues raise questions about the consistency with which HRQoL is modelled and reflect the challenges of generating robust HRQoL evidence for RDTs. </p>","PeriodicalId":12980,"journal":{"name":"Health and Quality of Life Outcomes","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13185199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147672844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of life in patients with pulmonary arterial hypertension: A systematic review and meta-analysis.","authors":"Ada Dm Carmona-Segovia, José M Morales-Asencio, Pilar Escribano-Subías, Jorge Rodríguez-Capitán, Manuel Jiménez-Navarro, Víctor M Becerra-Muñoz","doi":"10.1186/s12955-026-02516-w","DOIUrl":"10.1186/s12955-026-02516-w","url":null,"abstract":"<p><p>BACKGROUND: Pulmonary arterial hypertension (PAH) is a rare incurable disease characterized by pulmonary artery remodeling, which may eventually lead to right ventricular failure and death. Despite advancements in targeted therapies, PAH remains life-threatening with significant impact on patients’ quality of life (QoL). The importance of patient-reported outcome measures (PROMs) in assessing health-related QoL has been increasingly recognized, but their implementation remains inconsistent in clinical practice. This systematic review aims to assess and synthesize the available evidence on the impact of PAH on patients’ QoL measured by PROMs. METHODS: A systematic review was conducted following PRISMA guidelines. Studies were identified through searches in CINAHL, EMBASE, Web of Science, PubMed, Scopus, and BVS. Inclusion criteria encompassed observational studies and RCTs with non-pharmacological interventions assessing QoL in PAH patients. RCTs involving drugs were excluded. Risk of bias was assessed using the Joanna Briggs Institute (JBI) appraisal tools. A meta-analysis was performed using a random-effects model. RESULTS: A total of 3271 studies were retrieved; 44 met inclusion criteria. PROMs like SF-36 (14 studies), SF-12 (2), CAMPHOR (9), EQ-5D (7), and EmPHasis-10 (13) were utilized. Findings highlight a dichotomy in QoL outcomes, with significant physical impairments but relatively preserved mental health scores. Subgroup analyses revealed substantial heterogeneity, emphasizing the need for standardized tools. CONCLUSIONS: This review underscores the critical role of PROMs in understanding QoL in PAH patients. Findings advocate for integrating PROMs into clinical assessments and standardizing methodologies. REGISTRATION: The protocol was registered in PROSPERO (CRD42022292145). </p>","PeriodicalId":12980,"journal":{"name":"Health and Quality of Life Outcomes","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13188818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147672848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translation, cultural adaptation, and psychometric validation of the Persian caregiver empowerment scale for stroke survivors for use in Iran.","authors":"Kosar Pourhasan, Mohammad Fasih, Parvaneh Vasli","doi":"10.1186/s12955-026-02510-2","DOIUrl":"10.1186/s12955-026-02510-2","url":null,"abstract":"<p><p>BACKGROUND: Empowering family caregivers (FCGs) of stroke survivors can improve the quality of care they provide and reduce their stress levels. This study focused on translating, culturally adapting and testing the Persian version of Caregiver Empowerment Scale (CES) for FCGs of stroke survivors. METHODS: This methodological investigation was conducted in two large hospitals in Tehran, Iran, during the 2024–25 academic year. It comprised the following five steps: First, the CES was translated. Secondly, face validity was evaluated with 20 FCGs. Third, content validity was examined with ten experts. Fourthly, construct validity was assessed via exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) with 150 and 165 FCGs, respectively. Data analysis was performed using SPSS 26 and the lavaan package in R at a significance level of 0.05. RESULTS: After translating the CES into Persian, face validity confirmed that all items were clear and consistent, and none required removal. However, a quantitative content validity analysis led to the removal of items 28, 29 and 30 due to a low content validity ratio and index. EFA retained 25 items, which had loadings ranging from 0.438 to 0.918. Two items (1 and 19) were removed because their loadings were below 0.43. Four components were extracted — Personal, Social, Adaptive and Informational Self-Efficacy — explaining 80.66% of the total variance. Confirmatory factor analysis (CFA) confirmed the fit of the four-factor model (TLI = 0.903, df = 266, RMSEA = 0.077, SRMR = 0.065, CFI = 0.914). Cronbach’s alpha, McDonald’s omega coefficients and the intraclass correlation coefficient (ICC) were all above 0.90, indicating high reliability. CONCLUSIONS: The findings showed that the Persian version of the 25-item CES for Stroke Survivors is both valid and reliable. This tool allows healthcare providers to evaluate the empowerment of FCGs and identify training requirements for targeted interventions. </p>","PeriodicalId":12980,"journal":{"name":"Health and Quality of Life Outcomes","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13185291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discrepancies in the country versions of the WHOQOL-BREF as a potential source of error in assessing quality of life and a barrier to comparative research.","authors":"Stanisław Maksymowicz, Maria Libura, Andrzej Jarynowski, Michał B Paradowski","doi":"10.1186/s12955-026-02529-5","DOIUrl":"10.1186/s12955-026-02529-5","url":null,"abstract":"<p><p>BACKGROUND: The aim of this study was to determine whether different language versions of the WHOQOL-BREF questionnaire allow for obtaining comparable health-related quality of life measurement results across different countries. METHODS: We analysed 21 country versions published on the World Health Organization website. Each version was compared to the reference English questionnaire in terms of its translation, the timeframe of measurement, the inclusion of instructions for respondents, visual layout, and additional elements. To evaluate the accuracy of the questions and scales, selected versions were reviewed by native speakers, and all translations were subsequently reviewed using a large language model. RESULTS: The results reveal substantial discrepancies between the versions across all evaluated criteria. In some cases, translation errors were so severe that responses to certain questions could not be meaningfully compared. CONCLUSIONS: We conclude that the WHOQOL-BREF questionnaire translations should undergo a comprehensive review to ensure conceptual and structural consistency and comparability. Additionally, language versions developed by external institutions should be carefully vetted by the WHO. The common practice of adding a note that a certain version is not an official WHO translation proves insufficient, as these tools are routinely treated by researchers and clinicians as de facto official instruments. </p>","PeriodicalId":12980,"journal":{"name":"Health and Quality of Life Outcomes","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13185381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing family quality of life in families of people with brain injuries: a Delphi study.","authors":"José Luis Castillo, Alba Aza, María Fernández, Antonio Manuel Amor, Miguel Ángel Verdugo","doi":"10.1186/s12955-026-02530-y","DOIUrl":"10.1186/s12955-026-02530-y","url":null,"abstract":"<p><p>Acquired brain injury (ABI) has a profound impact on the lives of survivors and their loved ones. However, there is a paucity of research on the quality of life of the whole family. Also, there are no instruments for assessing family quality of life (FQoL) from a holistic and systemic perspective after ABI in the Spanish context. The goal of this study was to identify a set of indicators and items of FQoL for this population in order to develop a preliminary version of such an assessment tool. A modified Delphi study was conducted with twelve social and healthcare professionals (70% women; age: M = 42.52, SD = 6.39) from ABI rehabilitation services and organizations (four psychologists, three neuropsychologists, three social workers, one nurse and one physiotherapist), who were asked to assess a pool of items throughout three rounds according to two criteria (importance and sensitivity). Descriptive analysis and percentage of agreement were employed to select the best items, as well as coefficients of concordance for the final pool of items. As a result, a pool of 71 items for five domains—Individual well-being, Family relationships, Family resources, Community relationships, and Community resources—was obtained. The findings of this study provided content validity evidence for a field test version of a FQoL tool, which may help to inform assessment and family-centered support planning for people with ABI and their families.</p>","PeriodicalId":12980,"journal":{"name":"Health and Quality of Life Outcomes","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13185388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translation, cultural adaptation, and psychometric validation of the Chinese versions of the PROMIS + HF-27 and PROMIS + HF-10 profiles in patients with heart failure.","authors":"Wanhui Li, Zhiyi Pei, Wenpei Liu, Chen Zhang, Jiayi Lin, Meihua Piao, Xiaofeng Kang, Yin Zhou, Yingying Guo, Xiaoxuan Zhou, Dingyang Gao, Xiaoyin Yang, Yingying Hu, Hui Ma, Minhong Yu","doi":"10.1186/s12955-026-02527-7","DOIUrl":"10.1186/s12955-026-02527-7","url":null,"abstract":"&lt;p&gt;&lt;p&gt;BACKGROUND: Heart failure (HF) is a prevalent clinical syndrome characterized by dyspnea, fatigue, exercise intolerance, and oedema, significantly impairing patients’ health-related quality of life (HRQoL). The PROMIS + HF profile is a targeted instrument designed to evaluate novel interventions, enhance clinical care and shared decision-making, and assess quality of care. However, a linguistically validated Chinese version is currently lacking. This study aimed to translate and culturally adapt the PROMIS + HF into Chinese and evaluate its psychometric properties among Chinese patients with HF. METHODS: Following a standardized cross-cultural adaptation process, the psychometric properties of the Chinese PROMIS + HF profiles (PROMIS + HF-27 and PROMIS + HF-10) were evaluated. A cross-sectional study with a longitudinal component was conducted using convenience sampling to recruit eligible patients from tertiary hospitals in China between September 2022 and February 2023. Participants completed a sociodemographic questionnaire, the PROMIS + HF profiles, the Kansas City Cardiomyopathy Questionnaire (KCCQ), and the Minnesota Living with Heart Failure Questionnaire (MLHFQ). Psychometric evaluation included floor/ceiling effects, construct validity, criterion-related validity, convergent validity, known-groups validity, reliability and responsiveness. RESULTS: A total of 420 patients (mean age 57.68 years) were included. Both profiles exhibited an absence of floor and ceiling effects. Confirmatory Factor Analysis (CFA) supported the construct validity of both profiles, demonstrating acceptable fit indices after modification (PROMIS + HF-27: χ2/df = 3.874, CFI = 0.869, TLI = 0.855, SRMR = 0.055, RMSEA = 0.08; PROMIS + HF-10: χ2/df = 3.408, CFI = 0.958, TLI = 0.940, SRMR = 0.038, RMSEA = 0.073). Criterion-related validity was supported by significant correlations between overall, physical health scores and the 6-Minute Walk Test (6MWT). Convergent validity was demonstrated through strong correlations with KCCQ and MLHFQ scores, and known-groups validity was confirmed by the instruments’ ability to distinguish between New York Heart Association (NYHA) functional classes. Internal consistency was good to excellent for the PROMIS + HF-27 (Cronbach’s α: 0.87–0.95) and acceptable to good for PROMIS + HF-10 (Cronbach’ α/Spearman-Brown: 0.71–0.88). Test-retest reliability was excellent for both instruments (ICC: 0.89–0.97). Responsiveness was demonstrated in the longitudinal subsample, with medium to large effect sizes (Cohen’s d = 0.41–0.66) observed for most domains, except for the psychological and social scores in the PROMIS + HF-10, which showed small change (Cohen’s d = 0.26–0.29). CONCLUSIONS: The Chinese versions of the PROMIS + HF-27 and PROMIS + HF-10 profiles demonstrate satisfactory psychometric properties, supporting their use for the comprehensive evaluation of HRQoL in Chinese HF patients. The PROMIS + HF-27 is recommended for academic re","PeriodicalId":12980,"journal":{"name":"Health and Quality of Life Outcomes","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13181976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147653936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between persistent symptoms and health-related quality of life in the post-COVID-19 condition: a cross-sectional survey in a nationally representative sample of French adults.","authors":"Olivier Steichen, Joel Coste, Cyrille Delpierre, Olivier Robineau, Anne Gallay, Tatjana T Makovski, Cedric Lemogne, Sarah Tebeka","doi":"10.1186/s12955-026-02533-9","DOIUrl":"10.1186/s12955-026-02533-9","url":null,"abstract":"<p><strong>Background: </strong>Up to 30% of individuals infected with COVID-19 experience persistent symptoms, known as post-COVID-19 condition (PCC), which can impair health-related quality of life (HRQoL). While post-COVID-19 condition (PCC) is known to affect health-related quality of life (HRQoL), the specific contribution of individual symptoms remains underexplored. This study examined how specific symptoms affect HRQoL in individuals with PCC compared to those who had COVID-19 without PCC and those never infected.</p><p><strong>Methods: </strong>A cross-sectional survey was conducted among a nationally representative sample of 1,813 French adults through telephone and online interviews. Participants were grouped according to WHO PCC criteria, based on infection status and 31 persistent symptoms. HRQoL was measured using the Patient-Reported Outcomes Measurement Information System (PROMIS-29), and impairment was defined as having at least two affected domains. Logistic regressions adjusted for confounders were used to assess associations.</p><p><strong>Results: </strong>Among 1,813 participants (365 with PCC, 1,270 previously infected without PCC, 178 never infected), impaired HRQoL was significantly more frequent in with PCC (36%) than in those previously infected without PCC or never infected (adjusted odds ratio: 2.02; 95% CI 1.19-3.42]). The symptoms most strongly associated with HRQoL impairment in PCC were anxiety (OR 3.75; 95% CI: 1.80-7.80), joint pain (OR 2.31; 95% CI: 1.15-4.65), and sleep disturbances (OR 2.14; 95% CI 1.08-4.25), whereas fatigue, shortness of breath, and memory issues had a weaker association with impaired HRQoL in PCC than in other groups.</p><p><strong>Conclusion: </strong>PCC, and particularly joint pain, anxiety and sleep disturbance, are associated with impaired HRQoL. Targeted interventions for these symptoms may improve well-being in affected individuals.</p>","PeriodicalId":12980,"journal":{"name":"Health and Quality of Life Outcomes","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13188528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity and responsiveness of the EQ-5D-5L, EQ-HWB and EQ-HWB-9 to measure health and wellbeing impact of heatwaves among older adults.","authors":"Meixia Liao, Fanni Rencz, Zhihao Yang, Jianjun Xiang, Nan Luo","doi":"10.1186/s12955-026-02521-z","DOIUrl":"10.1186/s12955-026-02521-z","url":null,"abstract":"<p><p>BACKGROUND: The health impact of heatwaves is usually assessed using mortality, morbidity and healthcare service utilization. This study explored the feasibility of using subjective measures to capture and quantify the impact of heatwaves on the health and wellbeing of older adults. METHODS: A cohort of residents aged ≥ 60 living in Fuzhou city, China, were surveyed four times: before summer in May, during heatwaves in June to July and August, and after summer in October, 2023. At all timepoints, the EQ-5D-5L, experimental EQ-HWB and self-designed questions assessing self-perceived effects of heatwaves were administered through one-on-one, face-to-face interviews. We examined the known-groups validity (using Cohen’s d effect sizes) and responsiveness (using standardized response mean [SRM]) of EQ-5D-5L, EQ-HWB and EQ-HWB-9 (including index values and level sum scores [LSSs]). RESULTS: The responses of 579, 510, 473 and 508 residents were analysed in the four waves of survey, respectively. The ceiling effects for EQ-5D-5L items ranged from 58.2% (pain/discomfort) to 94.3% (self-care), while for EQ-HWB items, it ranged from 32.3% (accepted) to 94.0% (personal care). The EQ-5D-5L and EQ-HWB-9 index values, and EQ-HWB LSSs demonstrated discriminative ability in distinguishing between different groups based on the self-perceived impact of heatwaves, with most of the effect sizes being small (Cohen’s d: 0.04–0.31 for EQ-5D-5L; 0.16–0.34 for EQ-HWB-9; 0.28–0.45 for EQ-HWB). We found negligible responsiveness to improvements in self-perceived effects of heat (SRM: 0.07 to 0.18). Unexpectedly, improved health and wellbeing were observed during the first heatwave compared to pre-heatwave. CONCLUSION: The EQ-5D-5L, EQ-HWB and EQ-HWB-9 demonstrated satisfactory known-groups validity but limited responsiveness in measuring the health and wellbeing impact of heatwaves among Chinese older adults. Future research is recommended to further evaluate these measures as well as other outcomes measures for the purpose of quantifying the health and wellbeing impacts of heatwaves and other climate events. </p>","PeriodicalId":12980,"journal":{"name":"Health and Quality of Life Outcomes","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13182084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health-related quality of life and associated psychosocial and clinical factors among mothers whose neonates admitted to neonatal intensive care units in Amhara Regional State Referral Hospitals, Northwest Ethiopia: a multicenter study.","authors":"Alemken Eyayu Abuhay, Berihun Agegn Mengistie, Fisseha Yetwale Kassie, Getnet Azanaw, Tadele Amare Zeleke, Chilot Kassa Mekonnen, Degsew Ewunetie Anteneh, Gebeyehu Nigussie Amare, Serku Abate Mihret, Alemu Kefale Berihun, Mengstu Melkamu Asaye","doi":"10.1186/s12955-026-02534-8","DOIUrl":"10.1186/s12955-026-02534-8","url":null,"abstract":"<p><p>BACKGROUND: Mothers’ health-related quality of life (HRQoL) is frequently compromised when their neonates are admitted to neonatal intensive care units (NICUs), leading to psychological distress, sleep disturbances, and impaired maternal–infant bonding. These adverse experiences may be further intensified by neonatal clinical complications and maternal psychosocial vulnerabilities. Despite this, empirical evidence on HRQoL and its associated psychosocial and clinical determinants among Ethiopian mothers remains very limited. Therefore, this study aimed to assess mothers’ HRQoL and to identify the associated psychosocial and clinical factors among mothers of neonates admitted to NICUs in referral hospitals of the Amhara Regional State, Northwest Ethiopia. METHODS: A facility-based cross-sectional study was conducted from December 12, 2023, to March 15, 2024 among 636 mothers selected via systematic random sampling in the NICUs of selected referral hospitals. Health-related quality of life (HRQoL) was measured using the validated WHOQOL-BREF instrument, comprising 23 items in four domains. The mean score of each domain and the total HRQoL score (range 0–92) were calculated, with higher scores indicating better quality of life. Data were collected via structured interviews and hospital chart review. Simple and multiple linear regression analyses were conducted to identify psychosocial and clinical factors associated with HRQoL. RESULTS: A total of 651 eligible mothers were approached, of whom 636 participated, yielding a response rate of 97.7%. The overall mean (± SD) score of mothers’ health-related quality of life was 41.87 ± 3.47. The mean scores (± SD) for the physical, psychological, social, and environmental domains were 12.65 ± 2.09, 13.86 ± 1.99, 2.60 ± 1.04, and 13.72 ± 2.02, respectively. Factors significantly associated with mothers’ HRQoL included being married (β = 4.19; 95% CI: 3.02, 5.37), history of antenatal care follow-up at hospitals (β = -1.17; 95% CI: -1.99, -0.36), gestational age ≤ 34 weeks (β = -1.97; 95% CI: -3.21, -0.72), low birth weight (β = -1.15; 95% CI: -3.26, -1.06), receiving information about the neonate’s health status (β = 1.12; 95% CI: 1.03, 2.01), length of NICU stay (β = -0.24; 95% CI: -0.28, -0.04), and poor social support (β = -0.89; 95% CI: -1.40, -0.38). CONCLUSIONS: The findings of this study demonstrate that mothers whose neonates were admitted to the NICU experience reduced health-related quality of life. Therefore, to improve maternal quality of life, a range of effective interventions is needed, including strengthening social support and providing timely information about the health status of their neonates. </p>","PeriodicalId":12980,"journal":{"name":"Health and Quality of Life Outcomes","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13182108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}