Fatma BEŞİROĞLU ÇETİN, Fatma İSSİ IRLAYICI, Burcu Güven, M. Çakir
{"title":"Çölyak Hastalığı Tanısı Alan Obez Çocuk Hasta","authors":"Fatma BEŞİROĞLU ÇETİN, Fatma İSSİ IRLAYICI, Burcu Güven, M. Çakir","doi":"10.24938/kutfd.1339952","DOIUrl":"https://doi.org/10.24938/kutfd.1339952","url":null,"abstract":"Celiac disease is a systemic autoimmune disease that frequently presents with clinical manifestations such as malnutrition, abdominal distension and diarrhea in childhood. With the increase in the incidence of celiac disease in recent years, differences in findings in patients at the time of diagnosis have been observed. While classical symptoms are common in younger age groups, differences in symptoms are more commonly observed in the adolescent age group. These findings often include abdominal pain, treatment-resistant iron deficiency anemia, elevated transaminase levels and diarrhea. Celiac disease should be considered in the differential diagnosis, even when malnutrition is not evident in such patients. In this case report, we present a case of an obese patient diagnosed with celiac disease, who experienced intermittent abdominal pain.","PeriodicalId":129756,"journal":{"name":"Kırıkkale Üniversitesi Tıp Fakültesi Dergisi","volume":"81 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139320392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"ETIOLOGICAL FEATURES OF CASES WITH CHEST PAIN IN THE PEDIATRIC CARDIOLOGY OUTPATIENT CLINIC","authors":"Ecem BOSTAN ÇEVİK, C. Şanlı, Y. Kandur","doi":"10.24938/kutfd.1345562","DOIUrl":"https://doi.org/10.24938/kutfd.1345562","url":null,"abstract":"Objective: Chest pain in children, especially in adolescence, constitutes a significant proportion of the presentations to pediatric cardiology clinics. We aimed to determine the frequency of chest pain causes in the pediatric age group and the importance of echocardiography. Material and Methods: We retrospectively examined the etiological and epidemiological characteristics of patients with chest pain who were admitted to Kırıkkale University Medical Faculty Hospital Pediatric Cardiology Clinic and Pediatric Emergency Service between 2014 and 2019. Results: One thousand hundred sixty-four patients were enrolled in this study. The mean age of the patients was 12.9±2.0 years (range 10-17 years). Echocardiographic evaluation was performed in 87.9% (n=1023) of 1164 patients. In 769 (75.2%) patients, there was no cardiac abnormality. Mitral valve prolapse (MVP) was detected in 164 (16.0%) patients. Out of these patients, 116 (11.3%) also had mitral insufficiency (MI). There was a female preponderance (117/164, 71.4%) among the patients with MVP. Patients with normal echocardiography findings, were compared with patients who had MVP+MI with respect to mean hemoglobin, mean corpuscular volume, Creatine kinase, Creatine kinase- MB, troponin, pro-B-type natriuretic peptide, and C-reaktif protein levels. There was no significant difference between these groups with respect to these parameters. Conclusion: We showed that MVP/MI is the most common cause of cardiac related chest pain in children. Therefore, chest pain, especially with physical examination findings, such as a murmur, should be evaluated by a pediatric cardiologist, ideally by echocardiography.","PeriodicalId":129756,"journal":{"name":"Kırıkkale Üniversitesi Tıp Fakültesi Dergisi","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139324624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Kerimoğlu, Gamze Bi̇lgi̇n, Servet Keri̇moğlu, Nihal TÜRKMEN ALEMDAR, S. Demir, Y. Aliyazicioglu
{"title":"THE AMELIORATING EFFECTS OF BILBERRY ON METHOTREXATE-INDUCED INTESTINAL INJURY","authors":"G. Kerimoğlu, Gamze Bi̇lgi̇n, Servet Keri̇moğlu, Nihal TÜRKMEN ALEMDAR, S. Demir, Y. Aliyazicioglu","doi":"10.24938/kutfd.1347778","DOIUrl":"https://doi.org/10.24938/kutfd.1347778","url":null,"abstract":"Objective: Methotrexate (MTX) is a folic acid analogue chemotherapeutic used in the treatment of some malignant tumors and autoimmune diseases. In addition to its antitumoral properties, it can also exhibit toxic effects on the kidney and intestines. Bilberry (BB) fruit is a potent natural antioxidant rich in anthocyanidins. The purpose of this study was to investigate the potential ameliorating effects of BB against MTX-induced intestinal damage using biochemical and histological methods. Material and Methods: Twenty-one adult female Sprague Dawley rats were divided into three equal groups. No procedure was performed on the control group (ControlG), while the MTX group (MTXG) and MTX+BB extract group (MTX+BBG) received a single intraperitoneal dose of 30 mg/kg MTX on the first day of the experiment. MTX+BBG also received 200 mg/kg BB extract by oral gavage once daily for five days starting on the first day of the experiment. Half the intestinal tissues removed from the duodenal region at the experiment were used for biochemical evaluation, and the other half for histological examination. Results: Malondialdehyde (MDA), total oxidant status (TOS), oxidative stress index (OSI), and 8-oxo-2′-deoxyguanosine (8- OHdG) values were all higher in MTXG intestinal tissues than in ControlG. MDA, TOS, OSI, and 8-OHdG values were lower in MTX+BBG than in MTXG. In addition, caspase-3 levels in MTXG were higher than those in both ControlG and MTX+BBG, while total antioxidant status (TAS) values were lower. In terms of histology, villous hemorrhage, inflammatory cell infiltration, fusion, and degeneration in the villus epithelium were present in MTXG intestinal tissue, and the total damage score was also high. Improvement in all these parameters was present in MTX+BBG. Conclusion: Orally administered BB extract can improve MTX-induced intestinal damage through its antioxidant and anti-inflammatory effects.","PeriodicalId":129756,"journal":{"name":"Kırıkkale Üniversitesi Tıp Fakültesi Dergisi","volume":"252 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139337909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Aile Hekimliğinde Konuşma Bozukluğu Şikayeti: Nadir Bir Olgu Dilde Hemanjiom","authors":"Hacı Ahmet Aydemi̇r","doi":"10.24938/kutfd.1332301","DOIUrl":"https://doi.org/10.24938/kutfd.1332301","url":null,"abstract":"Hemangiomas are the most common benign tumors of the head and neck region, but are rarely seen in the oral cavity. Tongue localized hemangiomas are encountered in 7.8% of cases. Depending on their size, hemangiomas located on the tongue can cause recurrent spontaneous bleeding, pain, speech and chewing disorders and shortness of breath. In this article, a case of hemangioma of the tongue characterized by speech disorder in a 7-year-old boy who presented to our family medicine outpatient clinic is presented and discussed in the light of the literature.","PeriodicalId":129756,"journal":{"name":"Kırıkkale Üniversitesi Tıp Fakültesi Dergisi","volume":"114 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139341737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Viral Respiratory Infections in Newborns After The Pandemic","authors":"Ü. A. Tandircioğlu, S. Alan","doi":"10.24938/kutfd.1319593","DOIUrl":"https://doi.org/10.24938/kutfd.1319593","url":null,"abstract":"İnsanlarda ‘severe acute respiratory syndrome coronavirus 2’ (SARS-CoV-2) olarak adlandırılan yeni coronavirüs suşuna bağlı enfeksiyonlar ilk olarak 2019 yılında görülmeye başlamış ve Mart 2020 yılında dünya sağlık örgütü tarafından COVİD-19 pandemisi kabul edilmiştir. Bununla birlikte bireysel, toplumsal ve ülkesel bazda farmakolojik olmayan müdahaleler hayatımıza girmiş ve pandemi yavaşlatılmaya çalışılmıştır. Bu farmakolojik olmayan müdahaleler ile sadece SARS-CoV-2 değil, diğer solunum sistemini tutan viral ajanlarda etkilenmiştir. Özellikle küçük çocuklar ve yenidoğanlarda ciddi alt solunum yolu enfeksiyonu yapan başta respiratuvar sinsityal virüs, rinovirüs ve respiratuvar enterovirüsler olmak üzere diğer tüm virüslerin toplumda görülmesinde ve enfeksiyon şiddetinde değişiklikler ortaya çıkmıştır. Bu derlemede özellikle respiratuvar sinsityal virüs, influenza virüs, rinovirüs ve respiratuvar enterovirüsler, adenovirüs, insan metapnömovirüs ve parainfluenza üzerinde durularak pandemi öncesi, pandemi sırası ve pandemi sonrasında görülme sıklıkları ve yenidoğan üzerindeki farklılaşan etkilerine değinilmiştir. COVID-19 pandemisi sırasında elde edilen bu bulgular gelecekte başka bir virüsün yol açabileceği olası bir pandemi yönetiminde ışık tutucu olacaktır.","PeriodicalId":129756,"journal":{"name":"Kırıkkale Üniversitesi Tıp Fakültesi Dergisi","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121346347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Ki̇rki̇z, Özlem Arman Bilir, F. Azik, Ç. Sönmez, H. Yaralı
{"title":"DIAGNOSIS OF VITAMIN B12 DEFICIENCY IN CHILDREN BY USING METHYLMALONIC ACID, HOMOCYSTEINE AND HOLOTRANSCOBALAMINE","authors":"S. Ki̇rki̇z, Özlem Arman Bilir, F. Azik, Ç. Sönmez, H. Yaralı","doi":"10.24938/kutfd.1263790","DOIUrl":"https://doi.org/10.24938/kutfd.1263790","url":null,"abstract":"Objective: Vitamin B12 deficiency is a common health issue in children. Though the sensivity of serum vitamin B12 measurement for the diagnosis of vitamin B12 deficiency is low, combined methylmalonic acid, homocysteine and holotranscobalamin have been reported to be more specific biomarkers in early and accurate diagnosis. In this study, we aimed to verify the diagnosis of vitamin B12 deficiency in children by measuring methylmalonic acid, homocysteine, holotranscobalamin and to determine the accuracy of them. \u0000 \u0000Material and Methods: The study included 277 patients aged","PeriodicalId":129756,"journal":{"name":"Kırıkkale Üniversitesi Tıp Fakültesi Dergisi","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124754131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Incidentally Detected Radiopaque Lesions in The Jaw: Report of Three Cases","authors":"M. Misirlioglu, Aslı ATACAN ASLAN, Rabia Çeli̇k","doi":"10.24938/kutfd.1276695","DOIUrl":"https://doi.org/10.24938/kutfd.1276695","url":null,"abstract":"Çeşitli sistemik hastalıklarda, inflamatuar durumlarda, kemik displazilerinde, heterotropik kalsifikasyonlarda, ossifikasyonlarda, kistlerde ve tümörlerde lezyonun ihtiva ettiği kalsifiye yapıya bağlı olarak radyoopasite görülebilmektedir. Bu makalede klinikte tesadüfen tespit edilen üç farklı tip radyoopak lezyonun klinik ve radyolojik bulguları sunulmuştur.Çenede tesadüfen fark edilen radyoopasitelerin anlaşılması için bilgisayarlı tomografi, konik ışınlı bilgisayarlı tomografi, manyetik rezonans görüntüleme ve ultrasonografi gibi ileri görüntülemeye gerek duyulabilir. Muayene sırasında çenede görülen radyoopak lezyonların özelliklerinin iyi bilinmesi ve radyografik olarak doğru yorumlanması, ayrıcı tanılarının yapılması ve uygun tedavi yönteminin seçilmesi açısından önemlidir. Lezyonların doğru değerlendirilmesi, tanının doğru konulmasını sağlayarak hastayı potansiyel yan etkilerden koruyacaktır.","PeriodicalId":129756,"journal":{"name":"Kırıkkale Üniversitesi Tıp Fakültesi Dergisi","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114688963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of Child and Adolescents Mental Health and Diseases Consultation Requests from the Perspective of Pediatric Physician","authors":"Berker Okay, Zeynep ÜZE OKAY, Tunahan Şengün, Kamil Şahin","doi":"10.24938/kutfd.1307824","DOIUrl":"https://doi.org/10.24938/kutfd.1307824","url":null,"abstract":"Amaç: Çocuk kliniklerinden çocuk ve ergen ruh sağlığı ve hastalıkları uzmanına konsültasyona sıklıkla ihtiyaç duyulmaktadır. Çalışmamızda çocuk hekimlerine yol gösterici olması için, çocuk kliniğinden istenen çocuk ve ergen ruh sağlığı ve hastalıkları konsltasyonlarını değerlendirmeyi amaçladık. \u0000 \u0000Gereç ve Yöntemler: 31.12.2021-21.12.2022 tarihleri arasında Haseki Eğitim ve Araştırma Hastanesi’nden yapılan konsültasyonlar retrospektif olarak tarandı. Çocuk ve Ergen Ruh Sağlığı ve Hastalıklarına konsülte edilen 88 hasta çalışmaya alındı; demografik bilgileri, konsültasyon istem nedeni ve cevapları Hastane Bilgi Yönetim Sistemi üzerinden elde edildi. \u0000 \u0000Bulgular: Çalışmamızdaki 88 hastanın %84’ü kız, %16’sı erkekti. Çocuk ve ergen ruh sağlığı ve hastalıkları konsültasyonlarının %81.8’i pazartesi-perşembe günleri arasında yapılmıştı. Aylara göre dağılımda en yüksek başvurunun haziran (%23.9) ve eylül (%26.1) aylarında olduğu görüldü (p","PeriodicalId":129756,"journal":{"name":"Kırıkkale Üniversitesi Tıp Fakültesi Dergisi","volume":"302 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115075835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Şahin, Hüseyin Öztürk, Sinan Çetin, Emsal Aydın, İlknur Şenel, M. Yetkin
{"title":"AN UNUSUAL MALARIA CASE: MIXED INFECTION? RESISTANCE? MALADAPTIVE PATIENT?","authors":"A. Şahin, Hüseyin Öztürk, Sinan Çetin, Emsal Aydın, İlknur Şenel, M. Yetkin","doi":"10.24938/kutfd.1229345","DOIUrl":"https://doi.org/10.24938/kutfd.1229345","url":null,"abstract":"Malaria, a disease known since ancient times and constantly struggled by human beings, still maintains its currency as an important cause of morbidity and mortality today. Although no domestic cases have been observed in Turkey since 2010, around 200-250 malaria cases originating from abroad are observed every year. Resistance to many parasitic drugs has developed over the years since chloroquine resistance emerged in the 1970s. Artemisinin resistance was reported by WHO in Cambodia, Laos, Myanmar, Thailand and Vietnam in 2013 due to P. falciparum malaria, and resistance has been reported also in South Africa and Rwanda recently. It has been shown that resistance development is due to the Kelch 13 mutation detected in parasite and this leads to delayed clearance. According to WHO data, artemether-based combined therapy is still effective in the treatment of patients infected with artemisinin-resistant P. falciparum strains, but possible treatment unresponsiveness is followed meticulously by WHO. Our case is remarkable for its third recurrence despite artemether-based combined therapy twice in 28 days, and its persistent treatment response after quinine and doxycycline treatment.","PeriodicalId":129756,"journal":{"name":"Kırıkkale Üniversitesi Tıp Fakültesi Dergisi","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131833874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"SAĞLIK ÇALIŞANLARIN COVID-19 HAKKINDAKİ GÜNCEL BİLGİ VE FARKINDALIK DÜZEYLERİ","authors":"Arzu Babacan","doi":"10.24938/kutfd.1243938","DOIUrl":"https://doi.org/10.24938/kutfd.1243938","url":null,"abstract":"Amaç: Sağlık çalışanlarının COVID-19 konusundaki bilgi düzeyi ve farkındalıklarının, bireysel tutum ve davranışlarına olan etkisini belirlemek amaçlanmıştır. \u0000 \u0000Gereç ve Yöntemler: Etik kurul onayı alındıktan sonra Sağlık Bakanlığı \"COVID-19 (SARS-CoV-2 Enfeksiyon) rehberi\" doğrultusunda hazırlanan anket soruları, gönüllü sağlık çalışanlarına sorulmuştur. Anket birinci bölümünde demografik özellikler, ikinci bölümde COVID-19 hakkında genel bilgiler, risk değerlendirmesi temaslı takibi ve kişisel koruyucu ekipman (KKE) kullanımı ile ilgili toplam 20 soru ve üçüncü bölümde, katılımcılara COVID-19 hakkındaki bilgilerinin günlük yaşamlarındaki bireysel tutum ve davranışlarına etkisini değerlendirmek için 10 sorudan oluşmuştur. Toplam 397 sağlık çalışanı çalışmayı tamamlamıştır. \u0000 \u0000Bulgular: COVID-19 sıklığı sağlık çalışanlarında %22.7, sağlık çalışanlarının ailelerinde %35.5 ve arkadaşlarında %9.7 bulunmuştur. Katılımcıların yaklaşık dörtte biri, çevrelerinde veya ailelerinde COVID-19 kaynaklı bir ölüm yaşadıklarını bildirmiştir. Katılımcıların yaklaşık %60'ı sağlık bakanlığı tarafından hazırlanan rehberlerden bilgi almayı tercih ettiğini bildirmiştir. KKE’yi her zaman kullandığını belirten grupta COVID-19 prevalansı daha az bulunmuştur (p","PeriodicalId":129756,"journal":{"name":"Kırıkkale Üniversitesi Tıp Fakültesi Dergisi","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116712707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}