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[THE VIDEO HEAD IMPULSE TEST (VHIT): CAN WE RELY ON THE GAIN PARAMETER ALONE?] 视频头脉冲测试(vhit):我们能单独依靠增益参数吗?]
Harefuah Pub Date : 2023-08-01
Avi Shupak, Khaldon Abo-Saleh, Margalith Kaminer, Nabil Faranesh
{"title":"[THE VIDEO HEAD IMPULSE TEST (VHIT): CAN WE RELY ON THE GAIN PARAMETER ALONE?]","authors":"Avi Shupak,&nbsp;Khaldon Abo-Saleh,&nbsp;Margalith Kaminer,&nbsp;Nabil Faranesh","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>While the bedside head impulse test evaluates the presence of refixation saccades (RS) as a measure of failing vestibulo-ocular reflex (VOR) the VOR gain calculated by the video head-impulse test (vHIT) is considered the primary measure for semicircular canal function while the role RS is still under evaluation.</p><p><strong>Aims: </strong>To evaluate the benefit of various RS characteristics towards the diagnosis of the left horizontal semicircular function by vHIT.</p><p><strong>Methods: </strong>The vHIT recordings of 40 patients with left sided horizontal VOR gains <0.8 were retrospectively evaluated for the presence of RS. The study groups included 20 patients with a final diagnosis of left horizontal semicircular canal dysfunction and 20 patients for whom vestibular dysfunction was ruled out.</p><p><strong>Results: </strong>Gain values > 0.72 were found in all patients with no vestibular disease, and in 4 (20%) patients having vestibulopathy. Significantly higher average left-sided RS velocity and frequency were found among the vestibular patients. VOR gain < 0.72 was found to be highly specific for the diagnosis of vestibular dysfunction. However, for gain values in the range of 0.72-0.79 the presence of RS with frequency > 80% improved vHIT sensitivity.</p><p><strong>Conclusions: </strong>Although VOR gain<0.8 is considered to reflect dysfunction, a significant false positive rate for left-sided horizontal vHIT was found for gains in the range of 0.72-0.79. The presence of RS with frequency >80% could improve vHIT diagnostic accuracy in these patients.</p>","PeriodicalId":12965,"journal":{"name":"Harefuah","volume":"162 7","pages":"428-433"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10028072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[THE HIDDEN VESTIBULAR FEATURES OF MACHADO JOSEPH DISEASE (SPINOCEREBELLAR ATAXIA 3)]. [machado Joseph病(脊髓小脑性共济失调3)的隐蔽性前庭特征]。
Harefuah Pub Date : 2023-08-01
Zohar Elyoseph, Dario Geisinger, Roy Zaltzman, Matti Mintz, Carlos R Gordon
{"title":"[THE HIDDEN VESTIBULAR FEATURES OF MACHADO JOSEPH DISEASE (SPINOCEREBELLAR ATAXIA 3)].","authors":"Zohar Elyoseph,&nbsp;Dario Geisinger,&nbsp;Roy Zaltzman,&nbsp;Matti Mintz,&nbsp;Carlos R Gordon","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Machado-Joseph disease (MJD) is an inherited neurodegenerative disease with progressive cerebellar ataxia manifested through lack of coordination and balance. MJD patients also present significant Vestibulo-Ocular Reflex (VOR) deficit but their whole vestibular features have not been previously evaluated. We aimed to evaluate whether MJD patients have vestibular features fitting the diagnostic criteria of Bilateral Vestibulopathy established by the International Society for Neuro-otology.</p><p><strong>Methods: </strong>Sixteen MJD patients and 21 healthy controls underwent a detailed clinical neuro-otological examination including a quantitative evaluation of the VOR gain using the video Head Impulse Test (vHIT). Vestibular-related symptoms were evaluated by the Dizziness Handicap Inventory (DHI), the Activities-specific Balance Confidence Scale (ABC), the Vertigo Visual Scale (VVS). In addition, anxiety that is frequently present in vestibular disorders, was evaluated by the Beck Anxiety Inventory (BAI).</p><p><strong>Results: </strong>MJD patients had significantly reduced horizontal VOR gain with significantly higher scores in all vestibular-related symptoms questionnaires. These symptoms scores were like those reported in studies evaluating patients with bilateral peripheral vestibular loss.</p><p><strong>Conclusions: </strong>Beyond the cerebellar deficits, MJD patients have vestibular signs and symptoms fitting the diagnostic criteria of Bilateral Vestibulopathy established by the International Society for Neuro-otology. These findings are of relevance not only for the diagnosis and evaluation of progressive cerebellar diseases but also for the possible beneficial effect of vestibular rehabilitation techniques on dizziness, balance and the emotional, physiological and functional aspects of MJD.</p>","PeriodicalId":12965,"journal":{"name":"Harefuah","volume":"162 7","pages":"434-439"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10028069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[SLEEP HABIT MODIFICATION AS A POSSIBLE PREVENTION OF RECURRENT BENIGN PAROXYSMAL POSITIONAL VERTIGO]. [改变睡眠习惯可预防良性阵发性位置性眩晕复发]。
Harefuah Pub Date : 2023-08-01
Yoav Gimmon, Shay Izhak Duvdevani, Amit Wolfovitz, Yisgav Shapira, Doron Sagiv, Arkadi Yakirevitch
{"title":"[SLEEP HABIT MODIFICATION AS A POSSIBLE PREVENTION OF RECURRENT BENIGN PAROXYSMAL POSITIONAL VERTIGO].","authors":"Yoav Gimmon,&nbsp;Shay Izhak Duvdevani,&nbsp;Amit Wolfovitz,&nbsp;Yisgav Shapira,&nbsp;Doron Sagiv,&nbsp;Arkadi Yakirevitch","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Benign paroxysmal positional vertigo (BPPV) is effectively treated with a variety of repositioning maneuvers but one-third to one-half of patients experience recurrence, usually within 2 years after the first attack.</p><p><strong>Objectives: </strong>The aim of this study was to investigate possible prevention of recurrent BPPV by sleep habit modification.</p><p><strong>Methods: </strong>Patients diagnosed with posterior semicircular canal BPPV (p-BPPV) were asked their preferred lying side during nocturnal sleep. Following Epley maneuver they were recommended to change their head lying side at least every 2 hours during nocturnal sleep and to come back in case of recurrence.</p><p><strong>Results: </strong>A total of 266 patients were diagnosed with p-BPPV. The mean patient's age was 57 years (range 14-87 years). There were 167 patients with right p-BPPV and 99 patients with left p-BPPV; 134 (50%) patients habitually slept on the right side. Of those, 112 (84%) were diagnosed with right p-BPPV (P= 0.0006); 87 patients (33%) habitually slept on the left side; 56 of them (64%) were diagnosed with left p-BPPV (P <0.0001). Among the 45 patients (17%) who expressed no preference concerning their sleeping positions, the right versus left p-BPPV was nearly even. During the follow-up period (1-80 months, mean 41) 11 patients (4%) were diagnosed with recurrent p-BPPV. Of those, 9 had a recurrence in the same posterior semicircular canal and 2 in the contralateral one. All of them reported that they had not modified their sleep habits.</p><p><strong>Conclusions: </strong>The results of our study can shed some light on the etiology of BPPV and may be helpful in preventing recurrent BPPV by changing sleep-position habits.</p>","PeriodicalId":12965,"journal":{"name":"Harefuah","volume":"162 7","pages":"440-443"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10028071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[SPONTANEOUS CEREBROSPINAL FLUID LEAK OF THE TEMPORAL BONE]. [颞骨自发性脑脊液漏]。
Harefuah Pub Date : 2023-08-01
Amiel A Dror, Ophir Handzel
{"title":"[SPONTANEOUS CEREBROSPINAL FLUID LEAK OF THE TEMPORAL BONE].","authors":"Amiel A Dror,&nbsp;Ophir Handzel","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Spontaneous cerebrospinal fluid (CSF) leak into the temporal air spaces is a prominent risk factor for meningitis, often leading to debilitating neurological morbidities and even death. CSF leaks may arise due to trauma, congenital malformation, or surgery, but in most cases, they develop spontaneously. In spontaneous CSF leaks, no obvious triggering event is apparent in the patient's clinical history that points to this diagnosis, in contrast to some of the other etiologies. The clinical presentation of spontaneous CSF leaks is not unique and is characterized by patients' complaints, such as hearing loss and aural fullness. These symptoms are commonly associated with prevalent conditions, such as serous otitis media. For these reasons, a typical diagnostic delay of spontaneous CSF leaks, which can last for years in some cases, leaves the patients exposed to meningeal infection without being offered an efficient surgical treatment to keep them safe and protected.</p>","PeriodicalId":12965,"journal":{"name":"Harefuah","volume":"162 7","pages":"457-464"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10028073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[AUDITORY OUTCOMES OF COCHLEAR IMPLANTATION IN MENIERE'S DISEASE]. [梅尼埃病人工耳蜗植入的听觉结果]。
Harefuah Pub Date : 2023-08-01
Noga Lipschitz, Gavriel D Kohlberg, Ravi N Samy
{"title":"[AUDITORY OUTCOMES OF COCHLEAR IMPLANTATION IN MENIERE'S DISEASE].","authors":"Noga Lipschitz,&nbsp;Gavriel D Kohlberg,&nbsp;Ravi N Samy","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Cochlear implants are valuable in the auditory rehabilitation of patients with severe to profound hearing loss. However, there is limited data on the outcomes of cochlear implantation in patients with Meniere's disease (MD).</p><p><strong>Objectives: </strong>In this study, we aim to evaluate the auditory outcomes of cochlear implantation in patients with MD.</p><p><strong>Methods: </strong>A retrospective case series of patients with MD and severe to profound sensorineural hearing loss (SNHL), who underwent cochlear implantation at a tertiary academic center between 2006-2017. Patient's clinical characteristics and audiometric data were reviewed.</p><p><strong>Results: </strong>The study included 20 ears in 19 patients with MD who underwent cochlear implantation with available pre- and postoperative audiometric data. There were 10 males and 9 females with a mean age of 63 years and a mean follow-up duration of 70.8 months. Pre- and post-implant CNC word recognition scores were 18.31% and 66.89%, respectively (p<0.001). Pre- and post-implant AzBio and/or HINT sentence recognition scores were 12.25% and 68.28% in quiet, respectively (p<0.001), and 18.25% and 63.43% in noise, respectively (p<0.001).</p><p><strong>Conclusions: </strong>Cochlear implantation resulted in an improvement of word and sentence recognition scores in MD patients. These results support the role of cochlear implants in the auditory rehabilitation of MD.</p><p><strong>Discussion: </strong>Dr. Samy received research support from Cochlear Corporation.</p>","PeriodicalId":12965,"journal":{"name":"Harefuah","volume":"162 7","pages":"424-427"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10326947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[AUDITORY BRAINSTEM IMPLANTS (ABI) IN CHILDREN: CASE SERIES IN SHAARE ZEDEK MEDICAL CENTER]. [儿童听觉脑干植入(abi): shaare zedek医疗中心的病例系列]。
Harefuah Pub Date : 2023-08-01
Ronen Perez, Jean-Yves Sichel, Riki Salem, Dina Hildesheimer, John Thomas Roland, Nevo Margalit
{"title":"[AUDITORY BRAINSTEM IMPLANTS (ABI) IN CHILDREN: CASE SERIES IN SHAARE ZEDEK MEDICAL CENTER].","authors":"Ronen Perez,&nbsp;Jean-Yves Sichel,&nbsp;Riki Salem,&nbsp;Dina Hildesheimer,&nbsp;John Thomas Roland,&nbsp;Nevo Margalit","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Cochlear implants (CI) are the treatment of choice for individuals with severe to profound sensorineural hearing loss. A small group of patients, with pathology central to the cochlea, cannot benefit from CI. Examples in children include absence of the cochlear-nerve or cochlear aplasia. In these cases, implantation of an auditory brainstem implant (ABI), directly stimulating the cochlear nucleus, bypassing the inner-ear and auditory-nerve, may be beneficial.</p><p><strong>Objectives: </strong>Describe a series of children with ABI's treated in Shaare-Zedek, including the first ABI implantation in Israel (2017).</p><p><strong>Methods: </strong>Of 9 patients with ABI's treated in Shaare Zedek Medical Center ,7 were children implanted between ages 2-8.6 years. Five boys and two girls. Surgeries were conducted in collaboration between neurosurgeons, neurotologists and audiologists (five implanted in Shaare-Zedek and two in New-York University). Follow-up was between 2-6 years. Hearing evaluation was conducted, mainly, with audiograms, categories of auditory performance (CAP), speech perception testing when possible and estimation of device use per day.</p><p><strong>Results: </strong>Six of the seven children, who initially underwent unsuccessful CI, had deficient auditory-nerves. One child had cochlear-aplasia. In 3 children hearing loss was part of the CHARGE syndrome. CAP scores ranged from 0-7 (0,1,3,5,5,7). One child was able to achieve open-set speech perception.</p><p><strong>Conclusions: </strong>Although functional auditory outcomes for children with ABI are inferior to CI recipients and are highly variable, some children were able to obtain significant benefit. In these children, who are not candidates for CI, the ABI presents the only chance for auditory awareness and may be recommended.</p><p><strong>Discussion: </strong>John Thomas Roland is a consultant and recipient of research support from Cochlear Americas.</p>","PeriodicalId":12965,"journal":{"name":"Harefuah","volume":"162 7","pages":"413-418"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10028070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[OTONEUROLOGY- A MULTIFACETED FIELD]. [耳神经学-一个多方面的领域]。
Harefuah Pub Date : 2023-08-01
Ronen Perez
{"title":"[OTONEUROLOGY- A MULTIFACETED FIELD].","authors":"Ronen Perez","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Otoneurology is a broad, diverse and multidisciplinary field. On the one hand, it includes everything that relates to hearing: from complex surgery including life-changing implants to effective medical treatments and habilitation. On the other hand, it includes all that has to do with balance, from novel vestibular tests to complex medical treatments and recently, the development of a vestibular implant for patients suffering from bilateral peripheral vestibular loss. This special issue on otoneurology includes 8 original papers and 3 reviews. The first three articles deal with auditory implants. The first describes a series of children who underwent auditory brainstem implantation, including the first implantation in Israel 6 years ago. The second, presents patients with acoustic schwannomas undergoing cochlear implantation and the third relates to patients with Meniere's disease. Cochlear implants are one of the most significant developments in medicine in recent decades that enable most deaf individuals to hear, and develop normal language, heavily influencing all aspects of personal development and social integration.</p>","PeriodicalId":12965,"journal":{"name":"Harefuah","volume":"162 7","pages":"410-412"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10326944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[THE DIFFERENTIAL DIAGNOSIS OF EXTREMELY HIGH MATERNAL SERUM ALPHA FETOPROTEIN - A CASE REPORT]. [产妇血清甲胎蛋白异常高的鉴别诊断- 1例报告]。
Harefuah Pub Date : 2023-06-01
Hadas Allouche Kam, Dov Popper, Elias Castel, Simcha Yagel, Hagit Daum
{"title":"[THE DIFFERENTIAL DIAGNOSIS OF EXTREMELY HIGH MATERNAL SERUM ALPHA FETOPROTEIN - A CASE REPORT].","authors":"Hadas Allouche Kam,&nbsp;Dov Popper,&nbsp;Elias Castel,&nbsp;Simcha Yagel,&nbsp;Hagit Daum","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>A 34 years-old woman was referred to genetic counseling due to extremely high maternal serum alpha fetoprotein (MSAFP) of 58 MoM (541 IU/mL, 654 ng/mL) in the second trimester biochemical test. The couple has five healthy children, three of them were delivered by cesarean section. Current pregnancy follow-up was uneventful except for the demonstration of placenta percreta during anomaly scan. The test also ruled out neural tube or abdominal wall defect. AFP levels in amniotic fluid were normal thus fetal disease was ruled out as the etiology. Total body MRI ruled out space occupying lesion as a source of ectopic secretion of AFP. After exclusion of other ominous etiologies for this extremely high MSAFP, it was related to the placental pathology and probably to abnormal feto-maternal shunts. Fetal fraction in cell free DNA was 18%, considered relatively high, a hint for those speculated shunts. We reviewed the literature regarding the differential diagnosis of high MSAFP including fetal, maternal and placental sources.</p>","PeriodicalId":12965,"journal":{"name":"Harefuah","volume":"162 6","pages":"366-369"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9735452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[MOH SCREENING FOR TBCD IN COCHIN JEWS: COLLABORATION BETWEEN MEDICAL, RESEARCH AND COMMUNITY MEMBERS IN ACHIEVING PUBLIC HEALTH GOALS]. [卫生部筛查科钦犹太人的TBCD:医疗、研究和社区成员在实现公共卫生目标方面的合作]。
Harefuah Pub Date : 2023-06-01
Julia Grinshpun-Cohen, Rachel S Marans, Amihood Singer
{"title":"[MOH SCREENING FOR TBCD IN COCHIN JEWS: COLLABORATION BETWEEN MEDICAL, RESEARCH AND COMMUNITY MEMBERS IN ACHIEVING PUBLIC HEALTH GOALS].","authors":"Julia Grinshpun-Cohen,&nbsp;Rachel S Marans,&nbsp;Amihood Singer","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>PEBAT (Progressive Encephalopathy, Early-Onset, with Brain Atrophy and Thin Corpus Callosum) is a rare disease characterized by a significant and progressive, neurological deficit. The disease has autosomal recessive etiology and is caused by bi-allelic variants in the gene TBCD (Tubulin-Specific Chaperone D). In 2017 the disease was diagnosed in two sisters from Jewish Cochin ethnicity (originating in Karela in south India) in Israel. Genetic testing for the girls revealed the homozygous TBCD variant c.1423G>A (p.Ala475Thr). This variant was reported simultaneously in another unrelated patient of Cochin origin.</p>","PeriodicalId":12965,"journal":{"name":"Harefuah","volume":"162 6","pages":"359-361"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9742377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[INHERITED COLORECTAL CANCER - UPDATED REVIEW]. [遗传性结直肠癌-最新综述]。
Harefuah Pub Date : 2023-06-01
Aasem Abu Shtaya, Yael Goldberg
{"title":"[INHERITED COLORECTAL CANCER - UPDATED REVIEW].","authors":"Aasem Abu Shtaya,&nbsp;Yael Goldberg","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Significant progress has been achieved in recent years in the field of cancer genomics. The advancement in genomic technologies, molecular pathology and genetic testing, led to the discovery of novel genetic-hereditary factors, associated with colorectal cancer (CRC). There are currently ~20 identified genes that are linked to a higher risk of developing CRC; some of these genes are also linked to polyposis. The most prevalent hereditary syndrome to cause CRC is Lynch syndrome; its prevalence is believed to be 1:300 worldwide. Clinical data such as the age of onset, ancestry, number of polyps, histological features, molecular characteristics of the tumor and benign findings in other bodily systems, can be used to support the notion that the ailment is hereditary.</p>","PeriodicalId":12965,"journal":{"name":"Harefuah","volume":"162 6","pages":"393-400"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10127425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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