Haematologica最新文献_第4页

A phase IIb study of selinexor in combination with daratumumab in patients with daratumumab-refractory multiple myeloma. selinexor联合daratumumab治疗难治性多发性骨髓瘤的IIb期研究

IF 7.9 1区医学

Haematologica Pub Date : 2025-10-01 Epub Date: 2025-04-03 DOI: 10.3324/haematol.2024.287053

Noa Biran, Eli Zolotov, David Vesole, Harsh Parmar, Pooja Phull, Kimberley Doucette, Patrick Roney, Jaeil Ahn, Rena Feinman, Joshua Zenreich, Palka Anand, Monique Pace, Alexandra Della Pia, Bianca DeAgresta, Lisa Biamonte, Adolfo Aleman, Ella Rutanen, Aimee Chappell, Susan Kumka, David S Siegel

引用次数: 0

"Dexamethasing" acute myeloid leukemia: new opportunities for an "old" drug. 急性髓性白血病“去甲基化”：“老”药的新机遇。

IF 7.9 1区医学

Haematologica Pub Date : 2025-10-01 Epub Date: 2025-05-29 DOI: 10.3324/haematol.2025.287404

Jesús Duque-Afonso, Julian List, Michael Lübbert

引用次数: 0

Risk of leukemia in twins. 双胞胎患白血病的风险。

IF 7.9 1区医学

Haematologica Pub Date : 2025-10-01 Epub Date: 2025-04-03 DOI: 10.3324/haematol.2024.287135

Mel Greaves

引用次数: 0

Dexamethasone added to induction and post-remission therapy in older patients with newly diagnosed acute myeloid leukemia: a multicenter, phase II trial (DEXAML-02). 地塞米松加入新诊断急性髓性白血病老年患者诱导和缓解后治疗：一项多中心II期试验（DEXAML-02）

IF 7.9 1区医学

Haematologica Pub Date : 2025-10-01 Epub Date: 2025-02-06 DOI: 10.3324/haematol.2024.286807

Sarah Bertoli, Emilie Bérard, Pierre Peterlin, Romain Guieze, Yohan Desbrosses, Yosr Hicheri, Omar Benbrahim, Martin Carre, Corentin Orvain, Anne Banos, Marc Bernard, Emmanuel Gyan, Alain Saad, Safia Chebrek, Gabrielle Roth Guepin, Veronique Dorvaux, Laurence Sanhes, Maria Pilar Gallego-Hernanz, Carole Exbrayat, Laure Vincent, Chantal Himberlin, Célestine Simand, Norbert Vey, Cindy Fenoll, Ariane Mineur, Anne Huynh, Francois Vergez, Isabelle Luquet, Laetitia Largeaud, Eric Delabesse, Arnaud Pigneux, Christian Récher

引用次数: 0

MHC disparity hampers thymus-dependent T-cell recovery post-hematopoietic transplantation through dysregulation of TGF-β1 and LRP6 pathways. MHC差异通过TGF-β1和LRP6通路失调阻碍造血移植后胸腺依赖性t细胞恢复。

IF 10.1 1区医学

Haematologica Pub Date : 2025-09-25 DOI: 10.3324/haematol.2025.288464

Ning Wu,Wei Ding,Jiashuo Wu,Min Ling,Keli Yue,Cong Cheng,Mingzhu Jia,Jiangying Liu,Xiao-Jun Huang

{"title":"MHC disparity hampers thymus-dependent T-cell recovery post-hematopoietic transplantation through dysregulation of TGF-β1 and LRP6 pathways.","authors":"Ning Wu,Wei Ding,Jiashuo Wu,Min Ling,Keli Yue,Cong Cheng,Mingzhu Jia,Jiangying Liu,Xiao-Jun Huang","doi":"10.3324/haematol.2025.288464","DOIUrl":"https://doi.org/10.3324/haematol.2025.288464","url":null,"abstract":"Clinical studies have demonstrated that recipients of allogeneic hematopoietic cell transplantation (alloHCT), particularly those undergoing HLA-haploidentical alloHCT (haploHCT), exhibit significant immune deficiencies. However, the extent to which major histocompatibility complex (MHC) disparity independently contributes to the observed lymphocyte deficiency post-alloHCT remains unclear. While MHC matching is crucial for thymic selection of T lymphocytes, it has yet to be reported whether haploHCT alters recipient thymus homeostasis compared to MHC-matched HCT and which signaling pathways are implicated in this alteration. In this study, we established mouse models of MHC- matched and haploidentical HCT without any transplant-associated complications. Our findings indicated that MHC disparity significantly disrupted thymic architecture, suppressed thymus-specific gene expression, and resulted in impaired T-cell recovery and functionality following transplantation. Single-cell transcriptomic analysis revealed abnormally enhanced interactions involving TGFB1-TGFBR3 and LRP6-CKLF between thymic lymphocytes and epithelial cells in haploHCT recipients. Furthermore, agonists targeting the TGF-β1 and LRP6 pathways were found to compromise the functional characteristics of normal thymic T cells; conversely, appropriate inhibition of these pathways restored the differentiation and maturation phenotypes of thymic T cells derived from haploHCT recipients. Our study elucidates the independent role of MHC disparity in regulating thymus homeostasis and T-cell recovery while identifying the functional involvement of the TGF-β1 and LRP6 pathways in this context. These findings provide novel insights into the mechanisms underlying immune recovery as well as potential therapeutic strategies for modulating thymic functions following haploHCT.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"17 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145134039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic value of tumor bulk in modern management of common lymphoma subtypes: an Australasian Lymphoma and Related Diseases Registry study. 肿瘤体积在常见淋巴瘤亚型现代治疗中的预后价值：一项澳大利亚淋巴瘤及相关疾病登记研究。

IF 10.1 1区医学

Haematologica Pub Date : 2025-09-25 DOI: 10.3324/haematol.2025.287919

Eliza Chung,Luke Wang,Cameron Wellard,Allison Barraclough,Belinda A Campbell,Geoffrey Chong,Pietro Di Ciaccio,Gareth P Gregory,Greg Hapgood,Anna M Johnston,Constantine S Tam,Stephen Opat,Erica M Wood,Zoe K McQuilten,Eliza A Hawkes

{"title":"Prognostic value of tumor bulk in modern management of common lymphoma subtypes: an Australasian Lymphoma and Related Diseases Registry study.","authors":"Eliza Chung,Luke Wang,Cameron Wellard,Allison Barraclough,Belinda A Campbell,Geoffrey Chong,Pietro Di Ciaccio,Gareth P Gregory,Greg Hapgood,Anna M Johnston,Constantine S Tam,Stephen Opat,Erica M Wood,Zoe K McQuilten,Eliza A Hawkes","doi":"10.3324/haematol.2025.287919","DOIUrl":"https://doi.org/10.3324/haematol.2025.287919","url":null,"abstract":"The presence of a single large disease site or so-called tumor 'bulk' in lymphoma has been variably associated with outcomes and influenced management decisions. However, challenges arise in using bulk as a prognosticator due to varied definitions across different lymphoma subtypes but also within studies of each subtype, increased utility of positron emission tomography (PET) in decisionmaking and recent incorporation of novel therapies. We analyzed data from the Australasian Lymphoma Registry regarding presence and influence of bulk on outcomes and treatment decisions in six key subtypes: diffuse large B-cell (DLBCL), follicular, marginal zone, T-cell, Hodgkin (HL) and Burkitt lymphoma (BL). Of the 5090 eligible patients identified between 2016-2025, 88% had documented information on the presence of bulk (registry definition >5cm). Patients with bulk were more likely to receive systemic chemotherapy alone, and less likely to have localized treatment alone (radiotherapy and/or surgery), compared to those without bulk. Bulk was associated with inferior overall survival (OS) in DLBCL patients, and superior OS in HL patients, in the univariate analyses. Exploratory analysis using disease-specific bulk definitions from clinicians practising in Australia and New Zealand showed inferior progression-free survival in DLBCL (bulk >7.5cm) and OS in BL patients (bulk >10cm), but not other subtypes. We demonstrated real-world evidence of management heterogeneity for patients with bulk, with potential prognostic implications. International standardization of the definition of bulk is urged for uniform utility in PET-based and molecular prognostication across clinical studies. Trial registration at the Australian New Zealand Clinical Trials Registry: ANZCTRN12617000050358.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"14 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145134047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gatekeepers of mitochondrial metabolism: the emerging role of the SLC25 family in leukemia. 线粒体代谢的守门人：SLC25家族在白血病中的新作用。

IF 10.1 1区医学

Haematologica Pub Date : 2025-09-25 DOI: 10.3324/haematol.2025.288787

Arnon Haran,Boaz Nachmias

引用次数: 0

Hepatitis E virus infections in people with multiple myeloma: an emerging challenge in the era of immunotherapeutic approaches. 多发性骨髓瘤患者的戊型肝炎病毒感染：免疫治疗方法时代的新挑战。

IF 10.1 1区医学

Haematologica Pub Date : 2025-09-25 DOI: 10.3324/haematol.2025.288381

Maximilian Al-Bazaz,Sven Pischke,Winfried Alsdorf,Piet Sonnemann,Sophia Cichutek,Julian Schulze Zur Wiesch,Christoph Schaefers,Jule Artzenroth,Lisa Leypoldt,Abdulaziz Kamili,Carsten Bokemeyer,Katja Weisel,Ricardo Kosch

{"title":"Hepatitis E virus infections in people with multiple myeloma: an emerging challenge in the era of immunotherapeutic approaches.","authors":"Maximilian Al-Bazaz,Sven Pischke,Winfried Alsdorf,Piet Sonnemann,Sophia Cichutek,Julian Schulze Zur Wiesch,Christoph Schaefers,Jule Artzenroth,Lisa Leypoldt,Abdulaziz Kamili,Carsten Bokemeyer,Katja Weisel,Ricardo Kosch","doi":"10.3324/haematol.2025.288381","DOIUrl":"https://doi.org/10.3324/haematol.2025.288381","url":null,"abstract":"Hepatitis E virus (HEV) is an under-recognized cause of viral hepatitis, with rising incidence in high-income countries largely driven by zoonotic transmission. Patients with multiple myeloma (MM) are especially vulnerable to HEV, yet recommendations for antiviral treatment and impact on the management of myeloma treatment are missing. Here, we describe seven patients (five males, two females) with MM who were diagnosed with HEV infection at a tertiary care center in Western Europe within less than one year. All cases were confirmed by positive HEV RNA PCR in peripheral blood. Although no instances of fulminant hepatitis were observed, HEV prompted clinically relevant interruptions: autologous stem cell transplantation was postponed, lymphocyte apheresis for CAR T-cell manufacturing was delayed, and bispecific antibody regimens were suspended for up to five months. Ribavirin was initiated in four cases. The three patients undergoing T-cell-redirecting therapies, including one with prior ciltacabtagene autoleucel and two on bispecific antibodies, progressed to chronic infection despite ribavirin treatment. One patient, despite clearing HEV from peripheral blood, developed persistent vertigo and tested positive for HEV RNA in cerebrospinal fluid, indicating neuroinvasion. As the largest reported cohort of MM patients with HEV infections and the first to document chronic infection during treatment with T-cell-redirecting therapies, this study emphasizes the urgent need to increase awareness of HEV as an emerging threat, refine screening protocols at baseline or during unexplained aminotransferase flares, and to establish standardized therapeutic strategies in the era of novel immunotherapeutic approaches.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"319 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145134041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The sobering reality of fertility preservation in young female patients with acute leukemia. 年轻女性急性白血病患者生育能力保存的清醒现实。

IF 10.1 1区医学

Haematologica Pub Date : 2025-09-25 DOI: 10.3324/haematol.2025.288538

Avraham Frisch

引用次数: 0

Loss of life expectancy in patients with myeloproliferative neoplasms in Sweden. 瑞典骨髓增生性肿瘤患者预期寿命的减少。

IF 10.1 1区医学

Haematologica Pub Date : 2025-09-25 DOI: 10.3324/haematol.2024.286697

Yuliya Leontyeva,Anna Ravn Landtblom,Malin Hultcrantz,Mats Lambe,Hannah Bower,Paul C Lambert,Therese M-L Andersson

{"title":"Loss of life expectancy in patients with myeloproliferative neoplasms in Sweden.","authors":"Yuliya Leontyeva,Anna Ravn Landtblom,Malin Hultcrantz,Mats Lambe,Hannah Bower,Paul C Lambert,Therese M-L Andersson","doi":"10.3324/haematol.2024.286697","DOIUrl":"https://doi.org/10.3324/haematol.2024.286697","url":null,"abstract":"Myeloproliferative neoplasms (MPN) are chronic bone marrow malignancies. While the prognosis is generally good, patients can face complications leading to reduced life expectancy. However, no population-based studies have quantified the life expectancy (LEC) and loss in life expectancy (LLE) following MPN. In this population-based study, we included individuals diagnosed with MPN in Sweden aged 50 and older between 2002 and 2021, with follow-up until 2022. We used flexible parametric relative survival models with a period analysis (2012-2021) to estimate LEC and LLE. We also estimated 15-year restricted mean survival time (RMST) and the loss in 15-year restricted mean survival time (LRMST) for each MPN subtype: polycythaemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). The average LEC was 11.4 (95% CI, 11.2-11.7) and LLE was 4.3 years (95% CI, 4.1-4.6). For the MPN subtypes, the average 15-year LRMST was 1.8 (95% CI, 1.7-2.0) in PV, 1.3 (95% CI, 1.1-1.4) in ET, and 4.4 years (95% CI, 4.0-4.8) in PMF. Our study shows that life expectancy is lower in all MPN subtypes compared to the general population. By quantifying LEC and LLE, our research offers insights into the impact of MPN on an individual's lifespan beyond the diagnosis.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"94 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145134038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0