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The added value of Bayesian interim analysis in randomized phase II and phase III clinical trials in hemato-oncology. 贝叶斯中期分析在血液肿瘤随机II期和III期临床试验中的附加价值。
IF 10.1 1区 医学
Haematologica Pub Date : 2025-10-02 DOI: 10.3324/haematol.2025.288675
Anna J T Smit,Niek G Van der Maas,Bronno Van der Holt,Yvette Van Norden,Erik Van Werkhoven,Annette Juul Vangsted,Paula F Ypma,Heleen A Visser-Wisselaar,Rossella Troia,Mario Boccadoro,Bob Löwenberg,Jeroen J W M Janssen,Gert J Ossenkoppele,Fredrik Schjesvold,Pieter Sonneveld,Sonja Zweegman,Jurjen Versluis,Jan J Cornelissen
{"title":"The added value of Bayesian interim analysis in randomized phase II and phase III clinical trials in hemato-oncology.","authors":"Anna J T Smit,Niek G Van der Maas,Bronno Van der Holt,Yvette Van Norden,Erik Van Werkhoven,Annette Juul Vangsted,Paula F Ypma,Heleen A Visser-Wisselaar,Rossella Troia,Mario Boccadoro,Bob Löwenberg,Jeroen J W M Janssen,Gert J Ossenkoppele,Fredrik Schjesvold,Pieter Sonneveld,Sonja Zweegman,Jurjen Versluis,Jan J Cornelissen","doi":"10.3324/haematol.2025.288675","DOIUrl":"https://doi.org/10.3324/haematol.2025.288675","url":null,"abstract":"Not available.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"8 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145203969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intravenous immunoglobulins in the management of acute chest syndrome in two Jehovah's witnesses with sickle cell disease. ​
IF 10.1 1区 医学
Haematologica Pub Date : 2025-10-02 DOI: 10.3324/haematol.2025.287956
Francesca Begali,Jacopo Ceolan,Silvia Vitale,Simone Villaboni,Matteo Merlo,Rachele Zamperini,Roberto Bertazzo,Soraia Ribeiro Luz,Filippo Mazzi,Lucia De Franceschi
{"title":"Intravenous immunoglobulins in the management of acute chest syndrome in two Jehovah's witnesses with sickle cell disease.","authors":"Francesca Begali,Jacopo Ceolan,Silvia Vitale,Simone Villaboni,Matteo Merlo,Rachele Zamperini,Roberto Bertazzo,Soraia Ribeiro Luz,Filippo Mazzi,Lucia De Franceschi","doi":"10.3324/haematol.2025.287956","DOIUrl":"https://doi.org/10.3324/haematol.2025.287956","url":null,"abstract":"Not available.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"39 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145203967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Utility of the Central Nervous System International Prognostic Index in patients with primary mediastinal large B-cell lymphoma treated with rituximab-containing chemoimmunotherapy. 中枢神经系统国际预后指数在接受利妥昔单抗免疫化疗治疗的原发性纵隔大b细胞淋巴瘤患者中的应用
IF 10.1 1区 医学
Haematologica Pub Date : 2025-10-02 DOI: 10.3324/haematol.2025.288699
Jiayu Yang,Anna R Hayden,Diego Villa,Aixiang Jiang,Alina S Gerrie,Christopher P Venner,Pedro Farinha,David W Scott,Laurie H Sehn,Kerry J Savage
{"title":"Utility of the Central Nervous System International Prognostic Index in patients with primary mediastinal large B-cell lymphoma treated with rituximab-containing chemoimmunotherapy.","authors":"Jiayu Yang,Anna R Hayden,Diego Villa,Aixiang Jiang,Alina S Gerrie,Christopher P Venner,Pedro Farinha,David W Scott,Laurie H Sehn,Kerry J Savage","doi":"10.3324/haematol.2025.288699","DOIUrl":"https://doi.org/10.3324/haematol.2025.288699","url":null,"abstract":"Not available.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"96 7 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145203951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Taming neutrophil extravasation: a promising therapeutic approach to dampen inflammation? 抑制中性粒细胞外渗：抑制炎症的有希望的治疗方法？
IF 10.1 1区 医学
Haematologica Pub Date : 2025-10-02 DOI: 10.3324/haematol.2025.288835
Salma A Rizo-Téllez,János G Filep
{"title":"Taming neutrophil extravasation: a promising therapeutic approach to dampen inflammation?","authors":"Salma A Rizo-Téllez,János G Filep","doi":"10.3324/haematol.2025.288835","DOIUrl":"https://doi.org/10.3324/haematol.2025.288835","url":null,"abstract":"Not available.","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":"6 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145203972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Significant risk of venous thromboembolism associated with targeted anti-myeloma immunomodulatory drugs. Comment on "Targeted anti-cancer agents and risk of venous thromboembolism". 静脉血栓栓塞的显著风险与靶向抗骨髓瘤免疫调节药物相关。评论：靶向抗癌药物与静脉血栓栓塞的风险。
IF 7.9 1区 医学
Haematologica Pub Date : 2025-10-01 Epub Date: 2025-03-06 DOI: 10.3324/haematol.2025.287442
Catherine Duane, Siobhan Glavey, John Quinn, Philip Murphy
{"title":"Significant risk of venous thromboembolism associated with targeted anti-myeloma immunomodulatory drugs. Comment on \"Targeted anti-cancer agents and risk of venous thromboembolism\".","authors":"Catherine Duane, Siobhan Glavey, John Quinn, Philip Murphy","doi":"10.3324/haematol.2025.287442","DOIUrl":"10.3324/haematol.2025.287442","url":null,"abstract":"","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":"2552-2553"},"PeriodicalIF":7.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12485318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulation of immune responses to therapeutic factor VIII by transplacental delivery of Fc-fused immunodominant factor VIII domains or peptides. 经胎盘输送fc融合的免疫优势因子VIII结构域或肽对治疗性因子VIII的免疫反应的调节
IF 7.9 1区 医学
Haematologica Pub Date : 2025-10-01 Epub Date: 2025-03-13 DOI: 10.3324/haematol.2024.287057
Alejandra Reyes-Ruiz, Sandrine Delignat, Aurélien Azam, Victoria Daventure, Leslie Dourthe, Angelina Mimoun, Geneviève McCluskey, Maria T Georgescu, David Lillicrap, Jordan D Dimitrov, Sebastien Lacroix-Desmazes
{"title":"Regulation of immune responses to therapeutic factor VIII by transplacental delivery of Fc-fused immunodominant factor VIII domains or peptides.","authors":"Alejandra Reyes-Ruiz, Sandrine Delignat, Aurélien Azam, Victoria Daventure, Leslie Dourthe, Angelina Mimoun, Geneviève McCluskey, Maria T Georgescu, David Lillicrap, Jordan D Dimitrov, Sebastien Lacroix-Desmazes","doi":"10.3324/haematol.2024.287057","DOIUrl":"10.3324/haematol.2024.287057","url":null,"abstract":"<p><p>Patients with severe hemophilia A (HA) often develop undesired immune responses to therapeutic factor VIII (FVIII) that hamper replacement therapy with FVIII-derived products. The transplacental delivery of two Fc-fused FVIII domains in pregnant HA mice was shown to induce partial FVIII-specific immune tolerance in the offspring. Here, we evaluated whether the transplacental delivery of Fc-fused FVIII (rFVIIIFc) induces complete immune tolerance towards FVIII. rFVIIIFc injected to pregnant HA mice was poorly transferred to the fetal circulation and failed to confer tolerance to exogenous FVIII in the offspring. The poor transplacental delivery of rFVIIIFc was associated with the large size of the molecule and with the presence of positive patches at the surface of FVIII. It was, however, independent from the capacity of rFVIIIFc to bind Fcg receptors or von Willebrand factor in the maternal circulation. Conversely, the transplacental delivery of Fc-fused A2 and C2 immunodominant domains of FVIII, as well as of Fc-fused molecules containing seven different immunodominant FVIII-derived peptides decreased the levels of anti-FVIII antibodies following FVIII replacement therapy in the offspring. Our study paves the way towards the development of engineered Fc-fused molecules able to efficiently cross the placenta and confer potent and long-lasting immune tolerance to protein therapeutics.</p>","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":"2320-2331"},"PeriodicalIF":7.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12485324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to Comment on: Multimorbidity, comorbidity, frailty, and venous thromboembolism. 对多病、合并症、虚弱和静脉血栓栓塞的评论回应。
IF 7.9 1区 医学
Haematologica Pub Date : 2025-10-01 Epub Date: 2025-02-06 DOI: 10.3324/haematol.2025.287469
Bengt Zöller, Jean M Connors
{"title":"Response to Comment on: Multimorbidity, comorbidity, frailty, and venous thromboembolism.","authors":"Bengt Zöller, Jean M Connors","doi":"10.3324/haematol.2025.287469","DOIUrl":"10.3324/haematol.2025.287469","url":null,"abstract":"","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":"2550-2551"},"PeriodicalIF":7.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12485352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A first-born twin has a higher risk of acute leukemia in a population-based assessment of cancer in twins in California, and a lower than anticipated rate of twin concordance. 在加利福尼亚的一项基于人群的双胞胎癌症评估中，首胎双胞胎患急性白血病的风险较高，双胞胎一致性的发生率低于预期。
IF 7.9 1区 医学
Haematologica Pub Date : 2025-10-01 Epub Date: 2025-01-16 DOI: 10.3324/haematol.2024.286309
Eric M Nickels, Naying Zhou, Joseph L Wiemels
{"title":"A first-born twin has a higher risk of acute leukemia in a population-based assessment of cancer in twins in California, and a lower than anticipated rate of twin concordance.","authors":"Eric M Nickels, Naying Zhou, Joseph L Wiemels","doi":"10.3324/haematol.2024.286309","DOIUrl":"10.3324/haematol.2024.286309","url":null,"abstract":"","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":"2463-2468"},"PeriodicalIF":7.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12485339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ex vivo drug response profiling guides therapy in a case of high-risk acute undifferentiated leukemia with PICALM::MLLT10. 体外药物反应分析指导高危急性未分化白血病PICALM::MLLT10的治疗。
IF 7.9 1区 医学
Haematologica Pub Date : 2025-10-01 Epub Date: 2025-02-27 DOI: 10.3324/haematol.2024.286815
Elena Mastrodicasa, Luca Pagliaro, Valentina Pierini, Valentina Bardelli, Mariateresa Giaimo, Raffaella Zamponi, Anna Montanaro, Katia Tragni, Roberta Arcaleni, Maria Speranza Massei, Ilaria Capolsini, Katia Perruccio, Elena Varotto, Barbara Buldini, Andrea Gherli, Silvia Romoli, Caterina Matteucci, Maria Crocioni, Francesco Arcioni, Grazia Gurdo, Carla Cerri, Maurizio Caniglia, Giovanni Roti, Roberta La Starza
{"title":"<i>Ex vivo</i> drug response profiling guides therapy in a case of high-risk acute undifferentiated leukemia with <i>PICALM::MLLT10</i>.","authors":"Elena Mastrodicasa, Luca Pagliaro, Valentina Pierini, Valentina Bardelli, Mariateresa Giaimo, Raffaella Zamponi, Anna Montanaro, Katia Tragni, Roberta Arcaleni, Maria Speranza Massei, Ilaria Capolsini, Katia Perruccio, Elena Varotto, Barbara Buldini, Andrea Gherli, Silvia Romoli, Caterina Matteucci, Maria Crocioni, Francesco Arcioni, Grazia Gurdo, Carla Cerri, Maurizio Caniglia, Giovanni Roti, Roberta La Starza","doi":"10.3324/haematol.2024.286815","DOIUrl":"10.3324/haematol.2024.286815","url":null,"abstract":"","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":"2535-2542"},"PeriodicalIF":7.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12485308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on: Multimorbidity, comorbidity, frailty, and venous thromboembolism. 评论：多病、合并症、虚弱和静脉血栓栓塞。
IF 7.9 1区 医学
Haematologica Pub Date : 2025-10-01 Epub Date: 2025-02-06 DOI: 10.3324/haematol.2025.287356
Maria I Zervou, George N Goulielmos
{"title":"Comment on: Multimorbidity, comorbidity, frailty, and venous thromboembolism.","authors":"Maria I Zervou, George N Goulielmos","doi":"10.3324/haematol.2025.287356","DOIUrl":"10.3324/haematol.2025.287356","url":null,"abstract":"","PeriodicalId":12964,"journal":{"name":"Haematologica","volume":" ","pages":"2548-2549"},"PeriodicalIF":7.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12485345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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