Heart and VesselsPub Date : 2025-08-01Epub Date: 2024-12-28DOI: 10.1007/s00380-024-02511-5
Israel O Ajiboye, Sean M Lang, Michael D Taylor, Rupak K Banerjee
{"title":"Non-invasive pressure-volume loop derived temporal elastance, contractility, and efficiency indices for assessing Duchenne muscular dystrophy patients.","authors":"Israel O Ajiboye, Sean M Lang, Michael D Taylor, Rupak K Banerjee","doi":"10.1007/s00380-024-02511-5","DOIUrl":"10.1007/s00380-024-02511-5","url":null,"abstract":"<p><p>Ejection fraction is commonly used to assess Duchenne muscular dystrophy-associated cardiomyopathy (DMDAC), but it may remain normal (wrongly) despite significant myocardial dysfunction in patients. Therefore, better indicators of myocardial dysfunction are needed for longitudinal (with time) assessment and treatment of DMDAC patients. This study evaluates non-invasive LV PV loop-derived elastance, contractility and efficiency in relation to EF for patients developing DMDAC. The current retrospective study includes thirty DMDAC patients who underwent two serial CMR imaging from 2014 to 2023. The patients were divided into EF < 55% and EF ≥ 55%. Brachial pressures from cuff sphygmomanometer and CMR short axis steady-state free-precession images for the LV were acquired, and a non-invasive PV loop algorithm based on temporal elastance was used to derive mean elastance, contractility, and efficiency. While mean elastance and contractility showed moderate correlations (r = 0.56, p < 0.01, and r = 0.65, p < 0.001 respectively), efficiency exhibited a strong correlation with EF (r = 0.97, p < 0.01). Importantly, mean elastance, efficiency, and contractility were significantly lower in the EF < 55% group compared to EF ≥ 55% (p < 0.001). Therefore, these indices could serve as viable diagnostic endpoints for longitudinal evaluation of DMDAC.</p>","PeriodicalId":12940,"journal":{"name":"Heart and Vessels","volume":" ","pages":"696-706"},"PeriodicalIF":1.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart and VesselsPub Date : 2025-08-01Epub Date: 2024-12-01DOI: 10.1007/s00380-024-02496-1
Marlon V Gatuz, Rami Abu-Fanne, Dmitry Abramov, Mamas A Mamas, Ariel Roguin, Ofer Kobo
{"title":"Impact of polyvascular disease severity on acute heart failure prognosis.","authors":"Marlon V Gatuz, Rami Abu-Fanne, Dmitry Abramov, Mamas A Mamas, Ariel Roguin, Ofer Kobo","doi":"10.1007/s00380-024-02496-1","DOIUrl":"10.1007/s00380-024-02496-1","url":null,"abstract":"<p><p>Polyvascular disease, is a prevalent comorbidity among patients with acute heart failure (AHF). Previous research has shown that polyvascular disease is a poor prognostic factor in patients with heart failure. However, data on the relationship between the extent of vascular disease involvement and outcomes in AHF patients are limited. Using the National Inpatient Sample from 2016 to 2019, adult patients with AHF were stratified by number of diseased vascular beds and into heart failure with reduced ejection fraction (HFrEF) and with preserved ejection fraction (HFpEF). The study assessed in-hospital major adverse cardiovascular and cerebrovascular events (MACCE), mortality, cerebrovascular accident (CVA), and major bleeding. Multivariable regression models examined the association between outcomes and number of diseased vascular beds. This analysis included 652,710 patients hospitalized with AHF, of which 42.2% had disease of 1 vascular site and 57.8% had polyvascular disease. As the number of involved vascular beds increased, AHF patients tended to be older and with higher comorbidity burden. The mean length of stay and total hospital charge increased with a greater number of diseased vascular beds (p < 0.001). Moreover, the adjusted odds of MACCE, all-cause mortality, CVA, and major bleeding showed a significant increase with a greater number of diseased vascular beds (p trend < 0.001) with similar trends for patients with HFrEF and HFpEF. The extent of polyvascular disease involvement is associated with higher in-hospital adverse event rates in AHF patients. These findings highlight the importance of comprehensive vascular assessment and targeted interventions to improve outcomes in this high-risk population.</p>","PeriodicalId":12940,"journal":{"name":"Heart and Vessels","volume":" ","pages":"744-754"},"PeriodicalIF":1.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Efficacy and safety of atrial fibrillation ablation in patients with aged 80 years or older. Letter to the editor (response to Kataoka N, et al.).","authors":"Kenji Yodogawa, Yu-Ki Iwasaki, Nobuaki Ito, Toshiki Arai, Masato Hachisuka, Yuhi Fujimoto, Kanako Hagiwara, Hiroshige Murata, Yoshiyasu Aizawa, Wataru Shimizu, Kuniya Asai","doi":"10.1007/s00380-025-02519-5","DOIUrl":"10.1007/s00380-025-02519-5","url":null,"abstract":"","PeriodicalId":12940,"journal":{"name":"Heart and Vessels","volume":" ","pages":"757"},"PeriodicalIF":1.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Perioperative management of postinfarction ventricular septal rupture: a comparison of Impella with intra-aortic balloon pump.","authors":"Akihiro Tani, Kazuhiko Aramaki, Shota Uno, Natsumi Morisako, Takashi Hagiwara, Tsukasa Iwasaki, Shigeki Nishiyama, Junji Kaneyama, Ryoji Yanagisawa, Taro Shibasaki, Yutaka Koji, Takashi Iida, Tadanobu Irie, Yasuyuki Kato, Masahisa Yamane","doi":"10.1007/s00380-025-02513-x","DOIUrl":"10.1007/s00380-025-02513-x","url":null,"abstract":"<p><p>Postinfarction ventricular septal rupture (PIVSR) is a rare but serious complication of acute myocardial infarction. Determining how to conduct surgical repair safely is critical. We compared the outcomes of Impella and intra-aortic balloon pump (IABP) implantation during perioperative mechanical circulatory support management in patients with PIVSR (n = 22). The primary endpoint was the 12-month survival rate. Secondary endpoints included major adverse cardiovascular events (MACEs) and the number of waiting days for surgery. Using the log-rank test, we compared Kaplan-Meier curves between the groups. The 12-month survival rate was 87.5% and 53.6% in the Impella and IABP groups, respectively, with no significant difference (p = 0.17). The median number of days from circulatory support implantation to surgery was longer in the Impella group than in the IABP group (2.5 days vs. 1.0 days, interquartile range: 1.8-5.2 vs. 0-1.0; p = 0.003). In the subgroup analysis considering only the Society for Cardiovascular Angiography and Interventions (SCAI) shock stages B-D, the 12-month survival rate was higher (85.7% vs. 18.8%; p = 0.03) and the MACE rate was lower (14.3% vs. 53.3%; p = 0.010) in the Impella group than in the IABP group. In summary, when focusing on the SCAI shock stages B-D, the Impella group had significantly better outcomes than did the IABP group. In the perioperative management of PIVSR, the use of Impella may be more beneficial than the use of IABPs, particularly in patients with SCAI shock stages B-D.</p>","PeriodicalId":12940,"journal":{"name":"Heart and Vessels","volume":" ","pages":"726-735"},"PeriodicalIF":1.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143038259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Efficacy of a 16 Fr sheath strategy during Impella support to reduce access site bleeding in patients with cardiogenic shock.","authors":"Yuka Tanizaki, Motoki Fukutomi, Takayuki Onishi, Tomo Ando, Shuichiro Takanashi, Tetsuya Tobaru","doi":"10.1007/s00380-025-02514-w","DOIUrl":"10.1007/s00380-025-02514-w","url":null,"abstract":"<p><p>Access site bleeding is a complication which may occur during Impella support (Abiomed, Danvers, MA, USA), possibly due to unstable fixation of the device in the groin. Using a large-bore sheath for Impella insertion may reduce this complication. However, the efficacy and safety of this strategy are still unknown. The main aim of this study was to assess whether employing a large-bore sheath during Impella insertion mitigates access site bleeding without increasing limb ischemia. All consecutive patients who received either the Impella 2.5 or CP for cardiogenic shock from September 2019 to February 2023 were included in this study. We compared patients who underwent Impella insertion using the conventional peel-away introducer and the attached sheath (repositioning sheath) and patients in whom the Impella was inserted using a 16 Fr sheath. All patients received antegrade perfusion with a 4Fr sheath to prevent limb ischemia at the Impella site. The primary outcome was access site major bleeding: 36 patients were treated with a 16 Fr sheath and 39 were treated with a conventional sheath. The use of a 16 Fr sheath was associated with a significant reduction in major bleeding (33.0% vs. 64.0%, p = 0.01) in comparison to the conventional sheath. After adjusting for covariates, the risk of major bleeding at the access site in the 16 Fr sheath group was significantly lower than that in the conventional sheath group (adjusted odds ratio, 0.294; 95% confidence interval 0.087-0.991; p = 0.048). The insertion of Impella through a 16 Fr sheath significantly reduced the risk of major bleeding at the access site in comparison to the conventional sheath.</p>","PeriodicalId":12940,"journal":{"name":"Heart and Vessels","volume":" ","pages":"736-743"},"PeriodicalIF":1.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart and VesselsPub Date : 2025-08-01Epub Date: 2025-01-23DOI: 10.1007/s00380-025-02517-7
Naoya Kataoka, Teruhiko Imamura
{"title":"How to demonstrate feasibility and efficacy of catheter ablation for atrial fibrillation in elderly patients.","authors":"Naoya Kataoka, Teruhiko Imamura","doi":"10.1007/s00380-025-02517-7","DOIUrl":"10.1007/s00380-025-02517-7","url":null,"abstract":"","PeriodicalId":12940,"journal":{"name":"Heart and Vessels","volume":" ","pages":"755-756"},"PeriodicalIF":1.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart and VesselsPub Date : 2025-08-01Epub Date: 2025-01-03DOI: 10.1007/s00380-024-02512-4
Jinhui Zhuo, Canghao Chen, Junhua Lin, Jing Wang, Fayuan Fu
{"title":"A long-term clinical comparative study of left bundle branch pacing versus biventricular pacing in patients with heart failure and complete left bundle branch block.","authors":"Jinhui Zhuo, Canghao Chen, Junhua Lin, Jing Wang, Fayuan Fu","doi":"10.1007/s00380-024-02512-4","DOIUrl":"10.1007/s00380-024-02512-4","url":null,"abstract":"<p><p>Left bundle branch pacing (LBBP) is an emerging physiological pacing technique characterized by stable pacing parameters and a narrower QRS duration. This study aims to compare the long-term efficacy and safety of biventricular pacing (BIVP) and LBBP in patients with heart failure with reduced ejection fraction (HFrEF) and complete left bundle branch block (CLBBB). A retrospective analysis was conducted on 35 patients with chronic HFrEF accompanied by CLBBB treated at our center from April 2018 to October 2022. The patients were divided into two groups based on the surgical technique: the LBBP group and the BIVP group. Postoperative follow-up data were collected, including pacing parameters, QRS duration, echocardiographic indices (left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), left ventricular ejection fraction (LVEF), mitral and tricuspid regurgitation), NT-proBNP levels, and New York Heart Association (NYHA) classification. n addition, postoperative complications, heart failure readmission rates, and mortality rates were observed. 35 patients were recruited, 18 for LBBP and 17 for BIVP. The LBBP group demonstrated significantly lower pacing thresholds and impedance at 12 months post-surgery compared to the BIVP group (p < 0.05). The QRS duration in the LBBP group was significantly narrower than that in the BIVP group at 6, 12, and 24 months (p < 0.05). At 24 months post-surgery, LVEDD and LVESD were significantly lower in the LBBP group than those in the BIVP group (p < 0.05). No significant differences were observed between groups in response rates, tricuspid and mitral regurgitation, NYHA class, NT-proBNP levels, all-cause mortality, or heart failure rehospitalization rates (p > 0.05). LBBP may be a relatively safe and effective resynchronization therapy, serving as a complementary approach to BIVP for patients with HFrEF and CLBBB.</p>","PeriodicalId":12940,"journal":{"name":"Heart and Vessels","volume":" ","pages":"707-717"},"PeriodicalIF":1.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prognostic value of stress phase entropy for predicting major cardiac events in patients with known or suspected stable coronary artery disease.","authors":"Katsunori Fukumoto, Shunichi Yoda, Yudai Tanaka, Takumi Hatta, Yasuyuki Suzuki, Naoya Matsumoto, Yasuo Okumura","doi":"10.1007/s00380-024-02504-4","DOIUrl":"10.1007/s00380-024-02504-4","url":null,"abstract":"<p><p>There are no large-scale reports on the prediction of major cardiac events (MCEs) and risk stratification using phase entropy, a measure of left ventricular (LV) dyssynchrony, in Japanese patients with known or suspected coronary artery disease (CAD). We retrospectively investigated 5541 patients with known or suspected CAD who underwent rest <sup>201</sup>Tl and stress <sup>99m</sup>Tc-tetrofosmin electrocardiogram (ECG)-gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) and followed them for three years to confirm their prognosis. We excluded patients undergoing revascularization within 3 months before and after the SPECT and those with non-sinus rhythm. The composite endpoint was the onset of MCEs, consisting of cardiac death, non-fatal myocardial infarction (MI), and severe heart failure requiring hospitalization. Poststress phase standard deviation (SD), bandwidth, and entropy were calculated by phase analysis using Heart Risk View-F software. During follow-up, 401 patients experienced MCEs: cardiac death (n = 98), non-fatal MI (n = 76), and severe heart failure (n = 227). Multivariate analysis showed that age, diabetes, estimated glomerular filtration rate (eGFR), stress LV ejection fraction (EF), and stress phase entropy were independent predictors of MCEs. Kaplan-Meier analysis showed significant risk stratification between each group in the stress phase entropy quartile. The global chi-squared value predicting MCE onset was significantly improved in the model with summed stress score and LVEF plus entropy but was comparable in the model with added bandwidth or phase SD. Stress phase entropy was a strong predictor of MCEs in Japanese patients with CAD (known or suspected) and was considered the most useful left ventricular dyssynchrony index to improve risk stratification over prediction by perfusion and LVEF assessment alone.</p>","PeriodicalId":12940,"journal":{"name":"Heart and Vessels","volume":" ","pages":"677-687"},"PeriodicalIF":1.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Response to letter to the editor regarding \"HELT-E<sub>2</sub>S<sub>2</sub> score is a promising marker for predicting left atrial appendage dysfunction in patients with ischemic stroke\".","authors":"Naoto Hashimoto, Tetsu Watanabe, Atsushi Iizuka, Tomoki Kobayashi, Shunsuke Edamura, Takayuki Sugai, Masahiro Wanezaki, Harutoshi Tamura, Satoshi Nishiyama, Masafumi Watanabe","doi":"10.1007/s00380-025-02591-x","DOIUrl":"https://doi.org/10.1007/s00380-025-02591-x","url":null,"abstract":"","PeriodicalId":12940,"journal":{"name":"Heart and Vessels","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Response: Association of aerobic exercise habits with higher albumin-globulin ratio and lower cellular immune-inflammatory markers: implication of the preventive effect of aerobic exercise on atherosclerotic cardiovascular disease.","authors":"Shigemasa Tani, Kazuhiro Imatake, Yasuyuki Suzuki, Tsukasa Yagi, Atsuhiko Takahashi","doi":"10.1007/s00380-025-02586-8","DOIUrl":"https://doi.org/10.1007/s00380-025-02586-8","url":null,"abstract":"","PeriodicalId":12940,"journal":{"name":"Heart and Vessels","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}