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Haematology and blood transfusion最新文献

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Antigen receptor rearrangement and expression in acute leukemias. 急性白血病抗原受体重排及表达。
Haematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_8
M Volkmann, P Mar, K Pachmann, E Thiel, B Emmerich
{"title":"Antigen receptor rearrangement and expression in acute leukemias.","authors":"M Volkmann,&nbsp;P Mar,&nbsp;K Pachmann,&nbsp;E Thiel,&nbsp;B Emmerich","doi":"10.1007/978-3-642-74643-7_8","DOIUrl":"https://doi.org/10.1007/978-3-642-74643-7_8","url":null,"abstract":"<p><p>Twenty-two leukemias, 11 of which were undifferentiated with respect to surface antigen markers, were investigated for their antigen receptor gene rearrangement, transcription products of these antigen receptor genes, and surface antigen pattern of the cells. Among the three less-differentiated groups rearrangement was observed in 2/10 cases for the TCR beta-chain and in 4/11 cases for the heavy-chain gene. TCR beta-mRNA, however, was expressed in seven out of eight cases and the mu heavy-chain mRNA in eight out of ten cases investigated. Also mRNA of TCR alpha, the rearrangement of which could not be detected with our probes, was expressed as frequently as TCR beta. Although rearrangement of the appropriate gene was found regularly in the more mature leukemias, transcription of these genes was lower or even lacking. These findings indicate that expression of antigen receptor mRNA in undifferentiated leukemias can be activated by events other than maturational rearrangement.</p>","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"50-5"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13311093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Predictive models for achievement of complete remission and duration of first remission in adult acute myeloid leukemia. 成人急性髓性白血病实现完全缓解和首次缓解持续时间的预测模型。
Haematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_51
A Heinecke, M C Sauerland, T Büchner
{"title":"Predictive models for achievement of complete remission and duration of first remission in adult acute myeloid leukemia.","authors":"A Heinecke,&nbsp;M C Sauerland,&nbsp;T Büchner","doi":"10.1007/978-3-642-74643-7_51","DOIUrl":"https://doi.org/10.1007/978-3-642-74643-7_51","url":null,"abstract":"<p><p>Achievement of CR. Using the data of 501 patients treated identically with the TAD9 regimen we could not find any factor of predictive value besides age and state of health. The effect of FAB-M seems to be spurious as it disappeared using prospective data. Duration of Relapse-Free Survival. In patients with monthly maintenance, the maintenance overrides the possible effects of the considered factors. In patients without monthly maintenance we only found a slight effect of WBC.</p>","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"285-9"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13334707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Clonal analysis of human leukemias by molecular genetic approaches. 用分子遗传学方法分析人白血病克隆。
Haematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_3
C R Bartram, J W Janssen
{"title":"Clonal analysis of human leukemias by molecular genetic approaches.","authors":"C R Bartram,&nbsp;J W Janssen","doi":"10.1007/978-3-642-74643-7_3","DOIUrl":"https://doi.org/10.1007/978-3-642-74643-7_3","url":null,"abstract":"","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"17-22"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13335433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Karyotype of leukemia cells consistently predicts for response to therapy and survival following salvage therapy in acute myeloblastic leukemia. 白血病细胞的核型一致地预测对治疗的反应和挽救治疗后的生存在急性髓母细胞白血病。
Haematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_109
M J Keating, H Kantarjian, E Estey, W Plunkett, J Trujillo, K B McCredie
{"title":"Karyotype of leukemia cells consistently predicts for response to therapy and survival following salvage therapy in acute myeloblastic leukemia.","authors":"M J Keating,&nbsp;H Kantarjian,&nbsp;E Estey,&nbsp;W Plunkett,&nbsp;J Trujillo,&nbsp;K B McCredie","doi":"10.1007/978-3-642-74643-7_109","DOIUrl":"https://doi.org/10.1007/978-3-642-74643-7_109","url":null,"abstract":"","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"593-603"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13335240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Autologous bone marrow transplantation in acute myeloid leukemia in first remission: first Dutch prospective study. 自体骨髓移植治疗急性髓系白血病首次缓解:荷兰首次前瞻性研究。
Haematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_119
B Löwenberg, W L van Putten, L F Verdonck, A W Dekker, G C de Gast, R Willemze, F E Zwaan, J Abels, P Sonneveld, J van der Lelie
{"title":"Autologous bone marrow transplantation in acute myeloid leukemia in first remission: first Dutch prospective study.","authors":"B Löwenberg,&nbsp;W L van Putten,&nbsp;L F Verdonck,&nbsp;A W Dekker,&nbsp;G C de Gast,&nbsp;R Willemze,&nbsp;F E Zwaan,&nbsp;J Abels,&nbsp;P Sonneveld,&nbsp;J van der Lelie","doi":"10.1007/978-3-642-74643-7_119","DOIUrl":"https://doi.org/10.1007/978-3-642-74643-7_119","url":null,"abstract":"<p><p>We have prospectively compared the values of autologous BMT (auto-BMT) and allogeneic marrow transplantation (allo-BMT) in patients (age 15-60 years) with acute myeloid leukemia (AML) who attained complete remission (CR) following remission-induction therapy. In 90/117 cases CR was reached. In 32 of those complete responders auto-BMT was undertaken and in 21 eligible cases HLA-matched allo-BMT. AML relapse was the predominant cause of failure after auto-BMT (17/32). The incidence of relapse after allo-BMT was 6/21. Patients treated with auto-BMT and allo-BMT have an overall survival of 37% and 66% at 3 years posttransplant (P = 0.05). Survival of the nongrafted complete responders is less than 10%. Allo-BMT in adult patients with AML in first complete remission provides a superior outcome when directly compared with the results of auto-BMT.</p>","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"655-60"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13335247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Autologous bone marrow transplantation for acute leukemia in remission: an analysis of 1322 cases. 自体骨髓移植治疗急性白血病1322例疗效分析。
Haematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_120
N C Gorin, P Aegerter, B Auvert
{"title":"Autologous bone marrow transplantation for acute leukemia in remission: an analysis of 1322 cases.","authors":"N C Gorin,&nbsp;P Aegerter,&nbsp;B Auvert","doi":"10.1007/978-3-642-74643-7_120","DOIUrl":"https://doi.org/10.1007/978-3-642-74643-7_120","url":null,"abstract":"","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"660-6"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13335248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 50
Results and significance of six randomized trials in four consecutive ALL-BFM studies. 四项连续ALL-BFM研究中六项随机试验的结果和意义。
Haematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_81
H Riehm, H Gadner, G Henze, B Kornhuber, F Lampert, D Niethammer, A Reiter, G Schellong
{"title":"Results and significance of six randomized trials in four consecutive ALL-BFM studies.","authors":"H Riehm,&nbsp;H Gadner,&nbsp;G Henze,&nbsp;B Kornhuber,&nbsp;F Lampert,&nbsp;D Niethammer,&nbsp;A Reiter,&nbsp;G Schellong","doi":"10.1007/978-3-642-74643-7_81","DOIUrl":"https://doi.org/10.1007/978-3-642-74643-7_81","url":null,"abstract":"","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"439-50"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/978-3-642-74643-7_81","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13335930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 220
Treatment of acute lymphoblastic leukemia: protocol Fralle 83-85. 急性淋巴细胞白血病的治疗:方案Fralle 83-85。
Haematology and blood transfusion Pub Date : 1990-01-01
G Schaison, D Olive, G Leverger, J P Vannier, L de Lumley, A Bancillon, G Cornu
{"title":"Treatment of acute lymphoblastic leukemia: protocol Fralle 83-85.","authors":"G Schaison,&nbsp;D Olive,&nbsp;G Leverger,&nbsp;J P Vannier,&nbsp;L de Lumley,&nbsp;A Bancillon,&nbsp;G Cornu","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"467-72"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13335933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of early intensive reinduction therapy on event-free survival in children with low-risk acute lymphoblastic leukemia. 早期强化再诱导治疗对低风险急性淋巴细胞白血病儿童无事件生存的影响。
Haematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_87
G Henze, R Fengler, A Reiter, J Ritter, H Riehm
{"title":"Impact of early intensive reinduction therapy on event-free survival in children with low-risk acute lymphoblastic leukemia.","authors":"G Henze,&nbsp;R Fengler,&nbsp;A Reiter,&nbsp;J Ritter,&nbsp;H Riehm","doi":"10.1007/978-3-642-74643-7_87","DOIUrl":"https://doi.org/10.1007/978-3-642-74643-7_87","url":null,"abstract":"","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"483-8"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13335936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 33
Risk of CNS relapse after systemic relapse of childhood acute lymphoblastic leukemia. 儿童急性淋巴细胞白血病全身复发后中枢神经系统复发的风险。
Haematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_92
R Fengler, R Hartmann, U Bode, G Janka, H Jürgens, H Riehm, G Henze
{"title":"Risk of CNS relapse after systemic relapse of childhood acute lymphoblastic leukemia.","authors":"R Fengler,&nbsp;R Hartmann,&nbsp;U Bode,&nbsp;G Janka,&nbsp;H Jürgens,&nbsp;H Riehm,&nbsp;G Henze","doi":"10.1007/978-3-642-74643-7_92","DOIUrl":"https://doi.org/10.1007/978-3-642-74643-7_92","url":null,"abstract":"","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"511-5"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13335940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
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