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Cellular pharmacokinetics of daunomycin in human leukemic blasts in vitro and in vivo. 道诺霉素在人白血病细胞体内体外药动学研究。
Haematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_22
M E Scheulen, B Kramer, M Skorzec, W K Reich
{"title":"Cellular pharmacokinetics of daunomycin in human leukemic blasts in vitro and in vivo.","authors":"M E Scheulen, B Kramer, M Skorzec, W K Reich","doi":"10.1007/978-3-642-74643-7_22","DOIUrl":"https://doi.org/10.1007/978-3-642-74643-7_22","url":null,"abstract":"","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"122-8"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13473069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Pretherapeutic drug testing in acute leukemias for prediction of individual prognosis. 急性白血病治疗前药物试验预测个体预后。
Haematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_53
B Lathan, M von Tettau, K Verpoort, V Diehl
{"title":"Pretherapeutic drug testing in acute leukemias for prediction of individual prognosis.","authors":"B Lathan, M von Tettau, K Verpoort, V Diehl","doi":"10.1007/978-3-642-74643-7_53","DOIUrl":"https://doi.org/10.1007/978-3-642-74643-7_53","url":null,"abstract":"","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"295-8"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12855812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
Consolidation therapy with high-dose cytosine arabinoside: experiences of a prospective study in acute myeloid leukemia. 大剂量阿拉伯糖胞嘧啶巩固治疗:急性髓系白血病的前瞻性研究经验。
Haematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_46
E Kurrle, G Ehninger, E Fackler-Schwalbe, M Freund, G Heil, D Hoelzer, H Link, B Löffler, A Lösch, P S Mitrou
{"title":"Consolidation therapy with high-dose cytosine arabinoside: experiences of a prospective study in acute myeloid leukemia.","authors":"E Kurrle, G Ehninger, E Fackler-Schwalbe, M Freund, G Heil, D Hoelzer, H Link, B Löffler, A Lösch, P S Mitrou","doi":"10.1007/978-3-642-74643-7_46","DOIUrl":"https://doi.org/10.1007/978-3-642-74643-7_46","url":null,"abstract":"","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"254-60"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13334703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Intensive induction therapy with behenoyl, cytosine arabinoside, daunorubicin, and 6-mercaptopurine followed by intensive consolidation with mitoxantrone, etoposide, vincristine, and intermediate-dose continuous cytarabine (M-85 protocol) for adult acute myelogenous leukemia. 成人急性髓性白血病的强化诱导治疗包括:behenoyl、胞嘧啶arabinoside、柔红霉素和6-巯基嘌呤，随后强化巩固治疗米托蒽醌、依托泊苷、长春新碱和中剂量连续阿糖胞苷(M-85方案)。
Haematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_55
R Ohno, S Yokomaku, M Okumara, M Tanimoto, Y Morishita, Y Morishima, Y Kodera, H Saito
{"title":"Intensive induction therapy with behenoyl, cytosine arabinoside, daunorubicin, and 6-mercaptopurine followed by intensive consolidation with mitoxantrone, etoposide, vincristine, and intermediate-dose continuous cytarabine (M-85 protocol) for adult acute myelogenous leukemia.","authors":"R Ohno, S Yokomaku, M Okumara, M Tanimoto, Y Morishita, Y Morishima, Y Kodera, H Saito","doi":"10.1007/978-3-642-74643-7_55","DOIUrl":"https://doi.org/10.1007/978-3-642-74643-7_55","url":null,"abstract":"","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"304-8"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13334709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitoxantrone, cytosine arabinoside, and VP-16 in 36 patients with relapsed and refractory acute myeloid leukemia. 米托蒽醌、阿糖胞嘧啶和VP-16在36例复发和难治性急性髓性白血病中的应用。
Haematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_60
H Link, M Freund, H Diedrich, H Wilke, J Austein, M Henke, H Wandt, E Fackler-Schwalbe, G Schlimok, R Hoffmann
{"title":"Mitoxantrone, cytosine arabinoside, and VP-16 in 36 patients with relapsed and refractory acute myeloid leukemia.","authors":"H Link,&nbsp;M Freund,&nbsp;H Diedrich,&nbsp;H Wilke,&nbsp;J Austein,&nbsp;M Henke,&nbsp;H Wandt,&nbsp;E Fackler-Schwalbe,&nbsp;G Schlimok,&nbsp;R Hoffmann","doi":"10.1007/978-3-642-74643-7_60","DOIUrl":"https://doi.org/10.1007/978-3-642-74643-7_60","url":null,"abstract":"<p><p>Mitoxantrone in combination with VP-16 proved to be effective in refractory and relapsed acute myeloid leukemia (AML), with 42% of patients achieving complete remission (CR). The aim of this study was to assess whether the addition of cytosine arabinoside increased the response rate at a tolerable toxicity. The regimen consisted of mitoxantrone (M) 10 mg/m2 i.v. days 4-8, cytosine arabinoside (A) 100 mg/m2 continuous infusion days 1-8, and etoposide (VP-16) (V) 100-120 mg/m2 i.v. days 4-8 (MAV protocol) for relapsed and refractory AML. Thirty-six patients were treated, with a median age of 51 (20-73) years. For induction therapy one to two MAV cycles and for consolidation therapy two courses were scheduled. Twenty-one (58.3%) patients attained a complete remission (CR), with a median duration of 4.5 (1-12+) months. The median survival of all patients was 5.5 (0.5-15.5+) months. Four patients died in CR from chronic infections or after consolidation therapy with MAV. In evaluable patients, times to greater than 500 granulocytes/microliters and greater than 25,000 platelets/microliters were 23 (7-46) and 23 (6-44) days, respectively. In 54 evaluable MAV courses the following toxicity was observed (WHO grades 3/4): 26%, nausea and vomiting: 9%, hemorrhage; 6%, bilirubinemia; 11%, diarrhea; 22%, mucositis; 6%, local infection; 20%, septicemia; 13%, fever of unknown origin; 2%, cardiac arrhythmia; 7%, congestive heart failure. We conclude that MAV therapy is a highly active antileukemic combination with acceptable toxicity, which is recommended for further clinical trials in untreated AML.</p>","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"322-5"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13334711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
Acute megakaryoblastic leukemia: a case report. 急性巨核细胞白血病1例。
Haematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_69
R Donhuijsen-Ant, C Schadeck-Gressel, U Schmidt, H Löffler, M Westerhausen, L D Leder
{"title":"Acute megakaryoblastic leukemia: a case report.","authors":"R Donhuijsen-Ant,&nbsp;C Schadeck-Gressel,&nbsp;U Schmidt,&nbsp;H Löffler,&nbsp;M Westerhausen,&nbsp;L D Leder","doi":"10.1007/978-3-642-74643-7_69","DOIUrl":"https://doi.org/10.1007/978-3-642-74643-7_69","url":null,"abstract":"<p><p>We present a case of acute megakaryoblastic leukemia identified by electron microscopy and platelet-specific antibodies. The histological examination of bone marrow showed distinct myelofibrosis. In accordance with recent communications, low-dose cytosine arabinoside treatment (20 mg twice daily s.c. over 21 days) was initiated. The subsequent bone marrow examination showed a severe hypoplasia with persistent blasts. Amsacrine and VP-16 were given without success. Finally the patient died of septicemia without proof of pathogen uninfluenced by antibiotic and antiseptic therapy 6 weeks after diagnosis. Our case report confirms the poor prognosis of acute megakaryoblastic leukemia.</p>","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"362-7"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/978-3-642-74643-7_69","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13334714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Double intensive consolidation chemotherapy (ICC) for acute myeloid leukemia. 双强化巩固化疗(ICC)治疗急性髓系白血病。
Haematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_54
J L Harousseau, N Milpied, J Briere, B Desablens, P Y Le Prise, N Ifrah, C Gandhour, P Casassus
{"title":"Double intensive consolidation chemotherapy (ICC) for acute myeloid leukemia.","authors":"J L Harousseau,&nbsp;N Milpied,&nbsp;J Briere,&nbsp;B Desablens,&nbsp;P Y Le Prise,&nbsp;N Ifrah,&nbsp;C Gandhour,&nbsp;P Casassus","doi":"10.1007/978-3-642-74643-7_54","DOIUrl":"https://doi.org/10.1007/978-3-642-74643-7_54","url":null,"abstract":"","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"299-303"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13472977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Thrombin generation in acute myeloblastic leukemia. 急性髓母细胞白血病凝血酶的产生。
Haematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_68
R E Scharf, U Stoffels, W Schneider
{"title":"Thrombin generation in acute myeloblastic leukemia.","authors":"R E Scharf,&nbsp;U Stoffels,&nbsp;W Schneider","doi":"10.1007/978-3-642-74643-7_68","DOIUrl":"https://doi.org/10.1007/978-3-642-74643-7_68","url":null,"abstract":"","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"357-61"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13472986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemotherapy of acute myeloid leukemia of 35- to 60-year-old patients. 35 ~ 60岁急性髓性白血病患者的化疗。
Haematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_74
J Fleischer, U Reinhardt, H Wolf, W Helbig, G Anger, I Grau, G Schott, H Konrad, C Klinkenstein, J Steglich
{"title":"Chemotherapy of acute myeloid leukemia of 35- to 60-year-old patients.","authors":"J Fleischer,&nbsp;U Reinhardt,&nbsp;H Wolf,&nbsp;W Helbig,&nbsp;G Anger,&nbsp;I Grau,&nbsp;G Schott,&nbsp;H Konrad,&nbsp;C Klinkenstein,&nbsp;J Steglich","doi":"10.1007/978-3-642-74643-7_74","DOIUrl":"https://doi.org/10.1007/978-3-642-74643-7_74","url":null,"abstract":"","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"392-4"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13472992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute leukemias II. Prognostic factors and treatment strategies. 急性白血病II。预后因素和治疗策略。
Haematology and blood transfusion Pub Date : 1990-01-01
{"title":"Acute leukemias II. Prognostic factors and treatment strategies.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"1-769"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13473066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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