Haematology and blood transfusion最新文献_第9页

Mafosfamide induces less sister chromatid exchange in Ph-positive cells than in normal bone marrow. 与正常骨髓细胞相比，嗜碱性阳性细胞中磷素诱导的姐妹染色单体交换较少。

Haematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_24

R Becher, G Becker, C G Schmidt

{"title":"Mafosfamide induces less sister chromatid exchange in Ph-positive cells than in normal bone marrow.","authors":"R Becher, G Becker, C G Schmidt","doi":"10.1007/978-3-642-74643-7_24","DOIUrl":"https://doi.org/10.1007/978-3-642-74643-7_24","url":null,"abstract":"The frequency of induced sister chromatid exchange (SCE) is a sensitive tool for the monitoring of DNA damage and has been shown to indicate chemotherapy resistance. Mafosfamide is presently used for the purging of bone marrow in autologous bone marrow transplantation in the treatment of acute leukemia. We studied the SCE-inducing effect of mafosfamide on leukemic cells of Philadelphia (Ph)-positive chronic myeloid leukemia (CML) as a model for leukemic cells. Corresponding data from normal bone marrow were analyzed for comparison. A positive linear correlation (r = 0.99, P = 0.0005) was found between the dose of mafosfamide and induced SCE in Ph-positive CML and normal bone marrow. The concentration of mafosfamide used was 0.1, 0.2, 0.4, and 0.8 micrograms/ml. Additionally, we analyzed five cases of CML and six cases of normal bone marrow. A significant difference in the frequency of induced SCE/metaphase was found between CML and normal bone marrow even after addition of 0.8 micrograms/ml mafosfamide. Also, spontaneous SCE was significantly lower in CML. Our data indicate a lower sensitivity of the leukemic cells to mafosfamide as shown by the induction of a lower frequency of SCE events.","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"133-6"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13473071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of granulocyte-macrophage colony-stimulating factor on neutropenia and related morbidity induced by myelotoxic chemotherapy. 粒细胞-巨噬细胞集落刺激因子对骨髓毒性化疗所致中性粒细胞减少及相关发病率的影响。

Haematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_132

F Herrmann, G Schulz, M Wieser, K Kolbe, U Nicolay, M Noack, A Lindemann, R Mertelsmann

{"title":"Effect of granulocyte-macrophage colony-stimulating factor on neutropenia and related morbidity induced by myelotoxic chemotherapy.","authors":"F Herrmann, G Schulz, M Wieser, K Kolbe, U Nicolay, M Noack, A Lindemann, R Mertelsmann","doi":"10.1007/978-3-642-74643-7_132","DOIUrl":"https://doi.org/10.1007/978-3-642-74643-7_132","url":null,"abstract":"A phase Ib/II clinical study was undertaken to assess the efficacy of recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) to attenuate neutropenia and associated morbidity caused by high-dose anticancer chemotherapy administered in the presence or absence of autologous bone marrow support. We treated 22 patients with various solid tumors and lymphoid neoplasias with a single daily subcutaneous dose of GM-CSF (250 micrograms/m2) 48 h after a second cycle of highly myelotoxic chemotherapy for a period of 10 days and compared intraindividually neutropenia-related clinical and laboratory variables with data obtained from the same patients having previously received a first neutropenia-inducing cycle of identical chemotherapy in the absence of GM-CSF. We show that GM-CSF is active in neutropenic patients by significantly increasing the neutrophil nadir, reducing the time of relevant neutropenia, and reducing the duration of the patient's hospital stay and necessity for parenteral antibiotics. No significant toxicity was encountered with subcutaneous GM-CSF treatment.","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"717-23"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13335095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27

Regeneration of granulopoiesis with recombinant human granulocyte-macrophage colony-stimulating factor after bone marrow transplantation. 重组人粒细胞-巨噬细胞集落刺激因子对骨髓移植后粒细胞再生的影响。

Haematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_136

H Link, J Seidel, M Stoll, H Kirchner, C Linderkamp, M Freund, P Bucsky, K Welte, H Riehm, S Burdach

引用次数: 7

Prospective study on the influence of disease or treatment on pituitary function in 31 children with acute leukemia and non-Hodgkin's lymphoma. 疾病及治疗对31例急性白血病及非霍奇金淋巴瘤患儿垂体功能影响的前瞻性研究。

Haematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_104

U Mittler, K Mohnike, U Kluba, G Kröning, W Kapitza, V Aumann, R Röppnack

引用次数: 2

Complications of bone marrow transplantation in Chinese. 中国人骨髓移植的并发症。

Haematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_131

P M Chen, S Fan, C J Liu, R K Hsieh, J H Liu, M W Chuang, R S Liu, C H Tzeng

{"title":"Complications of bone marrow transplantation in Chinese.","authors":"P M Chen, S Fan, C J Liu, R K Hsieh, J H Liu, M W Chuang, R S Liu, C H Tzeng","doi":"10.1007/978-3-642-74643-7_131","DOIUrl":"https://doi.org/10.1007/978-3-642-74643-7_131","url":null,"abstract":"Forty-three patients with hematopoietic disease were treated with intensive chemotherapy and radiotherapy, followed by allogeneic bone marrow transplantation (BMT) from 28 HLA-identical and 10 one to two antigen haploidentical sibling donors and autologous BMT (5 cases). Of these cases, there were 21 with acute nonlymphocytic leukemia (ANLL), 5 with acute lymphocytic leukemia (ALL), 6 with chronic myelocytic leukemia (CML), 2 with Hodgkin's disease (HD), 8 with severe-form aplastic anemia (SAA) and 1 with thalassemia. Complications of BMT were evaluated including acute graft-versus-host disease (GVHD), interstitial pneumonia (IP), veno-occlusive liver disease (VOD), abnormalities of liver function (LF), and alteration of hepatitis B virus (HBV) markers. In thirty-three patients who were followed up for more than 3 months, we found that the incidence of moderate to severe acute GVHD (9.1%) and IP (two cases, 4.7%) were low. No VOD occurred in our series. During the follow-up period, 27 out of 35 patients (77%) had high alanine aminotransferase (ALT)/aspartate aminotransferase (AST) levels, even up to 1000 U/liter; however, only one patient succumbed to a hepatitis-related complication. Previous hepatic damage from HBV infection before BMT does not appear to increase the risk of posttransplant morbidity and mortality.","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"712-4"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13475523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Remission induction and postremission therapy in acute myelogenous leukemia: British MRC Study. 急性骨髓性白血病的缓解诱导和缓解后治疗:英国MRC研究。

Haematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_44

J K Rees, R G Gray

引用次数: 10

Osteoporosis in children with leukemia: a potentially debilitating anomaly? 白血病儿童骨质疏松症:一种潜在的衰弱异常?

Haematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_106

J A Leeuw, D A Piers, W A Kamps

引用次数: 0

Mitoxantrone in the treatment of acute leukemia. 米托蒽醌治疗急性白血病。

Haematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_59

M A Coccia-Portugal, G Falkson, A Uys

引用次数: 3

Treatment of recurrent acute myelogenous leukaemia at a single centre over a 10-year period. 治疗复发性急性髓性白血病在一个中心超过10年期间。

Haematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_64

C L Davis, A Z Rohatiner, J Amess, J Lim, T A Lister

引用次数: 1

Oral idarubicin in elderly acute leukemia and refractory anemia with excess of blasts. 口服伊达柔比星治疗老年急性白血病和伴原细胞过多的难治性贫血。

Haematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_65

A Berrebi, A Polliack

引用次数: 7