Haematology and blood transfusion最新文献_第3页

Combination therapy with mitoxantrone and etoposide in adult acute myelogenous leukemia. 米托蒽醌与依托泊苷联合治疗成人急性髓性白血病。

Haematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_57

W U Knauf, A D Ho, M Körbling, W Hunstein

引用次数: 1

Bone marrow transplantation from histocompatible sibling donors for patients with acute lymphoblastic leukemia. 急性淋巴细胞白血病患者的组织相容性兄弟姐妹骨髓移植。

Haematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_115

K G Blume, G M Schmidt, N J Chao, S J Forman

引用次数: 10

Comparison of allogeneic and autologous bone marrow transplantation for treatment of acute lymphocytic leukemia in childhood. 同种异体与自体骨髓移植治疗儿童急性淋巴细胞白血病的比较。

Haematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_126

F Zintl, J Hermann, D Fuchs, J Prager, B Reiners, A Müller, D Kob, I Goetz, G Metzner

引用次数: 4

Double marker analysis for terminal deoxynucleotidyl transferase and myeloid antigens in acute nonlymphocytic leukemia patients and healthy subjects. 急性非淋巴细胞白血病患者和健康人群中末端脱氧核苷酸转移酶和髓系抗原的双标记分析。

Haematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_7

H J Adriaansen, H Hooijkaas, M C Kappers-Klunne, K Hählen, M B van't Veer, J J van Dongen

引用次数: 14

Fibronectin in stomatitis therapy of leukemic children. 纤连蛋白在白血病儿童口炎治疗中的应用。

Haematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_108

M Matysiak, M Ochocka, M Kłos

引用次数: 0

Bone marrow transplantation with a fixed low number of T-cells in the graft. 骨髓移植在移植物中固定少量的t细胞。

Haematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_129

L F Verdonck, G C de Gast, H G van Heugten, A W Dekker

引用次数: 0

Magnetic resonance imaging follow-up in patients with acute leukemia during induction chemotherapy. 急性白血病诱导化疗期间的磁共振成像随访。

Haematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_67

C Kusnierz-Glaz, M Reiser, B Hagemeister, T Büchner, W Hiddemann, J van de Loo

引用次数: 3

Synergistic cytotoxicity of cytosine arabinoside and mitoxantrone for K562 and CFU-GM. 阿糖胞嘧啶和米托蒽醌对K562和CFU-GM的协同细胞毒性。

Haematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_23

C Krehmeier, M Zühlsdorf, T Büchner, W Hiddemann

{"title":"Synergistic cytotoxicity of cytosine arabinoside and mitoxantrone for K562 and CFU-GM.","authors":"C Krehmeier, M Zühlsdorf, T Büchner, W Hiddemann","doi":"10.1007/978-3-642-74643-7_23","DOIUrl":"https://doi.org/10.1007/978-3-642-74643-7_23","url":null,"abstract":"<p><p>High-dose cytosine arabinoside (Ara-C) plus mitoxantrone (MX) have proved to be effective in the treatment of refractory acute leukemia. The optimal sequence of drug administration was tested in a clonogenic assay with the leukemic myeloid cell line K562, and with CFU-GM of normal human bone marrow. The exposure times were 24 h for Ara-C and 1 h for MX with 1 h delay between incubations. Either order of the drugs and a wide range of drug concentrations were tested. Cytotoxicity was quantified by the survival fraction (fs) of colonies scored on day 7 (K562) or day 14 (CFU-GM). Drug synergism was evaluated by a cooperative index (CI). CI less than 1 indicates synergism, CI = 1 summation, and CI greater than 1 antagonism of the cytotoxic drugs. In K562 the sequence Ara-C much greater than MX was significantly more toxic (3.68 logs cell kill, CI = 0.02) than MX much greater than Ara-C (2.64 logs kill, CI = 0.31). The highest synergism was found by adding MX during the last hour of a 24 h Ara-C exposure. For CFU-GM, Ara-C much greater than MX showed higher synergistic toxicity (2.24 log cell kill, CI = 0.23) than MX much greater than Ara-C (1.44 logs, CI = 1.11). The clinical high dose Ara-C/MX protocol was transformed into an in vitro model and tested on K562. The highest synergism was found after the sequence of 3 h Ara-C followed by 0.5 h MX after 8.5 h delay (1.73 logs kill, whole sequence 2.01 logs kill), thus supporting the clinically applied sequence.</p>","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"129-32"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13473070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Antigen receptor rearrangement and expression in acute leukemias. 急性白血病抗原受体重排及表达。

Haematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_8

M Volkmann, P Mar, K Pachmann, E Thiel, B Emmerich

引用次数: 1

Predictive models for achievement of complete remission and duration of first remission in adult acute myeloid leukemia. 成人急性髓性白血病实现完全缓解和首次缓解持续时间的预测模型。

Haematology and blood transfusion Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_51

A Heinecke, M C Sauerland, T Büchner

引用次数: 3