Harvard Review of Psychiatry最新文献

{"title":"The Long-Term Outcomes of Prepubertal Depression and Internalizing Problems: A Scoping Review.","authors":"Adam Sands, Milenna T van Dijk, Eyal Abraham, Tenzin Yangchen, Ardesheer Talati, Myrna M Weissman","doi":"10.1097/HRP.0000000000000337","DOIUrl":"10.1097/HRP.0000000000000337","url":null,"abstract":"<p><strong>Learning objectives: </strong>After participating in this activity, learners should be better able to:• Discuss whether prepubertal depression shows longitudinal continuity with depression in adulthood.• Summarize existing literature on adult emotional and functional outcomes of prepubertal depression and internalizing problems.</p><p><strong>Background: </strong>Adolescent- and young adult-onset depression are common, recurrent, and can cause significant distress and psychosocial impairment across the life span, but recognition of prepubertal internalizing problems and depression, along with their prevalence, clinical course, and long-term outcomes, remains elusive.</p><p><strong>Objective: </strong>To examine whether prepubertal depression, which can manifest differently from adult depression, shows longitudinal continuity with depression in adulthood, and to summarize existing literature on adult emotional and functional outcomes of prepubertal depression and internalizing problems.</p><p><strong>Methods: </strong>A scoping review was conducted for peer-reviewed cohort articles published between 2000 and 2020 using PubMed and PsycINFO. From 4309 identified references, 17 articles were included.</p><p><strong>Results: </strong>Prepubertal depression confers increased risk of recurrence of depression in adulthood, with similar findings for prepubertal internalizing problems. No studies found prepubertal depression or internalizing problems predicting adult substance abuse, and no studies asked about adult bipolar diagnoses. More research is needed to draw clear conclusions regarding their implications for other psychiatric, medical, or psychosocial outcomes.</p><p><strong>Conclusion: </strong>The reviewed studies provide limited evidence that prepubertal depression onset predicts adult depression. The small evidence base and heterogeneous methodological assessments may limit, however, the ability to draw meaningful conclusions about the long-term course of prepubertal-onset depression. Well-designed studies with longer follow-up and multiple assessments in adulthood are needed to clarify and assess the potential effects of prepubertal depression on adult health and functioning. This information will eventually become available as the samples in recently initiated longitudinal cohort studies of children mature further.</p>","PeriodicalId":12915,"journal":{"name":"Harvard Review of Psychiatry","volume":"30 3","pages":"163-180"},"PeriodicalIF":2.5,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887604/pdf/nihms-1863717.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10643722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Integrated Neuroimaging Approach to Inform Transcranial Electrical Stimulation Targeting in Visual Hallucinations.","authors":"Nicolas Raymond, Robert M G Reinhart, Matcheri Keshavan, Paulo Lizano","doi":"10.1097/HRP.0000000000000336","DOIUrl":"10.1097/HRP.0000000000000336","url":null,"abstract":"<p><strong>Abstract: </strong>For decades, noninvasive brain stimulation (NIBS), such as transcranial electrical stimulation (tES), has been used to directly modulate human brain mechanisms of visual perception, setting the groundwork for the development of novel circuit-based therapies. While the field of NIBS has grown considerably over recent years, few studies have used these technologies to treat visual hallucinations (VH). Here, we review the NIBS-VH literature and find mixed results due to shortcomings that may potentially be addressed with a unique multimodal neuroimaging-NIBS approach. We highlight methodological advances in NIBS research that have provided researchers with more precise anatomical measurements that may improve our ability to influence brain activity. Specifically, we propose a methodology that combines neuroimaging advances, clinical neuroscience developments such as the identification of brain regions causally involved in VH, and personalized NIBS approaches that improve anatomical targeting. This methodology may enable us to reconcile existing discrepancies in tES-VH research and pave the way for more effective, VH-specific protocols for treating a number of neuropsychiatric disorders with VH as a core symptom.</p>","PeriodicalId":12915,"journal":{"name":"Harvard Review of Psychiatry","volume":"30 3","pages":"181-190"},"PeriodicalIF":3.8,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9179829/pdf/nihms-1791962.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10459826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment and Treatment of a Deaf Patient with Alcohol Use Disorder-Limitations and Special Considerations.","authors":"Ann Felhofer, Teresa V. Crowe, C. AhnAllen, L. Mistler, J. Suzuki","doi":"10.1097/HRP.0000000000000333","DOIUrl":"https://doi.org/10.1097/HRP.0000000000000333","url":null,"abstract":"","PeriodicalId":12915,"journal":{"name":"Harvard Review of Psychiatry","volume":"1 1","pages":""},"PeriodicalIF":3.8,"publicationDate":"2022-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43960580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Practice of Psychiatric E-Consultation: Current State and Future Directions","authors":"Thomas C E Adams, Christopher T. Lim, Hsiang Huang","doi":"10.1097/HRP.0000000000000338","DOIUrl":"https://doi.org/10.1097/HRP.0000000000000338","url":null,"abstract":"Objective This article summarizes the existing literature on psychiatric electronic consultation (e-consultation or e-consult) to provide guidance on psychiatric e-consult practice and suggest next steps in research on psychiatric e-consults. Method A narrative review was conducted using relevant search terms in PubMed and Google Scholar. Results and Discussion The psychiatric e-consult is a method of asynchronous consultation between primary care providers and psychiatric specialists that is associated with primary care provider satisfaction and promotes access to specialist guidance in mental health care. Major themes in the literature include contextual factors that affect implementation of psychiatric e-consult services, outcomes associated with psychiatric e-consults, and specific practical considerations that may affect psychiatric e-consult technique. Conclusions Psychiatric e-consults may help address the widespread lack of access to specialty psychiatric care. Further studies are needed to examine clinical outcomes based on psychiatry e-consults.","PeriodicalId":12915,"journal":{"name":"Harvard Review of Psychiatry","volume":"30 1","pages":"191 - 197"},"PeriodicalIF":3.8,"publicationDate":"2022-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46868568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Non-healing Wounds\": Addressing Complex Physical and Emotional Trauma in a Case of Factitious Disorder.","authors":"Cynthia S Peng, Amanda M. Koire, S. Eisendrath, Joshua L Abrams, M. Feldman, Carolina Jimenez-Madiedo","doi":"10.1097/HRP.0000000000000335","DOIUrl":"https://doi.org/10.1097/HRP.0000000000000335","url":null,"abstract":"","PeriodicalId":12915,"journal":{"name":"Harvard Review of Psychiatry","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46850723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suicide Prevention in Your Pocket: A Systematic Review of Ecological Momentary Interventions for the Management of Suicidal Thoughts and Behaviors","authors":"L. Jiménez-Muñoz, I. Peñuelas-Calvo, I. Díaz-Oliván, L. Gutiérrez-Rojas, E. Baca-García, A. Porras-Segovia","doi":"10.1097/HRP.0000000000000331","DOIUrl":"https://doi.org/10.1097/HRP.0000000000000331","url":null,"abstract":"Abstract Background This study reviews the evidence on ecological momentary interventions (EMIs) for managing and preventing suicidal thoughts and behaviors. Methods This review follows the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Its protocol was registered in the PROSPERO database. We conducted a systematic literature search of five databases: PubMed, EMBASE, Web of Science, PsycInfo, and Cochrane library. The most recent search date was 10 September 2021. Results After screening and full-text review, 27 studies were included, totaling 19 different interventions. Many of the available interventions have not yet been clinically tested. Those that have undergone effectiveness evaluation (10 interventions) showed good rates of effectiveness and feasibility, with some exceptions. The most widely used intervention model is the safety plan, which allows the user to implement coping and distracting strategies in case of suicidal ideation. Conclusions Ecological momentary interventions provide certain advantages, such as their wide availability, versatility, and potential for customization. These interventions can be useful complements to traditional care, especially in situations in which face-to-face care is not possible. Evidence on the effectiveness of such interventions is still scarce. Furthermore, barriers limiting implementation in clinical practice remain. The constant advance of technology means that these interventions have great potential for improvement in the coming years.","PeriodicalId":12915,"journal":{"name":"Harvard Review of Psychiatry","volume":"30 1","pages":"85 - 99"},"PeriodicalIF":3.8,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41933024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychiatric Symptoms Across the Menstrual Cycle in Adult Women: A Comprehensive Review","authors":"A. B. Handy, S. Greenfield, K. Yonkers, Laura A Payne","doi":"10.1097/HRP.0000000000000329","DOIUrl":"https://doi.org/10.1097/HRP.0000000000000329","url":null,"abstract":"Learning objective After participating in this activity, learners should be better able to: • Discuss and outline the general and overlapping effects of the menstrual cycle on women’s mental health Abstract A growing body of research demonstrates menstrual cycle–dependent fluctuations in psychiatric symptoms; these fluctuations can therefore be considered as prevalent phenomena. Possible mechanisms underlying these fluctuations posit behavioral, psychological, and neuroendocrine influences. Recent reviews document cyclic exacerbation of symptoms and explore these mechanisms in the context of specific and often single disorders. The question remains, however, as to whether there are general and overlapping effects of the menstrual cycle on women’s mental health. To address this gap, we synthesized the literature examining the exacerbation of a variety of psychiatric symptoms across the menstrual cycle in adult women. Results show that the premenstrual and menstrual phases are most consistently implicated in transdiagnostic symptom exacerbation. Specifically, strong evidence indicates increases in psychosis, mania, depression, suicide/suicide attempts, and alcohol use during these phases. Anxiety, stress, and binge eating appear to be elevated more generally throughout the luteal phase. The subjective effects of smoking and cocaine use are reduced during the luteal phase, but fewer data are available for other substances. Less consistent patterns are demonstrated for panic disorder, symptoms of posttraumatic stress disorder, and borderline personality disorder, and it is difficult to draw conclusions for symptoms of generalized anxiety disorder, social anxiety disorder, obsessive-compulsive disorder, and trichotillomania because of the limited data. Future research should focus on developing standardized approaches to identifying menstrual cycle phases and adapting pharmacological and behavioral interventions for managing fluctuations in psychiatric symptoms across the menstrual cycle.","PeriodicalId":12915,"journal":{"name":"Harvard Review of Psychiatry","volume":"30 1","pages":"100 - 117"},"PeriodicalIF":3.8,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47495422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Catatonia and Psychosis: A Multidisciplinary Approach and Perspective.","authors":"Roman Becicka,&nbsp;Mary Lou England,&nbsp;Sophie Kwass,&nbsp;Esra Guvenek-Cokol","doi":"10.1097/HRP.0000000000000317","DOIUrl":"https://doi.org/10.1097/HRP.0000000000000317","url":null,"abstract":"","PeriodicalId":12915,"journal":{"name":"Harvard Review of Psychiatry","volume":"30 2","pages":"155-161"},"PeriodicalIF":3.8,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39587420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Computations of a Traumatized Mind: A Latent Cause Model of Posttraumatic Stress Disorder.","authors":"Francesco Rigoli","doi":"10.1097/HRP.0000000000000327","DOIUrl":"https://doi.org/10.1097/HRP.0000000000000327","url":null,"abstract":"<p><strong>Abstract: </strong>In cognitive psychology, a recent perspective based on the notion of latent cause (LC) has offered new insight on how learning and memory work. Here I explore the implications of this novel perspective to understand posttraumatic stress disorder (PTSD). The proposal is that, because of a propensity to interpret events as manifestations of multiple LCs (a propensity facilitated by experiencing traumas in childhood), PTSD patients form an LC associated with the trauma and that this LC is responsible for typical symptoms of the illness (specifically, intrusive symptoms and associated fear). Later, after the trauma, some patients develop a second LC, now associated with the presence of trauma-related cues combined with absence of danger. Development of the latter LC would interfere with extinction and explain why, for some patients, exposure to trauma-related cues (even when supported by interventions such as exposure protocols) fails to provide much improvement. This proposal has potential clinical implications, raising the possibility that some patients might benefit from exposure to mildly painful aspects of the trauma in conjunction with trauma-related cues.</p>","PeriodicalId":12915,"journal":{"name":"Harvard Review of Psychiatry","volume":"30 2","pages":"146-154"},"PeriodicalIF":3.8,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39606780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ketamine in the Treatment of Obsessive-Compulsive Disorder: A Systematic Review","authors":"I. D. Bandeira, D. Lins-Silva, V. B. Cavenaghi, I. Dorea-Bandeira, D. Faria-Guimarães, J. L. Barouh, A. P. Jesus-Nunes, G. Beanes, Lucca S. Souza, G. C. Leal, G. Sanacora, E. Miguel, A. Sampaio, L. Quarantini","doi":"10.1097/HRP.0000000000000330","DOIUrl":"https://doi.org/10.1097/HRP.0000000000000330","url":null,"abstract":"Abstract Introduction First-line treatment for obsessive-compulsive disorder (OCD) includes exposure and response prevention behavioral therapy and serotonin reuptake inhibitors, particularly in combination. New and more effective treatments are needed, give that recent studies suggest that glutamatergic neurotransmission contributes to the pathophysiology of the disorder. In these circumstances, ketamine, as a potent N-methyl-D-aspartate receptor antagonist and glutamate modulator, offers alternative possibilities for OCD treatment. Methods This systematic review aims to investigate the effects of ketamine in OCD, following the Preferred Reporting Items for Systematic Review and Meta-analyses Protocols (PRISMA-P). Searches were carried out using the PubMed/MEDLINE, Embase, and PsycINFO databases. Results Nine articles were included, of which three were randomized controlled trials, three case reports, two open-label trials, and one a retrospective chart review. Reported data have shown a potential for fast onset of action and good tolerability of ketamine for OCD, even though the principal studies used only single-session racemic ketamine treatments, administered intravenously, and the results have been erratic. In addition, none of the available evidence demonstrates whether racemic ketamine, S-ketamine, or R-ketamine has the best efficacy in controlling OCD symptoms, and only sparse evidence suggests that a combination of ketamine and psychotherapy could benefit patients with OCD. Conclusion In order to advance clinical practice regarding the use of ketamine in treating OCD, future randomized, double-blind, placebo-controlled trials are required. These trials need to use larger samples to explore ketamine and its enantiomers, with different methods of administration, multiple sessions, and appropriate washout periods.","PeriodicalId":12915,"journal":{"name":"Harvard Review of Psychiatry","volume":"30 1","pages":"135 - 145"},"PeriodicalIF":3.8,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47602034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}