Harvard Review of Psychiatry最新文献

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From Alchemy to Psychiatry: A Glimpse into the Ethics and Mental Health Practices of Tenth-Century Muslim Physician Abū Bakr al-Rāzī. 从炼金术到精神病学:十世纪穆斯林医生阿布·巴克尔的伦理和心理健康实践一瞥al-Rāzī。
IF 3.8 4区 医学
Harvard Review of Psychiatry Pub Date : 2022-09-01 DOI: 10.1097/HRP.0000000000000347
Rania Awaad, Yusif Salaam Conn, Nahlah Kolkailah, Heba El-Haddad, Sara Ali, Soraya Fereydooni
{"title":"From Alchemy to Psychiatry: A Glimpse into the Ethics and Mental Health Practices of Tenth-Century Muslim Physician Abū Bakr al-Rāzī.","authors":"Rania Awaad, Yusif Salaam Conn, Nahlah Kolkailah, Heba El-Haddad, Sara Ali, Soraya Fereydooni","doi":"10.1097/HRP.0000000000000347","DOIUrl":"https://doi.org/10.1097/HRP.0000000000000347","url":null,"abstract":"TheIslamic Renaissance saw a flourishing and advancement in philosophy, the natural sciences, the humanities, and many other academic disciplines. Though this era is often confined in the historical literature as ranging from the eighth through thirteenth centuries CE, recent research has considered expanding its timeline to the nineteenth century. The early stages of this period were known for the synthesis of previous traditions that later led to the creation of a new canon of knowledge; this new canon heavily influenced those living within the Islamic empire and also those in Europe. In the early years of the Islamic Renaissance, the physician and philosopher Abū Bakr Muhammad ibn Zakarīyā al-Rāzī was a major figure whose works influenced the course of medicine. While he remains well-known to this day for his writings that later influenced the likes of Ibn Sīnā, many of his contributions to the world of psychiatry remain underappreciated. In revisiting the texts and life of al-Rāzī, what emerges is a portrait of a psychiatrist well ahead of his time and whose methodology brought tradition and innovation together as a means of providing the best care to his patients.","PeriodicalId":12915,"journal":{"name":"Harvard Review of Psychiatry","volume":"30 5","pages":"323-326"},"PeriodicalIF":3.8,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10861633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuromodulation Using Computer-Altered Music to Treat a Ten-Year-Old Child Unresponsive to Standard Interventions for Functional Neurological Disorder. 用电脑改变的音乐来治疗对功能性神经障碍标准干预无反应的10岁儿童。
IF 3.8 4区 医学
Harvard Review of Psychiatry Pub Date : 2022-09-01 Epub Date: 2022-05-26 DOI: 10.1097/HRP.0000000000000341
Nadia Rajabalee, Kasia Kozlowska, Seung Yeon Lee, Blanche Savage, Clare Hawkes, Daniella Siciliano, Stephen W Porges, Susannah Pick, Souraya Torbey
{"title":"Neuromodulation Using Computer-Altered Music to Treat a Ten-Year-Old Child Unresponsive to Standard Interventions for Functional Neurological Disorder.","authors":"Nadia Rajabalee, Kasia Kozlowska, Seung Yeon Lee, Blanche Savage, Clare Hawkes, Daniella Siciliano, Stephen W Porges, Susannah Pick, Souraya Torbey","doi":"10.1097/HRP.0000000000000341","DOIUrl":"10.1097/HRP.0000000000000341","url":null,"abstract":"CASE HISTORY Marie-Therese, known as MT by family and friends, was a ten-year-old girl in Year 5 of primary school referred to the Mind-Body Program by a pediatrician for treatment of functional somatic symptoms—unsteady gait, blurry vision, periods of confusion or appearing dazed, and persisting headache—that had been triggered in the context of a viral illness.MT livedwith her parents, a younger sister, and her grandmother. Both parents worked full time as architects. The family history included rheumatoid arthritis (mother), epilepsy (uncle), and type 2 diabetes (grandfather) on the mother’s side of the family, and colorectal cancer (grandfather) on the father’s side. MT had been diagnosed with celiac disease at age 6, which was being managed with a gluten-free diet.","PeriodicalId":12915,"journal":{"name":"Harvard Review of Psychiatry","volume":"30 5","pages":"303-316"},"PeriodicalIF":3.8,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fa/fe/hrp-30-303.PMC9470039.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10861610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Prevalence of Posttraumatic Stress Disorder Symptoms Following Traumatic Spinal Cord Injury: A Systematic Review and Meta-analysis. 外伤性脊髓损伤后创伤后应激障碍症状的患病率:系统回顾和荟萃分析。
IF 3.8 4区 医学
Harvard Review of Psychiatry Pub Date : 2022-09-01 DOI: 10.1097/HRP.0000000000000340
Mahmoud Yousefifard, Fatemeh Ramezani, Gholamreza Faridaalaee, Masoud Baikpour, Arian Madani Neishaboori, Alexander R Vaccaro, Mostafa Hosseini, Vafa Rahimi-Movaghar
{"title":"Prevalence of Posttraumatic Stress Disorder Symptoms Following Traumatic Spinal Cord Injury: A Systematic Review and Meta-analysis.","authors":"Mahmoud Yousefifard,&nbsp;Fatemeh Ramezani,&nbsp;Gholamreza Faridaalaee,&nbsp;Masoud Baikpour,&nbsp;Arian Madani Neishaboori,&nbsp;Alexander R Vaccaro,&nbsp;Mostafa Hosseini,&nbsp;Vafa Rahimi-Movaghar","doi":"10.1097/HRP.0000000000000340","DOIUrl":"https://doi.org/10.1097/HRP.0000000000000340","url":null,"abstract":"<p><strong>Background: </strong>Limited evidence is currently available on the prevalence of posttraumatic stress disorder (PTSD) following traumatic spinal cord injury (SCI). This systematic review and meta-analysis aims to assess the prevalence and geographic distribution of PTSD symptoms after SCI.</p><p><strong>Methods: </strong>After a search in the MEDLINE, Embase, Scopus, and Web of Science databases, two reviewers independently summarized relevant studies published through 20 October 2021. Observational studies were included. The studies were eligible if they assessed PTSD symptoms using standard self-report or clinician-based instruments. Data and results were reported using the overall prevalence and the odds ratio (OR), with 95% confidence intervals (CIs).</p><p><strong>Results: </strong>24 articles (5646 patients) met the inclusion criteria. The prevalence of PTSD symptoms ranged from 6.33% (95% CI, 2.73-13.97) to 61.76% (95% CI, 52.07-70.61). Pooled analysis demonstrated that the overall prevalence of PTSD symptoms in SCI patients was significantly higher in developing countries (41.64%; 95% CI, 31.11-52.55) than in developed countries (19.35%; 95% CI, 14.66-24.51) (OR = 1.24; 95% CI, 1.08-1.42; p = .003). The highest prevalence of PTSD symptoms was reported in South Africa (56.25%; 95% CI, 47.01-65.08), followed by Sri Lanka (45.71%; 95% CI, 30.47-61.81), and Greece (43.55%; 95% CI, 31.94-55.91). By contrast, Norway (6.33%; 95% CI, 2.73-13.97), Switzerland/Germany (8.65%; 95% CI, 4.8-13.42), and Denmark (10.71%; 95% CI, 6.89-16.30) were found to have the lowest prevalence of PTSD symptoms after SCI.</p><p><strong>Conclusion: </strong>Many traumatic SCI patients suffer from PTSD symptoms, and their prevalence seems to be higher in developing countries than in developed countries. These findings underscore the need to consider the psychological aspects of traumatic SCI.</p>","PeriodicalId":12915,"journal":{"name":"Harvard Review of Psychiatry","volume":"30 5","pages":"271-282"},"PeriodicalIF":3.8,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10861632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Men's Depression, Externalizing, and DSM-5-TR: Primary Signs and Symptoms or Co-occurring Symptoms? 男性抑郁症、外化与DSM-5-TR:主要体征和症状还是共同症状?
IF 3.8 4区 医学
Harvard Review of Psychiatry Pub Date : 2022-09-01 DOI: 10.1097/HRP.0000000000000346
Simon Rice, Zac Seidler, David Kealy, John Ogrodniczuk, Ian Zajac, John Oliffe
{"title":"Men's Depression, Externalizing, and DSM-5-TR: Primary Signs and Symptoms or Co-occurring Symptoms?","authors":"Simon Rice,&nbsp;Zac Seidler,&nbsp;David Kealy,&nbsp;John Ogrodniczuk,&nbsp;Ian Zajac,&nbsp;John Oliffe","doi":"10.1097/HRP.0000000000000346","DOIUrl":"https://doi.org/10.1097/HRP.0000000000000346","url":null,"abstract":"Major depressive disorder (MDD) is a highly heterogeneous diagnosis wherein the nine MDD criterion signs and symptoms reflect 256 unique symptom combinations. Accordingly, MDD comprises a broad set of phenotypes observed across clinical practice, including primary care. With intensifying global efforts to prevent male suicide, attention has rapidly focused on better understanding men’s experiences of MDD. Pertinent to these efforts is the operationalization of MDD, which is characterized by the two cardinal symptoms of depressed mood and anhedonia (the loss of interest or pleasure in all, or nearly all, activities for most of the day nearly every day). However, debate remains regarding the adequacy of this conceptualization of depression as applied to men socialized within dominant discourses of masculinity that prohibit men acknowledging or seeking help for depression.","PeriodicalId":12915,"journal":{"name":"Harvard Review of Psychiatry","volume":"30 5","pages":"317-322"},"PeriodicalIF":3.8,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10861631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Back to Basics: Lifestyle Interventions for Adolescent Depression. 回归基本:青少年抑郁症的生活方式干预。
IF 3.8 4区 医学
Harvard Review of Psychiatry Pub Date : 2022-09-01 DOI: 10.1097/HRP.0000000000000343
Talia S Benheim, Michelle Dalal, Juliana M Holcomb, Anamika Dutta, Daniel Hosker, Michael S Jellinek, J Michael Murphy
{"title":"Back to Basics: Lifestyle Interventions for Adolescent Depression.","authors":"Talia S Benheim,&nbsp;Michelle Dalal,&nbsp;Juliana M Holcomb,&nbsp;Anamika Dutta,&nbsp;Daniel Hosker,&nbsp;Michael S Jellinek,&nbsp;J Michael Murphy","doi":"10.1097/HRP.0000000000000343","DOIUrl":"https://doi.org/10.1097/HRP.0000000000000343","url":null,"abstract":"<p><strong>Learning objectives: </strong>After completing this activity, practitioners will be better able to:• Discuss and better understand the recently adopted screening standards for adolescents with depression and the potential advantages of using \"lifestyle medicine\"• Set up a process for providing effective interventions for the increased number of patients with adolescent depression• Design or update their toolbox of treatment options for adolescents with depression based on the new literature and increased demand.</p><p><strong>Abstract: </strong>Recently adopted quality standards recommend that pediatricians screen adolescents for depression and that they document follow-up plans for those who screen positive. As a result of these new recommendations, pediatricians and other pediatric providers, as well as psychiatrists and other mental health professionals, may face an increasing number of referrals and a growing need for effective interventions for adolescent depression. Given the widely acknowledged scarcity of traditional mental health resources, the current study reviewed the rapidly expanding array of evidence-based, but nontraditional, interventions applicable to outpatient pediatric and mental health care settings. Many of these interventions come from a lifestyle medicine framework. Lifestyle medicine interventions are congruent with the cultures of pediatrics and outpatient psychiatry, and offer additional evidence-based tools for providers managing adolescent depression. These interventions can be implemented individually or within group or community settings, and may be used in conjunction with more common interventions such as psychotherapy or psychotropic medications.</p>","PeriodicalId":12915,"journal":{"name":"Harvard Review of Psychiatry","volume":"30 5","pages":"283-302"},"PeriodicalIF":3.8,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10861636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Malignant Self-Regard: Overview and Future Directions. 恶性自我关注:综述与未来方向。
IF 3.8 4区 医学
Harvard Review of Psychiatry Pub Date : 2022-07-01 DOI: 10.1097/HRP.0000000000000342
Steven K Huprich, Brady C Malone
{"title":"Malignant Self-Regard: Overview and Future Directions.","authors":"Steven K Huprich,&nbsp;Brady C Malone","doi":"10.1097/HRP.0000000000000342","DOIUrl":"https://doi.org/10.1097/HRP.0000000000000342","url":null,"abstract":"<p><strong>Abstract: </strong>Malignant self-regard (MSR) is a self-representation that encompasses the shared features of depressive personality disorder, masochistic/self-defeating personality disorder, depressive-masochistic personality, and vulnerable narcissism. In this review we begin by describing the construct's historical precursors, which begin in early psychoanalytic/dynamic theory, and then trace its development across iterations of the Diagnostic and Statistical Manual of Mental Disorders. Special attention is paid to differentiating MSR from vulnerable narcissism. We then consider MSR's place within transdiagnostic, transtheoretical, and dimensional models of personality pathology. We focus heavily on MSR's impact on various personality systems (e.g., thought and affect systems) and also on overall personality functioning. The empirical research on MSR in relation to these systems is thoroughly reviewed and largely supports its psychometric properties and clinical significance. We suggest that MSR may map onto the distress subfactor in the hierarchical taxonomy of psychopathology (HiTOP) and that MSR seems to occupy the shared internalizing space across the neurotic and borderline level of personality organization in Kernberg's model of personality disorders. We also identify four major directions for future research: the possible benefits of self-defeating tendencies that involve pathological narcissism and self-esteem; MSR's relationship to overall health and well-being; depressive states and MSR severity; and how MSR fits within the Alternative Model for Personality Disorders and the personality disorder framework of the International Classification of Diseases.</p>","PeriodicalId":12915,"journal":{"name":"Harvard Review of Psychiatry","volume":"30 4","pages":"226-237"},"PeriodicalIF":3.8,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10865917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Medical Mistrust in Perinatal Mental Health. 围产期心理健康中的医疗不信任。
IF 3.8 4区 医学
Harvard Review of Psychiatry Pub Date : 2022-07-01 DOI: 10.1097/HRP.0000000000000345
Nkechi Conteh, Jane Gagliardi, Shunda McGahee, Rose Molina, Crystal T Clark, Camille A Clare
{"title":"Medical Mistrust in Perinatal Mental Health.","authors":"Nkechi Conteh,&nbsp;Jane Gagliardi,&nbsp;Shunda McGahee,&nbsp;Rose Molina,&nbsp;Crystal T Clark,&nbsp;Camille A Clare","doi":"10.1097/HRP.0000000000000345","DOIUrl":"https://doi.org/10.1097/HRP.0000000000000345","url":null,"abstract":"<p><strong>Abstract: </strong>Despite the advancement of telemedicine and recent innovations in treatment, minoritized women continue to bear a disproportionate burden of pregnancy-related psychiatric conditions and complications, which the pandemic has further exacerbated. Research demonstrates that medical mistrust and systemic racism play central roles in the underutilization of services by racially and ethnically diverse women during pregnancy and postpartum. To effectively address these disparities, it is imperative to understand the drivers of medical mistrust in perinatal health care systems. This Perspectives article describes the historical context of medical mistrust in psychiatric and obstetric health systems and offers solutions to mitigate mistrust and the impact of systemic racism on perinatal care.</p>","PeriodicalId":12915,"journal":{"name":"Harvard Review of Psychiatry","volume":"30 4","pages":"238-247"},"PeriodicalIF":3.8,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10848324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Adverse Childhood Experiences and Neurocognition in Borderline Personality Disorder: A Call-to-Action Perspective Review. 不良童年经历与边缘型人格障碍的神经认知:一项呼吁行动的观点综述。
IF 3.8 4区 医学
Harvard Review of Psychiatry Pub Date : 2022-07-01 DOI: 10.1097/HRP.0000000000000344
Clémentine Estric, Raffaella Calati, Jorge Lopez-Castroman
{"title":"Adverse Childhood Experiences and Neurocognition in Borderline Personality Disorder: A Call-to-Action Perspective Review.","authors":"Clémentine Estric,&nbsp;Raffaella Calati,&nbsp;Jorge Lopez-Castroman","doi":"10.1097/HRP.0000000000000344","DOIUrl":"https://doi.org/10.1097/HRP.0000000000000344","url":null,"abstract":"<p><strong>Abstract: </strong>Adverse childhood experiences (ACEs) contribute to the development of personality traits leading to adult borderline personality disorder (BPD). Neurocognitive changes could partly mediate the association between ACEs and BPD. We discuss how exposure to ACEs could induce alterations in neurocognition, which, in turn, would contribute to the development of BPD. We conducted a review of MEDLINE articles through 2021, documenting a link between ACEs, neurocognitive impairments, and BPD, and also focusing on the pairwise associations. ACEs appear to have a strong impact on neurocognition and are a predictive factor for BPD. Maltreated, abused, and emotionally invalidated children are more likely to present BPD traits. Neurocognitive impairments in adults exposed to ACEs and in patients with BPD arise from similar brain alterations in the amygdala, hippocampus, and prefrontal cortex. These impairments seem to be linked with clinical dimensions of BPD: increased impulsivity to altered inhibitory control; dissociative experiences to nonspecific autobiographical memory; and emotionally biased facial recognition to unstable interpersonal relationships. This perspective review highlights the contributory role of neurocognition in the association between ACEs and BPD. Additional research is needed, however, on the interconnections among ACEs, neurocognition, and BPD. Future studies could also focus on developing tools to assess early adversity in BPD specifically and on psychotherapeutic approaches to promptly remedy neurocognitive impairments.</p>","PeriodicalId":12915,"journal":{"name":"Harvard Review of Psychiatry","volume":"30 4","pages":"248-260"},"PeriodicalIF":3.8,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10848325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Catatonia and Schizophrenia in a Young Man with Autism Spectrum Disorder and Clozapine-Induced Myocarditis. 患有自闭症谱系障碍和氯氮平诱发心肌炎的年轻男性的紧张症和精神分裂症。
IF 3.8 4区 医学
Harvard Review of Psychiatry Pub Date : 2022-07-01 DOI: 10.1097/HRP.0000000000000334
Mohan Gautam, Mauran Sivananthan, Robert Cotes, Scott Beach
{"title":"Catatonia and Schizophrenia in a Young Man with Autism Spectrum Disorder and Clozapine-Induced Myocarditis.","authors":"Mohan Gautam,&nbsp;Mauran Sivananthan,&nbsp;Robert Cotes,&nbsp;Scott Beach","doi":"10.1097/HRP.0000000000000334","DOIUrl":"https://doi.org/10.1097/HRP.0000000000000334","url":null,"abstract":"","PeriodicalId":12915,"journal":{"name":"Harvard Review of Psychiatry","volume":"30 4","pages":"261-269"},"PeriodicalIF":3.8,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10848326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Menopausal Hormone Therapy and the Mind: The Role of Hormone Replacement in the Prevention and Treatment of Cognitive Decline, Dementia, and Cognitive Dysfunction of Depression. 绝经期激素治疗和心理:激素替代在预防和治疗认知衰退、痴呆和抑郁症认知功能障碍中的作用。
IF 3.8 4区 医学
Harvard Review of Psychiatry Pub Date : 2022-07-01 DOI: 10.1097/HRP.0000000000000339
Amanda Koire, Hadine Joffe, Rachel Buckley
{"title":"Menopausal Hormone Therapy and the Mind: The Role of Hormone Replacement in the Prevention and Treatment of Cognitive Decline, Dementia, and Cognitive Dysfunction of Depression.","authors":"Amanda Koire,&nbsp;Hadine Joffe,&nbsp;Rachel Buckley","doi":"10.1097/HRP.0000000000000339","DOIUrl":"https://doi.org/10.1097/HRP.0000000000000339","url":null,"abstract":"<p><strong>Learning objectives: </strong>After participating in this activity, learners should be better able to:• Outline the clinical recommendations for menopausal hormone treatment related to cognitive concerns• Debate and discuss the various research pieces on the use of menopausal hormone therapy cognitive decline, dysfunction, and dementia.</p><p><strong>Abstract: </strong>Menopause has been associated with subjective cognitive dysfunction and elevated rates of depression. While menopausal hormone therapy (MHT) is Food and Drug Administration-approved for the treatment of vasomotor symptoms related to menopause, a potential role for MHT in treating and preventing cognitive decline, dysfunction, and dementia has remained unclear and a topic of continued interest and debate across decades of research. Increasing numbers of patients are seeking help for subjective cognitive decline, and those with poorer mental health are substantially more likely to perceive themselves to be at high risk of developing dementia; thus, mental health professionals are likely to encounter such patients and may be asked to provide advice concerning MHT, cognition, and indications for MHT use. Here, we synthesize the neurobiological effects of MHT, make recommendations for its use in current clinical practice in the contexts of cognitive dysfunction associated with major depressive disorder, cognitive decline, and Alzheimer's disease, and discuss the frontiers being explored by ongoing research on this topic. We conclude that MHT to improve cognitive functioning has only a few scenarios where it would be recommended and that particular caution may be warranted for carriers of the APOE ε4 allele.</p>","PeriodicalId":12915,"journal":{"name":"Harvard Review of Psychiatry","volume":"30 4","pages":"215-225"},"PeriodicalIF":3.8,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10498864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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