Hemijska Industrija最新文献_第5页

Preparation of TGF-beta1/affinity-bound alginate macroporous scaffolds TGF-β1/亲和结合藻酸盐大孔支架的制备

IF 0.9 4区工程技术

Hemijska Industrija Pub Date : 2018-04-18 DOI: 10.2298/HEMIND171204022T

T. Re’em

{"title":"Preparation of TGF-beta1/affinity-bound alginate macroporous scaffolds","authors":"T. Re’em","doi":"10.2298/HEMIND171204022T","DOIUrl":"https://doi.org/10.2298/HEMIND171204022T","url":null,"abstract":"Spatio-temporal presentation of growth factors is one of the key attributes of the cell's microenvironment. The design of macroporous alginate scaffolds, wherein TGF-b1 or BMP-4 is electrostatically bound to affinity binding sites of alginate sulfate, mimicking their presentation by the extracellular matrix (ECM), was previously shown to enable sustained presentation and release of each factor, thus increasing their biological activity. Specifically, TGF-b1/affinity-bound scaffolds induced the chondrogenic differentiation of human mesenchymal stem cells (hMSCs) seeded within these scaffolds. The prolonged activity of the affinity-bound TGF-b1 enabled efficient induction of signaling pathways leading to chondrogenesis, up to the appearance of committed chondrocytes. Similarly, BMP-4 affinity-bound to the macroporous alginate scaffold enabled efficient induction of osteogenic differentiation in hMSC constructs. Subsequent construction of a multicompartment inductive system, spatially-presenting TGF-b1 and BMP-4 in two distinct layers, enabled complete differentiation of hMSC to chondrocytes and osteoblasts, depending on the type of factor in use in the respective layer. This paper describes in detail the preparation method of the TGF-b1 or BMP4/ affinity-bound alginate scaffolds, and the set of analyses performed to characterize the resultant scaffolds, including release profile study, released factor bioactivity, and functionality of the scaffolds as hMSC-inductive scaffolds.","PeriodicalId":12913,"journal":{"name":"Hemijska Industrija","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2018-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41711828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Microfiltration with periodic gas backwashing as an alternative technique for increasing permeate flux 微过滤与周期性气体反冲洗作为提高渗透通量的替代技术

IF 0.9 4区工程技术

Hemijska Industrija Pub Date : 2018-04-18 DOI: 10.2298/HEMIND170814021U

T. Urošević, D. Povrenović, P. Vukosavljević, I. Urosevic

{"title":"Microfiltration with periodic gas backwashing as an alternative technique for increasing permeate flux","authors":"T. Urošević, D. Povrenović, P. Vukosavljević, I. Urosevic","doi":"10.2298/HEMIND170814021U","DOIUrl":"https://doi.org/10.2298/HEMIND170814021U","url":null,"abstract":"U ovom radu je ispitan uticaj radnih parametara (transmembranski prtisak, temperatura, brzina strujanja retentata) na unakrsnu ( cross – flow ) mikrofiltraciju model rastvora vocnog soka i periodicno povratno ispiranje vazduhom. U eksperimentima je koriscena keramicka Kerasep W5 membrana sa granicom separacije od 0,2 µm. Određen je optimalni transmembranski pritisak, koji iznosi 2 bara. Optimalna temperatura procesa bistrenja vocnih sokova mikrofiltracijom je 55°C. Vise temperature se ne koriste zbog degradativnog efekta na hemijski sastav soka i dugog procesa mikrofiltracije. Sa porastom temperature retentata od 22°C do 55°C ostvaruje se porast fluksa permeata do 60 %. Povecanjem brzine strujanja retentata smanjuje se debljina formiranog sloja na povrsini membrane. Zbog ogranicenja koriscene aparature i velike povrsine membrane, postignute specificne brzine strujanja retentata su male, pa efekat unakrsne filtracije izostaje. Periodicnim povratnim ispiranjem se nataloženi sloj na membrani podiže, fluks permeata je u visokoj zoni i sprecava se uspostavljanje stacionarnog stanja u zoni niskih flukseva. Vreme utroseno na povratno ispiranje je malo u odnosu na povecanje sakupljene mase permeata. U svim eksperimentima sa povratnim ispiranjem sakupljena masa permeata je veca do 72,5 % u odnosu na eksperimente bez povratnog ispiranja. Povecanjem vremena trajanja povratnog ispiranja povecanje fluksa je do 5 %, sto može biti znacajno za mikrofiltraciju u industrijskim uslovima.","PeriodicalId":12913,"journal":{"name":"Hemijska Industrija","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2018-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41365648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel surfactant self-assembly process generates multi-scale surface topographies for stem cell growth and differentiation 新型表面活性剂自组装工艺为干细胞生长和分化提供了多尺度表面形貌

IF 0.9 4区工程技术

Hemijska Industrija Pub Date : 2018-04-18 DOI: 10.2298/HEMIND170508020X

E. Xie, C. Cook, W. Grayson, J. Benkoski

{"title":"Novel surfactant self-assembly process generates multi-scale surface topographies for stem cell growth and differentiation","authors":"E. Xie, C. Cook, W. Grayson, J. Benkoski","doi":"10.2298/HEMIND170508020X","DOIUrl":"https://doi.org/10.2298/HEMIND170508020X","url":null,"abstract":"Topographical features on a substrate can greatly influence stem cell fate through contact guidance. While the response of stem cells to topography at the nano-, micro-, and meso-scale has been studied extensively, little is known about the interplay of surface features acting simultaneously across multiple length scales. A limiting factor has been the availability of high throughput methods for probing the potentially unlimited parameter space. Herein we describe a facile method for rapidly generating a hierarchy of multi-scaled topographical features on polymer substrates via the self-assembly of surfactants at the monomer/water interface. Having previously assembled polydimethylsiloxane-diacrylate (PDMS-DA) into surfaces resembling multiple tissue morphologies, the current study refines this method to produce biocompatible substrates. To manage the large parameter space, we limit the scope of this study to surface features spanning nanometer (< 1 µm) and micrometer (1-50 µm) length scales, which arise both individually and in combination. Adipose-derived stem cells were plated onto five surface types and their morphology, proliferation, and osteogenic differentiation were assessed after non-inductive and osteogenic culture. We observed statistically significant differences in cellular responses to each surface. Among our observations, the increased osteogenesis of cells on surfaces with nano-scaled features superimposed over micro-scaled features suggests that such hierarchical surface structure mediates the osteogenic properties of a surface.","PeriodicalId":12913,"journal":{"name":"Hemijska Industrija","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2018-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46690585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Thermogravimetric kinetic study of solid recovered fuels pyrolysis 固体回收燃料热解热重动力学研究

IF 0.9 4区工程技术

Hemijska Industrija Pub Date : 2018-04-18 DOI: 10.2298/HEMIND171009002R

Miloš Radojević, M. Balac, V. Jovanović, D. Stojiljković, N. Manić

{"title":"Thermogravimetric kinetic study of solid recovered fuels pyrolysis","authors":"Miloš Radojević, M. Balac, V. Jovanović, D. Stojiljković, N. Manić","doi":"10.2298/HEMIND171009002R","DOIUrl":"https://doi.org/10.2298/HEMIND171009002R","url":null,"abstract":"In the Republic of Serbia there are significant quantities of coffee and tire wastes that can be utilized as Solid Recovered Fuel (SRF) and used as an additional fuel for co–combustion with coal and biomass in energy production and cement industry sectors. Differences between SRF and base fuel are cause of numerous problems in design of burners. The objective of this study was to determine the kinetic parameters for the thermochemical conversion of selected SRF using Simultaneous Thermal Analysis (STA). Samples of coffee and tire waste were used for the experimental tests. Thermal analysis was carried out in nitrogen atmosphere at three different heating rates 10, 15 and 20 K/min for each sample, while it was heated from room temperature up to 900°C. Two sample sizes x <0.25 mm and 0.25 < x <0.5 mm of each SRF were used in experiments, in order to obtain reliable Thermal Gravimetric Analysis (TGA) data for estimation of kinetic parameters for SRF pyrolysis. Experimental results were used for determination of pre-exponential factor and activation energy according to methods presented in the literature. Presented research provide valuable data of coffee and tire waste, that can be used for the burners design.","PeriodicalId":12913,"journal":{"name":"Hemijska Industrija","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2018-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48014977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Mineralogy and crystallographic properties of Heu-type zeolitic tuff from the Novakovic deposit, Bosnia and Herzegovina 波黑Novakovic矿床heu型沸石凝灰岩的矿物学和晶体学性质

IF 0.9 4区工程技术

Hemijska Industrija Pub Date : 2018-01-01 DOI: 10.2298/hemind180725026r

S. A. Radosavljevic-Mihajlovic, S. Dakovic, Vladan Kašić, V. Mitić, N. Stojanovic, D. Sokić, R. B. Markovic

引用次数: 0

Sorption of diclofenac to selectively oxidised cellulose 选择性氧化纤维素对双氯芬酸的吸附

IF 0.9 4区工程技术

Hemijska Industrija Pub Date : 2018-01-01 DOI: 10.2298/hemind180119010s

S. P. Sailovic, B. B. Rodić-Grabovac, M. S. Uletilovic

引用次数: 0

Oscillatory reaction as a system detector for doped and undoped phosphate tungsten bronzes 振荡反应作为掺杂和未掺杂磷酸钨青铜的系统检测器

IF 0.9 4区工程技术

Hemijska Industrija Pub Date : 2018-01-01 DOI: 10.2298/hemind180402018m

V. Maksimovic, P. Maksimovic, G. L. Joksovic, P. Z. Nedic, C. Pagnacco

引用次数: 0

Improvement of cavitation resistance of composite films using functionalized alumina particles 利用功能化氧化铝颗粒改善复合膜的抗空化性能

IF 0.9 4区工程技术

Hemijska Industrija Pub Date : 2018-01-01 DOI: 10.2298/hemind180308011a

A. Algellai, M. Vuksanović, Z. Tomić, A. Marinković, M. Dojčinović, T. Volkov-Husović, R. Jančić-Heinemann

{"title":"Improvement of cavitation resistance of composite films using functionalized alumina particles","authors":"A. Algellai, M. Vuksanović, Z. Tomić, A. Marinković, M. Dojčinović, T. Volkov-Husović, R. Jančić-Heinemann","doi":"10.2298/hemind180308011a","DOIUrl":"https://doi.org/10.2298/hemind180308011a","url":null,"abstract":"Composite films having the UV cured Bis-GMA (Bisphenol A glycidylmethacrylate)/TEGDMA (triethylene glycol dimethacrylate) as a matrix and the ferrous oxide doped alumina (Al2O3 Fe) based particles were prepared and subjected to cavitation. In order to improve the mechanical and adhesion properties of composites, four different surface modifications of filler particles were performed: 3-methacryloxypropyltrimethoxysilane (MEMO), vinyltris(2-methoxyethoxy)silane (VTMOEO), (3-aminopropyl)trimethoxysilane (APTMS) and biodiesel (BD). Composite films were made with 0.5, 1.5, and 3 wt.% of ferrous oxide doped alumina particles with each of the mentioned surface modifications. Composite films were prepared on brass substrates and exposed to cavitation erosion. The erosion was monitored using the mass loss while image analysis was used to observe surface defects. The composite film reinforced with Al2O3 Fe having VTMOEO as a surface modifier was the most resistant one in terms of mass loss, as well as the level of surface destruction. Results were compared to the same polymer matrix film and composite films prepared with fillers without surface modifications revealing that all composites with surface modified fillers exhibited some improvement in resistance to cavitation.","PeriodicalId":12913,"journal":{"name":"Hemijska Industrija","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68381401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Solid dispersions with carbamazepine: Optimization of formulation, characterization and examination of long-term stability 卡马西平固体分散体:配方优化、表征及长期稳定性考察

IF 0.9 4区工程技术

Hemijska Industrija Pub Date : 2018-01-01 DOI: 10.2298/hemind171025013k

M. Krstic, I. Lukić, Alma Bušatlić, N. Lazarevic, D. Vasiljević

引用次数: 0

A supervisory control system of a biodiesel production plant 生物柴油生产厂的监控系统

IF 0.9 4区工程技术

Hemijska Industrija Pub Date : 2018-01-01 DOI: 10.2298/hemind180726024s

P. Stankov

引用次数: 0