低水分淀粉提高新型益生菌植物乳杆菌299v制剂的活力和稳定性

IF 0.8 4区工程技术 Q4 ENGINEERING, CHEMICAL

Hemijska Industrija Pub Date : 2018-04-18 DOI:10.2298/HEMIND170913003K

D. Korcok, Olivera Čolić, N. Milanović, Bogdan Mitic

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引用次数: 1

摘要

由于越来越多的证据表明益生菌对人体健康有益，因此益生菌药物制剂越来越受欢迎。本研究的目的是确定和开发具有最佳填充量的活性成分-植物乳杆菌的胶囊益生菌制剂，该制剂将与其他活性成分:铁、维生素C和赋形剂淀粉结合，在满足治疗作用要求的同时保持生产工艺参数的要求。多组分益生菌制剂的最佳配方，满足维持所有活性成分的要求，同时尊重工艺流程要求，将使常规制药生产能够生产高效和安全的膳食产品。

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Low moisture starch for improved viability and stability of new probiotic L. plantarum 299v preparation

Probiotic pharmaceutical preparations are more and more popular because of the increasing level of evidence of their beneficial effect on human health. The goal of this study was to determine and develop the encapsulated probiotic formulation with the optimal filling amount of active ingredient - Lactobacillus plantarum that would, in combination with other active ingredients: iron, vitamin C and excipient starch, fulfil requirements for therapeutic action while maintaining process parameters’ requirements of manufacturing as well. The optimal formulation of a multicomponent probiotic-based formulation that fulfils requirements for sustaining all active ingredients while respecting technological process requirements, will enable a routine pharmaceutical manufacturing that could yield both efficient and safe dietary products.

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来源期刊

Hemijska Industrija 工程技术-工程：化工

CiteScore

1.60

自引率

11.10%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal Hemijska industrija (abbreviation Hem. Ind.) is publishing papers in the field of Chemical Engineering (Transport phenomena; Process Modeling, Simulation and Optimization; Thermodynamics; Separation Processes; Reactor Engineering; Electrochemical Engineering; Petrochemical Engineering), Biochemical Engineering (Bioreactors; Protein Engineering; Kinetics of Bioprocesses), Engineering of Materials (Polymers; Metal materials; Non-metal materials; Biomaterials), Environmental Engineeringand Applied Chemistry. The journal is published bimonthly by the Association of Chemical Engineers of Serbia (a member of EFCE - European Federation of Chemical Engineering). In addition to professional articles of importance to industry, scientific research papers are published, not only from our country but from all over the world. It also contains topics such as business news, science and technology news, information on new apparatus and equipment, and articles on environmental protection.