Hepatobiliary surgery and nutrition最新文献

{"title":"How to improve the care of decompensated cirrhosis: the intervention model for chronic disease management.","authors":"Beom Kyung Kim","doi":"10.21037/hbsn-2025-326","DOIUrl":"10.21037/hbsn-2025-326","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 4","pages":"680-682"},"PeriodicalIF":7.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12393109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New perspectives in biology-driven treatment of cholangiocarcinoma: from oncological resectability to genetic breakthroughs and AI-powered imaging.","authors":"Luca Viganò, Luca Risi, Angela Ammirabile","doi":"10.21037/hbsn-2025-261","DOIUrl":"10.21037/hbsn-2025-261","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 4","pages":"703-708"},"PeriodicalIF":7.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12393095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor burden score and borderline resectability criteria as predictors of survival in advanced hepatocellular carcinoma.","authors":"Chahrazed Dous","doi":"10.21037/hbsn-2025-312","DOIUrl":"10.21037/hbsn-2025-312","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 4","pages":"630-633"},"PeriodicalIF":7.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12393124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An intriguing case of macrolides-induced pancreatic injury mimicking pancreatic carcinoma.","authors":"Kun He, Zihan Yang, Ziqi Guo, Hongwei Wang, Jia Xu, Long Zou, Yunlu Feng, Wen Shi, Dong Wu, Aiming Yang","doi":"10.21037/hbsn-2025-269","DOIUrl":"10.21037/hbsn-2025-269","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 4","pages":"720-723"},"PeriodicalIF":7.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12393094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The value of tranexamic acid in liver resection should not be exaggerated or ignored.","authors":"Penglei Ge, Yang Wu","doi":"10.21037/hbsn-2025-502","DOIUrl":"10.21037/hbsn-2025-502","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 4","pages":"689-691"},"PeriodicalIF":7.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12393098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implications of the surgical approach for complex liver resection in the era of enhanced recovery programs: a critical appraisal of the \"Orange Segments\" randomized controlled trial.","authors":"Ambroise Ravenet, Rami Rhaiem","doi":"10.21037/hbsn-2025-265","DOIUrl":"10.21037/hbsn-2025-265","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 4","pages":"634-638"},"PeriodicalIF":7.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12393129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From critical care to organ preservation: the potential role of hemadsorption in transplantation-a narrative review.","authors":"Chunbao Jiao, Keyue Sun, Kumaran Shamugarajah, Mingyi Zhang, Chase J Wehrle, Rebecca Panconesi, Sangeeta Satish, Omer Karakaya, Robert L Fairchild, Koji Hashimoto, Charles Miller, Silvia Perez-Protto, Andrea Schlegel","doi":"10.21037/hbsn-24-446","DOIUrl":"10.21037/hbsn-24-446","url":null,"abstract":"<p><strong>Background and objective: </strong>Hemadsorption, a therapeutic modality traditionally used to mitigate cytokine storm in critically ill patients and is now being tested in other medical fields including organ transplantation, especially for organs from extended criteria donors. Such organs are susceptible to ischemia-reperfusion injury (IRI) during transplantation, which is known to release a cascade of innate immune mediators including damage-associated molecular patterns (DAMPs) and cytokines during reperfusion and ultimately leading to graft dysfunction based on the metabolic injury. To address this challenge, early studies have integrated hemadsorption filters into organ perfusion circuits, such as normothermic regional perfusion (NRP) in donors and <i>ex-situ</i> machine perfusion (MP) of grafts, with the aim to reduce inflammation and improve organ viability. While results indicated a benefit with this use, the data are limited, and the subcellular response mechanisms impacted by such filters remain unexplored. This narrative review explores the impact of hemadsorption devices from critical conditions to organ preservation, highlighting technical opportunities, benefits, current challenges, and potential effects on outcomes.</p><p><strong>Methods: </strong>This review examines the application of hemadsorption in critically ill patients and in organ transplantation.</p><p><strong>Key content and findings: </strong>In complex clinical scenarios like sepsis and cardiac surgery, where systemic inflammatory responses are severe, hemadsorption alone may not be sufficient, requiring a comprehensive approach involving antimicrobial therapy, resuscitation, and immunomodulatory treatments to achieve immune homeostasis. In organ transplantation, hemadsorption shows potential benefits, but further clinical research is needed to optimize its use and to understand the impact of perfusates recirculating molecules on tissue metabolism during MP.</p><p><strong>Conclusions: </strong>While hemadsorption requires thoughtful evaluation and adjunctive therapies in common critical clinical applications, it presents promising potential in the field of organ transplantation, particularly in organ preservation.</p>","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 4","pages":"608-629"},"PeriodicalIF":7.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12393119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of outcomes of robotic liver surgery using the IWATE criteria.","authors":"Francesco Toti, Marco Di Pangrazio, Federico Pinto, Alessandro Martinino, Lily Zhang, Colton Johnson, Francesco Maria Bianco, Pier Cristoforo Giulianotti","doi":"10.21037/hbsn-24-379","DOIUrl":"10.21037/hbsn-24-379","url":null,"abstract":"<p><strong>Background: </strong>Robotic liver resections (RLRs) are increasingly performed worldwide. The IWATE criteria offer a standardized classification to correlate the complexity of these procedures with surgical outcomes. This study analyzes a single surgeon's experience with RLR and evaluates the applicability and correlation of the IWATE criteria.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of 188 RLRs performed by a single surgeon at the University of Illinois at Chicago from June 2007 to May 2023. Data on patient demographics, surgical details, pathology, and 30-day morbidity and mortality were collected. Surgical data included operation duration, blood loss, conversion rates, intraoperative and perioperative complications, and length of hospital stay (LOS). Patients were categorized into four groups according to the IWATE criteria.</p><p><strong>Results: </strong>Patients were evenly distributed across the four groups, except for age and preoperative chemotherapy rates, which were significantly different. Operative times (OTs) and estimated blood loss (EBL) increased with procedure complexity, ranging from 148 to 350 minutes and 75 to 400 mL (P<0.001). There were 18 conversions (9.6%), with a significantly higher rate in the Expert and Advanced groups (P<0.001). Intraoperative transfusions followed the same pattern. Postoperative outcomes showed a significant difference in median hospital stay (P<0.001), varying from 3 to 7 days (Low to Expert groups). There were 8 major complications and a 3.7% readmission rate, with no 30-day mortality, and no significant difference in complication distribution among groups. The overall R0 resection rate was 96.3%.</p><p><strong>Conclusions: </strong>The IWATE criteria effectively correlate with surgical outcomes in our series, providing a valuable tool for standardizing procedure complexity and facilitating outcome comparisons.</p>","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 4","pages":"575-586"},"PeriodicalIF":7.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12393123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating the complexity of colorectal liver metastasis: molecular profiling and tumor sidedness.","authors":"Sung Jun Jo, Jongman Kim","doi":"10.21037/hbsn-2025-259","DOIUrl":"10.21037/hbsn-2025-259","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 4","pages":"700-702"},"PeriodicalIF":7.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12393104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of hepatic arterial infusion chemotherapy in advanced hepatocellular carcinoma: survival outcomes and prognostic factors from a systematic review and meta-analysis.","authors":"Di Zeng, Zhimeng Cheng, Jiong Lu, Geng Liu, Bei Li","doi":"10.21037/hbsn-2025-115","DOIUrl":"10.21037/hbsn-2025-115","url":null,"abstract":"<p><strong>Background: </strong>Advanced hepatocellular carcinoma (HCC) poses significant treatment challenges, with limited options and poor prognosis. Hepatic arterial infusion chemotherapy (HAIC) has emerged as a promising therapy, potentially offering superior outcomes compared to transarterial chemoembolization (TACE). This study aimed to systematically compare the survival outcomes and safety profiles of HAIC versus TACE in patients with advanced HCC, and to identify key prognostic factors influencing treatment efficacy to guide personalized therapeutic strategies.</p><p><strong>Methods: </strong>This meta-analysis included 14 studies assessing survival outcomes and safety profiles of HAIC versus TACE in advanced HCC. Overall survival (OS), progression-free survival (PFS), and adverse events were analyzed. Subgroup analyses evaluated the influence of prognostic factors such as tumor size, alpha-fetoprotein (AFP) levels, and vascular invasion.</p><p><strong>Results: </strong>HAIC significantly improved OS [hazard ratio (HR) =0.51] and PFS (HR =0.55) compared to TACE in advanced HCC. Subgroup analyses identified multiple prognostic factors favoring HAIC for better outcomes. For OS, HAIC showed significant benefits in subgroups including male gender (HR =0.57), AFP <400 ng/mL (HR =0.59), tumor number ≥3/5 (HR =0.75), hepatitis B virus (HBV)-positive patients (HR =0.50), vascular invasion (HR =0.50), extrahepatic metastasis (HR =0.55), and portal vein tumor thrombus (PVTT) presence (HR =0.34). For PFS, HAIC demonstrated superior outcomes in patients aged >60 years (HR =0.67), Eastern Cooperative Oncology Group (ECOG) ≥1 (HR =0.65), AFP ≥400 ng/mL (HR =0.48), tumor size ≥10 cm (HR =0.54), Child-Pugh A (HR =0.63), vascular invasion (HR =0.49), extrahepatic metastasis absence (HR =0.57), and Barcelona Clinic Liver Cancer (BCLC) Stage C (HR =0.64).</p><p><strong>Conclusions: </strong>HAIC offers significant survival benefits (OS and PFS) and a favorable safety profile compared to TACE in advanced HCC. These findings highlight HAIC as a valuable treatment option, particularly for patients with poor prognostic factors, and emphasize the need for personalized therapeutic strategies to optimize outcomes.</p>","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 4","pages":"587-607"},"PeriodicalIF":7.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12393126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}