{"title":"Second-line therapies in PBC-related cirrhosis: balancing efficacy and safety.","authors":"Pawel Rogalski, Magdalena Rogalska","doi":"10.21037/hbsn-2025-329","DOIUrl":"https://doi.org/10.21037/hbsn-2025-329","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 5","pages":"865-868"},"PeriodicalIF":7.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12521006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Technical performance, surgical workload and patient outcomes of robotic and laparoscopic surgery for pediatric choledochal cyst: a multicenter retrospective cohort and propensity score-matched study.","authors":"Meng-Xin Zhang, Jing-Feng Tang, Duo-Te Cai, Shuai Li, Kang Li, Shui-Qing Chi, Guo-Qing Cao, Xi Zhang, Yun Zhou, Zhi-Bin Luo, Li-Ying Rong, Yu Guo, Ming-Jing Zhang, Jun-Ni Ma, Zhu Jin, Zhi-Gang Gao, Shao-Tao Tang","doi":"10.21037/hbsn-24-439","DOIUrl":"https://doi.org/10.21037/hbsn-24-439","url":null,"abstract":"<p><strong>Background: </strong>Robotic surgery (RS) and laparoscopic surgery (LS) are increasingly used for pediatric choledochal cysts (CC); however, it remains unclear which technique is superior. We aimed to compare the clinical outcomes, technical performance and surgical workload between RS and LS.</p><p><strong>Methods: </strong>From January 2014 to February 2023, 604 CC patients (RS =302, LS =302) were enrolled in this multicenter retrospective cohort study after propensity score matching. Surgical videos were rated for technical performance using the Objective Structured Assessments of Technical Skills (OSATS) and Generic Error Rating Tool instruments.</p><p><strong>Results: </strong>During follow-up, overall complication rates were similar between two groups, but RS group had lower anastomotic stricture rate (1.32% <i>vs.</i> 4.30%, P=0.03). Despite longer total operative time, RS group had shorter cyst excision and hepaticojejunostomy time. Moreover, RS group had less estimated intraoperative blood loss, higher left/right hepatic duct exposure rate, higher intrapancreatic bile duct exposure rate, higher OSATS score {31.00 [interquartile range (IQR), 30.00-32.00] <i>vs.</i> 29.00 (IQR, 28.00-30.00), P<0.001}, lower number of errors [46.50 (IQR, 43.33-50.72) <i>vs.</i> 56.00 (IQR, 51.00-61.00) times/patient, P<0.001], lower number of events [4.33 (IQR, 3.51-5.17) <i>vs.</i> 9.33 (IQR, 7.83-11.00) times/patient, P<0.001] and lower National Aeronautics and Space Administration Task Load Index (NASA-TLX) score [61.00 (IQR, 60.00-62.00) <i>vs.</i> 69.00 (IQR, 67.00-72.00), P<0.001]. The total NASA-TLX scores was found to be moderately correlated with total OSATS score (r=-0.420, P<0.001), total number of errors (r=0.502, P<0.001) and events (r=0.614, P<0.001). These improvements in RS were more prominent in patients with aberrant right hepatic artery or small anastomotic diameter. RS had lower fever rate, shorter hospital stays, and lower interleukin-6 and C-reactive protein levels at postoperative days 1 and 3. No cyst malignancy or deaths occurred.</p><p><strong>Conclusions: </strong>RS for selected pediatric CC offers superior technical performance and less surgeon workload, as well as lower anastomotic stricture rate than LS in high-volume children's centers.</p>","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 5","pages":"726-741"},"PeriodicalIF":7.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12521014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Benedetto Ielpo, Patricia Sanchez-Velazquez, Gemma Vellalta, Alberto Garcia-Picazo, Simone Cremona, Fernando Burdio
{"title":"Laparoscopic surgery for gallbladder cancer: is skepticism still justified?","authors":"Benedetto Ielpo, Patricia Sanchez-Velazquez, Gemma Vellalta, Alberto Garcia-Picazo, Simone Cremona, Fernando Burdio","doi":"10.21037/hbsn-2025-328","DOIUrl":"https://doi.org/10.21037/hbsn-2025-328","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 5","pages":"892-894"},"PeriodicalIF":7.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12521021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Durvalumab plus cisplatin and gemcitabine in advanced biliary tract cancer: can we do it better?","authors":"Margherita Rimini, Andrea Casadei-Gardini","doi":"10.21037/hbsn-2025-393","DOIUrl":"https://doi.org/10.21037/hbsn-2025-393","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 5","pages":"839-842"},"PeriodicalIF":7.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12521034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luigi Colecchia, Giovanni Marasco, Elton Dajti, Alessandra Pivetti, Antonio Colecchia
{"title":"Role of non-invasive tests in the management of resectable hepatocellular carcinoma: future directions.","authors":"Luigi Colecchia, Giovanni Marasco, Elton Dajti, Alessandra Pivetti, Antonio Colecchia","doi":"10.21037/hbsn-2025-444","DOIUrl":"https://doi.org/10.21037/hbsn-2025-444","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 5","pages":"878-882"},"PeriodicalIF":7.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12521028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Edouard Wasielewski, Estelle Le Pabic, Kevin Preault, Fabien Robin, Karim Boudjema, Thierry Pecot, Laurent Sulpice
{"title":"Sarcopenia and gender disparities in liver transplant waiting lists: evaluating predictive scores and delisting risks.","authors":"Edouard Wasielewski, Estelle Le Pabic, Kevin Preault, Fabien Robin, Karim Boudjema, Thierry Pecot, Laurent Sulpice","doi":"10.21037/hbsn-24-531","DOIUrl":"https://doi.org/10.21037/hbsn-24-531","url":null,"abstract":"<p><strong>Background: </strong>The model for end-stage liver disease (MELD) and model for end-stage liver disease-sodium (MELD-Na) scores are the most widely used for prioritizing patients on the liver transplant (LT) waiting list. However, the quality and accuracy of these scores are questionable. Among the most significant limitations we found the disparity in access to transplantation by gender, with excess mortality demonstrated among women on the waiting list. There is also a lack of consideration for sarcopenic status, which negatively impacts those patients. The gender equity model for liver allocation (GEMA) score has recently been shown to be more discriminating, reducing mortality in women. However, this score still does not consider sarcopenic status. The main objectives of this study were to compare the different scores in order to highlight the one with the best discriminatory performance and to demonstrate the disparity in patients' discharge from the list according to their sarcopenic status.</p><p><strong>Methods: </strong>In order to identify patients registered on the LT waiting list between January 1, 2012 and December 31, 2022, at Rennes University Hospital, we contacted the French Biomedicine Agency, which is responsible for prospectively recording registrations. Data about the body composition and complications prior to liver transplantation were collected retrospectively.</p><p><strong>Results: </strong>Of the 1,488 patients on the waiting list, 900 cirrhotic patients were included in the analysis. The majority of patients on the list were men (n=746, 82.9%), with a median age of 61 (interquartile range, 55-65) years and a median MELD score of 16 [10-22]. In our study, the predictive score of 3-month delisting with the highest discriminatory power was the gender equity model for liver allocation-sodium (GEMA-Na) score, with a C-index of 0.7205. Of the 59 (6.6%) patients discharged at 3 months, 19 (32%) were women (P=0.002). Regarding body composition, sarcopenia was found in 36% of patients (n=326), mostly men (n=293, 89.9%). The Cox model showed an interaction between sarcopenia and gender on list exit (P=0.03). Sarcopenia was present in 60% (n=24) of men leaving the list, whereas it was in only 11% (n=2) of women leaving the list at 3 months (P=0.001).</p><p><strong>Conclusions: </strong>In our study, the GEMA-Na score was the most predictive of list deletion. However, this score does not consider sarcopenic status, which is relatively prejudicial to men. Considering sarcopenic status in men therefore seems essential in prioritizing patients on the waiting list, to avoid overlooking new disparities between men and women.</p>","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 5","pages":"755-765"},"PeriodicalIF":7.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12521030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Laparoscopic duodenum-preserving pancreatic head resection guided by the two-stage indocyanine green fluorescence imaging.","authors":"Wenjun Lin, Haisu Tao, Jian Yang","doi":"10.21037/hbsn-2025-449","DOIUrl":"https://doi.org/10.21037/hbsn-2025-449","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 5","pages":"902-905"},"PeriodicalIF":7.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12521009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrew Makary, Diego Rojo, Laura Pagès, Clara Sabiote, Alba Jiménez-Masip, Juan M Pericàs
{"title":"Opportunistic case-finding of liver fibrosis in metabolic dysfunction-associated steatotic liver disease (MASLD) by leveraging integrated care pathways of type 2 diabetes.","authors":"Andrew Makary, Diego Rojo, Laura Pagès, Clara Sabiote, Alba Jiménez-Masip, Juan M Pericàs","doi":"10.21037/hbsn-2025-324","DOIUrl":"https://doi.org/10.21037/hbsn-2025-324","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 5","pages":"824-828"},"PeriodicalIF":7.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12521010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}