{"title":"Beyond chemotherapy in biliary tract cancer: a closer look at the updated long-term follow-up data of the TOPAZ-1 trial.","authors":"Alexander Olkus, Michael T Dill","doi":"10.21037/hbsn-2025-316","DOIUrl":"10.21037/hbsn-2025-316","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 4","pages":"676-679"},"PeriodicalIF":7.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12393116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stephanie Y Ohara, Michelle C Nguyen, Amit K Mathur, Peter E Frasco, Bashar Aqel, Blanca C Lizaola-Mayo, Caroline C Jadlowiec
{"title":"Updates on the impact of the new liver allocation policy on national liver transplants.","authors":"Stephanie Y Ohara, Michelle C Nguyen, Amit K Mathur, Peter E Frasco, Bashar Aqel, Blanca C Lizaola-Mayo, Caroline C Jadlowiec","doi":"10.21037/hbsn-2025-221","DOIUrl":"10.21037/hbsn-2025-221","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 4","pages":"643-646"},"PeriodicalIF":7.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12393101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Navigating abdominal surgery in extrahepatic portal vein obstruction: new insights and remaining issues.","authors":"Tetsuya Shimizu, Hiroshi Yoshida, Yoichi Kawano, Akira Matsushita, Masato Yoshioka, Junji Ueda","doi":"10.21037/hbsn-2025-290","DOIUrl":"10.21037/hbsn-2025-290","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 4","pages":"665-668"},"PeriodicalIF":7.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12393114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Silvia Corcione, Damiano Patrono, Nour Shbaklo, Luca Mirabile, Maria Roberta Fortunato, Tommaso Lupia, Paola Maffezzoli, Antonio Curtoni, Alessandro Bondi, Cristina Costa, Renato Romagnoli, Francesco Giuseppe De Rosa
{"title":"Hypothermic oxygenated machine perfusion does not increase the risk of infection after liver transplantation: a retrospective cohort study.","authors":"Silvia Corcione, Damiano Patrono, Nour Shbaklo, Luca Mirabile, Maria Roberta Fortunato, Tommaso Lupia, Paola Maffezzoli, Antonio Curtoni, Alessandro Bondi, Cristina Costa, Renato Romagnoli, Francesco Giuseppe De Rosa","doi":"10.21037/hbsn-24-552","DOIUrl":"10.21037/hbsn-24-552","url":null,"abstract":"<p><strong>Background: </strong>Liver transplantation (LT) is a crucial treatment for end-stage liver disease, but the limited organ supply has led to the use of extended criteria donors (ECD). The implementation of dynamic preservation techniques like hypothermic oxygenated machine perfusion (HOPE) is crucial in improving outcomes for ECD grafts. However, graft contamination and infection are a concern. This study aimed to evaluate the risk of infections within 10 days from LT between HOPE and static cold storage (SCS) groups and postoperative complications.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted, including LT recipients transplanted at a single-center from March 2016 to June 2023. Patients were divided into HOPE and SCS groups, and propensity score matching was used to select comparable cohorts. Data on patient and donor characteristics were analyzed.</p><p><strong>Results: </strong>After propensity score matching, a cohort of 370 (HOPE, n=185; SCS, n=185) patients was selected for analysis. The study found no significant differences in the rate of clinically relevant infections, microbiological positive samples, or donor-derived infections within 10 days between HOPE and SCS groups. Postoperative outcomes, as well as patient and graft survival, were also similar between the two groups. The study showed that HOPE is a feasible and safe approach, with a comparable risk of infection.</p><p><strong>Conclusions: </strong>The study results indicate that HOPE use in LT does not increase the risk of infection and is associated with similar patient and graft survival outcomes compared to SCS. These findings confirm the safety and efficacy of HOPE in LT and its potential to expand the donor pool without compromising recipient outcomes.</p>","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 4","pages":"562-574"},"PeriodicalIF":7.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12393111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alberto Ferrarese, Andrea Gasperetti, Andrea Ermolao, Giacomo Germani, Patrizia Burra
{"title":"Running towards liver transplantation.","authors":"Alberto Ferrarese, Andrea Gasperetti, Andrea Ermolao, Giacomo Germani, Patrizia Burra","doi":"10.21037/hbsn-2025-215","DOIUrl":"10.21037/hbsn-2025-215","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 4","pages":"697-699"},"PeriodicalIF":7.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12393102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neuroendocrine liver metastasis.","authors":"Sonal Walia, Alexandra M Roch, Eugene P Ceppa","doi":"10.21037/hbsn-2025-252","DOIUrl":"10.21037/hbsn-2025-252","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 4","pages":"655-657"},"PeriodicalIF":7.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12393115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Congwei Jia, Jinyi Meng, Can Yin, Xuemei Sun, Yan You, Lei Zhang, Xiaoyan Chang
{"title":"Primary Epstein-Barr virus-positive inflammatory follicular dendritic cell sarcoma concurrent with lymphoepithelioma-like intrahepatic cholangiocarcinoma and cavernous hemangioma in liver.","authors":"Congwei Jia, Jinyi Meng, Can Yin, Xuemei Sun, Yan You, Lei Zhang, Xiaoyan Chang","doi":"10.21037/hbsn-2025-139","DOIUrl":"10.21037/hbsn-2025-139","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 4","pages":"716-719"},"PeriodicalIF":7.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12393112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bader Al Taweel, Gianluca Cassese, Azhar Meerun, Benjamin Rivière, Francis Navarro, Boris Guiu, Fabrizio Panaro
{"title":"Biliary and respiratory complications after right hepatectomy for hepatocellular carcinoma following selective internal radiation therapy (SIRT): a retrospective case-control study.","authors":"Bader Al Taweel, Gianluca Cassese, Azhar Meerun, Benjamin Rivière, Francis Navarro, Boris Guiu, Fabrizio Panaro","doi":"10.21037/hbsn-23-429","DOIUrl":"10.21037/hbsn-23-429","url":null,"abstract":"<p><strong>Background: </strong>Selective internal radiation therapy (SIRT) has emerged as a promising and recent treatment for downstaging hepatocellular carcinoma (HCC) before surgical intervention. However, the potential occurrence of postoperative biliary and respiratory complications following major hepatectomy subsequent to SIRT remains unclear. We hypothesized that SIRT can increase the rate of biliary leakage and cause diaphragmatic dysfunction, especially for huge HCC in contact with the diaphragm.</p><p><strong>Methods: </strong>We conducted a retrospective study including consecutive HCC patients from January 2015 to December 2022 undergoing right hepatectomy after SIRT in the Montpellier University Hospital. Patients were compared in a 1:1 ratio with non-SIRT-treated patients based on the following criteria: same diagnosis, same surgery, same American Society of Anesthesiologists (ASA) score, Child-Turcotte-Pugh (CTP) class, and similar tumor burden. Analysis was done using either a linear or logistic regression. Outcomes were the rate of biliary leakage and of 3 diaphragm-related complications: oxygen flow on day 1, need for intensive oxygen therapy, and pleural effusion.</p><p><strong>Results: </strong>Twenty patients with comparable preoperative characteristics were included in each group. Eight patients (40%) in the SIRT group experienced a postoperative bile leak versus only 2 (10%) in the other, with a significantly increased risk [odds ratio (OR) =6; 95% confidence interval (CI): 1.1-33.3; P<0.05]. Similarly, the risk of large postoperative pleural effusion was increased after SIRT, with 6 patients (30%) against 0, respectively (OR =10.5; 95% CI: 1.8-61.4; P<0.05).</p><p><strong>Conclusions: </strong>SIRT may increase the risk of postoperative biliary leakage and respiratory complications after right hepatectomy.</p>","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 4","pages":"552-561"},"PeriodicalIF":7.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12393128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Balancing efficacy and tolerability in metastatic pancreatic cancer: lessons from the ALPACA trial.","authors":"Tadahisa Inoue, Akihisa Kato, Michihiro Yoshida, Tomoya Kitada, Rena Kitano, Itaru Naitoh","doi":"10.21037/hbsn-2025-315","DOIUrl":"10.21037/hbsn-2025-315","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 4","pages":"673-675"},"PeriodicalIF":7.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12393121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"How to improve the care of decompensated cirrhosis: the intervention model for chronic disease management.","authors":"Beom Kyung Kim","doi":"10.21037/hbsn-2025-326","DOIUrl":"10.21037/hbsn-2025-326","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 4","pages":"680-682"},"PeriodicalIF":7.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12393109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}