Hiroshima journal of medical sciences最新文献_第3页

Efficacy of the Pulse Pressure Generator during Cardiopulmonary Bypass Training Using the Extracorporeal Circulation Simulator 体外循环模拟器在体外循环训练中脉冲压力发生器的作用

Hiroshima journal of medical sciences Pub Date : 2018-09-01 DOI: 10.24811/HJMS.67.3_71

S. Minami, T. Kurosaki, Shinji Ninomiya, T. Sueda

{"title":"Efficacy of the Pulse Pressure Generator during Cardiopulmonary Bypass Training Using the Extracorporeal Circulation Simulator","authors":"S. Minami, T. Kurosaki, Shinji Ninomiya, T. Sueda","doi":"10.24811/HJMS.67.3_71","DOIUrl":"https://doi.org/10.24811/HJMS.67.3_71","url":null,"abstract":"Objective: Cardiopulmonary bypass during cardiac surgery is an essential procedure, and the perfusionist needs to have sufficient education and training. Simulation training is suitable in such cases. We have developed a simulation system for cardiopulmonary bypass training (extracorporeal circulation simulator [ECCSIM]) and reported its efficacy. ECCSIM had no pulse pressure generator, so some perfusionists have mentioned that the operational feeling during training differs from that in real clinical cases. In this study, we have developed a new pulse pressure generator and examined the efficacy of this system during cardiopulmonary bypass training using ECCSIM. Materials and Methods: Results were observed as wave patterns during simulation of extracorporeal circulation with and without pulse pressure flow. Operational feeling during training of extracorporeal circulation was compared using a questionnaire survey, based on the Japanese version of the NASA Task Load Index (NASA-TLX), a subjective index, completed by seven perfusionists. Results: With the addition of pulse pressure flow, fluctuation of arterial flow at low speed with the centrifugal pump increased, and operation of extracorporeal circulation became unstable. The questionnaire survey, including ‘Operational feeling of centrifugal pump’, ‘Feeling of afterload’, and ‘Display of pressure monitor’, showed results similar to that of the clinical situation using pulse pressure flow. The difficulty of simulator operation in extracorporeal circulation was significantly greater in the group with pulse pressure flow. Mental/physical load examined with NASA-TLX increased with pulse pressure flow. Conclusion: Using a new pulse pressure generator with ECCSIM was effective in extracorporeal circulation training.","PeriodicalId":12860,"journal":{"name":"Hiroshima journal of medical sciences","volume":"67 1","pages":"71-81"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45927699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Case Oesophageal Perforation by a Fish Bone, Leading to Pericardial Penetration and Cardiac Tamponade 鱼骨致食道穿孔致心包穿透及心包填塞一例

Hiroshima journal of medical sciences Pub Date : 2018-06-01 DOI: 10.24811/HJMS.67.2_47

Emi Chikuie, Seiji Fugisaki, S. Fukuhara, Kouki Imaoka, Y. Hirata, S. Fukuda, Mamoru Takahashi, Hiroshi Sakai, M. Sueshiro, H. Sakimoto

引用次数: 3

Effects of Different Types of Dietary Fibers on Fermentation by Intestinal Flora 不同类型膳食纤维对肠道菌群发酵的影响

Hiroshima journal of medical sciences Pub Date : 2018-03-01 DOI: 10.24811/HJMS.67.1_1

A. Nagano, H. Ohge, Tomoko Tanaka, Shinya Takahashi, K. Uemura, Y. Murakami, T. Sueda

{"title":"Effects of Different Types of Dietary Fibers on Fermentation by Intestinal Flora","authors":"A. Nagano, H. Ohge, Tomoko Tanaka, Shinya Takahashi, K. Uemura, Y. Murakami, T. Sueda","doi":"10.24811/HJMS.67.1_1","DOIUrl":"https://doi.org/10.24811/HJMS.67.1_1","url":null,"abstract":"Tempeh gembus is fermented soy-pulp product contains high protein and its bioactive peptide \u0000components has potential antioxidant activities. In this study bromelain enzyme was applied in \u0000tempeh gembus to break up peptides bond and released bioactive peptides and amino acids. The aim \u0000of this research was to analyse antioxidant activity and soluble protein of tempeh gembus \u0000hydrolysate. Experimental research with 4 bromelain enzymes were applied in tempeh gembus as 0 \u0000ppm, 5000 ppm, 8000 ppm, and 10000 ppm. Antioxidant activities were measured by ABTS and \u0000DPPH radicals test. Whil e soluble protein content was measured by Bradford test. In general, \u0000antioxidant activity of tempeh gembus was higher when measured by ABTS radical (63.14±1.16 – \u000092.85±2.28%) compared to DPPH radical (52.21±5.76 – 65.70±5.89%). Antioxidant activity of tempeh \u0000gembus hydrolysate in ABTS test differed significantly between treatment groups (p=0.001), but not \u0000on DPPH test (p=0.110). While soluble protein content of these protein hydrolysate were 0.58±0.05 – \u00000.78±0.11% and significantly differed between treatment groups (p=0.019). Antioxidant activity was \u0000significantly higher when measured by ABTS radical compared to DPPH radical with different \u0000protein soluble content. \u0000Keywords: tempeh gembus, hydrolysate, antioxidant activity, soluble protein","PeriodicalId":12860,"journal":{"name":"Hiroshima journal of medical sciences","volume":"67 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48747532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Incidentally Found Primary Cerebral Malignant Melanoma Associated with Ota Nevus—Wide Dissemination after an Initial Phase of Slow Growth 偶然发现与太田痣相关的原发性脑恶性黑色素瘤——生长缓慢后广泛传播

Hiroshima journal of medical sciences Pub Date : 2018-03-01 DOI: 10.24811/HJMS.67.1_21

Natsuko Tanoue, Fauziah C. Ummah, Fauziah C. Ummah, T. Hanada, Tomoko Takajo, Muhammad Kamil, Muhammad Kamil, Rofat Askoro, Rofat Askoro, K. Arita

{"title":"Incidentally Found Primary Cerebral Malignant Melanoma Associated with Ota Nevus—Wide Dissemination after an Initial Phase of Slow Growth","authors":"Natsuko Tanoue, Fauziah C. Ummah, Fauziah C. Ummah, T. Hanada, Tomoko Takajo, Muhammad Kamil, Muhammad Kamil, Rofat Askoro, Rofat Askoro, K. Arita","doi":"10.24811/HJMS.67.1_21","DOIUrl":"https://doi.org/10.24811/HJMS.67.1_21","url":null,"abstract":"Primary cerebral malignant melanoma accounts for 1% of all melanomas and for 0.7% of all primary tumours of the central nervous system (CNS). We report an incidentally found primary malignant melanoma in the right temporal lobe of a 76-year-old woman with an Ota nevus on her right eyelid and sclera. The lesion was initially characterised by slow growth, followed by tumoural bleeding and wide leptomeningeal dissemination. Magnetic resonance imaging (MRI) during brain checkup demonstrated an 8-mm mass in the right uncus with high intensity on T1-weighted images. The mass grew slowly over the next two years, but asymptomatic tumoural haemorrhage eventually developed. The patient underwent tumour removal via right frontotemporal craniotomy. Extensive subarachnoid dissemination from the right temporal tumour was found; the pathologic diagnosis was malignant melanoma. Despite adjuvant therapy comprising wholebrain radiation and nivolumab, the patient died of severe leptomeningeal dissemination at 4.5 months after the operation (33 months after the initial MRI study). Our literature review found 46 cases of primary CNS malignant melanoma, predominantly in middle-aged to elderly individuals. The most frequent symptom was headache, followed by visual disturbance, nausea/vomiting, and hemiparesis. Only one other case of primary cerebral malignant melanoma had been found incidentally; 11 previously reported patients manifested congenital nevi (Ota nevus, n = 5; other nevi, n = 6). Six patients suffered tumoural haemorrhage, 4 experienced leptomeningeal dissemination, and 5 developed extracranial metastases. The median survival time of the patients was 31 months.","PeriodicalId":12860,"journal":{"name":"Hiroshima journal of medical sciences","volume":"67 1","pages":"21-29"},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43303395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Rationale and Design of a Prospective, Multicentre, Stop Tyrosine Kinase Inhibitor Trial of Paediatric Patients with Chronic Myeloid Leukaemia with Sustained Complete Molecular Response (STKI-14) 一项前瞻性、多中心、终止酪氨酸激酶抑制剂试验的原理和设计，该试验针对具有持续完全分子反应的慢性髓性白血病患儿（STKI-14）

Hiroshima journal of medical sciences Pub Date : 2018-03-01 DOI: 10.24811/HJMS.67.1_7

H. Shimada, A. Kada, H. Shima, C. Tono, Y. Yuza, H. Kurosawa, A. Watanabe, Masaki Ito, Hideko Uryu, K. Kamibeppu, N. Kiyokawa, S. Adachi, A. Saito, A. Tanizawa

{"title":"Rationale and Design of a Prospective, Multicentre, Stop Tyrosine Kinase Inhibitor Trial of Paediatric Patients with Chronic Myeloid Leukaemia with Sustained Complete Molecular Response (STKI-14)","authors":"H. Shimada, A. Kada, H. Shima, C. Tono, Y. Yuza, H. Kurosawa, A. Watanabe, Masaki Ito, Hideko Uryu, K. Kamibeppu, N. Kiyokawa, S. Adachi, A. Saito, A. Tanizawa","doi":"10.24811/HJMS.67.1_7","DOIUrl":"https://doi.org/10.24811/HJMS.67.1_7","url":null,"abstract":"Chronic myeloid leukaemia (CML) is a relatively rare disease in children, accounting for 2–3% of all paediatric leukaemia cases. Generally, children with CML can avoid hematopoietic stem cell transplantation and achieve molecular responses with tyrosine kinase inhibitors (TKI). However, CML stem cells are thought to survive in many patients, even after TKI treatment. Many aspects of the toxic effects of prolonged exposure to TKIs during childhood remain unclear, particularly those regarding growth impairment. This lack of clarity underscores the importance of the present clinical trial, which aims to clarify the feasibility of treatment-free remission (TFR) in children following TKI treatment. We aim to examine the long-term outcomes and complications of TKIs before and after cessation to better understand the unknown complications that could arise in adulthood. This trial targets patients who were diagnosed with CML at an age younger than 20 years, were in the chronic or accelerated phase at initial diagnosis and remained in complete molecular remission for at least 2 years after TKI administration. We will examine the utility of TKI cessation and assess the treatment results of patients who resumed TKI therapy after losing a major molecular response. We will also investigate factors related to the feasibility of a TFR after TKI cessation.","PeriodicalId":12860,"journal":{"name":"Hiroshima journal of medical sciences","volume":"67 1","pages":"7-13"},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44990892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Correlation Analysis between Antibiotic Resistance Gene Profile and Susceptibility to Gentamicin, Clindamycin, and Minocycline in Clinically Isolated Methicillin-resistant Staphylococcus aureus 临床分离耐甲氧西林金黄色葡萄球菌抗生素耐药基因谱与庆大霉素、克林霉素、米诺环素敏感性的相关性分析

Hiroshima journal of medical sciences Pub Date : 2017-12-21 DOI: 10.24811/HJMS.66.2_31

I. P. Pratomo, Fathiyah Isbaniyah, Yumiko Koba, H. Ohge, T. Sueda, E. Hiyama

引用次数: 0

Age-Dependent Contributions of Neck Circumference to Indices of Obesity Among Female College Students Aged 18 to 20 Years 颈围对18 ~ 20岁女大学生肥胖指标的年龄依赖性

Hiroshima journal of medical sciences Pub Date : 2017-12-01 DOI: 10.24811/HJMS.66.4_109

Y. Nitta, Yumiko Miki, S. Aoi, H. Ikeda, T. Iida, C. Chikamura, N. Tamura, K. Nitta, H. Miyaguchi, T. Harada, F. Ishizaki

{"title":"Age-Dependent Contributions of Neck Circumference to Indices of Obesity Among Female College Students Aged 18 to 20 Years","authors":"Y. Nitta, Yumiko Miki, S. Aoi, H. Ikeda, T. Iida, C. Chikamura, N. Tamura, K. Nitta, H. Miyaguchi, T. Harada, F. Ishizaki","doi":"10.24811/HJMS.66.4_109","DOIUrl":"https://doi.org/10.24811/HJMS.66.4_109","url":null,"abstract":"Measurement of neck circumference (NC) is an easy method to assess obesity. Our investigation to estimate risks for metabolic disease in Japanese postmenopausal women indicated that NC is significantly associated with whole-body obesity indices and visceral fat accumulation. To clarify the early stage of metabolic changes and confirm NC validity as a predictor of metabolic syndrome, NC’s association to the four obesity indices, namely, weight, body mass index (BMI), body fat, and waist circumference (WC), was examined in a college student group of 60 females aged 18.7±0.3 years. NC was mainly correlated with weight, followed by BMI, WC, and body fat. It was also significantly associated with weight and BMI, but not with body fat. The participants were divided into two subgroups: “sports-experienced” and “not-sports-experienced,” who had moderate and strong correlation coefficients with NC and WC, respectively. WC value was possibly predicted by NC values using linear functions for the group and its subgroups. The correlation between NC and WC, NC’s association to weight, and substitution of NC to WC were confirmed by the same analyses in another student group composed with 18 females aged 19.7±0.6 years. Our study showed that the distribution of body fat in college students is difficult to assess based on NC alone. Nevertheless, NC measurement is an easy, inexpensive, and reproducible method to assess obesity and a possible predictor to identify the risk for future metabolic diseases in Japanese college students with the four obesity indices, weight, BMI, body fat, and WC.","PeriodicalId":12860,"journal":{"name":"Hiroshima journal of medical sciences","volume":"66 1","pages":"109-115"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42602697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Features of Phyllodes Tumours and Fibroadenomas Differ on MR Images 叶状瘤和纤维腺瘤在MR图像上的特征不同

Hiroshima journal of medical sciences Pub Date : 2017-09-01 DOI: 10.24811/HJMS.66.3_77

Midori Noma, K. Matsuura, M. Ôhara, T. Itamoto, T. Nishisaka, H. Ohdan

{"title":"Features of Phyllodes Tumours and Fibroadenomas Differ on MR Images","authors":"Midori Noma, K. Matsuura, M. Ôhara, T. Itamoto, T. Nishisaka, H. Ohdan","doi":"10.24811/HJMS.66.3_77","DOIUrl":"https://doi.org/10.24811/HJMS.66.3_77","url":null,"abstract":"This retrospective study aimed to determine how the magnetic resonance imaging (MRI) and histopathological findings of phyllodes tumours (PT) and fibroadenomas (FA) correlate and verify whether they are useful for preoperative diagnosis. We retrospectively reviewed 12 PT and 43 FA that were surgically resected after MRI assessment between 2009 and 2015. The shape and signal intensity (SI) of the tumours on T2-weighted images (T2WI), the apparent diffusion coefficient, and SI were dynamically assessed. High SI areas suggestive of haemorrhage were significantly more frequent on pre-contrast T1WI of PT than that of FA (66.7% vs. 16.2%, p = 0.00034). The results of the SI analysis showed a higher intratumoural SI for PT than FA on T2WI (7.07 vs. 4.37, p = 0.0022). Overall enhancement was more intense among PT than FA, while SI was significantly higher at 100 seconds (2.03 vs. 1.60, p = 0.043) when enhanced effects on pre-enhanced tumours were quantified based on SI ratios. Not only can MRI morphologically differentiate PT from FA, it can also provide information about tissue composition and vascularization, the quantitation of which seems useful for differentiation.","PeriodicalId":12860,"journal":{"name":"Hiroshima journal of medical sciences","volume":"66 1","pages":"77-83"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45789179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetic Resonance Imaging Evidence of an Occipital- Straight Sinus Dural Arteriovenous Fistula Causing Severe Bilateral Thalamic Oedema: A Case Report 枕直窦硬脑膜动静脉瘘致双侧丘脑水肿的磁共振影像学证据1例

Hiroshima journal of medical sciences Pub Date : 2017-09-01 DOI: 10.24811/HJMS.66.3_91

F. Moinuddin, Nadia Delima Andini, N. I. Khairunnisa, Muhammad Kamil, Y. Sadamura, Sei Sugata, H. Hirano, Y. Kashida, K. Arita

{"title":"Magnetic Resonance Imaging Evidence of an Occipital- Straight Sinus Dural Arteriovenous Fistula Causing Severe Bilateral Thalamic Oedema: A Case Report","authors":"F. Moinuddin, Nadia Delima Andini, N. I. Khairunnisa, Muhammad Kamil, Y. Sadamura, Sei Sugata, H. Hirano, Y. Kashida, K. Arita","doi":"10.24811/HJMS.66.3_91","DOIUrl":"https://doi.org/10.24811/HJMS.66.3_91","url":null,"abstract":"An 81-year-old woman, with a 3-month history of tinnitus and vertigo, presented with a deterioration of symptoms. Magnetic resonance imaging (MRI) of the brain, using fluid attenuated inversion recovery (FLAIR) and T2 weighted (T2WI) images, demonstrated hyperintensity and swelling of the bilateral thalami, medial parietal lobes, occipital lobes, and left cerebellar hemisphere. She was referred to us with the suggestion of a brain tumour that had spread into the bilateral thalami, or encephalitis. A review of the MR images, however, demonstrated dilatation of a vein on the surface of the cerebellar hemisphere on the T2WI image. Susceptibility weighted imaging (SWI) revealed small and multiple hypointense lesions, indicating microhaemorrhages, in the bilateral thalami and left cerebellar hemisphere. The time of flight source imaging demonstrated small hyperintense dots in the wall of the occipital and straight sinus. Finally, a digital subtraction angiogram (DSA) revealed a dural arteriovenous fistula (DAVF) in the occipito-straight sinus with reflux flow into the straight sinus (Borden Type II). A transvenous embolization and trans-arterial embolization were performed, in an emergency setting, for the occipital sinus and dural shunt, respectively, with the aim of preserving the antegrade flow of the straight sinus. The DSA following the endovascular treatment showed the disappearance of shunt flow and recovery of the antegrade flow in the straight sinus. Therefore, this case report highlights that meticulous analysis of MRI scans help diagnose DAVF, which results in quick and radical treatment.","PeriodicalId":12860,"journal":{"name":"Hiroshima journal of medical sciences","volume":"66 1","pages":"91-95"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44699390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of the Hydrogen Breath Test to Determine the Influence of Antibiotic Prophylaxis on Intestinal Flora 用氢呼气试验测定抗生素预防对肠道菌群的影响

Hiroshima journal of medical sciences Pub Date : 2017-09-01 DOI: 10.24811/HJMS.66.3_71

Tomoko Tanaka, H. Ohge, M. Sakashita, A. Nagano, Yusuke Watadani, N. Shimada, Raita Yano, Shinya Takahashi, K. Uemura, Y. Murakami, T. Sueda

{"title":"Use of the Hydrogen Breath Test to Determine the Influence of Antibiotic Prophylaxis on Intestinal Flora","authors":"Tomoko Tanaka, H. Ohge, M. Sakashita, A. Nagano, Yusuke Watadani, N. Shimada, Raita Yano, Shinya Takahashi, K. Uemura, Y. Murakami, T. Sueda","doi":"10.24811/HJMS.66.3_71","DOIUrl":"https://doi.org/10.24811/HJMS.66.3_71","url":null,"abstract":"Purpose: This experimental study was designed to use the hydrogen (H2) breath test to investigate changes in the intestinal flora of patients that were administered prophylactic antibiotics for 48 hours after surgery. Methods: Altogether, 22 patients were divided into two groups and the antimicrobial prophylactics, cefazolin (3.0 g/day) or sulbactam/ampicillin (4.5 g/day), were administered on induction of anaesthesia for 48 hours after surgery. End expiratory breath samples were collected on the morning of the day of surgery and every morning for 1-6 days after surgery. Results: H2 breath concentration significantly decreased in each group on day 1 (cefazolin: 1.20 ± 0.39 ppm vs. sulbactam/ampicillin: 1.17 ± 0.34 ppm). On day 2, the H2 concentration in the sulbactam/ampicillin group was significantly lower than the cefazolin group (cefazolin: 6.4 ± 2.2 ppm vs. sulbactam/ampicillin: 1.0 ± 0.4 ppm, p < 0.05). H2 concentration was still lower in the sulbactam/ampicillin group (1.3 ± 0.3 ppm vs. 3.3 ± 1.0 ppm, p = 0.10) on day 3. On days 4-6, H2 concentration was essentially the same for both groups. Discussion: Colonic anaerobes are thought to be a reservoir of resistant organisms and prolonged antimicrobial treatment is a major cause for the development of resistance. Surgical prophylaxis is basically recommended for use within 24 hours after surgery. The breath H2 concentration in both groups significantly decreased 24 hours after administration. These results suggest that both antibiotics influence the activity of colonic anaerobes and the duration of surgical antibiotic prophylaxis should be as short as possible.","PeriodicalId":12860,"journal":{"name":"Hiroshima journal of medical sciences","volume":"66 1","pages":"71-76"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45191996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0