HeadachePub Date : 2025-09-01Epub Date: 2025-07-31DOI: 10.1111/head.15026
Amy S Grinberg
{"title":"Expanding access to behavioral interventions for headache: The evolution of the Veteran Affairs behavioral medicine program in the headache centers of excellence.","authors":"Amy S Grinberg","doi":"10.1111/head.15026","DOIUrl":"https://doi.org/10.1111/head.15026","url":null,"abstract":"","PeriodicalId":12844,"journal":{"name":"Headache","volume":"65 8","pages":"1457-1459"},"PeriodicalIF":4.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HeadachePub Date : 2025-09-01Epub Date: 2025-06-24DOI: 10.1111/head.14998
Christina Murphy, Ali Ladak, Christina L Szperka, Blanca Marquez De Prado, Andrew D Hershey, Carlyn Patterson Gentile
{"title":"Response to: Reassessing pediatric migraine disability: Toward an updated assessment tool in the era of novel therapeutics.","authors":"Christina Murphy, Ali Ladak, Christina L Szperka, Blanca Marquez De Prado, Andrew D Hershey, Carlyn Patterson Gentile","doi":"10.1111/head.14998","DOIUrl":"10.1111/head.14998","url":null,"abstract":"","PeriodicalId":12844,"journal":{"name":"Headache","volume":" ","pages":"1275"},"PeriodicalIF":4.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12272741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HeadachePub Date : 2025-09-01Epub Date: 2025-08-22DOI: 10.1111/head.15032
Rehab Magdy, Amr Hassan, Shaden Adel, Ahmed Dahshan, Mohamed Wagdy, Sara H Ali, Ahmed M Khallaf, Ahmed Essmat, Hebatallah N Abdelazeem, Noha A Mahfouz, Nada Mamdouh Elbehiry, Mohamed Abdelghaffar, Eman H Elsebaie, Mona Hussein
{"title":"Ramadan fasting in smokers with primary headache disorders: Impact of nicotine dependence on headache frequency and severity.","authors":"Rehab Magdy, Amr Hassan, Shaden Adel, Ahmed Dahshan, Mohamed Wagdy, Sara H Ali, Ahmed M Khallaf, Ahmed Essmat, Hebatallah N Abdelazeem, Noha A Mahfouz, Nada Mamdouh Elbehiry, Mohamed Abdelghaffar, Eman H Elsebaie, Mona Hussein","doi":"10.1111/head.15032","DOIUrl":"10.1111/head.15032","url":null,"abstract":"<p><strong>Background: </strong>Nicotine withdrawal has not been studied before as a contributing factor for headache exacerbations during Ramadan. Therefore, we aimed to explore the impact of smoking status and nicotine dependence on the frequency and severity of primary headache disorders during fasting.</p><p><strong>Methods: </strong>This prospective cohort study with pre-post comparisons was conducted on male smokers and nonsmokers with primary headache disorders. The patients were recruited from four headache clinics in three Egyptian governorates: Cairo, Beni-Suef, and Fayoum at the beginning of Shaaban. The patients were hand-delivered a questionnaire containing questions targeting the last week of Shaaban and another one targeting the first week of Ramadan. Participants were instructed to resubmit their completed questionnaires electronically at the end of the first week of Ramadan. The number of headache days (NHDs), Visual Analog Scale (VAS), and Headache Impact Test-6 (HIT-6) scores, as well as the Depression, Anxiety, and Stress Scale-12 items (DASS-12) scores, were compared during the first week of Ramadan to those during the last week of Shaaban. Intensity of nicotine dependence was assessed by the Fagerstrom Test for Cigarette Dependence (FTCD).</p><p><strong>Results: </strong>This study included 1023 males with primary headache disorders (400 smokers and 623 never-smokers). During the last week in Shaaban, smokers were found to have significantly higher NHDs, HIT-6 total, and DASS-12 scores than the never-smoked group (2 [1-3] vs. 1 [0-3], p = 0.001; 58 [50-63] vs. 56 [46-63], p = 0.021; and 16 [7.25-22] vs. 10 [2-18], p < 0.001, respectively). The changes in NHDs, VAS, HIT-6, and DASS-12 scores during the first week of Ramadan were significantly higher in smokers than in the never-smoked group (0 [0-2] vs. 0 [0-1], p = 0.003; 0 [0-2] vs. 0 [0-1], p = 0.001; 1 [-1 to 5] vs. 0 [-2 to 4], p = 0.008; and 0 [-1 to 2.75] vs. 0 [-2 to 0], p < 0.001, respectively). Moreover, FTCD scores were positively correlated with changes in the NHDs (r = 0.26, p < 0.001), VAS (r = 0.28, p < 0.001), HIT-6 (r = 0.27, p < 0.001), and DASS-12 (r = 0.38, p < 0.001) scores during the first week of Ramadan. Smoking increased the odds of clinically significant worsening in HIT-6 by 1.44 (95% confidence interval [CI], 1.04-2.01) times. Among smokers, higher FTCD scores and greater change in DASS-12 increased the odds of worsening by 1.17 (95% CI, 1.05-1.30) and 1.13 (95% CI, 1.07-1.19) times, respectively.</p><p><strong>Conclusion: </strong>Current smoking could adversely impact the frequency and severity of primary headaches during the first week of Ramadan, in particular in those with greater nicotine dependence and who experienced higher stress and negative emotions on nicotine withdrawal.</p>","PeriodicalId":12844,"journal":{"name":"Headache","volume":" ","pages":"1308-1317"},"PeriodicalIF":4.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HeadachePub Date : 2025-09-01Epub Date: 2025-06-19DOI: 10.1111/head.14993
Teshamae S Monteith, Asimina Lazaridou, Carolyn Bernstein
{"title":"Combination behavioral and pharmacological interventions through telehealth platforms: Opportunities for increasing access and optimizing migraine outcomes.","authors":"Teshamae S Monteith, Asimina Lazaridou, Carolyn Bernstein","doi":"10.1111/head.14993","DOIUrl":"10.1111/head.14993","url":null,"abstract":"","PeriodicalId":12844,"journal":{"name":"Headache","volume":" ","pages":"1276-1278"},"PeriodicalIF":4.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12455394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HeadachePub Date : 2025-09-01Epub Date: 2025-07-28DOI: 10.1111/head.15017
Giuseppe D Mangano, Vincenzo Antona, Giuseppe Santangelo, Gabriele Di Pasquale, Jacopo Colella, Vincenzo Salpietro, Giuseppa R Mangano, Vincenzo Raieli
{"title":"A novel de novo AP2M1 variant in a patient with attention-deficit/hyperactivity disorder, oppositional defiant disorder, and unexpected hemiplegic migraine.","authors":"Giuseppe D Mangano, Vincenzo Antona, Giuseppe Santangelo, Gabriele Di Pasquale, Jacopo Colella, Vincenzo Salpietro, Giuseppa R Mangano, Vincenzo Raieli","doi":"10.1111/head.15017","DOIUrl":"10.1111/head.15017","url":null,"abstract":"","PeriodicalId":12844,"journal":{"name":"Headache","volume":" ","pages":"1497-1499"},"PeriodicalIF":4.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12455470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144729937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ambient nitrogen dioxide, temperature exposure, and migraine incidence: A large prospective cohort study.","authors":"Shuzi Ye, Yinyan Gao, Yijuan Lin, Jiali Wang, Irene Xinyin Wu, Fang Xiao","doi":"10.1111/head.15037","DOIUrl":"10.1111/head.15037","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to quantify the associations of low-level ambient nitrogen dioxide (NO<sub>2</sub>) and seasonal temperatures with migraine incidence.</p><p><strong>Background: </strong>Migraine is a highly disabling neurovascular disorder in which attacks are affected by short-term high-level air pollution; however, the associations of long-term low-level air pollution and climate change on migraine incidence are unknown.</p><p><strong>Methods: </strong>In this prospective cohort study using data from the UK Biobank, 407,792 participants without migraine at baseline were included. Environmental exposures were assessed monthly and yearly using zip code-linked gridded data. We compared migraine incidence across populations with varying exposure levels of NO<sub>2</sub>, seasonal temperatures, and temperature variability to assess their associations with migraine risk.</p><p><strong>Results: </strong>During a median follow-up of 11.8 years (2316 migraine cases), migraine risk increased with higher NO<sub>2</sub> exposure (adjusted hazard ratio [aHR], 1.10 per 10 μg/m<sup>3</sup> increase; 95% confidence intervals [CI], 1.01-1.19), lower winter temperatures (aHR, 1.46 per 5°C decrease; 95% CI, 1.26-1.69), and higher temperature variability in both summer (aHR, 1.19 per 1°C increase; 95% CI, 1.07-1.32) and winter (aHR, 1.07 per 1°C increase; 95% CI, 1.01-1.13). Joint effects were observed between NO<sub>2</sub> and temperature patterns, with the highest risks associated with combinations of high NO<sub>2</sub>-low winter temperature (aHR, 1.67; 95% CI, 1.42-1.95), high NO<sub>2</sub>-high summer temperature variability (aHR, 1.48; 95% CI, 1.25-1.76), and high NO<sub>2</sub>-low winter temperature variability (aHR, 1.64; 95% CI, 1.39-1.93).</p><p><strong>Conclusions: </strong>The findings that NO<sub>2</sub> and temperature are associated with migraine incidence suggest that to mitigate further the environmental risk factors associated with migraine incidence, we may need to adopt a combination of public health measures of air quality management and climate change adaptation.</p>","PeriodicalId":12844,"journal":{"name":"Headache","volume":" ","pages":"1318-1330"},"PeriodicalIF":4.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HeadachePub Date : 2025-09-01DOI: 10.1111/head.15039
Alexis Espanioli, Nynke J van den Hoogen, Jonathan Kuziek, Kirsten Sjonnesen, Melanie Noel, Serena L Orr
{"title":"Exploring the relationship between pain catastrophizing and migraine in youth: A longitudinal clinical cohort study.","authors":"Alexis Espanioli, Nynke J van den Hoogen, Jonathan Kuziek, Kirsten Sjonnesen, Melanie Noel, Serena L Orr","doi":"10.1111/head.15039","DOIUrl":"10.1111/head.15039","url":null,"abstract":"<p><strong>Objective: </strong>This study explored the relationship between pain catastrophizing and migraine-related outcomes (i.e., migraine-related disability and headache frequency) between visits with a neurologist in a clinical population of children and adolescents with migraine.</p><p><strong>Background: </strong>Evidence from adult populations suggests that pain catastrophizing, the tendency to magnify the threat value of, and ruminate and feel helpless about, pain may be associated with migraine-related outcomes, but the association in children and adolescents is less clear.</p><p><strong>Methods: </strong>In this prospective longitudinal clinical cohort study, children and adolescents aged 8-18 years with migraine completed headache questionnaires and a validated measure of pain catastrophizing (Pain Catastrophizing Scale for Children) at baseline and initial follow-up visits with a neurologist. Recruitment spanned from May 2019 to July 2023. Headache frequency and migraine-related disability (Pediatric Migraine Disability Assessment) were assessed at both visits. Migraine outcomes at follow-up were examined in relation to baseline pain catastrophizing scores in models that controlled for sex, age, preventive treatment use, baseline headache frequency, and baseline disability.</p><p><strong>Results: </strong>For this study, 121 consenting participants were included. In models adjusted for age, sex, baseline headache frequency, baseline disability, and preventive treatment use, baseline pain catastrophizing scores were significantly associated with disability scores at follow-up (β = 0.81, 95% confidence interval [CI] = 0.13-1.48, p = 0.020), but not with headache frequency at follow-up (β = 0.04, 95% CI = -0.10 to 0.19, p = 0.575). When examining the specific subscales of pain catastrophizing in an adjusted model, only baseline pain magnification (β = 6.73, 95% CI = 2.95-10.51, p = 0.001) had a significant association with disability at follow-up, while feelings of helplessness (β = 0.08, 95% CI = -2.11 to 2.27, p = 0.944) and rumination did not (β = -1.83, 95% CI = -4.22 to 0.56, p = 0.133). In a subset of participants with pain catastrophizing measured at both visits (n = 65), pain catastrophizing total and subscale scores did not significantly differ between visits.</p><p><strong>Conclusion: </strong>Baseline pain catastrophizing scores were associated with migraine-related disability, but not headache frequency, at follow-up in a clinical population of children and adolescents with migraine. Pain magnification specifically appeared to drive this association. Future studies should aim to replicate our results and to investigate if interventions aimed specifically at reducing pain magnification may help to mitigate migraine-related disability in children and adolescents.</p>","PeriodicalId":12844,"journal":{"name":"Headache","volume":" ","pages":"1369-1380"},"PeriodicalIF":4.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12455422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HeadachePub Date : 2025-09-01Epub Date: 2025-06-24DOI: 10.1111/head.14969
Ali Reza Tavasoli, Eric V Hastriter, Robert D Little, Kavitha T Karnik, Kara S Lewis, Reena G Rastogi
{"title":"Reassessing pediatric migraine disability: Toward an updated assessment tool in the era of novel therapeutics.","authors":"Ali Reza Tavasoli, Eric V Hastriter, Robert D Little, Kavitha T Karnik, Kara S Lewis, Reena G Rastogi","doi":"10.1111/head.14969","DOIUrl":"10.1111/head.14969","url":null,"abstract":"","PeriodicalId":12844,"journal":{"name":"Headache","volume":" ","pages":"1272-1274"},"PeriodicalIF":4.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}