Helvetica Chimica Acta最新文献_第7页

The Two Janus Faces of CpRu-Based Deallylation Catalysts and Their Application for in Cellulo Prodrug Uncaging 基于 CpRu 的脱烯丙基催化剂的两面性及其在细胞内原药释放中的应用

IF 1.5 4区化学

Helvetica Chimica Acta Pub Date : 2024-04-15 DOI: 10.1002/hlca.202400053

Alain Baiyoumy, Robin Vinck, Thomas R. Ward

引用次数: 0

Controlled Release of Volatile Enones from Monomeric and Dimeric Thioether, Sulfoxide and Sulfone Profragrances 单体和二聚体硫醚、亚砜和砜类增殖体中挥发性烯酮的可控释放

IF 1.8 4区化学

Helvetica Chimica Acta Pub Date : 2024-04-10 DOI: 10.1002/hlca.202400046

Alain Trachsel, Sabine Leocata, Jean-Yves de Saint Laumer, Andreas Herrmann

{"title":"Controlled Release of Volatile Enones from Monomeric and Dimeric Thioether, Sulfoxide and Sulfone Profragrances","authors":"Alain Trachsel, Sabine Leocata, Jean-Yves de Saint Laumer, Andreas Herrmann","doi":"10.1002/hlca.202400046","DOIUrl":"10.1002/hlca.202400046","url":null,"abstract":"Thioether (sulfide) profragrances are readily prepared by 1,4-addition of alkanethiols to enones (thia-Michael reaction). Under ambient conditions, they slowly release the parent enones, thus generating a long-lasting perfumery effect. The fragrance release of profragrances obtained by 1,4-addition of S, O and N nucleophiles to enones was compared on cotton and on a hard surface for monomeric and dimeric structures. To avoid the uncontrolled generation of volatile sulfur compounds from thioethers, we investigated the extent to which different side reactions occurred next to the expected formation of enones and alkanethiols. Headspace analyses on cotton showed that enones and aldehydes were the major reaction products, whereas none or only traces of β-mercaptoketones, diketones or alkanethiols were detected. The absence of alkanethiols indicated that 1,4-elimination of thioethers was not a major pathway for fragrance release. Extraction of the cotton sheets after analysis showed that thioethers were oxidised to sulfoxides, which then can generate enones by 1,4-elimination. Thioethers, sulfoxides and sulfones were shown to efficiently release enones in practical applications.","PeriodicalId":12842,"journal":{"name":"Helvetica Chimica Acta","volume":"107 6","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140571705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Total Synthesis of Core 3 & Core 4-Type Mucin Glycan Derivatives 核心 3 型和核心 4 型粘蛋白聚糖衍生物的全合成

IF 1.5 4区化学

Helvetica Chimica Acta Pub Date : 2024-04-03 DOI: 10.1002/hlca.202400026

Carmen R. Cori, Rachel Hevey

{"title":"Total Synthesis of Core 3 & Core 4-Type Mucin Glycan Derivatives","authors":"Carmen R. Cori, Rachel Hevey","doi":"10.1002/hlca.202400026","DOIUrl":"10.1002/hlca.202400026","url":null,"abstract":"Recent studies have demonstrated the ability of mucin O-glycans to attenuate virulence in diverse, cross-kingdom pathogens, sparking interest in their development as a novel therapeutic approach against infection. Although their virulence attenuating activity is evident, mucin glycans obtained from native sources comprise mixtures of several hundred distinct structures, and therefore the specific active glycan epitopes and molecular mechanisms of virulence attenuation remain unclear. Individual mucin glycan structures cannot be purified from native sources and are not amenable to automated synthesis; therefore, to further investigate the phenomena of virulence attenuation we have been developing convergent and scalable methods (>30 mg per target glycan) to assemble a mucin O-glycan library in sufficient scale and purity to facilitate biological studies. Previously we described a method to obtain core 1 & core 2-type mucin glycan derivatives that have since been used to identify active epitopes in Candida albicans and Vibrio cholerae. In the current study, we describe the expansion of our glycan library to include core 3 & core 4-type derivatives, increasing the structural diversity of our platform for biological evaluation.","PeriodicalId":12842,"journal":{"name":"Helvetica Chimica Acta","volume":"107 7","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hlca.202400026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140571667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of N-Substituted Pyrrole-2,5-dicarboxylic Acids from Pyrroles 从吡咯合成 N-取代的吡咯-2,5-二羧酸

IF 1.8 4区化学

Helvetica Chimica Acta Pub Date : 2024-04-03 DOI: 10.1002/hlca.202400036

Jan-Simon Jeshua Friedrichs, Dr. Luca Schmermund, Dr. Corinna Urmann, Prof. Dr. Volker Sieber

引用次数: 0

Introduction for the Special Collection of Papers in the Honor of the President of the 56th Bürgenstock Conference, Alois Fürstner 第 56 届比尔根山会议主席 Alois Fürstner 纪念论文集导言

IF 1.8 4区化学

Helvetica Chimica Acta Pub Date : 2024-03-29 DOI: 10.1002/hlca.202400042

Prof. Alois Fürstner

引用次数: 0

Isolation of Fidaxomicin and Shunt Metabolites from Actinoplanes deccanensis 从 Actinoplanes deccanensis 中分离出菲达霉素和分流代谢物