Heart International最新文献

{"title":"Letter from the Editor-in-Chief.","authors":"Rajesh Davé","doi":"10.17925/HI.2019.13.2.9","DOIUrl":"https://doi.org/10.17925/HI.2019.13.2.9","url":null,"abstract":"","PeriodicalId":12836,"journal":{"name":"Heart International","volume":"13 2","pages":"9-10"},"PeriodicalIF":0.2,"publicationDate":"2019-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562419/pdf/heart-int-13-10.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40663807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of the Ultrathin Orsiro Biodegradable Polymer Drug-eluting Stent in the Treatment of Coronary Artery Disease.","authors":"James J Wu, Joshua Ah Way, David Brieger","doi":"10.17925/HI.2019.13.2.17","DOIUrl":"10.17925/HI.2019.13.2.17","url":null,"abstract":"<p><p>Drug-eluting stents (DES) have revolutionised the treatment of coronary artery disease (CAD) in patients undergoing percutaneous coronary intervention. In recent years, there has been a focus on a new generation of DES, such as biodegradable polymer DES (BP-DES). This novel stent platform was developed with the hope of eliminating the risk of very late stent thrombosis associated with the current gold-standard durable polymer DES (DP-DES). Ultrathin Orsiro BP-DES (Biotronik, Bülach, Switzerland) are based on a cobalt-chromium stent platform that is coated with a bioresorbable polymer coating containing sirolimus. These devices have one of the thinnest struts available in the current market and have the theoretical benefit of reducing a chronic inflammatory response in the vessel wall. In 2019, the United States Food and Drug Administration (FDA) approved the use of Orsiro BP-DES in patients with CAD based on promising results in recent landmark trials, such as BIOFLOW V and BIOSTEMI. The aim of the present review article was to discuss the history of stent technology and the continued opportunities for improvements, focusing on the potential benefits of Orsiro BP-DES.</p>","PeriodicalId":12836,"journal":{"name":"Heart International","volume":"13 2","pages":"17-24"},"PeriodicalIF":1.9,"publicationDate":"2019-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9559229/pdf/heart-int-13-17.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40663809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterising the Clinical Spectrum, Diagnosis and Outcomes in Secondary Stress Cardiomyopathy.","authors":"Puneet Gupta,&nbsp;Anand Chockalingam","doi":"10.17925/HI.2019.13.2.26","DOIUrl":"https://doi.org/10.17925/HI.2019.13.2.26","url":null,"abstract":"<p><strong>Introduction: </strong>Available literature on takotsubo cardiomyopathy excludes critically ill patients due to challenges in angiographic confirmation. Secondary stress cardiomyopathy (sSC) occurs in patients already hospitalised for other critical illnesses. Diagnosis of sSC is challenging, while clinical presentation and outcomes are significantly different from primary stress cardiomyopathy. Our aim was to better characterise the clinical picture of sSC.</p><p><strong>Methods: </strong>The diagnosis of sSC was confirmed based on characteristic clinical and morphological features, applying our diagnostic algorithm suited for critically ill patients. We were able to characterise these sSC patients and differentiate their presentation from takotsubo registry population. Data on selected patients was extracted manually on Microsoft Excel worksheets with relevant patient demographics, presenting features and outcomes.</p><p><strong>Results: </strong>We developed a profile of sSC based on 18 consecutive confirmed cases diagnosed at our university hospital between April 2016 and September 2018. sSC differed from takotsubo cardiomyopathy in several key clinical aspects - younger people may develop sSC (range 21-86 years) and men were more frequently affected in comparison to takotsubo cardiomyopathy (29%). Dyspnoea was noted in 22% of our patients and angina was rare. Apical ballooning occurred in only 33% of the patients, while mid (39%) and basal left ventricular (11%) variants accounted for half of the patients. Mortality was much higher (28%) due to underlying medical comorbidities.</p><p><strong>Conclusions: </strong>Our series illustrates significant clinical and morphologic differences in the presentation of sSC. Shifting the emphasis to serial echocardiography would reduce the need for invasive catheterisation and downstream comorbidity in critical care settings.</p>","PeriodicalId":12836,"journal":{"name":"Heart International","volume":"13 2","pages":"26-30"},"PeriodicalIF":0.2,"publicationDate":"2019-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9559225/pdf/heart-int-13-26.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40651557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating Equivocal Left Main Stenosis with Fractional Flow Reserve - Not all Daughter Vessels are Created Equally.","authors":"Ahmed Almomani,&nbsp;Abdul-Rahman Abdel-Karim,&nbsp;Barry F Uretsky","doi":"10.17925/HI.2019.13.2.38","DOIUrl":"https://doi.org/10.17925/HI.2019.13.2.38","url":null,"abstract":"<p><p>Fractional flow reserve (FFR) evaluation of intermediate left main coronary artery (LMCA) stenosis has been validated in clinical decision-making. However, the size of the daughter vessel, in which the FFR transducer is placed and the amount of myocardium it subtends, has received less attention. We present a case that demonstrates the importance of transducer location, size of the daughter vessel and the amount of subtended myocardium in evaluation of LMCA stenosis, pointing out potential pitfalls.</p>","PeriodicalId":12836,"journal":{"name":"Heart International","volume":"13 2","pages":"38-40"},"PeriodicalIF":0.2,"publicationDate":"2019-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9559224/pdf/heart-int-13-38.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40663808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantification of Seasonal Variation in Daily Physical Activity in Individuals with Heart Failure and Implantable Cardioverter Defibrillator/Cardiac Resynchronisation Therapy Devices.","authors":"Michael J Shoemaker,&nbsp;Amanda Ferrick,&nbsp;Cathryn Fischer,&nbsp;Colin Schuurman,&nbsp;Kelly Cartwright,&nbsp;Jessica McLeod,&nbsp;Emily Schuman,&nbsp;Ashley Van Dam,&nbsp;Michael G Dickinson","doi":"10.17925/HI.2019.13.2.31","DOIUrl":"https://doi.org/10.17925/HI.2019.13.2.31","url":null,"abstract":"<p><strong>Purpose: </strong>Understanding seasonal variation of daily physical activity (PA) in patients with heart failure (HF) has important implications for planning and interpretation of clinical trials, but the presence and magnitude of this seasonal variation in daily PA have yet to be established. The purpose of the present study was to determine the presence and magnitude of seasonal variation in daily PA in community-dwelling individuals with HF using several analytic approaches.</p><p><strong>Methods: </strong>Retrospective chart review of patients with HF and Medtronic implantable cardioverter defibrillator/cardiac resynchronisation therapy (ICD/CRT) devices. Data included in analyses (autocorrelation, analysis of covariance, one-way analysis of variance) were clinical characteristics, the patient activity measure of daily PA from the ICD/CRT devices, temperature and hours of daylight over the 1-year period of 1 November 2017-31 October 2018.</p><p><strong>Results: </strong>One hundred and sixty-eight patients were included. Visual analysis and autocorrelation demonstrated seasonal variation in daily PA. Daily PA seasonal difference between winter and summer months was 0.4 hours per day/24 minutes per day/2.8 hours per week/14.9%. This seasonal effect on daily PA is significantly greater in those with ≤8 comorbid conditions and an overall activity level of >2.2 hours per day compared to those with multiple comorbidities and low overall activity (0.7 versus 0.1 hours per day, respectively).</p><p><strong>Conclusions: </strong>The present study affirms the seasonality of daily PA in a cohort of patients with HF and ICD/CRT devices and reveals a disproportionate seasonal effect on those with fewer comorbidities and higher overall activity levels. Seasonal variation should be accounted for when interpreting change in daily PA in clinical practice and when designing and interpreting results of clinical trials investigating interventions to improve daily PA.</p>","PeriodicalId":12836,"journal":{"name":"Heart International","volume":"13 2","pages":"31-37"},"PeriodicalIF":0.2,"publicationDate":"2019-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524607/pdf/heart-int-13-31.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40651559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal Denervation in High-risk Patients with Hypertension.","authors":"Marshall J Heradien,&nbsp;Pieter van der Bijl,&nbsp;Paul A Brink","doi":"10.17925/HI.2019.13.2.12","DOIUrl":"https://doi.org/10.17925/HI.2019.13.2.12","url":null,"abstract":"<p><p>Hypertension is a common health problem, which leads to a substantial mortality and morbidity burden, globally. The management of patients with high-risk and treatment-resistant hypertension remains a major clinical challenge to the treating physician. Renal denervation (RD) is an emerging technique, comprising modification of the renal sympathetic nerve supply which courses around the renal arteries. Endovascular access is obtained to the renal arteries, followed by delivery of heat energy to the peri-renal sympathetic nerves. This leads to the reduction of blood pressure with or without the addition of anti-hypertensive pharmacotherapy. Earlier trials led to clinical equipoise, but more recent trials (e.g. SPYRAL HTN-OFF MED, SPYRAL HTN-ON MED and RADIANCE-HTN SOLO), which were designed to overcome the limitations of the initial studies, have provided support for the efficacy of RD in hypertension management. Evidence (from randomised, non-randomised, sham-controlled and non-sham-controlled trials) for the use of RD in the treatment of hypertension is reviewed in this article. Finally, the current clinical role, gaps in evidence, and the expected future evolution of RD are discussed.</p>","PeriodicalId":12836,"journal":{"name":"Heart International","volume":"13 2","pages":"12-16"},"PeriodicalIF":0.2,"publicationDate":"2019-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524839/pdf/heart-int-13-13.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40651558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Stent Enhancement Technique During Percutaneous Coronary Intervention - A Case Series.","authors":"Filippo Figini, Yves Louvard, Imad Sheiban","doi":"10.17925/HI.2019.13.1.28","DOIUrl":"10.17925/HI.2019.13.1.28","url":null,"abstract":"<p><p>Stent enhancement allows clear visualisation of implanted stents. This method, originally intended to assess stent under-expansion, can prove extremely valuable in several other situations. We present three cases illustrating its potential uses in assessment of stent failure, intraprocedural stent disruption and treatment of aorto-ostial and bifurcation lesions. Whilst stent enhancement cannot replace intravascular imaging, compared to simple angiography it can significantly improve percutaneous coronary intervention outcomes with no additional cost and with minimal procedural time.</p>","PeriodicalId":12836,"journal":{"name":"Heart International","volume":"13 1","pages":"28-31"},"PeriodicalIF":1.9,"publicationDate":"2019-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524748/pdf/heart-int-13-28.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40664274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved Dosing and Administration of Rivaroxaban when Prescribed by a Cardiologist.","authors":"Madeline R Leiter,&nbsp;Kathleen A Packard,&nbsp;Yongyue Qi,&nbsp;Steven K Krueger","doi":"10.17925/HI.2019.13.1.24","DOIUrl":"https://doi.org/10.17925/HI.2019.13.1.24","url":null,"abstract":"<p><p>Rivaroxaban is a direct oral anticoagulant (DOAC) indicated to reduce risk of stroke and systemic embolism in patients with non-valvular atrial fibrillation (AF). A discrepancy exists between the recommended dosage and real-world use of DOACs, especially rivaroxaban, thus putting patients at risk of thromboembolic events.</p><p><strong>Methods: </strong>This retrospective study assessed real-world prescribing and patient adherence to dietary requirements during use of rivaroxaban in 116 patients with AF. Associations between prescriber specialty and the correct dosing and administration were assessed using the Chi-Square test.</p><p><strong>Results: </strong>Most rivaroxaban prescriptions were ordered by cardiologists (50.9%). Sixty-nine patients (59.5%) were taking the right dose at the correct time with an adequate meal. Of the 47 (40.5%) taking rivaroxaban incorrectly, 39 (33.6%) had not been administered an adequate meal and eight (6.9%) were not prescribed the correct dose. Compared with other prescribers, patients were most likely to be taking the correct dose and administration when prescribed by cardiologists (72.9% versus 45.6%; p=0.003). Patients were least likely to be taking the correct dose and administration when prescribed by primary care providers (44.4% versus 69.0%; p=0.009). This difference was driven by patients who did not take the treatment with an adequate meal.</p><p><strong>Conclusion: </strong>Inappropriate prescribing, administration and non-adherence to DOACs can have devastating consequences. This highlights the importance of formal systematic education of patients prescribed DOACs across the whole health system. Future studies are warranted to explore the impact of non-adherence to rivaroxaban dietary requirements on clinical outcomes.</p>","PeriodicalId":12836,"journal":{"name":"Heart International","volume":"13 1","pages":"24-27"},"PeriodicalIF":0.2,"publicationDate":"2019-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562422/pdf/heart-int-13-24.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40664275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What are the Pathological Concerns and Limitations of Current Drug-coated Balloon Technology?","authors":"Yu Sato, Salomé H Kuntz, Dipti Surve, Hiroyuki Jinnouchi, Atsushi Sakamoto, Anne Cornelissen, Renu Virmani, Frank Kolodgie, Aloke V Finn","doi":"10.17925/HI.2019.13.1.15","DOIUrl":"10.17925/HI.2019.13.1.15","url":null,"abstract":"<p><p>The use of endovascular therapy for peripheral artery disease and coronary artery disease has increased and spread worldwide and is considered as the foremost, guideline-based invasive treatment. Drug-coated balloons (DCBs) utilise anti-proliferative drugs similar to drug-eluting stents; however, the do not leave any permanent metallic scaffold. Excipients and drug formulations play a crucial role in innovative DCB technologies and allow for treatment of lesions where stents are not suitable. Although the significance of downstream embolic effects after DCB use remains uncertain, several preclinical studies suggest such side effects might pose safety concerns. Recently, a meta-analysis of randomised controlled trials of paclitaxel devices suggested an association between increased mortality and paclitaxel device use. Subsequently, unfavourable criticism of paclitaxel devices attracted much attention and gave rise to a discussion about the safety of such devices. In this review, we will focus on the novel DCB technologies from the standpoint of preclinical studies and clinical trials, as well as discuss current controversies regarding the increase in death rates from paclitaxel-coated DCBs versus control devices seen in a recent meta-analysis of randomised controlled clinical trials.</p>","PeriodicalId":12836,"journal":{"name":"Heart International","volume":"13 1","pages":"15-22"},"PeriodicalIF":1.9,"publicationDate":"2019-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524611/pdf/heart-int-13-15.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40664273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter from the Editor-in-Chief.","authors":"Magdi El-Omar","doi":"10.17925/HI.2019.13.1.12","DOIUrl":"https://doi.org/10.17925/HI.2019.13.1.12","url":null,"abstract":"","PeriodicalId":12836,"journal":{"name":"Heart International","volume":"13 1","pages":"12-13"},"PeriodicalIF":0.2,"publicationDate":"2019-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524609/pdf/heart-int-13-12.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40664276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}