IF 5.1 2区医学

Heart Pub Date : 2025-04-16 DOI: 10.1136/heartjnl-2024-324681

Mark J Davies, Trudie Loban

引用次数: 0

Association between programmed electrical stimulation inducibility and arrhythmic risk in hypertrophic cardiomyopathy: a systematic review and meta-analysis. 肥厚性心肌病程序性电刺激诱导与心律失常风险之间的关系：一项系统综述和荟萃分析。

IF 5.1 2区医学

Heart Pub Date : 2025-04-16 DOI: 10.1136/heartjnl-2024-325043

Adil Salihu, Panagiotis Antiochos, Henri Lu, Niccolò Maurizi, Pierre Monney, Patrizio Pascale

{"title":"Association between programmed electrical stimulation inducibility and arrhythmic risk in hypertrophic cardiomyopathy: a systematic review and meta-analysis.","authors":"Adil Salihu, Panagiotis Antiochos, Henri Lu, Niccolò Maurizi, Pierre Monney, Patrizio Pascale","doi":"10.1136/heartjnl-2024-325043","DOIUrl":"https://doi.org/10.1136/heartjnl-2024-325043","url":null,"abstract":"Background: Risk stratification for sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM) remains challenging. Programmed electrical stimulation (PES) is not endorsed by current guidelines, and its role in risk stratification is debated. We conducted a systematic review and meta-analysis to assess the association between PES inducibility and major arrhythmic events (MAE) in patients with HCM and evaluate its predictive value.Methods: We searched PubMed/MEDLINE, Embase and the Cochrane Library up to 1 February 2024, for studies assessing MAE (SCD, resuscitated cardiac arrest or appropriate implantable cardioverter-defibrillator interventions) according to PES inducibility. A random-effects meta-analysis was performed to calculate pooled ORs and CIs. Sensitivity, specificity and predictive values were also calculated from the published information.Results: Five studies (587 patients, 66% male, mean age 38±14 years) were included. PES inducibility was observed in 188 (32%) patients. MAE occurred in 18% of inducible patients (34 events) and 2% of non-inducible patients (8 events) (OR 10.83, 95% CI 3.52 to 33.34, p<0.001, I²=27%). The sensitivity of PES for MAE was 81%, specificity was 72%, positive predictive value was 18%, and negative predictive value was 98%.Conclusion: PES inducibility is associated with a 10 times higher risk of MAE in patients with HCM. Further prospective studies are needed to validate its independent predictive value in the context of contemporary risk stratification tools.Prospero registration number: CRD42024497521.","PeriodicalId":12835,"journal":{"name":"Heart","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Would you fly with this pilot? 你愿意和这个飞行员一起飞行吗？

IF 5.1 2区医学

Heart Pub Date : 2025-04-15 DOI: 10.1136/heartjnl-2025-325907

Eddie Davenport

引用次数: 0

TAVI for asymptomatic aortic stenosis? More compelling outcome data are needed. TAVI治疗无症状主动脉瓣狭窄？需要更令人信服的结果数据。

IF 5.1 2区医学

Heart Pub Date : 2025-04-15 DOI: 10.1136/heartjnl-2025-325767

Gerry P McCann, David E Newby, Graham S Hillis

引用次数: 0

Unmasking arrhythmic risk in apical hypertrophic cardiomyopathy: the imperative of genetic stratification. 根尖肥厚性心肌病心律失常风险的揭示：基因分层的必要性。

IF 5.1 2区医学

Heart Pub Date : 2025-04-15 DOI: 10.1136/heartjnl-2025-325900

Yi Zheng, Tong Liu

引用次数: 0

Bacteraemia and infective endocarditis after transcatheter aortic valve replacement: prevention is the key. 经导管主动脉瓣置换术后菌血症和感染性心内膜炎：预防是关键。

IF 5.1 2区医学

Heart Pub Date : 2025-04-10 DOI: 10.1136/heartjnl-2024-325410

Bleri Celmeta, Antonio Miceli

引用次数: 0

Non-malignant gynaecological disease and risk of cardiovascular or cerebrovascular disease: a systematic review and meta-analysis. 非恶性妇科疾病和心脑血管疾病的风险：一项系统综述和荟萃分析

IF 5.1 2区医学

Heart Pub Date : 2025-04-10 DOI: 10.1136/heartjnl-2024-324675

Giorgia Elisabeth Colombo, Yahya Mahamat-Saleh, Mike Armour, Kedar Madan, Angelo Sabag, Marina Kvaskoff, Stacey A Missmer, George Condous, Faraz Pathan, Mathew Leonardi

{"title":"Non-malignant gynaecological disease and risk of cardiovascular or cerebrovascular disease: a systematic review and meta-analysis.","authors":"Giorgia Elisabeth Colombo, Yahya Mahamat-Saleh, Mike Armour, Kedar Madan, Angelo Sabag, Marina Kvaskoff, Stacey A Missmer, George Condous, Faraz Pathan, Mathew Leonardi","doi":"10.1136/heartjnl-2024-324675","DOIUrl":"10.1136/heartjnl-2024-324675","url":null,"abstract":"Background: Cardiovascular disease is the leading cause of death globally. Non-malignant gynaecological diseases (NMGD) significantly affect patient health and well-being and may be associated with cardiovascular or cerebrovascular disease (C/CVD).Methods: Seven databases were searched for relevant studies up to 21 April 2024. Observational studies reporting risk estimates and 95% CIs for the association between NMGD and C/CVD were included. Data were extracted by two independent reviewers. Random effects models were used to calculate summary relative risk (SRR) with 95% CI. Composite C/CVD outcome was defined as a combination of ischaemic heart disease, cerebrovascular disease, heart failure, and peripheral vascular disease. The ROBINS-I tool defined study quality and risk of bias.Results: We screened 6639 studies, of which 59 were eligible for full-text review and 28 were included in our analysis, comprising a total of 3 271 242 individuals. The majority (53.5%) of the studies were scored as having a 'serious'/'critical' risk of bias. Overall, individuals with an NMGD had a significantly greater risk of composite C/CVD with low heterogeneity among contributing studies (SRR 1.28, 95% CI 1.20 to 1.37; n=16 studies, I2=65.3%), ischaemic heart disease (SRR 1.41, 95% CI 1.31 to 1.51; n=21 studies, I2=73.7%), and cerebrovascular disease (SRR 1.33, 95% CI 1.18 to 1.51; n=16 studies, I2=91.5%). In NMGD-specific analyses, the risk of C/CVD and its components was greater among those with a history of endometriosis or polycystic ovary syndrome.Conclusions: We found an overall association between NMGD and C/CVD across all studies. However, estimates from individual studies varied substantially.","PeriodicalId":12835,"journal":{"name":"Heart","volume":" ","pages":"402-411"},"PeriodicalIF":5.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From back pain to chest pain: what is the cause of chest pain after thoracic spine fracture surgery? 从背痛到胸痛：胸椎骨折术后胸痛的原因是什么？

IF 5.1 2区医学

Heart Pub Date : 2025-04-10 DOI: 10.1136/heartjnl-2024-325454

Hairui Wang, Yihua He, Xiaoyan Gu

引用次数: 0

Bacteraemia after transcatheter aortic valve implantation: a nationwide cohort study. 经导管主动脉瓣植入术后菌血症：一项全国性队列研究。

IF 5.1 2区医学

Heart Pub Date : 2025-04-10 DOI: 10.1136/heartjnl-2024-324803

Katra Hadji-Turdeghal, Jeppe K Petersen, Peter Laursen Graversen, Jawad Haider Butt, Jarl Emanuel Strange, Nikolaj Ihlemann, Jordi Sanchez Dahl, Jonas Agerlund Povlsen, Marianne Voldstedlund, Christian Juhl Terkelsen, Christian H Møller, Philip Freeman, Henrik Nissen, Ole De Backer, Lars Koeber, Lauge Østergaard, Emil Loldrup Fosbøl

{"title":"Bacteraemia after transcatheter aortic valve implantation: a nationwide cohort study.","authors":"Katra Hadji-Turdeghal, Jeppe K Petersen, Peter Laursen Graversen, Jawad Haider Butt, Jarl Emanuel Strange, Nikolaj Ihlemann, Jordi Sanchez Dahl, Jonas Agerlund Povlsen, Marianne Voldstedlund, Christian Juhl Terkelsen, Christian H Møller, Philip Freeman, Henrik Nissen, Ole De Backer, Lars Koeber, Lauge Østergaard, Emil Loldrup Fosbøl","doi":"10.1136/heartjnl-2024-324803","DOIUrl":"10.1136/heartjnl-2024-324803","url":null,"abstract":"Background: Bacteraemia and infective endocarditis (IE) are rare but severe complications of transcatheter aortic valve implantation (TAVI). Limited data exist on the incidence and microbiological profile of early bacteraemia in this population. This study aimed to evaluate the 6-month incidence of bacteraemia, IE and associated mortality following TAVI.Methods: Using Danish nationwide registries, all patients who underwent TAVI from 2012 to 2021 were identified and matched 1:1 by age, sex and index year with patients who underwent elective coronary angiography (CAG). Outcomes were assessed with cumulative incidence functions and adjusted HRs.Results: Among 5990 patients with first-time TAVI (57% male, mean age 80 years, SD 6.9), bacteraemia occurred in 4.2% within 6 months, compared with 2.6% in the CAG group (adjusted HR 1.57, 95% CI 1.26 to 1.96). Common pathogens post-TAVI included Streptococci (20%), Coagulase-negative staphylococci (19%) and Enterococci (18%), differing from the CAG group, where Coagulase-negative staphylococci (22%) and Staphylococcus aureus (16%) predominated. IE developed in 1.1% of patients with TAVI versus 0.1% of patients with CAG (adjusted HR 20.01, 95% CI 5.97 to 67.48).Conclusion: Bacteraemia and IE rates are substantially elevated within 6 months following TAVI compared with elective CAG. The bacterial profile post-TAVI suggests that current prophylactic antibiotic regimens may not provide adequate coverage.","PeriodicalId":12835,"journal":{"name":"Heart","volume":" ","pages":"412-420"},"PeriodicalIF":5.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142964430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiologists and recognition of iron deficiency in patients with heart failure. 心脏科医生与心衰患者缺铁的认识。

IF 5.1 2区医学

Heart Pub Date : 2025-04-10 DOI: 10.1136/heartjnl-2024-325383

Iain Squire, Paul R Kalra

引用次数: 0

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