Gut最新文献

{"title":"Research priorities for cancers of the oesophagus and stomach: recommendations from a UK and Ireland patient and healthcare professional partnership exercise.","authors":"Christopher M Jones,Wee Han Ng,Laura Tincknell,Dylan P McClurg,Emily Adam,Pradeep Bhandari,Karen Campbell,Pinkie Chambers,Francesca Ciccarelli,Helen G Coleman,Tom Crosby,Carmel Doyle,Jason M Dunn,Jessie Elliott,Rebecca C Fitzgerald,Kieran G Foley,Vicky Goh,Heike I Grabsch,Trevor A Graham,Mike Grocott,Sarah Gwynne,Jo Harvey,Marnix Jansen,Pernilla Lagergren,Claire Lamb,Lauren Leigh-Doyle,Farida Malik,Catriona Mayland,Mimi McCord,Alan Moss,Somnath Mukherjee,Russell Petty,Siddharth Rananaware,Joanne Reid,Gregory Rubin,Elizabeth Smyth,Nigel J Trudgill,Richard C Turkington,Timothy J Underwood,Fiona M Walter,Jessica Williams,Christopher J Peters","doi":"10.1136/gutjnl-2025-336421","DOIUrl":"https://doi.org/10.1136/gutjnl-2025-336421","url":null,"abstract":"BACKGROUNDCancers of the oesophagus and stomach are a major cause of morbidity and mortality. Research is crucial to improving outcomes. However, to maximise value and impact, areas of focus should be prioritised in partnership with patients.OBJECTIVEWe undertook a comprehensive analysis of UK and Ireland patient and healthcare professional (HCP) priorities for research into oesophagogastric cancers across the domains of prevention, diagnosis and staging, treatment, palliative care and survivorship.DESIGNA scoping exercise sourced research questions from patients and HCPs. These were consolidated and then confirmed by systematic review to represent a true research uncertainty. Research questions were scored on potential impact by an interdisciplinary group of HCPs and prioritised using a weighting derived from a patient survey.RESULTSThere were 835 (395 HCP, 440 patient) respondents to the scoping (n=455) and prioritisation (n=380) surveys. Across these, 4295 suggested research uncertainties were consolidated to 92 uncertainties that were prioritised. HCP respondents represented 25 professional groups from community and hospital settings. Patient weighting changed 22.2-46.3% of priority rankings established by HCPs. All domains were represented by the 20 highest priority questions, 5 of which focused on personalising and optimally combining treatment modalities. Two other key themes related to optimising nutrition and improving quality of life during and after treatment, including in patients not cured of their cancer.CONCLUSIONThis work highlights the impact of patient input on HCP-ranked research priorities and provides a robust list of priorities to guide funders, policymakers and researchers to support and undertake impactful research.","PeriodicalId":12825,"journal":{"name":"Gut","volume":"34 1","pages":""},"PeriodicalIF":24.5,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145059174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Holdemanella biformis augments washed microbiota transplantation for the treatment of radiation enteritis.","authors":"Weihong Wang,You Yu,Rui Wang,Yaxue Wang,Xiao Ding,Gaochen Lu,Chen Lu,Chenchen Liang,Sheng Zhang,Bo Yi,Jianling Bai,Lizhen Zhang,Pan Li,Quan Wen,Bota Cui,Faming Zhang","doi":"10.1136/gutjnl-2025-335230","DOIUrl":"https://doi.org/10.1136/gutjnl-2025-335230","url":null,"abstract":"BACKGROUNDCurrent microbiome-based therapeutics face two prominent issues: the limited clinical efficacy of probiotics and the significant variability in the efficacy of microbiota transplantation across different diseases. Although washed microbiota transplantation (WMT) is a new faecal microbiota transplantation, a single therapeutic agent cannot be universally effective for multiple dysbiosis-related diseases.OBJECTIVEWe introduced a new therapeutic concept, X-augmented WMT (X-auWMT), which combines a disease-specific beneficial microbe, 'X', with WMT to enhance its effectiveness. Our goal was to identify a candidate 'X' bacterium to augment WMT efficacy and examine the efficacy of X-auWMT in animal models of radiation enteritis (RE).DESIGNWe conducted a prospective, non-randomised cohort study on a cohort of abdominal or pelvic cancer patients who developed RE after radiotherapy to identify a potential beneficial microbe. We used RE mouse models to evaluate the efficacy of X-auWMT compared with WMT. Multiomics analyses and experiments were undertaken to elucidate the underlying mechanisms.RESULTSWMT significantly alleviated multiple clinical symptoms in RE patients compared with routine treatments. We identified Holdemanella biformis as a candidate 'X' bacterium within the RE cohort and developed Hb-auWMT. Hb-auWMT significantly mitigated radiation-induced injury compared with WMT, exhibiting enhanced anti-apoptotic effects, improved maintenance of epithelial hypoxia, increased Treg cell levels and elevated butyrate and valerate levels in the RE mouse model. PPAR-γ is an essential pathway for the therapeutic efficacy of Hb-auWMT.CONCLUSIONSThis study overcomes the aforementioned recognised limitations with probiotics and microbiota transplantation and provides a new research paradigm in the concept of microbiome-based therapeutics.","PeriodicalId":12825,"journal":{"name":"Gut","volume":"17 1","pages":""},"PeriodicalIF":24.5,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145059042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"British Society of Gastroenterology adult guidelines on inflammatory bowel disease: what can we learn for children and young people?","authors":"James J Ashton, Zachary Green, R Mark Beattie","doi":"10.1136/gutjnl-2025-336739","DOIUrl":"https://doi.org/10.1136/gutjnl-2025-336739","url":null,"abstract":"It is reported that up to 10–25% of all diagnoses of inflammatory bowel disease (IBD) occur in those aged less than 18 years.1 The long-term impact of disease for those likely to live 70+ years with the condition can be significant. Prompt diagnosis and enduring effective therapy are key to long-term disease control and minimising morbidity. Standardisation of IBD management has proven to be highly effective, and the latest iteration of the British Society of Gastroenterology (BSG) guidelines is hugely welcomed.2 This behemoth of a document, running to over 100 print pages and 781 references, provides a high-quality and comprehensive framework for best-practice decision-making. The document is highly relevant for children and young people without setting out to address paediatric-specific issues. There is no doubt that paediatric patients will benefit from the highly evidenced statements in this publication, although, as paediatricians, we also advocate for specific considerations for those aged <18 years at diagnosis. A potential benefit of these paediatric considerations will be to provide future benefit to adult populations with IBD. While international ECCO/ESPGHAN guidelines for paediatric IBD exist,3 the BSG document presents a leading, and contemporary, resource for disease management. Considering how the evidence can benefit children and young people is important. Concurrently, considering which aspects of paediatric IBD understanding and care may be relevant to adult practice is important, and we would like to highlight areas which may fulfil these criteria. The primary increases in IBD incidence are now within paediatric populations as adult-onset incidence has plateaued within developed countries.1 Many industrialised nations have now begun to reach the epidemiological stage of prevalence equilibrium.4 Within our own …","PeriodicalId":12825,"journal":{"name":"Gut","volume":"20 1","pages":""},"PeriodicalIF":24.5,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145035227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fructose drives colorectal cancer progression by regulating crosstalk between cancer-associated fibroblasts and tumour cells","authors":"Yanfen Cui, Hui Liu, Laoming Zhang, He Zhang, Zhaosong Wang, Jiefu Wang, Zhiyong Wang, Lanlan Song, Hui Guo, Liming Liu, Weijie Song, Ruifang Niu, Fei Zhang","doi":"10.1136/gutjnl-2025-335014","DOIUrl":"https://doi.org/10.1136/gutjnl-2025-335014","url":null,"abstract":"Background Fructose has been identified as a potential alternative energy source for cancer cells, facilitated by the fructose-specific transporter GLUT5. Elevated GLUT5 expression in cancer cells has been associated with increased tumour aggressiveness. However, the role of fructose in remodelling the tumour microenvironment, particularly in modulating cancer-associated fibroblast (CAF) behaviour, remains underexplored. Objective This study aimed to elucidate the regulatory effects and molecular mechanisms of fructose-mediated CAF reprogramming in colorectal cancer (CRC) progression. Design The effects of fructose and fructose-cultured tumour cells on biological function of CAFs were detected. Metabolomics and transcriptomic analyses were used to characterise the fructose-regulated crosstalk network of tumour cells and CAFs. Furthermore, the relationships between GLUT5 expression level in CAFs and clinicopathological features and prognosis of patients with CRC were analysed. Results We demonstrate that fructose plays a dual role in promoting CRC progression by influencing both tumour cells and CAFs. GLUT5 is expressed in both CRC cells and CAFs, with its expression correlating with more advanced tumour stages and poorer outcomes in patients. Fructose metabolism in CAFs enhances their proliferation, migration and activation, while fructose utilisation by CRC cells leads to the release of nucleotides and amino acids. These metabolites activate CAFs and upregulate the expression of the chemokine CXCL14. This, in turn, promotes tumour cell migration and metastasis. Conclusions These findings reveal a novel mechanism by which fructose fosters tumour progression through the modulation of tumour-stroma interactions, and highlight the therapeutic potential of targeting fructose metabolism in CRC to disrupt the tumour-stroma crosstalk that drives malignancy. Data are available upon reasonable request.","PeriodicalId":12825,"journal":{"name":"Gut","volume":"130 1","pages":""},"PeriodicalIF":24.5,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145035228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disease-associated hepatocytes are predictive of outcomes and survival in MASLD beyond fibrosis staging.","authors":"Rodrigo Carlessi,Timothy James Kendall,John K Olynyk,Benjamin J Dwyer,Michael C Wallace,Jonathan A Fallowfield,Janina Ee Tirnitz-Parker","doi":"10.1136/gutjnl-2025-336627","DOIUrl":"https://doi.org/10.1136/gutjnl-2025-336627","url":null,"abstract":"","PeriodicalId":12825,"journal":{"name":"Gut","volume":"16 1","pages":""},"PeriodicalIF":24.5,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sucrase-isomaltase hypomorphic variant Val15Phe affects the response to a sucrose challenge test in patients with IBS.","authors":"Andreea Zamfir-Taranu,Britt-Sabina Löscher,Andre Franke,Ferdinando Bonfiglio,Bodil Ohlsson,Mauro D'Amato","doi":"10.1136/gutjnl-2025-336393","DOIUrl":"https://doi.org/10.1136/gutjnl-2025-336393","url":null,"abstract":"","PeriodicalId":12825,"journal":{"name":"Gut","volume":"45 1","pages":""},"PeriodicalIF":24.5,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic Retrograde Cholangiopancreatography (ERCP) services across the UK.","authors":"Wafaa Ahmed,Emily Haworth,Linda Sharp,Christina Dobson,Bettina Kluettgens,Beverly C Oates,Kofi Oppong,Ian Penman,Colin J Rees,Simon M Everett","doi":"10.1136/gutjnl-2025-335548","DOIUrl":"https://doi.org/10.1136/gutjnl-2025-335548","url":null,"abstract":"","PeriodicalId":12825,"journal":{"name":"Gut","volume":"42 1","pages":""},"PeriodicalIF":24.5,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic papillectomy: ‘be prepared for unexpected’","authors":"Livia Archibugi, Mohan Ramchandani, Priscilla Lopez, Anuradha Sekaran, Duvvur Nageshwar Reddy, Sundeep Lakhtakia","doi":"10.1136/gutjnl-2025-335279","DOIUrl":"https://doi.org/10.1136/gutjnl-2025-335279","url":null,"abstract":"An elderly patient presented with dyspeptic symptoms. Endoscopic evaluation, including side-view evaluation, revealed a bulky major ampulla with smooth mucosa and eccentric papillary orifice opening (figures 1 and 2). Endoscopic ultrasound confirmed a 29×16 mm subepithelial mass lesion within the papilla, with dilation of both the common bile duct (12 mm) and pancreatic duct (PD) (8 mm) (double-duct sign) (online supplemental video). The lesion was limited to the papilla with intact muscularis propria and no ductal infiltration. Endoscopic snare papillectomy was performed using a duodenoscope. Immediately after the papillectomy, a large defect (6 mm) was identified in the central part of …","PeriodicalId":12825,"journal":{"name":"Gut","volume":"35 1","pages":""},"PeriodicalIF":24.5,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145025305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Revisiting the role of sphincterotomy in sphincter of oddi disorder: a critical appraisal of the RESPOnD study.","authors":"","doi":"10.1136/gutjnl-2025-334837corr1","DOIUrl":"10.1136/gutjnl-2025-334837corr1","url":null,"abstract":"","PeriodicalId":12825,"journal":{"name":"Gut","volume":" ","pages":"e19"},"PeriodicalIF":25.8,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiota-related neuroinflammation at the crossroad of food reward alterations: implications for eating disorders.","authors":"Sabrina J P Huwart, Nuria Morales-Puerto, Amandine Everard","doi":"10.1136/gutjnl-2024-333397","DOIUrl":"10.1136/gutjnl-2024-333397","url":null,"abstract":"<p><p>The link between gut microbiome and eating behaviours, especially palatable food intake, is a growing focus of scientific investigation. The complex ecosystem of microorganisms in the gut influences host metabolism, immune function and neurobehavioural signalling. This review explores the role of neuroinflammation in dysregulations of food-induced reward signalling and the potential causal role of the gut microbiota on these proinflammatory processes. Particular attention is given to eating disorders (ED, specifically anorexia nervosa, binge eating disorder and bulimia nervosa) and potential links with the gut microbiota, food reward alterations and neuroinflammation. Finally, we propose gut microbiota modulation as a promising therapeutic strategy in food reward alterations and ED.</p>","PeriodicalId":12825,"journal":{"name":"Gut","volume":" ","pages":"1728-1740"},"PeriodicalIF":25.8,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}