Annals of Neurology最新文献

{"title":"Calibration before Allocation: The Next Step for SeLECT-EEG.","authors":"Mingming Dong","doi":"10.1002/ana.78325","DOIUrl":"10.1002/ana.78325","url":null,"abstract":"","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":" ","pages":"900-901"},"PeriodicalIF":7.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148756738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to \"Biomarker Stratification of Hyperacute Thromboinflammation after Large Vessel Occlusion\".","authors":"Justine Münsterberg, Eckhard Schlemm, Mathias Gelderblom","doi":"10.1002/ana.78336","DOIUrl":"10.1002/ana.78336","url":null,"abstract":"","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":" ","pages":"905"},"PeriodicalIF":7.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to \"Calibration before Allocation: The Next Step for SeLECT-EEG\".","authors":"Kai Michael Schubert, Sándor Beniczky, Carla Bentes, Nicolas Gaspard, Vineet Punia, Marian Galovic","doi":"10.1002/ana.78327","DOIUrl":"10.1002/ana.78327","url":null,"abstract":"","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":" ","pages":"901-902"},"PeriodicalIF":7.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148710810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological and Sampling Considerations in the Evaluation of Intravascular Inflammation during Ischemic Stroke.","authors":"Muhammad Mazhar Rehman, Nimra Khan Yousafzai, Hameed Ullah, Muhammad Mustafa Khan, Abdullah Abdullah","doi":"10.1002/ana.78332","DOIUrl":"10.1002/ana.78332","url":null,"abstract":"","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":" ","pages":"902-903"},"PeriodicalIF":7.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compared with What? A Missing Comparator for Continuous EEG after Ischemic Stroke.","authors":"Shaher Yar, Soraya Osswa Chquiry, Ishvah Shashwat Nag","doi":"10.1002/ana.78324","DOIUrl":"10.1002/ana.78324","url":null,"abstract":"","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":" ","pages":"899"},"PeriodicalIF":7.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148756913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to \"Compared with What? A Missing Comparator for Continuous EEG after Ischemic Stroke\".","authors":"Kai Michael Schubert, Sándor Beniczky, Carla Bentes, Nicolas Gaspard, Vineet Punia, Marian Galovic","doi":"10.1002/ana.78326","DOIUrl":"10.1002/ana.78326","url":null,"abstract":"","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":" ","pages":"899-900"},"PeriodicalIF":7.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148757033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomarker Stratification of Hyperacute Thromboinflammation after Large Vessel Occlusion.","authors":"Miaomiao Chen, Baoming Xie","doi":"10.1002/ana.78333","DOIUrl":"10.1002/ana.78333","url":null,"abstract":"","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":" ","pages":"904"},"PeriodicalIF":7.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biallelic PIGB Variants Cause Motor Neuropathy with Conduction Blocks and Peripheral Nerve Hyperexcitability.","authors":"Gorka Fernández-Eulate, Romain Duval, Marina Konyukh, Alessandro Bertini, Ayse Candayan, Albena Jordanova, Theresa Brunet, Wolfgang Müller-Felber, Helena F Pernice, Katrin Hahn, Nadja Ehmke, Juliane Beuschlein, Bertrand Isidor, Benjamin Cogné, Yann Péréon, Annabelle Chaussenot, John Rendu, Aysylu Murtazina, Dmitrii Subbotin, Artem Borovikov, Andrey Marakhonov, Chiara Pisciotta, Paola Saveri, Daniele Cazzato, Lucie Lemeray, Bérengère Koehl, Jean-Madeleine de Sainte-Agathe, Stefano Facchini, Ilaria Quartesan, Andrea Cortese, Yesim Parman, Arman Cakar, Davide Pareyson, Slim Azouzi, Tanya Stojkovic","doi":"10.1002/ana.78358","DOIUrl":"https://doi.org/10.1002/ana.78358","url":null,"abstract":"<p><strong>Objective: </strong>Glycosylphosphatidylinositol (GPI)-anchored proteins play critical roles in nervous system function. Pathogenic variants in genes involved in GPI-anchor biosynthesis cause early-onset multisystem disorders known as inherited GPI deficiencies. We describe a novel neuromuscular phenotype associated with PIGB deficiency.</p><p><strong>Methods: </strong>Patients with neuromuscular disease carrying PIGB variants were identified, and clinical data collected. GPI-anchored protein and free-GPI expression were assessed by flow cytometry and variants validated in a PIGB knockout cellular model.</p><p><strong>Results: </strong>Biallelic PIGB variants were identified in 12 patients (median age 32 years, range 15-52 years) from 9 independent families. Of 15 variants, 13 were novel, including a de novo inversion generating a PIGB::RAB27A gene fusion. Of 12 patients, 10 presented with distal lower-limb weakness, and neurophysiological studies demonstrated a motor-predominant neuropathy with frequent conduction blocks in all patients. Signs of nerve hyperexcitability were observed in 9 patients, with electromyography neuromyotonic discharges and myokymia compatible with peripheral nerve hyperexcitability in 6. A total of 3 patients showed a decremental response on repetitive nerve stimulation; 2 were symptomatic and responded to pyridostigmine, consistent with neuromuscular junction transmission defect. Neurodevelopmental features were inconsistent. Flow cytometry revealed variable reductions of GPI-anchored proteins, but consistent reduction of free GPI in blood cells. Novel variants impaired GPI-anchor expression in vitro.</p><p><strong>Interpretation: </strong>We expand the phenotypic spectrum of inherited GPI deficiencies with a novel neuromuscular syndrome encompassing motor neuropathy with conduction blocks, peripheral nerve hyperexcitability, and occasional neuromuscular junction defects associated with PIGB variants. PIGB and other GPI-anchor biosynthesis genes should be considered in motor neuropathy with conduction blocks. ANN NEUROL 2026.</p>","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Making of Women Leaders in Academic Neurology.","authors":"Ifrah Zawar, Frances E Jensen, M Elizabeth Ross, Jennifer Hurley, Sarah E Nelson","doi":"10.1002/ana.78376","DOIUrl":"https://doi.org/10.1002/ana.78376","url":null,"abstract":"","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Intensive Blood Pressure Lowering on Perihematomal Edema in Acute Intracerebral Hemorrhage: Pooled Analysis of the Four INTERACT Trials.","authors":"Xinwen Ren, Qiang Li, Xiaoying Chen, Menglu Ouyang, Candice Delcourt, Jiguang Wang, Thompson Robinson, Hisatomi Arima, Lu Ma, Xin Hu, Gang Li, Jie Yang, Yapeng Lin, Leibo Liu, Paula Muñoz-Venturelli, Sheila Martins, Octavio M Pontes-Neto, Lili Song, Craig S Anderson, Xia Wang","doi":"10.1002/ana.78377","DOIUrl":"https://doi.org/10.1002/ana.78377","url":null,"abstract":"<p><strong>Objective: </strong>Uncertainty persists over the effect of intensive blood pressure (BP) lowering on perihematomal edema (PHE) growth in acute spontaneous intracerebral hemorrhage (ICH). We aimed to investigate the effect of intensive BP lowering on PHE growth in acute ICH.</p><p><strong>Methods: </strong>We undertook an individual patient data pooled analysis of the 4 INTERACT trials, which all had consistent BP-lowering protocols (targeting systolic BP <140 mmHg [intensive] vs <180 mmHg [guideline] within 1 hour). PHE growth was defined as absolute volume increase and growth rate (volume increase divided by time interval [ml/h]) at 24 hours and 7 days. Linear regression models were used to evaluate the treatment effect, adjusting for covariates including baseline hematoma volume. Heterogeneity analysis was undertaken to assess the interaction with time from symptom onset to randomization and other characteristics.</p><p><strong>Results: </strong>A total of 2,549 ICH patients (mean age 64 years, 35% female) with available 24-hour PHE growth data were included. Early intensive BP lowering attenuated the absolute growth at 24 hours (mean difference -1.13 mL, 95% CI -1.94 to -0.33, p = 0.006), but did not influence growth rate or the 7-day measures after adjustment. Furthermore, the treatment effect on the 24-hour PHE growth decreased with increasing time from symptom onset to randomization, with the greatest benefit observed when treatment was initiated within 2.2 h (p for interaction = 0.009).</p><p><strong>Interpretation: </strong>Early intensive BP lowering significantly attenuates PHE growth at 24 hours in acute ICH, with greater benefit when initiated earlier-emphasizing the importance of early initiation of intensive BP lowering. ANN NEUROL 2026.</p>","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149068844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}