Genome Biology and Evolution最新文献_第3页

Evolutionary Complexity of Primate Immune System Uncovered by the Extensive Phylogenomic Sampling. 广泛的系统基因组取样揭示了灵长类免疫系统的进化复杂性。

IF 2.8 2区生物学

Genome Biology and Evolution Pub Date : 2026-04-01 DOI: 10.1093/gbe/evag087

Xiuping Zhang, Boyang Wu, Yong Shao

{"title":"Evolutionary Complexity of Primate Immune System Uncovered by the Extensive Phylogenomic Sampling.","authors":"Xiuping Zhang, Boyang Wu, Yong Shao","doi":"10.1093/gbe/evag087","DOIUrl":"10.1093/gbe/evag087","url":null,"abstract":"The immune system mediates the complex interaction between pathogenic microorganisms and their hosts. Despite its significance, the evolutionary mechanisms underlying immune system complexity in primates remain largely elusive. In this study, we investigated the evolution of the primate immune system by generating the first comprehensive catalog of immune-related genes through extensive phylogenomic sampling. Our analyses uncovered substantial genetic diversity in the evolution of the primate immune system, in the form of modules that vary in their sequences and functional capabilities. We identified a novel module (Type 3c) that has experienced long-term coevolution between primates and lentiviruses over a long evolutionary timescale. Furthermore, we found that social system complexity, rather than diet or group size, may potentially shape the immune system evolution of primates. We further uncovered the evolutionary histories of key immune-associated genes, including IFNAR2 and C5AR1, which are implicated in SARS-CoV-2 infection. More importantly, we revealed a divergence in the selective pressures on immune-associated genes between experimental primates and humans. This finding provides a critical caveat, suggesting that extreme caution is warranted when using these primates as models for human diseases such as HIV-1, Hepatitis C, and Influenza A. In summary, this work uncovers key evolutionary mechanisms that have fundamentally shaped the complexity of immune systems across primates.","PeriodicalId":12779,"journal":{"name":"Genome Biology and Evolution","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13089530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147591701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Template Switching as a Driver of Promoter Evolution in Yeast: Case Study of the GRE2 Gene. 模板转换作为酵母启动子进化的驱动因素：以GRE2基因为例。

IF 2.8 2区生物学

Genome Biology and Evolution Pub Date : 2026-04-01 DOI: 10.1093/gbe/evag078

Michal Rozenfeld, Maayan Bachar, Raz Cohen, Evgeniya Marcos-Hadad, Shira Milo, Shay Covo, Einat Hazkani-Covo

{"title":"Template Switching as a Driver of Promoter Evolution in Yeast: Case Study of the GRE2 Gene.","authors":"Michal Rozenfeld, Maayan Bachar, Raz Cohen, Evgeniya Marcos-Hadad, Shira Milo, Shay Covo, Einat Hazkani-Covo","doi":"10.1093/gbe/evag078","DOIUrl":"10.1093/gbe/evag078","url":null,"abstract":"Inverted repeats (IRs) are sequences with internal symmetry that can form non-canonical DNA structures. DNA polymerase template switching between imperfect IR arms can homogenize the arms and expand their size. IRs play an important role in the binding of transcription factors (TFs), particularly those that function as dimers. We used comparative genomics to identify recent IR-expansions in the vicinity of promoter regions in the lineage of Saccharomyces cerevisiae. From the thousands of events identified, we further focused on ones with significant expansion, outside of simple repeats and within confirmed binding sites of TFs. These events are located at 107 loci next to 130 genes and could be observed across the phylogenetic tree, with some events that occurred independently several times. We further focused on 2 genes that showed the longest IR expansion and created IR-expanded mutants in the BY4741 lab strain. While the expansion did not change much at the ERT1 gene, the gre2 mutant with IR expansion was very different from BY4741. In the GRE2 IR-expanded mutant, GRE2 expression was higher than in wild-type; the mutant grew more slowly but was relatively more resistant to glycolaldehyde, a substrate of Gre2p. Taken together, we show here that IR-expansion at promoters is frequent and can shape the evolution of transcription regulation.","PeriodicalId":12779,"journal":{"name":"Genome Biology and Evolution","volume":"18 4","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13100816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147769829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detecting Positive Selection by Modeling Structure Within Images of Genetic Variation. 通过在遗传变异图像中建模结构来检测正选择。

IF 2.8 2区生物学

Genome Biology and Evolution Pub Date : 2026-04-01 DOI: 10.1093/gbe/evag085

Md Ruhul Amin, Sandipan Paul Arnab, Mohammad Khan, Michael DeGiorgio

{"title":"Detecting Positive Selection by Modeling Structure Within Images of Genetic Variation.","authors":"Md Ruhul Amin, Sandipan Paul Arnab, Mohammad Khan, Michael DeGiorgio","doi":"10.1093/gbe/evag085","DOIUrl":"10.1093/gbe/evag085","url":null,"abstract":"A major challenge in population genomics is accurately identifying and characterizing natural selection from genomic data. The wide availability of dense whole-genome datasets has enabled researchers to analyze and localize genetic variation within populations. Powerful supervised machine learning methods allow researchers to extract spatial information about genetic variation across the genome and identify traces of natural selection. While convolutional neural networks capture correlations among neighboring features, design choices such as heavy-pooling or limited receptive fields can lead to loss of fine-grained spatial resolution. Extensions like dilated convolutions or attention mechanisms mitigate this issue of loss of spatial resolution but at the cost of increased architectural complexity and parameter count when capturing correlations at different scales. In contrast, trend filtering directly models the autocovariation of neighboring features, ensuring that spatial relationships remain intact without any architectural extensions. When integrated into a classical machine learning model, such as a support vector machine, trend filtering offers a natural framework to create powerful predictive models while retaining the spatial integrity of the input. Here, we introduce SKINET, which employs a novel trend filter kernel within a support vector machine framework and apply it to the task of detecting and characterizing regions affected by positive natural selection. Specifically, SKINET not only distinguishes regions under positive natural selection from neutrally evolving regions but also functions in a regression framework to estimate associated adaptive parameters. Moreover, applying SKINET to empirical human genome variation identifies adaptive candidate genes consistent with previous findings while also uncovering novel adaptation targets, such as FAM177A1, that are linked to cancer.","PeriodicalId":12779,"journal":{"name":"Genome Biology and Evolution","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13089544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147608645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Empirical Validation of the Nearly Neutral Theory at Divergence and Population-Genomic Scales Using 144 Placental Mammal Genomes. 144个胎盘哺乳动物基因组在分化和种群-基因组尺度上近中性理论的实证验证。

IF 2.8 2区生物学

Genome Biology and Evolution Pub Date : 2026-04-01 DOI: 10.1093/gbe/evag030

Mélodie Bastian, David Enard, Nicolas Lartillot

{"title":"Empirical Validation of the Nearly Neutral Theory at Divergence and Population-Genomic Scales Using 144 Placental Mammal Genomes.","authors":"Mélodie Bastian, David Enard, Nicolas Lartillot","doi":"10.1093/gbe/evag030","DOIUrl":"10.1093/gbe/evag030","url":null,"abstract":"By limiting the efficacy of selection, random drift is expected to play a major role in genome evolution. Formalizing this idea, the nearly-neutral theory predicts that the ratio of non-synonymous over synonymous polymorphism (πN/πS) within populations, and divergence (dN/dS) between species, should both correlate negatively with Ne. This has previously been tested in mammals and other groups. However, most studies have focused on either dN/dS or on πN/πS, thus not addressing the problem across evolutionary scales. In addition, many studies at the macro scale have used life-history traits (LHT) as a proxy of Ne, assuming that large-bodied organisms have lower Ne than small-bodied species. However, this assumption itself has rarely been validated against more objective measures of Ne, such as genetic diversity πS=4Neμ, in part because πS estimates are scarce. Here we propose an integrative test of the nearly-neutral predictions on 150 mammalian species, using 6000 orthologous genes, spanning the macro and the micro-evolutionary scale, using for the latter a measure of heterozygosity on each of the assembled diploid genomes. At the micro scale, we observe, for the first time in mammalian nuclear genomes, a relationship between πN/πS and πS. At the macro scale, we confirm the positive correlation between dN/dS and LHT but, more importantly, establish that LHT and dN/dS are correlated with πS, although weakly so. Together, these results provide the first global test of the nearly-neutral theory in mammals across time scales, suggesting all variables are correlated with a single hidden variable: Ne.","PeriodicalId":12779,"journal":{"name":"Genome Biology and Evolution","volume":"18 4","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13050581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147622636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: The Missing Piece: Functional Telomerase Restored in the Beetle Model. 修正：缺失的部分：功能性端粒酶在甲虫模型中恢复。

IF 2.8 2区生物学

Genome Biology and Evolution Pub Date : 2026-04-01 DOI: 10.1093/gbe/evag100

引用次数: 0

Cosmopolitan Gene Families With Known Functions Are Hotspots for the Evolution of Novel Genes in Stony Corals. 具有已知功能的世界性基因家族是石珊瑚新基因进化的热点。

IF 2.8 2区生物学

Genome Biology and Evolution Pub Date : 2026-04-01 DOI: 10.1093/gbe/evag072

Timothy G Stephens, Arkadiusz W Kulczyk, Debashish Bhattacharya

{"title":"Cosmopolitan Gene Families With Known Functions Are Hotspots for the Evolution of Novel Genes in Stony Corals.","authors":"Timothy G Stephens, Arkadiusz W Kulczyk, Debashish Bhattacharya","doi":"10.1093/gbe/evag072","DOIUrl":"10.1093/gbe/evag072","url":null,"abstract":"Climate change has accelerated research on biodiverse coral reef ecosystems. However, this area of investigation is limited by our understanding of the biology of these organisms, with many of the genes identified as important for stress response in corals being \"dark,\" that is, with no ascribable biological function. To aid reverse genetic efforts, and help explore dark gene evolution in this lineage, we analyzed available genomic and transcriptomic data from corals with the goal of identifying well conserved (often lineage specific) dark gene families and interrogating their putative roles in coral biology using available multi-omics data and bioinformatic approaches. Many of the well conserved dark gene families are stress responsive, enriched in specific cell types, or have predicted 3D protein structures with significant similarity to known proteins that may be adaptive in corals. We demonstrate that dark genes form cosmopolitan (broadly shared) families which originated via bursts of lineage specific duplication, often involving genes with known functions. Analysis of single cell gene expression data suggests that dark gene provenance may have precipitated or been concomitant with the origin of novel coral functions such as biomineralization. Our results open a new window into coral evolution that integrates knowledge from known and dark genes to elucidate how these species achieved their remarkable success in diverse marine environments. The dark gene families we identified also provide a significant resource for future studies into the role of novel genes in coral biology and adaptation to climate change.","PeriodicalId":12779,"journal":{"name":"Genome Biology and Evolution","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13044578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147503651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genomes of Wiebesia Fig Wasps Reveal the Adaptation and Codiversification in the Fig-Fig Wasp Mutualism. 威伯氏无花果黄蜂的基因组揭示了无花果黄蜂在互惠共生中的适应和共多样化。

IF 2.8 2区生物学

Genome Biology and Evolution Pub Date : 2026-04-01 DOI: 10.1093/gbe/evag080

Bai-Wei Lo, Hsin-Fu Lin, Siu-Wah Kong, Wen-Jer Wu, Yi-Lun Peng, Selina Cai-Ling Wang, Xuemei Lu, Hurng-Yi Wang

{"title":"Genomes of Wiebesia Fig Wasps Reveal the Adaptation and Codiversification in the Fig-Fig Wasp Mutualism.","authors":"Bai-Wei Lo, Hsin-Fu Lin, Siu-Wah Kong, Wen-Jer Wu, Yi-Lun Peng, Selina Cai-Ling Wang, Xuemei Lu, Hurng-Yi Wang","doi":"10.1093/gbe/evag080","DOIUrl":"10.1093/gbe/evag080","url":null,"abstract":"Figs and fig wasps represent one of the most intimate examples of plant-pollinator coevolution. As figs diversified into geographically isolated populations, both figs and fig wasps underwent selective pressures driven by local adaptation and coevolution. Ficus pumila comprises two ecologically distinct varieties: the creeping fig (F. pumila var. pumila), which is widely distributed across the lowlands of East Asia, and the jelly fig (F. pumila var. awkeotsang), endemic to Taiwan and found at mid-elevations. To elucidate how codiversification with fig hosts influences the evolutionary trajectories of fig wasps, we analyzed the genomes of Wiebesia sp. 2 and sp. 3, the respective pollinators of creeping fig and jelly fig. Our demographic analysis indicates that vicariance during the Last Glacial Period facilitated ecological differentiation between these two fig-fig wasp pairs. Through comparative and population genomic analyses, we identified selection signals linked to habitat adaptation, with evolutionary rates corresponding to the life history traits of their host figs. Variations in host preference behavior, chemosensory gene expression, and adaptive duplications in olfactory receptors highlight potential mechanisms for adaptation to host floral scents. These findings collectively underscore how the obligate mutualism between figs and their pollinating wasps allows the ecological traits and habitat preferences of fig hosts to shape the evolutionary pathways of their pollinators, leaving distinct molecular imprints in the fig wasp genomes. This study demonstrates the capacity of tightly intertwined life cycles between plants and pollinators to drive adaptation and diversification.","PeriodicalId":12779,"journal":{"name":"Genome Biology and Evolution","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pressure-tolerant Evolution in Rhodopsin of Deep-diving Whales. 深潜鲸视紫红质的耐压进化。

IF 2.8 2区生物学

Genome Biology and Evolution Pub Date : 2026-04-01 DOI: 10.1093/gbe/evag068

Hayate Takeuchi, Takashi Hayakawa

{"title":"Pressure-tolerant Evolution in Rhodopsin of Deep-diving Whales.","authors":"Hayate Takeuchi, Takashi Hayakawa","doi":"10.1093/gbe/evag068","DOIUrl":"10.1093/gbe/evag068","url":null,"abstract":"Life in the deep sea presents extreme challenges to protein structure and function, with hydrostatic pressure serving as a significant source of molecular stress. Although cetacean rhodopsins have been thoroughly examined concerning their spectral tuning to the underwater light environment, their possible adaptations to pressure have yet to be explored. In this study, we investigated whether rhodopsin has undergone structural modifications that facilitate visual function during deep dives. Using a physicochemical property-based codon substitution model, we found that amino acid replacements associated with a radical shift in amino acid compressibility preferentially accumulated in deep-diving cetaceans belonging to the superfamily Physeteroidea and the family Ziphiidae. Molecular dynamics simulations further revealed that alanine at residue 2997.46a confers enhanced pressure tolerance of rhodopsin relative to serine, as evidenced by lower isothermal compressibility, diminished flexibility, and reduced free-energy costs under high pressure. These findings identify residue 2997.46a as a recurrent target for pressure adaptation in deep-diving cetaceans. More broadly, our study offers a novel perspective on cetacean visual adaptation, demonstrating that rhodopsins have evolved not only for spectral sensitivity but also for structural resilience under extreme hydrostatic pressure. This integrative framework, which combines evolutionary modeling with molecular dynamics simulations, advances our understanding of protein adaptation in the deep-sea environment.","PeriodicalId":12779,"journal":{"name":"Genome Biology and Evolution","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13089582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147467712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genome Sequence Data Reveal Complex and Variable Ploidy in the Amoebozoan Acanthamoeba castellanii. 基因组序列数据揭示了castellanii棘阿米巴变形虫的复杂和可变倍性。

IF 2.8 2区生物学

Genome Biology and Evolution Pub Date : 2026-04-01 DOI: 10.1093/gbe/evag051

Morgan J Colp, John M Archibald

{"title":"Genome Sequence Data Reveal Complex and Variable Ploidy in the Amoebozoan Acanthamoeba castellanii.","authors":"Morgan J Colp, John M Archibald","doi":"10.1093/gbe/evag051","DOIUrl":"10.1093/gbe/evag051","url":null,"abstract":"Acanthamoeba castellanii is a free-living amoeba that is emerging as a model organism for the study of eukaryotic microbiology. This species is one of the most widely studied members of the Amoebozoa and is both an important grazer in soil communities and an opportunistic human pathogen; A. castellanii is thus of evolutionary, ecological, and biomedical significance. Despite its potential as a lab workhorse, the genome biology of A. castellanii is complex and poorly understood. Polyploidy is a common feature of many amoebozoan genomes, and members of the genus Acanthamoeba are no exception; they appear to be not only polyploid, where genome copy number is inflated beyond the conventional haploid and diploid states, but also aneuploid, i.e. with inter-chromosomal copy number variation. To better understand aneuploidy in A. castellanii and how it may vary over time and between closely related strains, we analyzed nanopore and Illumina sequence datasets from several wild-type and mutant A. castellanii lines, with a focus on quantifying single nucleotide polymorphism and structural variant allele frequencies across chromosome-scale scaffolds. Sequence depth of coverage was also considered. Our findings suggest that intragenomic chromosome copy number is highly variable in Acanthamoeba, consistent with a considerable degree of aneuploidy, but is predominantly stable in laboratory culture and on the evolutionary scale of the species or genus.","PeriodicalId":12779,"journal":{"name":"Genome Biology and Evolution","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Big Spider, Big Genome: Chromosome-Level Genome of a North American Tarantula (Aphonopelma marxi) and Comparative Genomics Across 300 Million Years of Spider Evolution. 大蜘蛛，大基因组：北美狼蛛（Aphonopelma marxi）的染色体水平基因组和3亿年蜘蛛进化的比较基因组学。

IF 2.8 2区生物学

Genome Biology and Evolution Pub Date : 2026-04-01 DOI: 10.1093/gbe/evag081

Ethan J Briggs, Andrea J Noble-Stuen, Chris A Hamilton

{"title":"Big Spider, Big Genome: Chromosome-Level Genome of a North American Tarantula (Aphonopelma marxi) and Comparative Genomics Across 300 Million Years of Spider Evolution.","authors":"Ethan J Briggs, Andrea J Noble-Stuen, Chris A Hamilton","doi":"10.1093/gbe/evag081","DOIUrl":"10.1093/gbe/evag081","url":null,"abstract":"The comparison of chromosome-level genomes allows biologists to investigate new axes of organismal evolution. Spiders comprise a significant proportion of known arachnid diversity, with many complex morphologies and unique natural histories, yet comparative genomics in spiders has been limited due to the number of available genomes. We present a de novo chromosomal reference genome of a mature male tarantula, Aphonopelma marxi, and comparatively examine spider genome evolution across the order Araneae. Using PacBio HiFi and Hi-C sequencing, the final 6.5 Gb assembly consists of 17 autosomes, 1 X chromosome, and 127 unplaced scaffolds, with an N50 of 370 Mb and Arachnida (odb10; 2,934 genes) BUSCO of 96.7%. By comparing 20 additional spider genomes from 15 families, we find mygalomorphs (trapdoor spiders and their kin) generally possess more repetitive genomes with similar composition compared to their much more diverse sister lineage, the araneomorphs. We report mygalomorphs recover a lower number of completed BUSCOs than araneomorph spiders, a finding not correlated with sequencing coverage, as mygalomorphs have a portion of missing or derived BUSCOs in the current arachnid dataset. Across the Araneoidea (orb-weaving spiders and their kin), there is a correlation between decreasing genome size and repeat content, suggesting repetitive elements are being lost or removed. Importantly, visualization of macrosynteny across available genomes highlights structural rearrangements and allows identification of previously unreported sex chromosomes. This new, high-quality mygalomorph genome will provide new avenues of exploration for arachnid evolutionary biology.","PeriodicalId":12779,"journal":{"name":"Genome Biology and Evolution","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13127426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0