Gland surgeryPub Date : 2025-03-31Epub Date: 2025-03-24DOI: 10.21037/gs-2024-494
Justin M Broyles, Jose G Bazan, Ko Un Park
{"title":"Navigating the complexities of preoperative radiotherapy in breast reconstruction: a new paradigm?","authors":"Justin M Broyles, Jose G Bazan, Ko Un Park","doi":"10.21037/gs-2024-494","DOIUrl":"https://doi.org/10.21037/gs-2024-494","url":null,"abstract":"","PeriodicalId":12760,"journal":{"name":"Gland surgery","volume":"14 3","pages":"272-275"},"PeriodicalIF":1.5,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12004294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The predictive value of postoperative intact parathyroid hormone for symptomatic hypocalcemia in older patients with thyroid cancer.","authors":"Lu-Lu Zheng, Ke-Hao Chen, Zhi-Jian Liu, Ling-Hui Dai, Jia-Bo Qin, Yi-Xuan Li, Wen-Xian Guan","doi":"10.21037/gs-2024-526","DOIUrl":"https://doi.org/10.21037/gs-2024-526","url":null,"abstract":"<p><strong>Background: </strong>Due to the unique characteristics of older patients, they are more susceptible to develop symptomatic hypocalcemia (SH). This study aimed to analyze the potential relationship between the occurrence of SH and various indicators in older patients after thyroid cancer surgery, and to further discuss the predictive value of postoperative intact parathyroid hormone (iPTH) for SH, which can provide reference for clinical prevention and treatment of hypocalcemia in older patients.</p><p><strong>Methods: </strong>A total of 137 older patients with thyroid cancer (≥60 years old) admitted to the Department of Thyroid Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School from January 2020 to December 2022 were selected. They were divided into the SH group and the asymptomatic group according to whether they developed SH. Relevant clinical data were collected and retrospectively analyzed. The measurement data of normal distribution were expressed by mean ± standard deviation (SD). Univariate and multivariate analyses were used to determine the risk factors for SH in older patients after thyroid cancer surgery. Statistical significance was set as P<0.05. Receiver operating characteristic (ROC) curve was constructed to study the predictive value of postoperative iPTH for SH occurrence in older patients with thyroid cancer.</p><p><strong>Results: </strong>Among 137 older patients, 48 cases (35.04%) developed SH and 89 cases (64.96%) were asymptomatic. There were significant differences in preoperative iPTH (SH group: 7.00±5.25 pmol/L; asymptomatic group: 5.52±1.80 pmol/L; P=0.004) and postoperative iPTH (SH group: 0.69±0.95 pmol/L; asymptomatic group: 3.30±2.28 pmol/L; P<0.001) between the SH group and the asymptomatic group, with statistical significance (P<0.05). The area under the curve (AUC) of postoperative iPTH predicting SH occurrence in older patients with thyroid cancer was 0.855, cut-off was 0.5941 [95% confidence interval (CI): 0.794-0.917; sensitivity, 87.5%; specificity, 71.9%].</p><p><strong>Conclusions: </strong>Postoperative iPTH is an independent risk factor for predicting SH in older patients with thyroid cancer. In order to avoid the occurrence of postoperative SH and reduce hospitalization costs and length, calcium supplementation should be given as soon as possible according to the level of postoperative iPTH.</p>","PeriodicalId":12760,"journal":{"name":"Gland surgery","volume":"14 3","pages":"510-519"},"PeriodicalIF":1.5,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12004332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gland surgeryPub Date : 2025-03-31Epub Date: 2025-03-25DOI: 10.21037/gs-2024-550
Yaping Zhang, Feng Chen, Jiasheng Cao, Domenech Asbun, Kai Siang Chan, Jose M Ramia, Dongju Xiao, Jun Fang, Jiliang Shen
{"title":"Development and validation of a new formula to predict standard pancreas volume in Chinese adults using body surface area.","authors":"Yaping Zhang, Feng Chen, Jiasheng Cao, Domenech Asbun, Kai Siang Chan, Jose M Ramia, Dongju Xiao, Jun Fang, Jiliang Shen","doi":"10.21037/gs-2024-550","DOIUrl":"https://doi.org/10.21037/gs-2024-550","url":null,"abstract":"<p><strong>Background: </strong>Changes in pancreas volume have been reported in many disorders. In clinical practice, pre-disease total pancreas volume (TPV) is often unavailable for patients with pancreatic pathologies (e.g., tumors, cysts, or pancreatitis), as prior imaging may not exist or may reflect abnormal volumes. While three-dimensional (3D) computed tomography (CT) reconstruction provides accurate TPV measurements, its utility is limited in these scenarios, necessitating a predictive formula. However, no widely clinically accepted standard pancreas volume (SPV) formula currently exists. This study aims to develop an SPV prediction formula based on 3D CT reconstruction and the characteristics of Chinese adults.</p><p><strong>Methods: </strong>The TPV of 377 Chinese adults were obtained via CT 3D reconstruction estimation, 287 of whom were used to construct the formula and 90 of whom were used to validate the formula. The associations of age, gender, weight, height, body mass index (BMI), and body surface area (BSA) with TPV were assessed using Pearson correlation analysis. Stepwise multiple linear regression analysis was used to identify the independent correlation factors that could predict TPV.</p><p><strong>Results: </strong>Age, gender, weight, height, BMI, and BSA significantly correlated with TPV. In addition, stepwise multiple linear regression showed that BSA was the only independent correlation factor for TPV. Therefore, BSA was used as the factor in the following formula for calculating SPV: SPV (cm<sup>3</sup>) = 52.40 × BSA (m<sup>2</sup>) - 21.33 (R<sup>2</sup>=0.384).</p><p><strong>Conclusions: </strong>We created a BSA-based formula to predict SPV in Chinese adults. It can be used to evaluate pancreas volume changes in patients with diabetes or other pancreatic diseases.</p>","PeriodicalId":12760,"journal":{"name":"Gland surgery","volume":"14 3","pages":"479-487"},"PeriodicalIF":1.5,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12004316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gland surgeryPub Date : 2025-03-31Epub Date: 2025-03-26DOI: 10.21037/gs-2024-559
Donglun Li, Yue Hu, Yingjun Zheng, Lin Chun, Jiayi Song, Caihong Cao, Jianxiong Wang
{"title":"The 100 most-cited articles in thyroid surgery from 1990 to 2023: a bibliometric analysis.","authors":"Donglun Li, Yue Hu, Yingjun Zheng, Lin Chun, Jiayi Song, Caihong Cao, Jianxiong Wang","doi":"10.21037/gs-2024-559","DOIUrl":"https://doi.org/10.21037/gs-2024-559","url":null,"abstract":"<p><strong>Background: </strong>The 2015 U.S. guidelines for the diagnosis and treatment of thyroid nodules are recognized as authoritative in the industry, but lack a comprehensive assessment of the development of this field. The purpose of this bibliometric analysis is to identify and assess the 100 most-cited articles that have shaped the modern history of thyroid surgery.</p><p><strong>Methods: </strong>The Web of Science Core Collection database was used to search the 100 most-cited articles in the field of thyroid surgery. VOSviewer was used to visually analyse countries/regions, institutions, authors, keywords, and characteristics of the top-100 articles.</p><p><strong>Results: </strong>The citations of the 100 most-cited articles published between January 1990 and January 2023 ranged from 279 to 7,073. The 100 most-cited articles were published by 25 countries, over half of which were from the USA (n=54). Harvard University (14 articles) and University System of Ohio (14 articles) from the USA (The United States of America) were the top institutions. Schlumberger M from the Institute Gustave Roussy and University Paris Sud was the most productive author with 10 articles. The top-cited article was published by Haugen Bryan R <i>et al.</i> in <i>Thyroid</i> [2015] (citations =7,073). The keywords with the most co-occurrences were carcinoma, followed by fine-needle-aspiration, management, follow up, biopsy, radioactive iodine, and braf (v600e) mutation.</p><p><strong>Conclusions: </strong>The top 100 articles in thyroid surgery have been cited widely and have had a profound impact. The USA was the most influential and productive country. Harvard University and University System of Ohio contributed most to the top 100 articles. Schlumberger M was the most productive and influential author. Moreover, especially thyroid papillary carcinoma, fine needle aspiration, is a research hotspot and potential direction in the future for thyroid surgery.</p>","PeriodicalId":12760,"journal":{"name":"Gland surgery","volume":"14 3","pages":"498-509"},"PeriodicalIF":1.5,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12004318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gland surgeryPub Date : 2025-03-31Epub Date: 2025-03-26DOI: 10.21037/gs-2024-483
Jingke He, Chengcheng Wei, Shuai Su, Yu Luo, Yunfan Li, Kun Han, Lincen Jiang, Jindong Zhang, Delin Wang
{"title":"Frontiers and hotspots of 3D technology in prostatectomy from 1999 to 2024: a bibliometric analysis and visualization.","authors":"Jingke He, Chengcheng Wei, Shuai Su, Yu Luo, Yunfan Li, Kun Han, Lincen Jiang, Jindong Zhang, Delin Wang","doi":"10.21037/gs-2024-483","DOIUrl":"https://doi.org/10.21037/gs-2024-483","url":null,"abstract":"<p><strong>Background: </strong>Prostate cancer is a major global health issue. Radical prostatectomy is an effective treatment for prostate cancer. The integration of three-dimensional (3D) technology in prostatectomy offers numerous benefits. We intended to perform a bibliometric analysis of the role of 3D technology in prostatectomy.</p><p><strong>Methods: </strong>Articles and review articles related to \"3D\" and \"prostatectomy\" were retrieved from Web of Science Core Collection. Microsoft Office Excel, CiteSpace, and VOSviewer were utilized for analysis and visualization.</p><p><strong>Results: </strong>A total of 441 articles were collected. The annual publication volume and journal distribution were illustrated. Visualizations of collaborations among countries/regions, institutions, and authors were provided. Networks of reference co-citations and keyword co-occurrences, along with their respective clusters were plotted.</p><p><strong>Conclusions: </strong>The number of published papers significantly increased over the last 25 years. The most productive and influential country was the USA, and The University of California System was the most influential institution. The journal with the highest number of publications was <i>BJU International</i>. Among all authors in this field, Wijkstra H has published the most papers. Porpiglia F was the most cited author. Previous hot topics included advanced imaging and clinical trials, whereas augmented reality (AR) and robotics are likely to be hot topics in the future.</p>","PeriodicalId":12760,"journal":{"name":"Gland surgery","volume":"14 3","pages":"436-450"},"PeriodicalIF":1.5,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12004326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gland surgeryPub Date : 2025-03-31Epub Date: 2025-03-26DOI: 10.21037/gs-24-421
Yun Zhao, Hwee Leong Tan, Darren Weiquan Chua, Brian Kim Poh Goh, Ye Xin Koh
{"title":"Surgery and neoadjuvant therapy in locally advanced pancreatic cancer: an umbrella review of survival, resection outcomes, and cost-effectiveness.","authors":"Yun Zhao, Hwee Leong Tan, Darren Weiquan Chua, Brian Kim Poh Goh, Ye Xin Koh","doi":"10.21037/gs-24-421","DOIUrl":"https://doi.org/10.21037/gs-24-421","url":null,"abstract":"<p><strong>Background: </strong>Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a poor prognosis, particularly for patients with locally advanced pancreatic cancer (LAPC). Neoadjuvant therapy (NAT) has emerged as a promising strategy to improve resectability and survival outcomes in LAPC. This umbrella review aimed to synthesize the available evidence on the effectiveness of NAT and surgical interventions in LAPC, focusing on resection and R0 resection rates and overall survival (OS).</p><p><strong>Methods: </strong>This study was registered with PROSPERO (CRD42024565454). A comprehensive literature search was conducted in June 2024 across four databases. Studies reporting on NAT and/or surgery in LAPC were selected, and the methodological quality of each meta-analysis was assessed using the A Measurement Tool to Assess Systematic Reviews 2 (AMSTAR-2) tool. A cost-effectiveness analysis (CEA) was performed comparing FOLFIRINOX (leucovorin calcium, fluorouracil, irinotecan, and oxaliplatin) and gemcitabine/nab-paclitaxel as NAT regimens.</p><p><strong>Results: </strong>Nine systematic reviews with meta-analyses published between 2014 and 2023 were included. They covered a variety of treatment strategies, including NAT followed by resection, induction therapy comparing FOLFIRINOX versus gemcitabine/nab-paclitaxel, and different surgical techniques. FOLFIRINOX demonstrated significantly higher R0 resection rates [risk ratio (RR): 0.77, 95% confidence interval (CI): 0.60-0.97, P<0.05] and improved OS compared to gemcitabine/nab-paclitaxel [hazard ratio (HR): 0.68, 95% CI: 0.46-0.99, P<0.05]. Surgical resection following NAT was associated with significantly better survival outcomes than induction therapy alone or palliative treatments. The CEA revealed that FOLFIRINOX, despite its higher cost, yielded an incremental OS benefit of 5.19 months and maintained a 60-63% probability of being cost-effective within a willingness-to-pay (WTP) threshold of $150,000 per additional month of OS gained.</p><p><strong>Conclusions: </strong>This review highlights the superior efficacy of FOLFIRINOX as a NAT regimen for LAPC, particularly in increasing resectability and R0 resection rates. Combining NAT with surgery offers significant survival benefits, making this strategy a standard of care for eligible LAPC patients.</p>","PeriodicalId":12760,"journal":{"name":"Gland surgery","volume":"14 3","pages":"529-542"},"PeriodicalIF":1.5,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12004333/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Video-assisted submuscular breast reconstruction: evaluating a novel technique in high-risk patients.","authors":"Leonardo Barellini, Simone Miccoli, Benedetta Daicampi, Pietro Susini, Ishith Seth, Mirco Pozzi, Roberto Cuomo, Luca Grimaldi, Gianluca Marcaccini","doi":"10.21037/gs-2024-485","DOIUrl":"10.21037/gs-2024-485","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer is one of the most prevalent oncological diseases worldwide, with mastectomy often necessary for treatment. Post-mastectomy breast reconstruction is essential for restoring physical integrity and improving patients' quality of life, especially in high-risk individuals with advanced age, obesity, diabetes, smoking habits, or a history of radiotherapy. Traditional submuscular reconstruction techniques are effective but often associated with higher rates of complications in this patient population. This study aimed to evaluate the efficacy and safety of a novel video-assisted procedure (VAP) for submuscular breast reconstruction, focusing on its ability to reduce complications and enhance outcomes.</p><p><strong>Methods: </strong>A retrospective analysis compared 17 high-risk patients who underwent VAP with 127 patients treated using traditional non-video-assisted procedures (NVAP) between September 2022 and June 2024. Both groups were comparable in age, body mass index (BMI), and risk factors. Data on postoperative complications, including bleeding, wound dehiscence, and infections, were collected and analyzed. Statistical significance was determined using appropriate tests, with a P value <0.05 considered significant.</p><p><strong>Results: </strong>The VAP group demonstrated significant reductions in complications compared to the NVAP group. No cases of postoperative bleeding were reported in the VAP group, while 8.66% of NVAP patients experienced bleeding. Wound dehiscence rates were also lower in the VAP group (5.88%) compared to the NVAP group (10.24%). The minimally invasive nature of VAP allowed for precise dissection and reduced tissue trauma without prolonging surgical times.</p><p><strong>Conclusions: </strong>The findings suggest that VAP is a safer and more effective alternative for high-risk patients requiring submuscular breast reconstruction. By minimizing complications and enhancing both functional and aesthetic outcomes, VAP offers a promising innovation in reconstructive surgery. Larger, randomized trials are necessary to validate these results and establish VAP as a standard of care in diverse clinical settings.</p>","PeriodicalId":12760,"journal":{"name":"Gland surgery","volume":"14 2","pages":"172-178"},"PeriodicalIF":1.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gland surgeryPub Date : 2025-02-28Epub Date: 2025-02-25DOI: 10.21037/gs-24-477
Sijuan Chen, Xianjiao Cao, Gaoyuan Xu, Dan Wang, Dayong Zhuang, Peng Zhou, Tao Yue, Qingqing He, Xiaolei Li
{"title":"Safety and feasibility of robotic reoperation via a bilateral axillo-breast approach for patients with locally recurrent thyroid cancer: a single-center retrospective study.","authors":"Sijuan Chen, Xianjiao Cao, Gaoyuan Xu, Dan Wang, Dayong Zhuang, Peng Zhou, Tao Yue, Qingqing He, Xiaolei Li","doi":"10.21037/gs-24-477","DOIUrl":"10.21037/gs-24-477","url":null,"abstract":"<p><strong>Background: </strong>For patients with recurrent thyroid cancer, traditional open re-operative surgeries often leave conspicuous cervical scars, significantly impacting patients' long-term quality of life. The potential for robotic surgery to enhance the aesthetic outcomes of re-operative surgery and improve the quality of life for these patients has rarely been studied. This study aimed to assess the feasibility and effectiveness of robotic reoperation for recurrent thyroid cancer following initial surgery, offering a viable surgical alternative tailored to patients with heightened aesthetic concerns.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of patients with recurrent thyroid cancer who underwent robotic reoperation via the bilateral axillo-breast approach (BABA) at the 960th Hospital of People's Liberation Army between September 2018 and March 2024. The study design involved a comprehensive review of clinical data, including patient demographics, surgical outcomes, and postoperative complications.</p><p><strong>Results: </strong>A cohort of 24 patients (18 females, 6 males) with a mean age of 34.13±10.06 years successfully underwent robotic BABA reoperation without conversion to open surgery. Two patients underwent completion total thyroidectomy (CTT) with central neck node dissection (CND), four underwent CTT with lateral neck dissection (LND), and the remaining 18 patients received LND alone. Histopathological examination revealed papillary thyroid carcinoma (PTC) in 23 patients and medullary thyroid carcinoma (MTC) in one patient. The mean number of lymph nodes retrieved from LND was 14.21±12.30, with 2.74±2.64 nodes harboring metastases. Postoperative complications were transient, including hypoparathyroidism in four patients and temporary vocal cord palsy in one patient, with no permanent complications reported. During an average follow-up period of 29.71±19.29 months, no recurrences were detected. Cosmetic satisfaction was assessed and yielded a median satisfaction score of 9.2.</p><p><strong>Conclusions: </strong>Robotic BABA reoperation emerges as a feasible and safe surgical modality for managing recurrent thyroid cancer, offering effective treatment while catering to patients' high aesthetic demands.</p>","PeriodicalId":12760,"journal":{"name":"Gland surgery","volume":"14 2","pages":"163-171"},"PeriodicalIF":1.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gland surgeryPub Date : 2025-02-28Epub Date: 2025-02-25DOI: 10.21037/gs-24-411
Ke Ma, Zeyu Yang, Yinde Huang, Supeng Yin, Yizeng Sun, Weihua Wang, Tingjie Yin, Junping Zhu, Chunmeng Shi, Fan Zhang
{"title":"Development and application of primary rat parathyroid cells for transplantation in hypoparathyroidism.","authors":"Ke Ma, Zeyu Yang, Yinde Huang, Supeng Yin, Yizeng Sun, Weihua Wang, Tingjie Yin, Junping Zhu, Chunmeng Shi, Fan Zhang","doi":"10.21037/gs-24-411","DOIUrl":"10.21037/gs-24-411","url":null,"abstract":"<p><strong>Background: </strong>Hypoparathyroidism (HPO) is characterized by deficient secretion of parathyroid hormone (PTH), leading to hypocalcemia and disrupted calcium homeostasis. Current treatments rely on calcium and vitamin D supplementation, which do not adequately mimic physiological PTH function. Cell-based therapies offer a potential solution, but optimal culture conditions to preserve the functional properties of primary parathyroid cells remain unclear. This study aims to develop primary rat parathyroid cell cultures that maintain hormone secretion and calcium-sensing abilities and to evaluate their therapeutic potential in a rat model of HPO.</p><p><strong>Methods: </strong>An HPO model was established in rats through surgical excision of the parathyroid glands. Primary parathyroid cells were isolated from these rats and sorted by flow cytometry using epithelial cell adhesion molecule (EpCAM) and calcium-sensing receptor (CaSR) markers. Four different culture media (CM) were tested to determine optimal conditions for sustaining cell functionality. The most effective CM was supplemented with Sonic Hedgehog (Shh), Activin A, and inhibitors of epithelial-mesenchymal transition (EMT). The cultured cells were then transplanted into HPO rats, and serum calcium and PTH levels were monitored to assess therapeutic efficacy.</p><p><strong>Results: </strong>The optimized CM successfully preserved the hormone-secreting and calcium-sensing functions of primary parathyroid cells over multiple passages. Transplanted cells in HPO rats led to a significant increase in serum calcium and PTH levels compared to untreated controls. The restoration of these levels correlated with the alleviation of hypocalcemic symptoms, indicating effective functional integration of the transplanted cells.</p><p><strong>Conclusions: </strong>Primary rat parathyroid cells cultured under optimized conditions retained essential functional properties and, upon transplantation, effectively restored calcium homeostasis in an HPO rat model. These results highlight the potential of using cultured primary parathyroid cells as a viable cell-based therapy for HPO, offering a promising alternative to conventional treatments.</p>","PeriodicalId":12760,"journal":{"name":"Gland surgery","volume":"14 2","pages":"139-152"},"PeriodicalIF":1.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ultrasound-guided thermal ablation therapy for papillary thyroid carcinoma: a bibliometric analysis from 2000 to 2023.","authors":"Junping Zhang, Shanshan Li, Mengya Zhu, Wen Chen, Anqi Huo, Yuanyuan Deng, Fang Lu, Ying Liu, Jixiong Xu","doi":"10.21037/gs-24-466","DOIUrl":"10.21037/gs-24-466","url":null,"abstract":"<p><strong>Background: </strong>Papillary thyroid cancer (PTC) is increasingly treated with procedures. However, there is a lack of relevant systematic evaluation articles. Therefore, this study aims to explore the research landscape of PTC thermal ablation through bibliometric analysis.</p><p><strong>Methods: </strong>We searched publications related to PTC thermal ablation therapy from January 1, 2000 to December 31, 2023, from the Web of Science Core Collection (WoSCC). Subsequently, bibliometric analyses were then performed using the R package \"bibliometrix\", as well as VOSviewer and CiteSpace software, to visualize data on countries, institutions, journals, authors, keywords, and references.</p><p><strong>Results: </strong>A total of 283 publications from 17 countries were retrieved, and the number of publications had shown a steady increase over the past decade, with China, the USA and South Korea being the top three contributing countries. The Chinese People's Liberation Army General Hospital was the most prolific institution, with the <i>International Journal of Hyperthermia</i> being the most frequent publisher. The author with the highest number of publications was Yukun Luo. \"Radiofrequency ablation\" was identified as the most commonly used keyword, indicating a potential research hotspot for the future.</p><p><strong>Conclusions: </strong>This bibliometric study comprehensively analyzed publications on PTC thermal ablation, providing valuable insights into the history and current status of this research field, while also offering guidance for future research directions.</p>","PeriodicalId":12760,"journal":{"name":"Gland surgery","volume":"14 2","pages":"153-162"},"PeriodicalIF":1.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}