Green Processing and Synthesis最新文献

{"title":"Synthesis, characterization, anticancer, anti-inflammatory activities, and docking studies of 3,5-disubstituted thiadiazine-2-thiones","authors":"H. Ali, Rasool Khan, Xian-dao Pan, F. Shaheen, A. Jabeen, A. Rauf, M. Shah, Umer Rashid, Yahya S. Al-Awthan, O. Bahattab, Mohammed A. Al-Duais, M. S. Mubarak","doi":"10.1515/gps-2022-8136","DOIUrl":"https://doi.org/10.1515/gps-2022-8136","url":null,"abstract":"Abstract In the search for potent bioactive compounds, a series of tetrahydro-2H-1,3,5-thiadiazine-2-thiones (1–13) were synthesized in good yield and characterized by means of 1H NMR, 13C NMR, and mass spectral data. The anticancer activity of the compounds was evaluated against HeLa cell line and anti-inflammatory potential via nitric oxide (NO) inhibition. Among the screened compounds, 2-(5-(3-methoxypropyl)-6-thioxo-1,3,5-thiadiazinan-3-yl) propionic acid (3), 2-(5-cyclopropyl-6-thioxo-1,3,5-thiadiazinan-3-yl) propionic acid (5), 2-(5-cyclopropyl)-6-thioxo-1,3,5-thiadiazinan-3-yl) acetic acid (6), and 2-(5-butyl-6-thioxo-1,3,5-thiadiazinan-3-yl) acetic acid (9) were the most potent against HeLa cell line with IC50 values <4 µM, whereas the rest of the series exhibited moderate-to-good activities. All the compounds were potent NO inhibitors with IC50 values ranging from <0.4 to 14.9 µM. Docking studies, binding orientations, and interaction plots showed strong interaction of the studied compounds with the inducible NO synthase enzyme via strong hydrogen bonds and hydrophobic interactions, which authenticate the in vitro results. These newly synthesized compounds could lead to the discovery of anticancer drugs.","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42676284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of apigenin nanoparticles prepared by planetary ball milling: In vitro and in vivo studies","authors":"Abdullah A. Alshehri, M. Ibrahim, Sultan Mohamed Alshehri, D. Alshora, E. Elzayat, Osaid T. Almeanazel, Badr S. Alsaadi, Gamal A. El Sherbiny, S. Osman","doi":"10.1515/gps-2022-8107","DOIUrl":"https://doi.org/10.1515/gps-2022-8107","url":null,"abstract":"Abstract This study intended to optimize apigenin (APG) nanoparticle formulation prepared by planetary ball milling to enhance its dissolution rate and bioavailability using a design of experiment (DoE). In this study, polyvinyl pyrrolidone (PVP K30) was used as a nanoparticle stabilizer. The independent parameters of milling speed, milling ball size, and drug to solvent ratio were evaluated for their impacts on APG nanoparticles concerning the nanoparticle size (Y1), zeta potential (Y2), and drug dissolution efficiency after 60 min, notated as % DE60 (Y3). The milling ball size showed a significant antagonistic effect (P = 0.0210) on the size of APG nanoparticles, while milling speed had an agonistic effect on the zeta potential values of drug nanoparticles, ranging from low to medium speed levels. In addition, ANOVA analysis indicated that the effect of the drug-to-solvent ratio on the % DE60 of APG from the nanoparticle formulations was antagonistically significant (P = 0.015), and the quadratic effect of milling speed (AA) also had a significant antagonistic effect (P = 0.025) on the % DE60. Risk assessment analytical tools revealed that milling ball size and milling speed significantly affect the nanoparticle size. The drug/solvent ratio exerted a strong impact on % DE60. Furthermore, the maximum plasma concentration (C max) of the optimized APG nanoparticle formula increased by four folds. In addition, AUC0–t (ng·mL−1·h−1) for APG nanoparticle (353.7 ± 185.3 ng·mL−1·h−1) was higher than that noticed in the case of the untreated drug (149 ± 137.5 ng·mL−1·h−1) by more than two folds.","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45450819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Excellent photocatalytic degradation of rhodamine B over Bi2O3 supported on Zn-MOF nanocomposites under visible light","authors":"Qiuyun Zhang, Dandan Wang, Rongfei Yu, Linmin Luo, Weihua Li, Jin-Tian Cheng, Yutao Zhang","doi":"10.1515/gps-2022-8123","DOIUrl":"https://doi.org/10.1515/gps-2022-8123","url":null,"abstract":"Abstract In this article, Bi2O3@Zn-MOF hybrid nanomaterials were synthesized by supporting Zn-based metal–organic framework (Zn-MOF) through the hydrothermal method. X-ray diffractometer, Fourier transform infrared, scanning electron microscopy, energy-dispersive X-ray, N2 physisorption, X-ray photoelectron spectroscopy, and UV-Vis were used to characterize the physical and chemical properties of Bi2O3@Zn-MOF nanomaterials. The photocatalytic activity of the as-prepared hybrid has been studied over the degradation of rhodamine B (RhB). A catalytic activity of 97.2% was achieved using Bi2O3@Zn-MOF nanocomposite with the loading of 0.18 g Bi2O3, after 90 min of exposure to visible light irradiation, and the high photocatalytic performance was mainly associated with the nanorod structures, larger pore size, and broaden visible light absorption region due to the synergistic effect of the constituting materials. Furthermore, the Bi2O3@Zn-MOF nanocomposite can be reused three times and the degradation rate of RhB was maintained at 77.9%. Thus, the Bi2O3@Zn-MOF nanocomposite can act as a potential photocatalyst for the photodegradation of organic dyes in environmental applications.","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45816074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photocatalytic research performance of zinc oxide/graphite phase carbon nitride catalyst and its application in environment","authors":"Haiyang Liu, Zhe Wang, Heng Zhang, Lixia Jin, Yuehui Zhao","doi":"10.1515/gps-2023-0058","DOIUrl":"https://doi.org/10.1515/gps-2023-0058","url":null,"abstract":"Abstract In this article, ZnO quantum dots (QDs)-g-C3N4 complexes were prepared by a combined sol–gel method and ultrasound-assisted chemical method, and ZnO-g-C3N4 composites with different doping ratios were also prepared for photocatalytic degradation of dye wastewater. The composites were characterized by scanning electron microscopy, transmission electron microscopy, X-ray diffractometry, Fourier transform infrared, X-ray photoelectron spectroscopy, diffuse reflectance spectroscopy, and photoluminescence. The photocatalytic performance of the best ZnO QDs-g-C3N4 complexes with different g-C3N4 doping amounts was investigated, and the kinetics of their photocatalytic reactions were analyzed, and it was found that the best effect of ZnO-g-C3N4 10% could reach 89.08% and ZnO QDs-g-C3N4 could reach 91.53%. It was also demonstrated that ZnO-g-C3N4 10%, ZnO QDs-g-C3N4 cyclic stability is better, and the reaction mechanism of ZnO QDs-g-C3N4 was investigated. It can be used for the degradation of dyes in environmental wastewater and the removal of harmful substances from the natural environment.","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47739765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Putative anti-proliferative effect of Indian mustard (Brassica juncea) seed and its nano-formulation","authors":"P. Virk, M. Awad, M. Alanazi, A. Hendi, M. Elobeid, K. Ortashi, A. W. Alrowaily, Taghreed Bahlool, F. Aouaini","doi":"10.1515/gps-2022-8119","DOIUrl":"https://doi.org/10.1515/gps-2022-8119","url":null,"abstract":"Abstract Over the past few decades, nanotechnology has shown promising prospects in biomedicine and has a proven impact on enhancing therapeutics by facilitating drug delivery. The present study brings an amalgamation of nanoscience and “clean technology” by fabricating nature-friendly nanoparticles (NPs) sans the use of chemical surfactants using Indian mustard seed, Brassica juncea L. The as-synthesized NPs were characterized to assess their average size, crystallinity, morphology, and constituent functional groups through conventional techniques: dynamic light scattering (DLS), X-ray diffraction (XRD), scanning electron microscopy (SEM), and Fourier-transform infrared spectroscopy (FTIR). The NPs were crystalline in nature and exhibited a mean size of 205.5 nm (PDI of 0.437) being primarily polygonal in shape. Additionally, the therapeutic efficacy of the green NPs was evaluated based on their cytotoxic effect against two human cancer lines, MCF-7 and HepG-2. Both the NPs and the bulk seeds showed a dose-dependent cytotoxic effect. However, an assessment of the antiproliferative/cytotoxic potential of the green NPs versus the bulk seeds showed that the NPs were relatively more efficacious on both cell lines. Taken together, the mustard seed NPs could be potential nutraceuticals considering the green credential in their mode of biosynthesis.","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49052028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green-synthesized nanoparticles and their therapeutic applications: A review","authors":"Shilpa Borehalli Mayegowda, Gitartha Sarma, Manjula Nagalapur Gadilingappa, Saad Alghamdi, A. Aslam, Bassem Refaat, M. Almehmadi, M. Allahyani, A. Alsaiari, A. Aljuaid, Issa Saad Al-Moraya","doi":"10.1515/gps-2023-0001","DOIUrl":"https://doi.org/10.1515/gps-2023-0001","url":null,"abstract":"Abstract Antibiotic-resistant microorganisms are a rising issue when it comes to human health. Microbial pathogens that cause harmful infections are quickly becoming resistant to the antimicrobial action of traditional antibiotics. Nanotechnology, an innovative sector being an indispensable part of healthcare and research, has in-depth and extensive applications. Nano-compounds have been promising antimicrobial agents, anti-cancerous mediators, vehicles for drug delivery, formulations for functional foods, identification of pathogens, food and drug packaging industry, and many more. However, the chemical synthesis of nanoparticles (NPs) has certain drawbacks such as causing toxicity and other adverse effects. For more than a decade, the use of NPs that are conjugated or green-synthesized has gained popularity due to the two-fold action of metallic NPs mixed with biological sources. In contrast, NPs synthesized using plant or microbial extracts, conjugated with biologically active components, appear to be a safe alternative approach as they are environmentally friendly and cost-effective. Such environmentally safe techniques are referred to as “green nanotechnology” or “clean technology” and are feasible alternatives to chemical methods. Furthermore, NPs conjugated with natural biomolecules have improved bioavailability and have minimal side effects, as they are smaller in size and have higher permeability in addition to being reducing and stabilizing agents possessing excellent antioxidant activity. NPs serve as potential antimicrobial agents due to their affinity towards sulphur-rich amino acids, adhere to microbial cell walls by means of electrostatic attraction, and disrupt the cytoplasmic membrane along with the nucleic acid of microbes. They possess anticancer activity owing to oxidative stress, damage to cellular DNA, and lipid peroxidation. The green-synthesized NPs are thus a promising and safe alternative for healthcare therapeutic applications.","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48398626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adsorption/desorption performance of cellulose membrane for Pb(ii)","authors":"Baiwang Zhao, Jiaofeng He, Li Wang","doi":"10.1515/gps-2023-0014","DOIUrl":"https://doi.org/10.1515/gps-2023-0014","url":null,"abstract":"Abstract Cellulose membrane (CM) was successfully prepared by phase conversion (L–S). The adsorption performance of CM for Pb(ii) under different adsorption conditions was investigated, and the adsorption isothermal models and kinetic models were established. Additionally, desorption performance of CM for Pb(ii) under different conditions were also investigated. Scanning electron microscope (SEM), energy dispersion spectroscopy (EDS), and Fourier transform infrared (FT-IR) methods were used to evaluate changes in the microstructure, element content, and functional groups of CM. The maximum adsorption capacity (343 mg·g−1) of Pb(ii) was achieved (initial concentration of Pb(ii) solution was 1,200 mg·L−1, pH was 4.5, adsorption time was 120 min, adsorption temperature was 30°C). Meanwhile, the process conforms to multi-molecular layer chemical adsorption. The desorption results showed that the maximum desorption capacity was 90.00 mg·g−1 (HNO3 concentration was 0.04 mol·L−1, desorption time was 120 min, desorption temperature was 60°C). SEM showed that the pores were saturated after adsorption of Pb(ii). Mapping and EDS analysis revealed that CM contained 72.14% Pb(ii) after adsorption. In the FT-IR curve, Pb(ii) chelated the C═O group of the CM. This method showed great potential for adsorption of Pb(ii) from aqueous solutions.","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49160182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Removal efficiency of dibenzofuran using CuZn-zeolitic imidazole frameworks as a catalyst and adsorbent","authors":"Thanh Q. C. Nguyen, Huy B. Tran, N. Nguyen, Nhut Nguyen, Giao H. Dang","doi":"10.1515/gps-2022-8112","DOIUrl":"https://doi.org/10.1515/gps-2022-8112","url":null,"abstract":"Abstract Dioxins/furans are classified as highly toxic chemicals that seriously affect human health. To remove dioxin residues from contaminated water, CuZn-ZIFs, a material from bimetallic zeolitic imidazolate frameworks (ZIFs) has been synthesized and explored its efficacy treatment with dibenzofuran (DBF). The pristine structure of CuZn-ZIFs was confirmed using powder X-ray diffraction, Fourier-transform infrared, thermogravimetric analysis, energy-dispersive X-ray, Brunauer–Emmett–Teller, and scanning electron microscopy. CuZn-ZIFs exhibited its role as a heterogeneous catalyst promoting H2O2 oxidation and as an adsorbent in DBF treatment. Herein, at room temperature, more than 86% of DBF adsorbed and 90% of DBF degraded in the presence of H2O2 with 10 mg catalyst dosage, 30 ppm of DBF within 40 and 60 min, respectively. Remarkably, the CuZn-ZIFs’ reusability of each process showed a high efficacy removal with over 80% after five cycles. Therefore, CuZn-ZIFs synthesized could be a prospective candidate for the indirect or direct degradation of dioxins/DBF derivatives from contaminated water. Graphical abstract","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47962895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of phytogenic iron nanoparticles on the bio-fortification of wheat varieties","authors":"Ubaid ul Hassan, Maarij Khan, Zohaib Younas, N. Raja, Z. Mashwani, Sohail","doi":"10.1515/gps-2023-8002","DOIUrl":"https://doi.org/10.1515/gps-2023-8002","url":null,"abstract":"Abstract Bio-fortification is a potential technique to tackle micronutrient deficiencies that remain. Wheat grain bio-fortification has the ability to decrease malnutrition because it represents one of the most essential staple crops. Bio-fortification is cost-effective and evidence-based sustainable technique to address malnutrition in wheat varieties possessing additional micronutrient contents. Nano-biofortification is a novel approach, enriching crops with essential nutrients in order to supplement human diets with balanced diets. The current study was designed to explore the potential role of phytogenic iron nanoparticles (Fe-NPs) to enhance nutritional contents in wheat plants to fulfill the nutrient deficiency important for human and animal health. In the current study, Fe-NPs were fabricated by using the extract of Mentha arvensis L. that were irregular in shape with an approximate size range of 40–100 nm. Further, Fourier transform infrared (FT-IR) analyses were deployed to confirm the presence of t of various functional groups involved in the green and eco-friendly fabrication of Fe-NPs. The effects of phytogenic Fe-NPs were examined on various physiological and biochemical parameters such as total proline, total chlorophyll, carbohydrates, protein, crude fibers, and lipids contents. Moreover, wheat physiological and biochemical profiling was carried out, and it was noticed that Fe-NPs significantly altered the physico-biochemical profiling of wheat plants. Multiple methods of administration of Fe-NPs were used to fortify the wheat crop. However, the Fe-NPs assisted seed priming along with foliar applications at various concentrations (10, 20, and 30 mg·L−1) were found more suitable to enhance the contents of proline, Chlorophyll a, b, total chlorophyll, carbohydrate, proteins, fibers, and lipids (20.22%, 18.23%, 17.25%, 16.32%, 12.34%, 24.31%, 19.52%, and 11.97%, respectively) in wheat plants. Further, wheat flour was exposed to digestive enzymes, with the iron content gradually increased in a dose-dependent manner. The nutritional analysis of wheat zinc (Zn), molybdenum (Mo), magnesium (Mg), iron (Fe), yttrium (Y), and copper (Cu) and the fatty acid profile have demonstrated divergent patterns of behavior. Similarly, iron content was also increased significantly in response to the exposure to Fe-NPs.","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41488249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attenuation of di(2-ethylhexyl)phthalate-induced hepatic and renal toxicity by naringin nanoparticles in a rat model","authors":"Malak Abdullah Al-Qahtani, P. Virk, M. Awad, M. Elobeid, Khawlah Sultan Alotaibi","doi":"10.1515/gps-2022-8122","DOIUrl":"https://doi.org/10.1515/gps-2022-8122","url":null,"abstract":"Abstract This study assessed the protective effect of citrus flavanone, naringin (Nar), and its nanoformulation against di(2-ethylhexyl)phthalate (DEHP) toxicity in albino rats. Keeping green nanotechnology as the cornerstone, nanoparticles of Nar were synthesized and characterized using electron microscopy (transmission electron microscopy and scanning electron microscopy), particle size distribution, Fourier transform infrared spectroscopy, and X-ray diffraction. The synthesized nanoparticles were primarily spherical with an average size of 109 nm and a low polydispersity index of 0.175. Mature male albino rats were used for the exposure study. Group I was negative control. Groups II, III, and IV were exposed to (250 mg·kg b·wt−1) DEHP for 3 weeks. Group III was treated with bulk Nar (5 mg·kg b·wt−1), and group IV was treated with non-naringin (NNar) (5 mg·kg b·wt−1). Group V was exposed only to NNar. Exposure to DEHP significantly enhanced serum levels of pro-inflammatory cytokines, interleukin-1β, 6, 8 (IL-1β, IL-6, IL-8), and tumour necrosis factor (TNF-α). In addition, the repression of hepatic mRNA expression of nuclear factor-erythroid 2-related factor 2 was also observed. In addition, marked histopathological alterations were observed in the hepatic and renal tissues. Treatment with both Nar and NNar significantly alleviated the DEHP-induced oxidative stress/inflammatory response along with the associated histological alterations. However, therapeutic utility of NNar was more profound underlining its potential in nutraceutical therapeutics with high green credentials. Graphical abstract Effect of naringin and its nanoparticles against DEHP toxicity in a rat.","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45005745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}