Annals of Clinical and Translational Neurology最新文献

{"title":"Association of the ICH Score With Withdrawal of Life-Sustaining Treatment Over a 10-Year Period.","authors":"Nina Massad, Lili Zhou, Brian Manolovitz, Negar Asdaghi, Hannah Gardener, Hao Ying, Carolina M Gutierrez, Angus Jameson, David Rose, Mohan Kottapally, Amedeo Merenda, Kristine O'Phelan, Sebastian Koch, Jose G Romano, Tatjana Rundek, Ayham Alkhachroum","doi":"10.1002/acn3.70136","DOIUrl":"10.1002/acn3.70136","url":null,"abstract":"<p><strong>Objective: </strong>The intracerebral hemorrhage (ICH) score was developed to enhance provider communication and facilitate early severity assessment. We examined the association of the ICH score with mortality and withdrawal of life-sustaining treatment (WLST) in a large, multicenter stroke registry, and evaluated temporal trends in these associations.</p><p><strong>Methods: </strong>We identified ICH patients from the Florida Stroke Registry from 2013 to 2022. Outcomes were WLST and in-hospital mortality. ICH scores were grouped as 0-2, 3-4, and 5-6. Importance plots identified key predictors of WLST. Model performance was assessed using AUC-ROC for logistic regression and random forest, adjusted for relevant confounders. Secondary analyses compared outcomes between 2015-2018 and 2019-2022 using stratified univariate logistic regression.</p><p><strong>Results: </strong>In total, 12,426 patients were included (mean age 69, 55% male, 56% white). The most predictive factors associated with WLST were ICH score, age, state region, presenting level of consciousness, insurance status, and race (RF AUC = 0.94, LR AUC = 0.82). Mortality was 6.6%, 41.5%, and 66% for ICH score 0-2, 3-4, and 5-6. WLST occurred more frequently in higher ICH score groups (OR 9.35 [95% CI: 8.5-10.3] for scores 3-4; OR 18.64 [95% CI: 15.28-22.74] for scores 5-6). Early WLST (< 48 h) was more common in higher score groups (OR 2.97 [95% CI: 2.48-3.55] for 3-4; OR 9.51 [95% CI: 7.33-12.35] for 5-6).</p><p><strong>Interpretation: </strong>Higher ICH scores were strongly associated with mortality and WLST, including early withdrawal decisions. These associations remained largely consistent over time. These observational findings underscore the need for continued attention to how prognostic scores may influence WLST decisions.</p>","PeriodicalId":126,"journal":{"name":"Annals of Clinical and Translational Neurology","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding Mechanisms of Whole Brain and Regional Grey Matter Atrophy in Children With MOGAD.","authors":"Ermelinda De Meo, Riccardo Nistri, Michael Eyre, Cheryl Hemingway, Ming Lim, Thomas Rossor, Asthik Biswas, Kshitij Mankad, Ata Siddiqui, Sniya Sudhakar, Declan Chard, Frederik Barkhof, Arman Eshaghi, Olga Ciccarelli, Yael Hacohen","doi":"10.1002/acn3.70123","DOIUrl":"https://doi.org/10.1002/acn3.70123","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the mechanisms driving whole brain and regional grey matter (GM) volume changes along with their clinical correlates in paediatric myelin oligodendrocyte glycoprotein antibody (MOG-Ab)-associated disease (MOGAD).</p><p><strong>Methods: </strong>One-hundred-nine paediatric MOGAD patients from two UK centres underwent MRI at attack nadir and follow-up (at least 1) ≥ 6 weeks later. Normative trajectories from 317 typically developing children informed volumetric comparisons. MRI segmentation with SynthSeg+ enabled volumetric analysis. Linear mixed-effects models examined impact of brain lesions, disease course, MOG-Ab serostatus and age at onset on brain volumes and changes over time, along with clinical correlates.</p><p><strong>Results: </strong>Brain lesions were present in 71/109 patients, who were younger and more likely to present with acute disseminated encephalomyelitis. At onset, 79% showed reduced brain growth, particularly those with brain lesions. Over time, 46% developed atrophy, associated with lesion presence and relapsing disease. All patients exhibited cortical and deep GM growth reduction at onset, with brain lesions driving progressive atrophy. Brian lesion complete resolution mitigated atrophy in the left supramarginal and right inferior parietal gyri. Relapsing disease was linked to greater GM atrophy in the frontal, temporal and parietal lobes. Persistent MOG-Ab positivity correlated with GM atrophy in the cingulate and entorhinal cortices and temporal pole. Disability progression was linked to deep GM, temporal pole and lateral orbitofrontal atrophy, while learning difficulties were associated with lateral occipital and parietal atrophy.</p><p><strong>Interpretation: </strong>Brain lesions at onset and their persistence, relapsing disease and MOG-Ab positivity are key risk factors for GM atrophy and clinical impairment in paediatric MOGAD.</p>","PeriodicalId":126,"journal":{"name":"Annals of Clinical and Translational Neurology","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-Frequency Fingerprint Analysis in SEEG Source-Space to Identify the Epileptogenic Zone.","authors":"Yash Shashank Vakilna, Deniz Atilgan, Johnson Hampson, Chinmay Chinara, Takfarinas Medani, Richard M Leahy, Nuria Lacuey, Samden D Lhatoo, Sandipan Pati, John C Mosher, Jay R Gavvala","doi":"10.1002/acn3.70115","DOIUrl":"https://doi.org/10.1002/acn3.70115","url":null,"abstract":"<p><p>This case study highlights the application of seizure fingerprint analysis in the source-space of stereo-EEG (SEEG) data to accurately localize the epileptogenic zone (EZ) in patients with complex cortical malformations. A 25-year-old female with extensive bilateral perisylvian polymicrogyria (PMG) presented with intractable focal seizures. The source-level analysis performed in Brainstorm using the sLORETA imaging algorithm subsequently showed EZ fingerprint analysis. The patient underwent MR-guided laser interstitial thermal therapy (LITT), targeting the identified EZ, resulting in postoperative seizure freedom with minimal complications. Extending the analysis from the sensor-space to the source-space could further enhance surgical planning and improve outcomes in complex epilepsy cases.</p>","PeriodicalId":126,"journal":{"name":"Annals of Clinical and Translational Neurology","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Efgartigimod for Generalized Myasthenia Gravis: A Multicenter Real-World Cohort Study in China\".","authors":"","doi":"10.1002/acn3.70126","DOIUrl":"https://doi.org/10.1002/acn3.70126","url":null,"abstract":"","PeriodicalId":126,"journal":{"name":"Annals of Clinical and Translational Neurology","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cervical Spinal Cord Magnetization Transfer Ratio and Its Relationship With Clinical Outcomes in Multiple Sclerosis.","authors":"Lisa Eunyoung Lee, Julien Cohen-Adad, Irene M Vavasour, Melanie Guenette, Katherine Sawicka, Neda Rashidi-Ranjbar, Nathan Churchill, Akash Chopra, Adelia Adelia, Pierre-Louis Benveniste, Anthony Traboulsee, Nathalie Arbour, Fabrizio Giuliani, Larry D Lynd, Scott B Patten, Alexandre Prat, Alice Schabas, Penelope Smyth, Roger Tam, Yunyan Zhang, Simon J Graham, Mojgan Hodaie, Anthony Feinstein, Shannon Kolind, Tom A Schweizer, Jiwon Oh","doi":"10.1002/acn3.70113","DOIUrl":"https://doi.org/10.1002/acn3.70113","url":null,"abstract":"<p><strong>Objective: </strong>The cervical spinal cord (cSC) is highly relevant to clinical dysfunction in multiple sclerosis (MS) but remains understudied using quantitative magnetic resonance imaging (MRI). We assessed magnetization transfer ratio (MTR), a semi-quantitative MRI measure sensitive to MS-related tissue microstructural changes, in the cSC and its relationship with clinical outcomes in radiologically isolated syndrome (RIS) and MS.</p><p><strong>Methods: </strong>MTR data were acquired from 52 RIS, 201 relapsing-remitting MS (RRMS), 47 primary progressive MS (PPMS), and 43 control (CON) participants across four sites in the Canadian Prospective Cohort Study to Understand Progression in MS (CanProCo) using 3.0 T MRI systems. Mean MTR was compared between groups in whole cSC and sub-regions between C2-C4. Multiple linear regression was used to evaluate relationships between MTR and clinical outcomes, including the expanded disability status scale (EDSS), walking speed test (WST), and manual dexterity test (MDT).</p><p><strong>Results: </strong>There were consistent group differences in MTR, which were most pronounced between PPMS and CON (-5.8% to -3.7%, p ≤ 0.01). In PPMS, lower MTR was associated with greater disability as measured by EDSS (β = -0.3 to -0.1, p ≤ 0.03), WST (β = -0.9 to -0.5, p ≤ 0.04), and MDT (β = -0.6 and - 0.5, p = 0.04). In RRMS, MTR was associated with only EDSS (β = -0.1, p ≤ 0.03).</p><p><strong>Interpretation: </strong>In this large sample of RIS and MS, cSC MTR was lowest in PPMS, with associations between MTR and clinical outcomes in MS but not RIS. These findings suggest that MTR provides important information about the underlying tissue microstructural integrity of the cSC relevant to clinical disability in established MS.</p>","PeriodicalId":126,"journal":{"name":"Annals of Clinical and Translational Neurology","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144525670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relevance of Kappa and Lambda Free Light Chains in Autoimmune Astrocytopathy Associated With Anti-GFAP Antibodies.","authors":"Michael Levraut, Romain Marignier, Mikael Cohen, Jeanne Benoit, Cassandre Landes-Chateau, Elisabeth Maillart, Marion Cremoni, Barbara Seitz-Polski, Anne-Laurie Pinto, Pauline Dumez, Jérôme Honnorat, Christine Lebrun-Frenay","doi":"10.1002/acn3.70103","DOIUrl":"https://doi.org/10.1002/acn3.70103","url":null,"abstract":"<p><strong>Introduction: </strong>The kappa-free light chain (κ-FLC) index is known to be highly sensitive and specific for diagnosing multiple sclerosis (MS), while little is understood about lambda (λ)-FLC. This study assessed the κ-FLC and λ-FLC indices in autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy.</p><p><strong>Methods: </strong>This multicenter study compares κ-FLC and λ-FLC indexes among patients with autoimmune GFAP astrocytopathy and sex- and age-matched MS (positive control group) as well as symptomatic controls (headaches and small cerebral vessel disease, as the negative control group). We describe the correlation of both indexes with clinical variables and outcomes in the GFAP astrocytopathy cohort.</p><p><strong>Results: </strong>A total of 93 patients were included (31 in each group). The median κ-FLC index was higher in the MS group (65.5 [35.7; 118.3]) compared to the GFAP astrocytopathy group (26.1 [11.4; 78.4], p = 0.062). With a κ-FLC index threshold of 6.1, the proportion of patients with a positive κ-FLC index was similar between the MS (94%) and GFAP-astrocytopathy groups (84%, p = 0.425). The median λ-FLC index was higher in the GFAP astrocytopathy group (45.5 [28.4; 96.9]) than in the MS group (10.6 [2.2; 29.1], p < 0.001). In the GFAP-astrocytopathy group, both CSF λ-FLC and the λ-FLC index at baseline were correlated with the last follow-up mRS (⍴ = 0.46, r² = 0.088, p = 0.014, and ⍴ = 0.32, r² = 0.12, p = 0.101, respectively).</p><p><strong>Conclusion: </strong>The κ-FLC index alone cannot distinguish between autoimmune GFAP astrocytopathy and MS. We indicate a potential diagnostic and prognostic role of the λ-FLC index in GFAP astrocytopathy that needs confirmation in independent cohorts.</p>","PeriodicalId":126,"journal":{"name":"Annals of Clinical and Translational Neurology","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144525671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics of Parkinsonism in HTLV-1-Associated Myelopathy.","authors":"Mika Dozono, Satoshi Nozuma, Shota Hirakata, Takashi Yoshida, Daisuke Kodama, Masakazu Tanaka, Eiji Matsuura, Ryuji Kubota, Hiroshi Takashima","doi":"10.1002/acn3.70121","DOIUrl":"https://doi.org/10.1002/acn3.70121","url":null,"abstract":"<p><strong>Objective: </strong>Human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is the classic neurological manifestation of HTLV-1 infection; however, this virus has also been associated with other neurological disorders. Concurrent parkinsonism is relatively rare and presents diagnostic challenges. The present study aimed to identify the clinical characteristics of HAM/TSP with parkinsonism.</p><p><strong>Methods: </strong>This retrospective study included HAM/TSP patients hospitalized in Kagoshima University Hospital from January 2000 to March 2022. Clinical and laboratory findings of the HAM/TSP patients with parkinsonism (P-HAM) were collected from the medical records and compared with HAM/TSP patients without parkinsonism (typical HAM/TSP [T-HAM]). P-HAM cases were defined as patients presenting with any combination of rigidity, resting tremor, bradykinesia, and/or postural instability, with these symptoms not attributed to HAM/TSP.</p><p><strong>Results: </strong>Of 246 HAM/TSP patients, 11 (4.5%) presented with parkinsonism. Compared with T-HAM, the age of onset was significantly older (65.0 vs. 48.8 years, p = 0.001) in patients with P-HAM. Moreover, despite a shorter illness duration (8.5 vs. 12.5 years, p = 0.151), the Osame Motor Disability Score was significantly higher in P-HAM cases than in T-HAM cases (6.3 vs. 4.6, p = 0.0132), and all P-HAM cases had scores ≥ 4. Laboratory findings showed no differences between the groups.</p><p><strong>Interpretation: </strong>In our cohort, 4.5% of HAM/TSP patients had concomitant parkinsonism, which was associated with a later age of onset and greater disease severity. The coexistence of parkinsonism in HAM/TSP may be underrecognized, and our findings expand the clinical spectrum of neurological disease with HTLV-1 infection.</p>","PeriodicalId":126,"journal":{"name":"Annals of Clinical and Translational Neurology","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D MRI Tract-Specific Spinal Cord Lesion Pattern Improves Prediction of Distinct Neurological Recovery.","authors":"Lynn Farner, Tim M Emmenegger, Simon Schading-Sassenhausen, Julia Berroth, Maryam Seif, Armin Curt, Patrick Freund","doi":"10.1002/acn3.70087","DOIUrl":"https://doi.org/10.1002/acn3.70087","url":null,"abstract":"<p><strong>Objective: </strong>To distinguish lateralized motor- and sensory-tract damage after acute spinal cord injury (SCI) and explore its predictive power for motor and sensory recovery.</p><p><strong>Methods: </strong>Thirty-five SCI patients (two female) from a multi-center data set (placebo-arm of the Nogo-A-Inhibition in SCI trial) underwent routine T2-weighted sagittal MRI scans at the lesion site at baseline (19.9 days, 95% confidence interval [CI]: 17.9-21.8), 1-month (54.2 days, 95% CI: 52.1-56.2), and 6-month (192.4 days, 95% CI: 181.3-203.6) post-injury. Concurrently with the MRI scans, clinical examinations were performed. Lesions were manually segmented across all slices, and 3D-tract damage was assessed by determining the overlap between segmented lesions and identified motor and sensory tracts in the axial plane. The relationship between lesion assessments and baseline-adjusted clinical outcomes at 6 months was explored.</p><p><strong>Results: </strong>Over the 6-month, patients recovered by 4.95 motor points/month (95% CI: 3.89-5.89, p < 0.001) on the International Standards for the Neurological Classification of SCI scale, 2.28 light-touch points/month (95% CI: 1.43-3.12, p < 0.001), and 2.06 pinprick points/month (95% CI: 1.21-2.91, p < 0.001). Lesion volume decreased from 381.82mm ³ (95% CI: 295.78-467.87) by -14.04 mm³/month (95% CI: -25.39 to -1.56, p = 0.023). MRI visible changes in motor tract damage over the 6-month were marginal (0.02%/month, 95% CI: -0.81 to -1.02, p = 0.971). Changes in the sensory tracts were more pronounced, decreasing by -0.69%/month (95% CI: -1.29 to -0.09, p = 0.05). Left-and-right motor-tract damage at baseline significantly predicted left-and-right motor score recovery (R² = 0.75, p = 0.015), while baseline left-and-right sensory-tract damage significantly predicted improvements in left-and-right pin-prick scores (R² = 0.79, p = 0.024).</p><p><strong>Interpretation: </strong>Revealing the extent of damage to spinal motor-and sensory-pathways early after SCI is a valuable predictor of related neurological recovery. Tracking 3D dynamics of major spinal pathways has the potential to enhance diagnostic accuracy and patient stratification for future clinical trials.</p>","PeriodicalId":126,"journal":{"name":"Annals of Clinical and Translational Neurology","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 72-Year-Old Man With a History of Rheumatoid Arthritis Presenting With Unilateral Eye and Jaw Pain.","authors":"Mohamad Rani Hassoun, Neena R Cherayil","doi":"10.1002/acn3.70030","DOIUrl":"https://doi.org/10.1002/acn3.70030","url":null,"abstract":"","PeriodicalId":126,"journal":{"name":"Annals of Clinical and Translational Neurology","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detecting rs-fMRI Networks in Disorders of Consciousness: Improving Clinical Interpretability.","authors":"Jean Paul Medina Carrion, Mario Stanziano, Ludovico D'Incerti, Davide Sattin, Stefania Ferraro, Davide Rossi Sebastiano, Francesca Giulia Magnani, Alice Deruti, Davide Fedeli, Ludovico Minati, Francesca Epifani, Marina Grisoli, Matilde Leonardi, Maria Grazia Bruzzone, Anna Nigri, Cristina Rosazza","doi":"10.1002/acn3.70094","DOIUrl":"https://doi.org/10.1002/acn3.70094","url":null,"abstract":"<p><strong>Background: </strong>Preserved resting-state functional MRI (rs-fMRI) networks are typically observed in Disorders of Consciousness (DOC). Despite the widespread use of rs-fMRI in DOC, a systematic assessment of networks is needed to improve the interpretability of data in clinical practice. We investigated functional connectivity of the main networks, combining structural MRI to obtain a description of the most observed networks in DOC, their diagnostic ability, and whether they can be related to clinical assessment.</p><p><strong>Methods: </strong>A group of 109 chronic patients [65 vegetative state/unresponsive wakefulness state (VS/UWS), 34 minimally conscious state (MCS), and 10 emerged from MCS (eMCS)], with different etiologies, and 34 control subjects underwent multimodal assessment. Rs-fMRI data were analyzed with a semi-automatic pipeline to assess residual functional activity in terms of number, type, mean intensity, and structural preservation of networks.</p><p><strong>Results: </strong>The more networks observed, the better the patient's clinical condition is likely to be. VS/UWS patients display 0-9, MCS 5-9, and eMCS 8-10 networks. Both the presence and intensity of 5 networks (visual networks, temporal, left fronto-parietal and default mode network) are relevant to distinguish VS/UWS from MCS, with AUCs of 0.64-0.69 (95% confidence interval). Etiology and disease duration have an impact on the number and type of preserved networks. High residual functional connectivity observed in VS/UWS patients, as in MCS, is in agreement with neurophysiological and metabolic evaluations.</p><p><strong>Conclusions: </strong>This systematic assessment of the main rs-fMRI networks in DOC provides basic measures of functional connectivity that can enhance their interpretability in clinical practice.</p>","PeriodicalId":126,"journal":{"name":"Annals of Clinical and Translational Neurology","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}